Iodine deficiency

Endocrine Reviews

Volumn 30, Issue 4, 2009, Pages 376-408

  Zimmermann, Michael B ^a,b  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

IODINE; SODIUM IODIDE; THYROGLOBULIN; THYROTROPIN;

ABORTION; BODY GROWTH; CHILD DEVELOPMENT; CLINICAL TRIAL; CONGENITAL HYPOTHYROIDISM; CONGENITAL MALFORMATION; CONTROLLED CLINICAL TRIAL; COST EFFECTIVENESS ANALYSIS; DIET SUPPLEMENTATION; ENTERIC FEEDING; GOITER; GROWTH RETARDATION; HUMAN; HYPERTHYROIDISM; HYPOTHYROIDISM; INFANT MORTALITY; IODINE DEFICIENCY; LACTATION; MENTAL DISEASE; META ANALYSIS; NERVE CELL DIFFERENTIATION; PARENTERAL NUTRITION; PERINATAL MORTALITY; PREGNANCY; PREVALENCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECOMMENDED DRUG DOSE; REVIEW; SINGLE DRUG DOSE; STILLBIRTH; SYSTEMATIC REVIEW; THYROID DISEASE; THYROID WEIGHT; TOXIC GOITER;

COGNITION DISORDERS; GROWTH DISORDERS; HUMANS; IODINE; PREVALENCE; SODIUM CHLORIDE, DIETARY; THYROID DISEASES; THYROID HORMONES;

EID: 67449164619     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/er.2009-0011     Document Type: Review

References (290)

1. Baumann F 1896 Ueber das normale Vorkommen von Jod im Thierkörper. Z Physiol Chem 21:319-330
2. Marine D, Kimball OP 1917 The prevention of simple goiter in man. J Lab Clin Med 3:40-48
3. Hetzel BS 1983 Iodine deficiency disorders (IDD) and their eradication. Lancet 2:1126-1129 (Pubitemid 14245963)
4. Zimmermann MB, Jooste PL, Pandav CS 2008 The iodine deficiency disorders. Lancet 372:1251-1262
5. Goldschmidt VW 1954 Geochemistry. Oxford, UK: Oxford University Press
6. Pennington JAT, Schoen SA, Salmon GD, Young B, Johnson RD, Marts RW 1995 Composition of core foods in the U.S. food supply, 1982-1991. J Food Comp Anal 8:171-217
7. Haldimann M, Alt A, Blanc A, Blondeau K 2005 Iodine content of food groups. J Food Comp Anal 18:461-471 (Pubitemid 40277327)
8. Institute of Medicine, Academy of Sciences 2001 Dietary reference intakes for vitamin A, Vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press
9. Pearce EN, Pino S,HeX, Bazrafshan HR, Lee SL, Braverman LE 2004 Sources of dietary iodine: bread, cows' milk, and infant formula in the Boston area. J Clin Endocrinol Metab 89:3421-3424 (Pubitemid 38951914)
10. Chavasit V, Malaivongse P, Judprasong K 2002 Study on stability of iodine in iodated salt by use of different cooking model conditions. J Food Comp Anal 15:265-276 (Pubitemid 35012108)
11. Alexander WD, Harden RM, Harrison MT, Shimmins J 1967 Some aspects of the absorption and concentration of iodide by the alimentary tract in man. Proc Nutr Soc 26: 62-66
12. +/I-symporter mediates active iodide uptake in the intestine. Am J Physiol Cell Physiol 296:C654-C662
13. HaysMT,NielsenKR1994Humanthyroxine absorption: age effects and methodological analyses. Thyroid 4:55-64
14. DeGroot LJ 1966 Kinetic analysis of iodine metabolism. J Clin Endocrinol Metab 26:149-173
15. Stanbury JB, Brownell GL, Riggs DS, Perinetti H, Itoiz J, Del Castillo EB 1954 Endemic goiter. In: Stanbury JB, ed. The adaptation of man to iodine deficiency. Cambridge, MA: Harvard University Press; 1-209
16. WayneEJ, KoutrasDA,AlexanderWD1964Clinical aspects of iodine metabolism. Oxford, UK: Blackwell Scientific
17. Weaver JC, Kamm ML, Dobson RL 1960 Excretion of radioiodine in human milk. JAmMedAssoc 173:872-875
18. Fisher DA, Oddie TH 1969 Thyroid iodine content and turnover in euthyroid subjects: validity of estimation of thyroid iodine accumulation from short-term clearance studies. J Clin Endocrinol Metab 29:721-727
19. Eskandari S, LooDD,Dai G, Levy O, WrightEM,Carrasco N 1997 Thyroid Na+/I- symporter. Mechanism, stoichiometry, and specificity. J Biol Chem 272:27230-27238
20. Smanik PA, Ryu KY, Theil KS, Mazzaferri EL, Jhiang SM 1997 Expression, exon-intron organization, and chromosome mapping of the human sodium iodide symporter. Endocrinology 138:3555-3558 (Pubitemid 27345712)
21. Eng PH, Cardona GR, Fang SL, PrevitiM,Alex S, Carrasco N, Chin WW, Braverman LE 1999 Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. Endocrinology 140:3404-3410 (Pubitemid 30645394)
22. Dunn JT 1995 Thyroglobulin, hormone synthesis and thyroid disease. Eur J Endocrinol 132:603-604
23. Dunn JT, Dunn AD 2001 Update on intrathyroidal iodine metabolism. Thyroid 11:407-414 (Pubitemid 32494590)
24. Oppenheimer JH, Schwartz HL, Surks MI 1975 Determination of common parameters of iodothyronine metabolism and distribution in man by noncompartmental analysis. J Clin Endocrinol Metab 41:319-324
25. Taki K, Kogai T, Kanamoto Y, Hershman JM, Brent GA 2002 A thyroid-specific far-upstream enhancer in the human sodium/iodide symporter gene requires Pax-8 binding and cyclic adenosine 3′,5′-monophosphate response element- like sequence binding proteins for full activity and is differentially regulated in normal and thyroid cancer cells. Mol Endocrinol 16:2266-2282 (Pubitemid 35155539)
26. Abrams GM, Larsen PR 1973 Triiodothyronine and thyroxine in the serum and thyroid glands of iodine-deficient rats. J Clin Invest 52:2522-2531
27. Delange F 2000 Iodine deficiency. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's the thyroid: a fundamental and clinical text. 8th ed. Philadelphia: JD Lippincott; 295-316
28. Dumont JE, Ermans AM, Maenhaut C, Coppée F, Stanbury JB 1995 Large goitre as a maladaptation to iodine deficiency. Clin Endocrinol (Oxf) 43:1-10
29. Kopp P, Kimura ET, Aeschimann S, Oestreicher M, Tobler A, Fey MF, Studer H 1994 Polyclonal and monoclonal thyroid nodules coexist within human multinodular goiters. J Clin Endocrinol Metab 79:134-139 (Pubitemid 24221172)
30. Laurberg P, Bülow Pedersen I, Knudsen N, Ovesen L, Andersen S 2001 Environmental iodine intake affects the type of nonmalignant thyroid disease. Thyroid 11:457-469 (Pubitemid 32494595)
31. Delange F, Camus M, Ermans AM 1972 Circulating thyroid hormones in endemic goiter. J Clin Endocrinol Metab 34:891-895
32. Van Herle AJ, Hershman JM, Hornabrook RW, Chopra IJ 1976 Serum thyroglobulin in inhabitants of an endemic goiter region of New Guinea. J Clin Endocrinol Metab 43:512-516
33. Dumont JE, Ermans AM, Bastenie PA 1963 Thyroid function in a goiter endemic. V. Mechanism of thyroid failure in the Uele endemic cretins. J Clin Endocrinol Metab 23: 847-860
34. Morreale de Escobar G, Obregon MJ, Escobar del Rey F 2004 Role of thyroid hormone during early brain development. Eur J Endocrinol 151(Suppl 3):U25-U37 (Pubitemid 39627053)
35. Gaitan E 1989 Environmental goitrogenesis. Boca Raton, FL: CRC Press
36. Ermans AM, Delange F, Van der Velden M, Kinthaert J 1972 Possible role of cyanide and thiocyanate in the etiology of endemic cretinism. Adv Exp Med Biol 30:455-486
37. Laurberg P, Nøhr SB, Pedersen KM, Fuglsang E 2004 Iodine nutrition in breast-fed infants is impaired by maternal smoking. J Clin Endocrinol Metab 89:181-187 (Pubitemid 38183879)
38. Messina M, Redmond G 2006 Effects of soy protein and soybean isoflavones on thyroid function in healthy adults and hypothyroid patients: a review of the relevant literature. Thyroid 16:249-258
39. Blount BC, Pirkle JL, Osterloh JD, Valentin-Blasini L, Caldwell KL 2006 Urinary perchlorate and thyroid hormone levels in adolescent and adult men and women living in the United States. Environ Health Perspect 114:1865-1871 (Pubitemid 44873687)
40. Braverman LE, Pearce EN, He X, Pino S, Seeley M, Beck B, Magnani B, Blount BC, FirekA2006 Effects of six months of daily low-dose perchlorate exposure on thyroid function in healthy volunteers. J Clin Endocrinol Metab 91:2721-2724 (Pubitemid 44024643)
41. Zimmermann MB, Köhrle J 2002 The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health. Thyroid 12: 867-878 (Pubitemid 35332991)
42. Zimmermann MB 2006 The influence of iron status on iodine utilization and thyroid function. Ann Rev Nutr 26: 367-389
43. Zimmermann MB, Burgi H, Hurrell RF 2007 Iron deficiency predicts poor maternal thyroid status during pregnancy. J Clin Endocrinol Metab 92:3436-3440 (Pubitemid 47435316)
44. Zimmermann MB, Wegmüller R, Zeder C, Chaouki N, Torresani T 2004 The effects of vitamin A deficiency and vitaminAsupplementation on thyroid function in goitrous children. J Clin Endocrinol Metab 89:5441-5447 (Pubitemid 39518423)
45. Zimmermann MB, Jooste PL, Mabapa NS, Schoeman S, Biebinger R, Mushaphi LF, MbhenyaneX2007 VitaminA supplementation in iodine-deficient African children decreases TSH stimulation of the thyroid and reduces the goiter rate. Am J Clin Nutr 86:1040-1044 (Pubitemid 47538307)
46. Fisher DA, Oddie TH 1969 Thyroidal radioiodine clearance and thyroid iodine accumulation: contrast between random daily variation and population data. J Clin Endocrinol Metab 29:111-115
47. Teng W, Shan Z, Teng X, Guan H, Li Y, Teng D, Jin Y, Yu X, Fan C, Chong W, Yang F, Dai H, Yu Y, Li J, Chen Y, Zhao D, Shi X,HuF,MaoJ,GuX, Yang R, Tong Y, Wang W, Gao T, Li C 2006 Effect of iodine intake on thyroid diseases in China. N Engl J Med 354:2783-2793 (Pubitemid 43974196)
48. Oddie TH, Fisher DA, Long JM 1964 Factors affecting the estimation of iodine entering the normal thyroid gland using short-term clearance studies. J Clin Endocrinol Metab 24:924-933
49. Dworkin HJ, Jacquez JA, BeierwaltesWH1966 Relationship of iodine ingestion to iodine excretion in pregnancy. J Clin Endocrinol Metab 26:1329-1342
50. Harrison MT 1968 Iodine balance in man. Postgrad Med J 44:69-71
51. Harrison MT, Harden R, Alexander WD, Wayne E 1965 Iodine balance studies in patients with normal and abnormal thyroid function. J Clin Endocrinol Metab 25:1077-1084
52. Malamos B, Koutras DA, Marketos SG, Rigopoulos GA, Yataganas XA, Binopoulos D, Sfontouris J, Pharmakiotis AD, Vought RL, London WT 1967 Endemic goiter in Greece: an iodine balance study in the field. J Clin Endocrinol Metab 27:1372-1380
53. Vought RL, LondonWT1967 Iodine intake, excretion and thyroidal accumulation in healthy subjects. J Clin Endocrinol Metab 27:913-919
54. World Health Organization, United Nations Children's Fund, International Council for the Control of Iodine Deficiency Disorders 2007 Assessment of iodine deficiency disorders and monitoring their elimination. 3rd ed. Geneva: WHO
55. GlinoerD1997 The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev 18:404-433
56. Delange F 1989 Iodine nutrition and congenital hypothyroidism. In: Delange F, FisherDA,Glinoer D, eds. Research in congenital hypothyroidism. NewYork: Plenum Press; 157-161
57. Delange F, Bourdoux P, Vo Thi LD, Ermans AM, Senterre J 1984 Negative iodine balance in preterm infants. Ann Endocrinol 45:77
58. Romano R, Jannini EA, Pepe M, Grimaldi A, Olivieri M, Spennati P, Cappa F, D'Armiento M 1991 The effects of iodoprophylaxis on thyroid size during pregnancy. Am J Obstet Gynecol 164:482-485
59. PedersenKM,Laurberg P, Iversen E, Knudsen PR, Gregersen HE, Rasmussen OS, Larsen KR, EriksenGM,Johannesen PL 1993 Amelioration of some pregnancy-associated variations in thyroid function by iodine supplementation. J Clin Endocrinol Metab 77:1078-1083 (Pubitemid 23301489)
60. Glinoer D, De Nayer P, Delange F, Lemone M, Toppet V, Spehl M, Grün JP, Kinthaert J, Lejeune B 1995 A randomized trial for the treatment of mild iodine deficiency during pregnancy: maternal and neonatal effects. J Clin Endocrinol Metab 80:258-269
61. Hollowell JG, Staehling NW, Hannon WH, Flanders DW, Gunter EW, Maberly GF, Braverman LE, Pino S, Miller DT, Garbe PL, DeLozier DM, Jackson RJ 1998 Iodine nutrition in the United States. Trends and public health implications: iodine excretion data from National Health and Nutrition Examination Surveys I and III (1971-1974 and 1988-1994). J Clin Endocrinol Metab 83:3401-3408 (Pubitemid 28500863)
62. Zimmermann MB 2007 The impact of iodized salt or iodine supplements on iodine status during pregnancy, lactation and infancy. Public Health Nutr 10:1584-1595 (Pubitemid 350224316)
63. Ingenbleek Y, Malvaux P 1974 Iodine balance studies in protein-calorie malnutrition. Arch Dis Child 49:305-309
64. Malvaux P, Beckers C, De VisscherM1969 Iodine balance studies in nongoitrous children and in adolescents on low iodine intake. J Clin Endocrinol Metab 29:79-84
65. Zimmermann M, Saad A, Hess S, Torresani T, ChaoukiN 2000 Thyroid ultrasound compared with World Health Organization 1960 and 1994 palpation criteria for determination of goiter prevalence in regions of mild and severe iodine deficiency. Eur J Endocrinol 143:727-731
66. Zimmermann MB, Hess SY, Molinari L, De Benoist B, Delange F, Braverman LE, Fujieda K, Ito Y, Jooste PL, Moosa K, Pearce EN, Pretell EA, Shishiba Y 2004 New reference values for thyroid volume by ultrasound in iodine- sufficient schoolchildren: a World Health Organization/ Nutrition for Health and Development Iodine Deficiency Study Group Report. Am J Clin Nutr 79:231-237 (Pubitemid 41095975)
67. Brunn J, Block U, Ruf G, Bos I, Kunze WP, Scriba PC 1981 Volumetrie der Schilddrüsenlappen mittels Real-time- Sonographie. Dtsch Med Wochenschr 106:1338-1340 (Pubitemid 11020280)
68. Zimmermann MB, Molinari L, Spehl M, Weidinger-Toth J, Podoba J, Hess S, Delange F 2001 Toward a consensus on reference values for thyroid volume in iodine-replete schoolchildren: results of a workshop on inter-observer and inter-equipment variation in sonographic measurement of thyroid volume. Eur J Endocrinol 144:213-220 (Pubitemid 32266289)
69. Aghini-Lombardi F, Antonangeli L, Pinchera A, Leoli F, Rago T, Bartolomei AM, Vitti P 1997 Effect of iodized salt on thyroid volume of children living in an area previously characterized by moderate iodine deficiency. J Clin Endocrinol Metab 82:1136-1139 (Pubitemid 27166654)
70. Zimmermann MB, Hess SY, Adou P, Toresanni T, Wegmüller R, Hurrell RF 2003 Thyroid size and goiter prevalence after introduction of iodized salt: a 5-y prospective study in schoolchildren in Cote d'Ivoire. Am J Clin Nutr 77:663-667 (Pubitemid 36258577)
71. Yu X, Fan C, Shan Z, Teng X, Guan H, Li Y, Teng D, Jin Y, Chong W, Yang F, Dai H, Yu Y, Li J, Chen Y, Zhao D, Shi X, Hu F, Mao J, Gu X, Yang R, Tong Y, Wang W, Gao T, Li C, Teng W 2008 A five-year follow-up study of goiter and thyroid nodules in three regions with different iodine intakes in China. J Endocrinol Invest 31: 243-250 (Pubitemid 351638404)
72. Andersen S, Karmisholt J, Pedersen KM, Laurberg P 2008 Reliability of studies of iodine intake and recommendations for number of samples in groups and in individuals. Br J Nutr 99:813-818 (Pubitemid 351351635)
73. Knudsen N, Christiansen E, Brandt-Christensen M, Nygaard B, Perrild H 2000 Age- and sex-adjusted iodine/ creatinine ratio. A new standard in epidemiological surveys? Evaluation of three different estimates of iodine excretion based on casual urine samples and comparison to 24h values. Eur J Clin Nutr 54:361-363 (Pubitemid 30201458)
74. Delange F 1997 Neonatal screening for congenital hypothyroidism: results and perspectives. Horm Res 48:51-61 (Pubitemid 27331288)
75. Zimmermann MB, Aeberli I, Torresani T, Bürgi H 2005 Increasing the iodine concentration in the Swiss iodized salt program markedly improved iodine status in pregnant women and children: a 5-y prospective national study. Am J Clin Nutr 82:388-392
76. Spencer CA, Wang CC 1995 Thyroglobulin measurement. Techniques, clinical benefits, and pitfalls. Endocrinol Metab Clin North Am 24:841-863
77. Knudsen N, Bülow I, Jørgensen T, Perrild H, Ovesen L, Laurberg P 2001 Serum Tg: a sensitive marker of thyroid abnormalities and iodine deficiency in epidemiological studies. J Clin Endocrinol Metab 86:3599-3603 (Pubitemid 32755949)
78. Benmiloud M, Chaouki ML, Gutekunst R, Teichert HM, Wood WG, Dunn JT 1994 Oral iodized oil for correcting iodine deficiency: optimal dosing and outcome indicator selection. J Clin Endocrinol Metab 79:20-24 (Pubitemid 24221152)
79. Missler U, Gutekunst R,WoodWG1994 Thyroglobulin is a more sensitive indicator of iodine deficiency than thyrotropin: development and evaluation of dry blood spot assays for thyrotropin and thyroglobulin in iodine-deficient geographical areas. Eur J ClinChemClin Biochem 32:137-143 (Pubitemid 24096837)
80. Zimmermann MB, Moretti D, Chaouki N, Torresani T 2003 Development of a dried whole-blood spot thyroglobulin assay and its evaluation as an indicator of thyroid status in goitrous children receiving iodized salt.AmJ Clin Nutr 77:1453-1458
81. Zimmermann MB, de Benoist B, Corigliano S, Jooste PL, Molinari L, Moosa K, Pretell EA, Al-Dallal ZS, Wei Y, Zu-Pei C, Torresani T 2006 Assessment of iodine status using dried blood spot thyroglobulin: development of reference material and establishment of an international reference range in iodine-sufficient children. J Clin Endocrinol Metab 91:4881-4887 (Pubitemid 44917322)
82. Zimmermann MB, Moretti D, Chaouki N, Torresani T 2003 Introduction of iodized salt to severely iodine-deficient children does not provoke thyroid autoimmunity: a one-year prospective trial in northern Morocco. Thyroid 13:199-203 (Pubitemid 36596717)
83. Loviselli A, Velluzzi F, Mossa P, Cambosu MA, Secci G, Atzeni F, Taberlet A, Balestrieri A, Martino E, Grasso L, Songini M, Bottazzo GF, Mariotti S 2001 The Sardinian autoimmunity study: 3. Studies on circulating antithyroid antibodies in Sardinian schoolchildren: relationship to goiter prevalence and thyroid function. Thyroid 11:849-857
84. Mattsson S, Lindström S 1995 Diuresis and voiding pattern in healthy schoolchildren. Brit J Urol 76:783-789
85. Larsson G, VictorA1988 Micturition patterns in a healthy female population, studied with a frequency/volume chart. Scand J Urol Nephrol Suppl 114:53-57
86. Dafnis E, Sabatini S 1992 The effect of pregnancy on renal function: physiology and pathophysiology. Am J Med Sci 303:184-205
87. Aboul-Khair SA, Crooks J, Turnbull AC, Hytten FE 1964 The physiological changes in thyroid function during pregnancy. Clin Sci 27:195-207
88. Liberman CS, Pino SC, Fang SL, Braverman LE, Emerson CH 1998 Circulating iodide concentrations during and after pregnancy. J Clin Endocrinol Metab 83:3545-3549 (Pubitemid 28500887)
89. WHOSecretariat, Andersson M, de Benoist B, Delange F, Zupan J 2007 Prevention and control of iodine deficiency in pregnant and lactating women and in children less than 2-years-old: conclusions and recommendations of the technical consultation. Public Health Nutr 10:1606-1611 (Pubitemid 350224320)
90. Caldwell KL, Miller GA, Wang RY, Jain RB, Jones RL 2008 Iodine status of the U.S. population, National Health and Nutrition Examination Survey 2003-2004. Thyroid 18:1207-1214
91. Ategbo EA, Sankar R, SchultinkW,van der Haar F, Pandav CS 2008 An assessment of progress toward universal salt iodization in Rajasthan, India, using iodine nutrition indicators in school-aged children and pregnant women from the same households. Asia Pac J Clin Nutr 17:56-62
92. Gowachirapant S, Winichagoon P, Wyss L, Tong B, Baumgartner J, Melse-Boonstra A, Zimmermann MB 2009 Urinary iodine concentrations indicate iodine deficiency in pregnant Thai women but iodine sufficiency in their school-aged children. J Nutr 139:1169-1172
93. Moleti M, Lo Presti VP, Campolo MC, Mattina F, Galletti M, Mandolfino M, Violi MA, Giorgianni G, De Domenico D, Trimarchi F, Vermiglio F 2008 Iodine prophylaxis using iodized salt and risk of maternal thyroid failure in conditions of mild iodine deficiency. J Clin Endocrinol Metab 93:2616-2621 (Pubitemid 352008528)
94. Vermiglio F, Lo Presti VP, Finocchiaro MD, Battiato S, Grasso L, Ardita FV, Mancuso A, Trimarchi F 1992 Enhanced iodine concentration capacity by the mammary gland in iodine deficient lactating women of an endemic goiter region in Sicily. J Endocrinol Invest 15:137-142
95. Dorea JG 2002 Iodine nutrition and breast feeding. J Trace Elem Med Biol 16:207-220 (Pubitemid 36024950)
96. Pearce EN, Leung AM, Blount BC, Bazrafshan HR, He X, Pino S, Valentin-Blasini L, Braverman LE 2007 Breast milk iodine and perchlorate concentrations in lactating Bostonarea women. J Clin Endocrinol Metab 92:1673-1677 (Pubitemid 46997170)
97. Semba RD, Delange F 2001 Iodine in human milk: perspectives for human health. Nutr Rev 59:269-278 (Pubitemid 32757677)
98. Dorey CM, Zimmermann MB 2008 Reference values for spot urinary iodine concentrations in iodine-sufficient newborns using a new pad collection method. Thyroid 18: 347-352
99. National Research Council 1989 Recommended dietary allowances. 10th rev. ed. Washington, DC: National Academy Press; 215
100. Delange F, Heidemann P, Bourdoux P, Larsson A, Vigneri R, Klett M, Beckers C, Stubbe P 1986 Regional variations of iodine nutrition and thyroid function during the neonatal period in Europe. Biol Neonate 49:322-330 (Pubitemid 16094189)
101. Nordenberg D, Sullivan K, Maberly G, Wiley V, Wilcken B, Bamforth F, Jenkins M, Hannon H, Adam B 1993 Congenital hypothyroid screening programs and the sensitive thyrotropin assay: strategies for the surveillance of iodine deficiency disorders In: Delange F, Dunn J, Glinoer D, eds. Iodine deficiency in Europe: a continuing concern. New York: Plenum Publishing; 211-217
102. Carta Sorcini M, Diodato A, Fazzini C, Sabini G, Carta S, Grandolfo ME, Guidi M, Vasta M, Locatelli De Maestri J, Donati L 1988 Influence of environmental iodine deficiency on neonatal thyroid screening results. J Endocrinol Invest 11:309-312 (Pubitemid 18183262)
103. SullivanKM,MayW,Nordenberg D, Houston R, Maberly GF 1997 Use of thyroid stimulating hormone testing in newborns to identify iodine deficiency. J Nutr 127:55-58 (Pubitemid 27069016)
104. Copeland DL, SullivanKM,Houston R,MayW,Mendoza I, Salamatullah Q, Solomons N, Nordenberg D, Maberly GF2002 Comparison of neonatal thyroid-stimulating hormone levels and indicators of iodine deficiency in school children. Public Health Nutr 5:81-87
105. Glinoer D 2004 The regulation of thyroid function during normal pregnancy: importance of the iodine nutrition status. Best Practice Res Clin Endocrinol Metab 18:133-152 (Pubitemid 38801662)
106. Zimmermann MB 2009 Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review. Am J Clin Nutr 89:668S-672S
107. Elnagar B, Eltom A, Wide L, Gebre-Medhin M, Karlsson FA 1998 Iodine status, thyroid function and pregnancy: study of Swedish and Sudanese women. Eur J Clin Nutr 52:351-355 (Pubitemid 28230701)
108. Morreale de Escobar G, Obregon MJ, Escobar del Rey F 2004 Role of thyroid hormone during early brain development. Eur J Endocrinol 151(Suppl 3):U25-U37 (Pubitemid 39627053)
109. McCarrisonR1908 Observations on endemic cretinism in the Chitral and Gilgit Valleys. Lancet 2:1275-1280
110. Halpern JP, Boyages SC, Maberly GF, Collins JK, Eastman CJ, Morris JGL 1991 The neurology of endemic cretinism. Brain 114:825-841
111. Delange F 1974 Endemic goitre and thyroid function in Central Africa. Monographs in pediatrics. Basel, Switzerland: S. Karger; 1-171
112. Haddow JE, Palomaki GE, AllanWC,Williams JR, Knight GJ, Gagnon J, O'Heir CE, Mitchell ML, Hermos RJ, Waisbren SE, Faix JD, Klein RZ 1999 Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 341:549-555 (Pubitemid 29384162)
113. Pop VJ, Kuijpens JL, van Baar AL, Verkerk G, van Son MM, de Vijlder JJ, Vulsma T, Wiersinga WM, Drexhage HA, Vader HL 1999 Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin Endocrinol (Oxf) 50:149-155 (Pubitemid 29099999)
114. Pharoah POD, Buttfield IH, Hetzel BS 1971 Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy. Lancet 1:308-310
115. Pharoah PO, Connolly KJ 1987 A controlled trial of iodinated oil for the prevention of endemic cretinism: a long term follow up. Int J Epidemiol 16:68-73 (Pubitemid 17029832)
116. Pharoah PO, Connolly KJ 1991 Effects of maternal iodine supplementation during pregnancy. Arch Dis Child 66:145-147
117. Thilly CH, Delange F, Lagasse R, Bourdoux P, Ramioul L, Berquist H, Ermans AM 1978 Fetal hypothyroidism and maternal thyroid status in severe endemic goiter. J Clin Endocrinol Metab 47:354-360 (Pubitemid 8393534)
118. Thilly C, Lagasse R, Roger G, Bourdoux P, Ermans AM 1980 Impaired fetal and postnatal development and high perinatal death rate in a severe iodine deficient area. Thyroid Research VIII. Proc 8th International Thyroid Congress, Australian Academy of Research, Sydney, Australia, 1980, pp 20-23
119. Thilly CH, Swennen B, Moreno-Reyes R, Hindlet JY, Bourdoux P, Vanderoas JB 1994 Maternal, fetal and juvenile hypothyroidism, birthweight and infant mortality in the etiopathogenesis of the IDD spectrum in Zaire and Malawi. In: Stanbury JB, ed. The damaged brain of iodine deficiency. New York: Cognizant Communication; 241-250
120. Cao XY, Jiang XM, Dou ZH, Rakeman MA, Zhang ML, O'Donnell K, Ma T, Amette K, DeLong N, DeLong GR 1994 Timing of vulnerability of the brain to iodine deficiency in endemic cretinism. N Engl J Med 331:1739-1744
121. O'Donnell KJ, RakemanMA,Zhi-Hong D, Xue-Yi C, Mei ZY, DeLong N, Brenner G, Tai M, Dong W, DeLong GR 2002 Effects of iodine supplementation during pregnancy on child growth and development at school age. Dev Med Child Neurol 44:76-81 (Pubitemid 34168246)
122. Pretell EA, Palacios P, Tello L, Wan M, Utiger RD, Stanbury JB 1974 Iodine deficiency and the maternal/fetal relationship. In: Dunn JG, Medeiros-Neto GA, eds. Endemic goiter and cretinism. Continuing threats to world health. Pan American Health Organization Science Publication 292. Washington, DC: WHO; 143-155
123. Pretell EA, Caceres A 1994 Impairment of mental development by iodine deficiency and its correction. A retrospective view of studies in Peru. In: Stanbury JB, ed. The damaged brain of iodine deficiency. New York: Cognizant Communication; 187-191
124. Fierro-Benitez R, Cazar R, Stanbury JB, Rodriguez P, Garces F, Fierro-Renoy F, Estrella E 1988 Effects on schoolchildren of prophylaxis of mothers with iodized oil in an area of iodine deficiency. J Endocrinol Invest 11:327-335 (Pubitemid 18161614)
125. Greene LS 1994 A retrospective view of iodine deficiency, brain development and behavior from studies in Ecuador. In: Stanbury JB, ed. The damaged brain of iodine deficiency. New York: Cognizant Communication; 173-185
126. Liesenkötter KP, Göpel W, Bogner U, Stach B, Grüters A 1996 Earliest prevention of endemic goiter by iodine supplementation during pregnancy. Eur J Endocrinol 134: 443-448 (Pubitemid 26155506)
127. Nøhr SB, Jørgensen A, Pedersen KM, Laurberg P 2000 Postpartum thyroid dysfunction in pregnant thyroid peroxidase antibody-positive women living in an area with mild to moderate iodine deficiency: is iodine supplementation safe? J Clin Endocrinol Metab 85:3191-3198 (Pubitemid 30944524)
128. Antonangeli L, Maccherini D, Cavaliere R, Di Giulio C, Reinhardt B, Pinchera A, Aghini-Lombardi F 2002 Comparison of two different doses of iodide in the prevention of gestational goiter in marginal iodine deficiency: a longitudinal study. Eur J Endocrinol 147:29-34 (Pubitemid 34814736)
129. Pedersen IB, Laurberg P, Knudsen N, Jørgensen T, Perrild H, Ovesen L, Rasmussen LB 2007 An increased incidence of overt hypothyroidism after iodine fortification of salt in Denmark: a prospective population study. J Clin Endocrinol Metab 92:3122-3127 (Pubitemid 47236380)
130. Glinoer D, Lemone M, Bourdoux P, De Nayer P, DeLange F, Kinthaert J, LeJeune B 1992 Partial reversibility during late postpartum of thyroid abnormalities associated with pregnancy. J Clin Endocrinol Metab 74:453-457
131. Rotondi M, Amato G, Biondi B, Mazziotti G, Del Buono A, Rotonda Nicchio M, Balzano S, Bellastella A, Glinoer D, Carella C 2000 Parity as a thyroid size-determining factor in areas with moderate iodine deficiency. J Clin Endocrinol Metab 85:4534-4537 (Pubitemid 32157629)
132. Knudsen N, Bülow I, Laurberg P, Ovesen L, Perrild H, Jørgensen T 2002 Parity is associated with increased thyroid volume solely among smokers in an area with moderate to mild iodine deficiency. Eur J Endocrinol 146:39-43 (Pubitemid 34126417)
133. Pharoah PO, Ellis SM, Ekins RP, Williams ES 1976 Ma-ternal thyroid function, iodine deficiency and fetal development. Clin Endocrinol (Oxf) 5:159-166
134. DeLong GR, Leslie PW, Wang SH, Jiang XM, Zhang ML, Rakeman M, Jiang JY, Ma T, Cao XY 1997 Effect on infant mortality of iodination of irrigation water in a severely iodine-deficient area of China. Lancet 350:771-773 (Pubitemid 27387205)
135. Thilly CH, Swennen B, Moreno-Reyes R, Hindlet J-Y, Bourdoux P, Vanderpas JB 1994 Maternal, fetal and juvenile hypothyroidism, birth weight and infant mortality in the etiopathogenesis of the IDD spectra in Zaire and Malawi. In: JB Stanbury, ed. The damaged brain of iodine deficiency. New York: Cognizant Communication; 241-250
136. Chaouki ML, Benmiloud M 1994 Prevention of iodine deficiency disorders by oral administration of lipiodol during pregnancy. Eur J Endocrinol 130:547-551 (Pubitemid 24203406)
137. Semba RD, de Pee S, Hess SY, Sun K, Sari M, BloemMW 2008 Child malnutrition and mortality among families not utilizing adequately iodized salt in Indonesia. Am J Clin Nutr 87:438-444
138. Cobra C, Muhilal, Rusmil K, Rustama D, Djatnika, Suwardi SS, Permaesih D, Muherdiyantiningsih, Martuti S, Semba RD 1997 Infant survival is improved by oral iodine supplementation. J Nutr 127:574-578 (Pubitemid 27163622)
139. Boyages SC, Collins JK, Maberly GF, Jupp JJ, Morris J, Eastman CJ 1989 Iodine deficiency impairs intellectual and neuromotor development in apparently-normal persons. A study of rural inhabitants of north-central China. Med J Aust 150:676-682 (Pubitemid 19160827)
140. Choudhury N, Gorman KS 2003 Subclinical prenatal iodine deficiency negatively affects infant development in Northern China. J Nutr 133:3162-3165 (Pubitemid 37222234)
141. Gao TS, Teng WP, Shan ZY, Jin Y, Guan HX, Teng XC, Yang F, Wang WB, Shi XG, Tong YJ, Li D, ChenW2004 Effect of different iodine intake on schoolchildren's thyroid diseases and intelligence in rural areas. Chin Med J 117:1518-1522 (Pubitemid 39530232)
142. Amarra MS, Bongga DC, Peñano-Ho L, Cruz FB, Solis JS, Barrios EB 2007 Effect of iodine status and other nutritional factors on psychomotor and cognitive performance of Filipino schoolchildren. Food Nutr Bull 28:47-54 (Pubitemid 46510612)
143. Vermiglio F, Sidoti M, Finocchiaro MD, Battiato S, Lo Presti VP, Benvenga S, Trimarchi F 1990 Defective neuromotor and cognitive ability in iodine-deficient schoolchildren of an endemic goiter region in Sicily. J Clin Endocrinol Metab 70:379-384 (Pubitemid 20056472)
144. Fenzi GF, Giusti LF, Aghini-Lombardi F, Bartalena L, Marcocci C, Santini F, Bargagna S, Brizzolara D, Ferretti G, Falciglia G 1990 Neuropsychological assessment in schoolchildren from an area of moderate iodine deficiency. J Endocrinol Invest 13:427-431 (Pubitemid 20186191)
145. Vitti P, AghiniLombardiF, Antonangeli L,RagoT, Chiovato L, Pinchera A, MarcheschiM,Bargagna S, Bertuccelli B, Ferretti G 1992 Mild iodine deficiency in fetal/neonatal life and neuropsychological performances. Acta Med Austriaca 19(Suppl 1):57-59
146. Aghini Lombardi FA, Pinchera A, Antonangeli L, Rago T, Chiovato L, Bargagna S, Bertucelli B, Ferretti G, Sbrana B, Marcheschi M 1995 Mild iodine deficiency during fetal/ neonatal life and neuropsychological impairment in Tuscany. J Endocrinol Invest 18:57-62
147. Vermiglio F, Lo Presti VP, Moleti M, Sidoti M, Tortorella G, Scaffidi G, Castagna MG, Mattina F, Violi MA, Crisà A, Artemisia A, Trimarchi F 2004
148. Santiago-Fernandez P, Torres-Barahona R, Muela-Martínez JA, Rojo-Martínez G, García-Fuentes E, Garriga MJ, León AG, Soriguer F 2004 Intelligence quotient and iodine intake: a cross-sectional study in children. J Clin Endocrinol Metab 89:3851-3857 (Pubitemid 39071484)
149. Azizi F, Sarshar A, Nafarabadi M, Ghazi A, Kimiagar M, Noohi S, Rahbar N, Bahrami A, Kalantari S 1993 Impairment of neuromotor and cognitive development in iodinedeficient schoolchildren with normal physical growth. Acta Endocrinol (Copenh) 129:501-504 (Pubitemid 24047626)
150. Azizi F, Kalani H, Kimiagar M, Ghazi A, Sarshar A, Nafarabadi M, Rahbar N, Noohi S, Mohajer M, YassaiM 1995 Physical, neuromotor and intellectual impairment in non-cretinous schoolchildren with iodine deficiency. Int J Vitam Nutr Res 65:199-205
151. Salarkin N, Mirmiran P, Azizi F 2004 Timing of the effect of iodine supplementation on intelligence quotient of schoolchildren. Int J Endocrinol Metab 2:95-102
152. Tiwari BD, Godbole MM, Chattopadhyay N, Mandal A, Mithal A 1996 Learning disabilities and poor motivation to achieve due to prolonged iodine deficiency. Am J Clin Nutr 63:782-786 (Pubitemid 26126600)
153. Huda SN, Grantham-McGregor SM, Rahman KM, Tomkins A 1999 Biochemical hypothyroidism secondary to iodine deficiency is associated with poor school achievement and cognition in Bangladeshi children. J Nutr 129: 980-987 (Pubitemid 29214448)
154. Ojule AC, Osotimehin BO 1998 The influence of iodine deficiency on the cognitive performance of school children in Saki, south-west Nigeria. Afr J Med Sci 27:95-99
155. Sameroff AJ, Seifer R, Baldwin A, Baldwin C 1993 Stability and intelligence from preschool to adolescence: the influence of social and family risk factors. Child Dev 64: 80-97
156. Bleichrodt N, Born MP 1994 A metaanalysis of research on iodine and its relationship to cognitive development. In: Stanbury JB, ed. The damaged brain of iodine deficiency. New York: Cognizant Communications; 195-200
157. Qian M, Wang D, Watkins WE, Gebski V, Yan YQ, Li M, Chen ZP 2005 The effects of iodine on intelligence in children: a meta-analysis of studies conducted in China. Asia Pacific J Clin Nutr 14:32-42 (Pubitemid 40528373)
158. Bautista A, Barker PA, Dunn JT, Sanchez M, Kaiser DL 1982 The effects of oral iodized oil on intelligence, thyroid status, and somatic growth in school-age children from an area of endemic goiter. Am J Clin Nutr 35:127-134
159. Shrestha RM 1994 Effect of iodine and iron supplementation on physical, psychomotor and mental development in primary school children in Malawi. Doctoral thesis, Wageningen Agricultural University, Wageningen, The Netherlands
160. Huda SN, Grantham-McGregor SM, Tomkins A 2001 Cognitive and motor functions of iodine deficient but euthyroid children in Bangladesh do not benefit from iodized poppy seed oil (Lipiodol). J Nutr 131:72-77 (Pubitemid 32060625)
161. Isa ZM, Alias IZ, Kadir KA, Ali O 2000 Effect of iodized oil supplementation on thyroid hormone levels and mental performance among Orang Asli schoolchildren and pregnant mothers in an endemic goitre area in Peninsular Malaysia. Asia Pac J Clin Nutr 9:274-281
162. Zimmermann MB, Connolly K, Bozo M, Bridson J, Rohner F, Grimci L 2006 Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study.AmJ Clin Nutr 83:108-114
163. Koutras DA, Christakis G, Trichopoulos D, Dakou- Voutetaki A, Kyriakopoulos V, Fontanares P, Livadas DP, Gatsios D, Malamos B 1973 Endemic goiter in Greece: nutritional status, growth, and skeletal development of goitrous and nongoitrous populations. Am J Clin Nutr 26:1360-1368
164. Bautista A, Barker PA, Dunn JT, SanchezM1977 Lack of correlation between thyroid size and body growth in an area of endemic goiter. Am J Clin Nutr 30:275-279
165. Ali O, Tan TT, Sakinah O, Khalid BA, Wu LL, Wan Nazaimoon WM, Ng ML 1994 Thyroid function and pubertal development in malnutrition. Ann Acad Med Singapore 23:852-855
166. Neumann CG, Harrison GG 1994 Onset and evolution of stunting in infants and children. Examples from the Human Nutrition Collaborative Research Support Program. Kenya and Egypt studies. Eur J Clin Nutr 48(Suppl 1): S90-S102 (Pubitemid 24064710)
167. Lal RB, Srivastava VK, Chandra R 1996 A study of the spectrum of iodine deficiency disorders in rural area of Uttar Pradesh. Indian J Public Health 40:10-12
168. Mason JB, Deitchler M, Gilman A, Gillenwater K, Shuaib M, Hotchkiss D, Mason K, Mock N, Sethuraman K 2002 Iodine fortification is related to increased weight-for-age and birthweight in children in Asia. Food Nutr Bull 23: 292-308
169. van Stuijvenberg ME, Kvalsvig JD, Faber M, Kruger M, Kenoyer DG, Benadé AJ 1999 Effect of iron-, iodine-, and beta-carotene-fortified biscuits on the micronutrient status of primary school children: a randomized controlled trial. Am J Clin Nutr 69:497-503 (Pubitemid 29104572)
170. Rivera JA, González-Cossío T, Flores M, Romero M, Rivera M, Téllez-Rojo MM, Rosado JL, Brown KH 2001 Multiple micronutrient supplementation increases the growth of Mexican infants. Am J Clin Nutr 74:657-663 (Pubitemid 33015152)
171. Moreno-Reyes R, Mathieu F, Boelaert M, Begaux F, Suetens C, Rivera MT, Nève J, Perlmutter N, Vanderpas J 2003 Selenium and iodine supplementation of rural Tibetan children affected by Kashin-Beck osteoarthropathy. Am J Clin Nutr 78:137-144
172. Hernández-Cassis C, Cure-Cure C, López-Jaramillo P 1995 Effect of thyroid replacement therapy on the stature of Colombian children with minimal thyroid dysfunction. Eur J Clin Invest 25:454-456
173. Crew MD, Spindler SR 1986 Thyroid hormone regulation of the transvected rat growth hormone promoter. J Biol Chem 261:5018-5022 (Pubitemid 17204296)
174. Samuels MH, Wierman ME, Wang C, Ridgway EC 1989 The effect of altered thyroid status on pituitary hormone messenger ribonucleic acid concentration in the rat. Endocrinology 124:2277-2282 (Pubitemid 19132027)
175. Hochberg Z, Bick T, Harel Z 1990 Alterations of human growth hormone binding by rat liver membranes during hypo-and hyperthyroidism. Endocrinology 126:325-329 (Pubitemid 20037160)
176. Burstein PJ, Draznin B, Johnson CJ, Schalch DS 1979 The effect of hypothyroidism on growth, serum growth hormone, the growth hormone-dependent somatomedin, insulin- like growth factor, and its carrier protein in rats. Endocrinology 104:1107-1111 (Pubitemid 9179162)
177. Näntö-Salonen K, Muller HL, Hoffman AR, Vu TH, Rosenfeld RG 1993 Mechanisms of thyroid hormone action on the insulin-like growth factor system: all thyroid hormone effects are not growth hormone mediated. Endocrinology 132:781-788 (Pubitemid 23056139)
178. Miell JP, Zini M, Quin JD, Jones J, Portioli I, Valcavi R 1994 Reversible effects of cessation and recommencement of thyroxine treatment on insulin-like growth factors (IGFs) and IGF-binding proteins in patients with total thyroidectomy. J Clin Endocrinol Metab 79:1507-1512 (Pubitemid 24369874)
179. Iglesias P, Bayón C, Méndez J, Gancedo PG, Grande C, Diez JJ 2001 Serum insulin-like growth factor type 1, insulin- like growth factor-binding protein-1, and insulinlike growth factor-binding protein-3 concentrations in patients with thyroid dysfunction. Thyroid 11:1043-1048 (Pubitemid 33107917)
180. Wan Nazaimoon WM, Osman A, WuLL, Khalid BA 1996 Effects of iodine deficiency on insulin-like growth factor-I, insulin-like growth factor-binding protein-3 levels and height attainment in malnourished children. Clin Endocrinol (Oxf) 45:79-83 (Pubitemid 26248935)
181. Aydin K, Bideci A, Kendirci M, Cinaz P, Kurtoglu S 2002 Insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels of children living in an iodine- and selenium-deficient endemic goiter area. Biol Trace Elem Res 90:25-30 (Pubitemid 36110738)
182. Alikapifodlu A, Ozön A, Yordam N 2002 Serum insulinlike growth factor-I (IGF-I) and IGF-binding protein-3 levels in severe iodine deficiency. Turk J Pediatr 44:215-218
183. Ozön A, Alikapifodlu A, Yordam N 2004 Influence of iodine supplementation on serum insulin-like growth factor- I (IGF-I) and IGF-binding protein-3 (IGFBP-3) levels in severe iodine deficiency. Turk J Pediatr 46:303-308 (Pubitemid 40074033)
184. Zimmermann MB, Jooste PL, Mabapa NS, Mbhenyane X, Schoeman S, Biebinger R, Chaouki N, Bozo M, Grimci L, Bridson J 2007 Treatment of iodine deficiency in schoolage children increases IGF-1 and IGFBP-3 concentrations and improves somatic growth. J Clin Endocrinol Metab 92:437-442
185. Biondi B, Cooper DS 2008 The clinical significance of subclinical thyroid dysfunction. Endocr Rev 29:76-131 (Pubitemid 351252748)
186. Paoli-Valeri M, Guzman M, Jimenez-Lopez V, Arias- Ferreira A, Briceno-Fernandez M, Arata-Bellabarba G 2005 Atherogenic lipid profile in children with subclinical hypothyroidism. An Pediatr (Barc) 62:128-134 (Pubitemid 40461444)
187. Elnagar B, Eltom M, Karlsson FA, Ermans AM, Gebre- Medhin M, Bourdoux PP 1995 The effects of different doses of oral iodized oil on goiter size, urinary iodine, and thyroid-related hormones. J Clin Endocrinol Metab 80: 891-897
188. Rönnefarth G, Kauf E, Deschner F, Forberger M 1996 Therapy of iodine deficiency goiter in adolescents with iodine or a combination of iodine and levothyroxine with special reference to lipid parameters. Klin Padiatr 208:123-128 (Pubitemid 26176826)
189. Zimmermann MB, Aeberli I, Melse-Boonstra A, Grimci L, Bridson J, Chaouki N, Mbhenyane X, Jooste PL 2009 Iodine treatment in children with subclinical hypothyroidism due to chronic iodine deficiency decreases TSH and C-peptide concentrations and improves the lipid profile. Thyroid, in press
190. Delange F, Bürgi H, Chen ZP, Dunn JT 2002 World status of monitoring iodine deficiency disorders control programs. Thyroid 12:915-924 (Pubitemid 35332997)
191. de Benoist B, McLean E, Andersson M, Rogers L 2008 Iodine deficiency in 2007: global progress since 2003. Food Nutr Bull 29:195-202
192. Li M, Eastman CJ, Waite KV, Ma G, Zacharin MR, Topliss DJ, Harding PE, Walsh JP, Ward LC, Mortimer RH, Mackenzie EJ, Byth K, Doyle Z 2006 Are Australian children iodine deficient? Results of the Australian National Iodine Nutrition Study. Med J Aust 184:165-169 (Pubitemid 43316271)
193. UNICEF 2002 Fact sheet. IDD: achievements and challenges. Available at: http://www.unicef.org/media/14946.html
194. Ministry of Health and Family Welfare, Government of India 2007 2005-2006 National Family Health Survey (NFHS-3). New Delhi: Government of India
195. Sankar R, Pandav CS 2005 Ban on sale of non-iodized salt for human consumption: A step in the right direction. Natl Med J India 18:169-171 (Pubitemid 41448441)
196. UNICEF 2007 The State of the world's children 2007. Available at: www.unicef.org/SOWC/
197. Egbuta J, Onyezili F, Vanormelingen K 2003 Impact evaluation of efforts to eliminate iodine deficiency disorders in Nigeria. Public Health Nutr 6:169-173 (Pubitemid 36542433)
198. Okosieme OE 2006 Impact of iodination on thyroid pathology in Africa. J R Soc Med 99:396-401 (Pubitemid 44386899)
199. Walker SP, Wachs TD, Gardner JM, Lozoff B, Wasserman GA, Pollitt E, Carter JA; International Child Development Steering Group 2007 Child development: risk factors for adverse outcomes in developing countries. Lancet 369:145-157 (Pubitemid 46073134)
200. UNICEF Nutrition Section, Eastern and Southern Africa Regional Office 2007 Protecting children's brain development: a strategic review on sustained universal salt iodization in Eastern and Southern Africa. Nairobi: UNICEF; 1-40
201. DunnJT 2000 Complacency: the most dangerous enemy in the war against iodine deficiency. Thyroid 10:681-683
202. Zimmermann MB, Wegmüller R, Zeder C, Torresani T, ChaoukiN2004 Rapid relapse of thyroid dysfunction and goiter in school-age children after discontinuation of salt iodization. Am J Clin Nutr 79:642-645
203. WHO2005 The 58th World Health Assembly WHA58.24: Sustaining the elimination of iodine deficiency disorders. Available at: http://www.who.int/gb/ ebwha/pdf-files/WHA58/ WHA58-24-en.pdf.
204. Diosady LL, Alberti JO, Venkatesh Mannar MG, Stone TG 1997 Stability of iodine in iodized salt used for correction of iodine-deficiency disorders, I. Food Nutr Bull 18:388-396 (Pubitemid 28441188)
205. Diosady LL, Alberti JO, Venkatesh Mannar MG, FitzGerald S 1998 Stability of iodine in iodized salt used for correction of iodine-deficiency disorders, II. Food Nutr Bull 19:240-250 (Pubitemid 28497347)
206. Engle PL, Black MM, Behrman JR, Cabral de Mello M, Gertler PJ, Kapiriri L, Martorell R, Young ME; International Child Development Steering Group 2007 Strategies to avoid the loss of developmental potential in more than 200 million children in the developing world. Lancet 369: 229-242 (Pubitemid 46107686)
207. AguayoVM,Scott S, Ross J; PROFILES Study Group 2003 Sierra Leone-investing in nutrition to reduce poverty: a call for action. Public Health Nutr 6:653-657 (Pubitemid 37314354)
208. Caulfield LE, Richard SA, Rivera JA, Musgrove P, Black RE 2006 Stunting, wasting, and micronutrient deficiency disorders 2006. In: Dean T, Jamison DT, Breman JG, Measham AR, Alleyne G, Claeson M, Evans DB, Jha P, Mills A, Musgrove P, eds. Disease control priorities in developing countries. 2nd ed. New York: Oxford University Press; 551-568
209. Horton S 2006 The economics of food fortification. J Nutr 136:1068-1071
210. Seal JA, Doyle Z, Burgess JR, Taylor R, CameronAR2007 Iodine status of Tasmanians following voluntary fortification of bread with iodine. Med J Aust 186:69-71
211. Cao XY, Jiang XM, Kareem A, Dou ZH, Abdul Rakeman M, Zhang ML, Ma T, O'Donnell K, DeLong N, DeLong GR 1994 Iodination of irrigation water as a method of supplying iodine to a severely iodine-deficient population in Xinjiang, China. Lancet 344:107-110 (Pubitemid 24214140)
212. Squatrito S, Vigneri R, Runello F, Ermans AM, Polley RD, Ingbar SH 1986 Prevention and treatment of endemic iodine- deficiency goiter by iodination of a municipal water supply. J Clin Endocrinol Metab 63:368-375 (Pubitemid 16035683)
213. Dunn JT 2003 Iodine should be routinely added to complementary foods. J Nutr 133:3008S-3010S (Pubitemid 37099793)
214. Untoro J, Schultink W, West CE, Gross R, Hautvast JG 2006 Efficacy of oral iodized peanut oil is greater than that of iodized poppy seed oil among Indonesian schoolchildren. Am J Clin Nutr 84:1208-1214 (Pubitemid 44730394)
215. Bülow Pedersen I, Laurberg P, Knudsen N, Jørgensen T, Perrild H, Ovesen L, Rasmussen LB 2006 Increase in incidence of hyperthyroidism predominantly occurs in young people after iodine fortification of salt in Denmark. J Clin Endocrinol Metab 91:3830-3834 (Pubitemid 44536851)
216. Delange F 1996 Administration of iodized oil during pregnancy: a summary of the published evidence. Bull World Health Organ 74:101-108 (Pubitemid 26183180)
217. Todd CH, Dunn JT 1998 Intermittent oral administration of potassium iodide solution for the correction of iodine deficiency. Am J Clin Nutr 67:1279-1283 (Pubitemid 28259519)
218. Azizi F 2007 Iodine nutrition in pregnancy and lactation in Iran. Public Health Nutr 10:1596-1599 (Pubitemid 350224317)
219. Yan YQ, Chen ZP, YangXM,Liu H, Zhang JX, Zhong W, Yao W, Zhao JK, Zhang ZZ, Hua JL, Li JS, Yu XQ, Wang FR 2005 Attention to the hiding iodine deficiency in pregnant and lactating women after universal salt iodization: a multi-community study in China. J Endocrinol Invest 28: 547-553 (Pubitemid 43162889)
220. Berghout A, Wiersinga W 1998 Thyroid size and thyroid function during pregnancy: an analysis. Eur J Endocrinol 138:536-542 (Pubitemid 28238189)
221. Zimmermann M, Delange F 2004 Iodine supplementation of pregnant women in Europe: a review and recommendations. Eur J Clin Nutr 58:979-984 (Pubitemid 39077142)
222. Public Health Committee of the American Thyroid Association, Becker DV, Braverman LE, Delange F, Dunn JT, Franklyn JA, Hollowell JG, Lamm SH, Mitchell ML, Pearce E, Robbins J, Rovet JF 2006 Iodine supplementation for pregnancy and lactation-United States and Canada: recommendations of the American Thyroid Association. Thyroid 16:949-951 (Pubitemid 46141294)
223. Gushurst CA, Mueller JA, Green JA, Sedor F 1984 Breast milk iodine: reassessment in the 1980s. Pediatrics 73:354-357 (Pubitemid 14193881)
224. Pretell EA, Moncloa F, Salinas R, Kawano A, Guerra-Garcia R, Gutierrez L, Beteta L, Pretell J, WanM1969 Prophylaxis and treatment of endemic goiter in Peru with iodized oil. J Clin Endocrinol Metab 29:1586-1595
225. Nøhr SB, Laurberg P, Børlum KG, Pedersen KM, Johannesen PL, Damm P, Fuglsang E, Johansen A 1994 Iodine status in neonates in Denmark: regional variations and dependency on maternal iodine supplementation. Acta Paediatrica 83:578-582 (Pubitemid 24197610)
226. Seibold-Weiger K, Wollmann H, Rendl J, Ranke M, Speer C 1999 Iodine concentration in the breast milk of mothers of premature infants. Z Geburtshilfe Neonatol 203:81-85 (Pubitemid 29266295)
227. Delange F, Bourdoux P, Chanoine JP, Ermans AM 1988 Physiology of iodine nutrition during pregnancy, lactation, and early postnatal life. In: Berger H, ed. Vitamins and minerals in pregnancy and lactation: Nestle nutrition workshop series. New York: Vevey/Raven Press; 16:205-214
228. Ares S, Escobar-Morreale HF, Quero J, Durán S, Presas MJ, Herruzo R, Morreale de Escobar G 1997 Neonatal hypothyroxinemia: effects of iodine intake and premature birth. J Clin Endocrinol Metab 82:1704-1712 (Pubitemid 127495172)
229. Ibrahim M, de Escobar GM, Visser TJ, Durán S, van Toor H, Strachan J, Williams FL, Hume R 2003 Iodine deficiency associated with parenteral nutrition in extreme preterm infants. Arch Dis Child Fetal Neonatal Ed 88:F56-F57 (Pubitemid 36084210)
230. Ares S, Quero J, Durán S, Presas MJ, Herruzo R, Morreale de Escobar G 1994 Iodine content of infant formulas and iodine intake of premature babies: high risk of iodine deficiency. Arch Dis Child Fetal Neonatal Ed 71:F184-F191 (Pubitemid 2152616)
231. Greene HL, Hambidge KM, Schanler R, Tsang RC 1988 Guidelines for the use of vitamins, trace elements, calcium, magnesium, and phosphorus in infants and children receiving total parenteral nutrition: report of the Subcommittee on Pediatric Parenteral Nutrient Requirements from the Committee on Clinical Practice Issues of the American Society for Clinical Nutrition. Am J Clin Nutr 48:1324-1342 (Pubitemid 18271947)
232. Koletzko B, Goulet O, Hunt J, Krohn K, Shamir R; Parenteral Nutrition Guidelines Working Group; European Society for Clinical Nutrition and Metabolism; European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN); European Society of Paediatric Research (ESPR) 2005 Guidelines on Paediatric Parenteral Nutrition of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and Metabolism (ESPEN), Supported by the European Society of Paediatric Research (ESPR). J Pediatr Gastroenterol Nutr 41(Suppl 2):S1-S87
233. Moukarzel AA, Buchman AL, Salas JS, Vargas J, Guss W, Baron HI, Reyen L, Ament ME 1992 Iodine supplementation in children receiving long-term parenteral nutrition. J Pediatr 121:252-254
234. Smerdely P, Lim A, Boyages SC, Waite K,WuD, Roberts V, Leslie G, Arnold J, John E, Eastman CJ 1989 Topical iodine containing antiseptics and neonatal hypothyroidism in very-low-birthweight infants. Lancet 2:661-664 (Pubitemid 19220234)
235. Mimoz O, Villeminey S, Ragot S, Dahyot-Fizelier C, Laksiri L, Petitpas F, Debaene B 2007 Chlorhexidinebased antiseptic solution vs alcohol-based povidoneiodine for central venous catheter care. Arch Intern Med 167:2066-2072 (Pubitemid 350036705)
236. Reuss ML, Leviton A, Paneth N, Susser M 1997 Thyroxine values from newborn screening of 919 infants born before 29 weeks' gestation. Am J Public Health 87:1693-1697 (Pubitemid 27465251)
237. Lucas A, Morley R, Fewtrell MS 1996 Low triiodothyronine concentration in preterm infants and subsequent intelligence quotient (IQ) at 8 year follow up. BMJ 312:1132-1133 (Pubitemid 126447684)
238. Reuss ML, Paneth N, Pinto-Martin JA, Lorenz JM, Susser M 1996 The relation of transient hypothyroxinemia in preterm infants to neurologic development at two years of age. N Engl J Med 334:821-827 (Pubitemid 26099604)
239. Rogahn J, Ryan S, Wells J, Fraser B, Squire C, Wild N, Hughes A, Amegavie L 2000 Randomised trial of iodine intake and thyroid status in preterm infants. Arch Dis Child Fetal Neonatal Ed 83:F86-F90 (Pubitemid 30666761)
240. Ibrahim M, Sinn J, McGuire W 2006 Iodine supplementation for the prevention of mortality and adverse neurodevelopmental outcomes in preterm infants. Cochrane Database of Syst Rev 2:CD005253
241. van Wassenaer AG, Kok JH, de Vijlder JJ, Briët JM, Smit BJ, Tamminga P, van Baar A, Dekker FW, Vulsma T 1997 Effects of thyroxine supplementation on neurologic development in infants born at less than 30 weeks' gestation. N Engl J Med 336:21-26 (Pubitemid 26428283)
242. Osborn DA, Hunt RW 2007 Prophylactic postnatal thyroid hormones for prevention of morbidity and mortality in preterm infants. Cochrane Database Syst Rev 24: CD005948 (Pubitemid 351820558)
243. Cicalese MP, Assante L, Vicinanza A, Terlizzi V, Squeglia V, Bruzzese E, Guarino A, Spagnuolo MI 2008 Asking for iodine supplementation in children on parenteral nutrition. Dig Liver Dis 40:A115
244. Fresenius Kabi AG 2009 Peditrace: Bad Homburg, Germany. http://www.fresenius-kabi.com/internet/kabi/corp/ fkintpbn.nsf
245. Hopkins B 1994 Enteral nutrition products. In: Zaloga GP, ed. Nutrition in critical care. St. Louis, MO: Mosby; 439-468
246. Atkinson M, Worthley LI 2003 Nutrition in the critically ill patient: part II. Parenteral nutrition. Crit Care Resusc 5:121-136
247. Koretz RL, Lipman TO, Klein S, American Gastroenterological Association 2001 AGA technical review on parenteral nutrition. Gastroenterology 121:970-1001 (Pubitemid 32959408)
248. Grant JP 1992 Handbook of total parenteral nutrition. Philadelphia: W.B. Saunders Company; 280
249. Gough DC, Laing I, Astley P 1982 Thyroid function on short-term total parenteral nutrition without iodine supplements. JPEN J Parenter Enteral Nutr 6:439-440
250. Leung FY 1995 Trace elements in parenteral micronutrition. Clin Biochem 28:561-566
251. Navarro AM, Suen VM, Souza IM, De Oliveira JE, Marchini JS 2005 Patients with severe bowel malabsorption do not have changes in iodine status. Nutrition 21: 895-900 (Pubitemid 41188086)
252. Iodopen (Sodium Iodide Injection) 2008 APP Pharmaceuticals, Schaumburg, IL. http://www.apppharma.com/ProductDetail.aspx?Id=63&name=Iodopen-Sodium- Iodide-Injection
253. Suzuki H, Higuchi T, Sawa K, Ohtaki S, Horiuchi Y 1965 "Endemic coast goitre" in Hokkaido, Japan. Acta Endocrinol (Copenh) 50:161-176
254. Nagataki S 2008 The average of dietary iodine intake due to the ingestion of seaweeds is 1.2 mg/day in Japan. Thyroid 18:667-668 (Pubitemid 351918455)
255. Li M, Liu DR, Qu CY, Zhang PY, Qian QD, Zhang CD, JiaQZ,WangHX,Eastman CJ, BoyagesSC1987 Endemic goitre in central China caused by excessive iodine intake. Lancet 2:257-259
256. Zhao J, Chen Z, Maberly G 1998 Iodine-rich drinking water of natural origin in China. Lancet 352:2024 (Pubitemid 29000891)
257. Sigurdsson G, Franzson L 1988 Urine excretion of iodine in an Icelandic population. Icelandic Med J 74: 179-181
258. London WT, Vought RL, Brown FA 1966 Bread- dietary source of large quantities of iodine.NEngl J Med 223:338
259. Scientific Committee on Food, Health and Consumer Protection Directorate-General 2002 Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of Iodine. Brussels: European Commission
260. Pennington JA 1990 A review of iodine toxicity reports. J Am Diet Assoc 90:1571-1581 (Pubitemid 20376134)
261. Parsad D, Saini R 1998 Acneform eruption with iodized salt. Int J Dermatol 37:478 (Pubitemid 28284887)
262. Chow CC, Phillips DI, Lazarus JH, Parkes AB 1991 Effect of low dose iodide supplementation on thyroid function in potentially susceptible subjects: are dietary iodide levels in Britain acceptable? Clin Endocrinol (Oxf) 34:413-416
263. Gardner DF, Centor RM, Utiger RD 1988 Effects of low dose oral iodide supplementation on thyroid function in normal men. Clin Endocrinol (Oxf) 28:283-288 (Pubitemid 18079397)
264. Laurberg P, Pedersen KM, Vestergaard H, Sigurdsson G 1991 High incidence of multinodular toxic goitre in the elderly population in a low iodine intake area vs. high incidence of Graves' disease in the young in a high iodine intake area: comparative surveys of thyrotoxicosis epidemiology in East-Jutland Denmark and Iceland. J Intern Med 229:415-420
265. Aghini-Lombardi F, Antonangeli L, Martino E, Vitti P, Maccherini D, Leoli F, Rago T, Grasso L, Valeriano R, Balestrieri A, Pinchera A 1999 The spectrum of thyroid disorders in an iodine-deficient community: the Pescopagano survey. J Clin Endocrinol Metab 84:561-566 (Pubitemid 29075684)
266. Laurberg P, Pedersen KM, Hreidarsson A, Sigfusson N, Iversen E, Knudsen PR 1998 Iodine intake and the pattern of thyroid disorders: a comparative epidemiological study of thyroid abnormalities in the elderly in Iceland and in Jutland, Denmark. J Clin Endocrinol Metab 83: 765-769 (Pubitemid 28496981)
267. Seck T, Scheidt-Nave C, Ziegler R, Pfeilschifter J 1997 Prevalence of thyroid gland dysfunctions in 50- to 80-yearold patients. An epidemiologic cross-sectional study in a southwestern community. Med Klin (Munich) 92: 642-646
268. Hintze G, Burghardt U, Baumert J, Windeler J, Köbberling J 1991 Prevalence of thyroid dysfunction in elderly subjects from the general population in an iodine deficiency area. Aging (Milano) 3:325-331
269. Szabolcs I, Podoba J, Feldkamp J, Dohan O, Farkas I, SajgóM, Takáts KI, Góth M, Kovács L, Kressinszky K, Hnilica P, Szilágyi G 1997 Comparative screening for thyroid disorders in old age in areas of iodine deficiency, long-term iodine prophylaxis and abundant iodine intake. Clin Endocrinol (Oxf) 47:87-92 (Pubitemid 27313993)
270. Konno N, Makita H, Yuri K, Iizuka N, Kawasaki K 1994 Association between dietary iodine intake and prevalence of subclinical hypothyroidism in the coastal regions of Japan. J Clin Endocrinol Metab 78:393-397 (Pubitemid 24061759)
271. Roti E, Gardini E, Minelli R, Bianconi L, Braverman LE 1992 Prevalence of anti-thyroid peroxidase antibodies in serum in the elderly: comparison with other tests for antithyroid antibodies. Clin Chem 38:88-92
272. Ozbakir O, Dodukan A, Kelestimur F 1995 The prevalence of thyroid dysfunction among elderly subjects in an endemic goiter area of Central Anatolia. Endocr J 42:713-716
273. Nygaard B, Gideon P, Dige-Petersen H, Jespersen N, Solling K, Veje A 1993 Thyroid volume and morphology and urinary iodine excretion in a Danish municipality. Acta Endocrinol (Copenh) 129:505-510 (Pubitemid 2031547)
274. Knudsen N, Jorgensen T, Rasmussen S, Christiansen E, Perrild H 1999 The prevalence of thyroid dysfunction in a population with borderline iodine deficiency. Clin Endocrinol (Oxf) 51:361-367 (Pubitemid 29439057)
275. Knudsen N, Bülow I, Jørgensen T, Laurberg P, Ovesen L, PerrildH2000 Comparative study of thyroid function and types of thyroid dysfunction in two areas in Denmark with slightly different iodine status. Eur J Endocrinol 143:485-491 (Pubitemid 30781296)
276. Knudsen N, Bulow I, Jorgensen T, Laurberg P, Ovesen L, Perrild H 2000 Goitre prevalence and thyroid abnormalities at ultrasonography: a comparative epidemiological study in two regions with slightly different iodine status. Clin Endocrinol (Oxf) 53:479-485 (Pubitemid 30802466)
277. Tajiri J, Higashi K, Morita M, Umeda T, Sato T 1986 Studies of hypothyroidism in patients with high iodine intake. J Clin Endocrinol Metab 63:412-417 (Pubitemid 16035691)
278. Sato K, Okamura K, Hirata T, Yamasaki K, Ikenoue H, Kuroda T, Mizokami T, Inokuchi K, Fujishima M 1996 Immunological and chemical types of reversible hypothyroidism; clinical characteristics and long-term prognosis. Clin Endocrinol (Oxf) 45:519-528 (Pubitemid 26411351)
279. Safran M, Paul TL, Roti E, Braverman LE 1987 Environmental factors affecting autoimmune thyroid disease. Endocrinol Metab Clin North Am 16:327-342 (Pubitemid 18088080)
280. Harach HR, Escalante DA, Onativia A, Lederer Outes J, Saravia Day E, Williams ED 1985 Thyroid carcinoma and thyroiditis in an endemic goitre region before and after iodine prophylaxis. Acta Endocrinol (Copenh) 108:55-60 (Pubitemid 15199350)
281. Sehestedt T, Knudsen N, Perrild H, Johansen C 2006 Iodine intake and incidence of thyroid cancer in Denmark. Clin Endocrinol (Oxf) 65:229-233 (Pubitemid 44088360)
282. Feldt-Rasmussen U 2001 Iodine and cancer. Thyroid 11: 483-486 (Pubitemid 32496288)
283. Zimmermann MB, Ito Y, Hess SY, Fujieda K, Molinari L 2005 High thyroid volume in children with excess dietary iodine intakes. Am J Clin Nutr 81:840-844 (Pubitemid 41724992)
284. Roti E, Uberti ED 2001 Iodine excess and hyperthyroidism. Thyroid 11:493-500 (Pubitemid 32494598)
285. ZimmermannMB2008 Iodine requirements and the risks and benefits of correcting iodine deficiency in populations. J Trace Elem Med Biol 22:81-92
286. Bourdoux PP, Ermans AM, Mukalay wa Mukalay A, Filetti S, Vigneri R 1996 Iodine-induced thyrotoxicosis in Kivu, Zaire. Lancet 347:552-553 (Pubitemid 26061637)
287. Todd CH, Allain T, Gomo ZA, Hasler JA, Ndiweni M, Oken E 1995 Increase in thyrotoxicosis associated with iodine supplements in Zimbabwe. Lancet 346: 1563-1564
288. Delange F, de Benoist B, Alnwick D 1999 Risks of iodineinduced hyperthyroidism after correction of iodine deficiency by iodized salt. Thyroid 9:545-556 (Pubitemid 29296116)
289. Bürgi H, Kohler M, Morselli B 1998 Thyrotoxicosis incidence in Switzerland and benefit of improved iodine supply. Lancet 352:1034 (Pubitemid 28438580)
290. Yang F, Shan Z, Teng X, Li Y, Guan H, Chong W, Teng D, Yu X, Fan C, Dai H, Yu Y, Yang R, Li J, Chen Y, Zhao D, Mao J, TengW2007 Chronic iodine excess does not increase the incidence of hyperthyroidism: a prospective community-based epidemiological survey in China. Eur J Endocrinol 156:403-408 (Pubitemid 46672640)