-
1
-
-
84975478637
-
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
-
Kennedy BK, Lamming DW: The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging. Cell Metab. 2016; 23(6): 990-1003.
-
(2016)
Cell Metab
, vol.23
, Issue.6
, pp. 990-1003
-
-
Kennedy, B.K.1
Lamming, D.W.2
-
2
-
-
84894523716
-
Making new contacts: the mTOR network in metabolism and signalling crosstalk
-
Shimobayashi M, Hall MN: Making new contacts: the mTOR network in metabolism and signalling crosstalk. Nat Rev Mol Cell Biol. 2014; 15(3): 155-62.
-
(2014)
Nat Rev Mol Cell Biol
, vol.15
, Issue.3
, pp. 155-162
-
-
Shimobayashi, M.1
Hall, M.N.2
-
3
-
-
84920504512
-
mTOR: a pharmacologic target for autophagy regulation
-
Kim YC, Guan KL: mTOR: a pharmacologic target for autophagy regulation. J Clin Invest. 2015; 125(1): 25-32.
-
(2015)
J Clin Invest
, vol.125
, Issue.1
, pp. 25-32
-
-
Kim, Y.C.1
Guan, K.L.2
-
5
-
-
78650510609
-
mTOR: from growth signal integration to cancer, diabetes and ageing
-
Zoncu R, Efeyan A, Sabatini DM: mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol. 2011; 12(1): 21-35.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, Issue.1
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
7
-
-
0030881836
-
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
-
Brunn GJ, Hudson CC, Sekulic A, et al.: Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science. 1997; 277(5322): 99-101.
-
(1997)
Science
, vol.277
, Issue.5322
, pp. 99-101
-
-
Brunn, G.J.1
Hudson, C.C.2
Sekulic, A.3
-
8
-
-
84947292931
-
Signalling to eIF4E in cancer
-
Siddiqui N, Sonenberg N: Signalling to eIF4E in cancer. Biochem Soc Trans. 2015; 43(5): 763-72.
-
(2015)
Biochem Soc Trans
, vol.43
, Issue.5
, pp. 763-772
-
-
Siddiqui, N.1
Sonenberg, N.2
-
9
-
-
79953183694
-
Differing effects of rapamycin and mTOR kinase inhibitors on protein synthesis
-
Huo Y, Iadevaia V, Proud CG: Differing effects of rapamycin and mTOR kinase inhibitors on protein synthesis. Biochem Soc Trans. 2011; 39(2): 446-50.
-
(2011)
Biochem Soc Trans
, vol.39
, Issue.2
, pp. 446-450
-
-
Huo, Y.1
Iadevaia, V.2
Proud, C.G.3
-
10
-
-
84863045210
-
Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis
-
Iadevaia V, Huo Y, Zhang Z, et al.: Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis. Biochem Soc Trans. 2012; 40(1): 168-72.
-
(2012)
Biochem Soc Trans
, vol.40
, Issue.1
, pp. 168-172
-
-
Iadevaia, V.1
Huo, Y.2
Zhang, Z.3
-
12
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, et al.: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 2005; 307(5712): 1098-101.
-
(2005)
Science
, vol.307
, Issue.5712
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
-
13
-
-
84878796897
-
Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2
-
Humphrey SJ, Yang G, Yang P, et al.: Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2. Cell Metab. 2013; 17(6): 1009-20.
-
(2013)
Cell Metab
, vol.17
, Issue.6
, pp. 1009-1020
-
-
Humphrey, S.J.1
Yang, G.2
Yang, P.3
-
14
-
-
68749116494
-
Hengstschlager M. Functional interaction of mammalian target of rapamycin complexes in regulating mammalian cell size and cell cycle
-
Rosner M, Fuchs C, Siegel N, et al.: Hengstschlager M. Functional interaction of mammalian target of rapamycin complexes in regulating mammalian cell size and cell cycle. Hum Mol Genet. 2009; 18(17): 3298-310.
-
(2009)
Hum Mol Genet
, vol.18
, Issue.17
, pp. 3298-3310
-
-
Rosner, M.1
Fuchs, C.2
Siegel, N.3
-
15
-
-
84947023702
-
A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation
-
Yang G, Murashige DS, Humphrey SJ, et al.: A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation. Cell Rep. 2015; 12(6): 937-43.
-
(2015)
Cell Rep
, vol.12
, Issue.6
, pp. 937-943
-
-
Yang, G.1
Murashige, D.S.2
Humphrey, S.J.3
-
16
-
-
79960716001
-
Akt signalling in health and disease
-
Hers I, Vincent EE, Tavaré JM: Akt signalling in health and disease. Cell Signal. 2011; 23(10): 1515-27.
-
(2011)
Cell Signal
, vol.23
, Issue.10
, pp. 1515-1527
-
-
Hers, I.1
Vincent, E.E.2
Tavaré, J.M.3
-
17
-
-
84946231699
-
The SIN1-PH Domain Connects mTORC2 to PI3K
-
Yuan HX, Guan KL: The SIN1-PH Domain Connects mTORC2 to PI3K. Cancer Discov. 2015; 5(11): 1127-9.
-
(2015)
Cancer Discov
, vol.5
, Issue.11
, pp. 1127-1129
-
-
Yuan, H.X.1
Guan, K.L.2
-
18
-
-
78651330430
-
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
-
Forbes SA, Bindal N, Bamford S, et al.: COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res. 2011; 39(Database issue): D945-50.
-
(2011)
Nucleic Acids Res
, vol.39
, Issue.DATABASE ISSUE
, pp. D945-D950
-
-
Forbes, S.A.1
Bindal, N.2
Bamford, S.3
-
19
-
-
56249147509
-
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
-
Choo AY, Yoon SO, Kim SG, et al.: Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc Natl Acad Sci U S A. 2008; 105(45): 17414-9.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.45
, pp. 17414-17419
-
-
Choo, A.Y.1
Yoon, S.O.2
Kim, S.G.3
-
20
-
-
77953091045
-
Structure of the human mTOR complex I and its implications for rapamycin inhibition
-
Yip CK, Murata K, Walz T, et al.: Structure of the human mTOR complex I and its implications for rapamycin inhibition. Mol Cell. 2010; 38(5): 768-74.
-
(2010)
Mol Cell
, vol.38
, Issue.5
, pp. 768-774
-
-
Yip, C.K.1
Murata, K.2
Walz, T.3
-
21
-
-
84952950121
-
Architecture of human mTOR complex 1
-
Aylett CH, Sauer E, Imseng S, et al.: Architecture of human mTOR complex 1. Science. 2016; 351(6268): 48-52.
-
(2016)
Science
, vol.351
, Issue.6268
, pp. 48-52
-
-
Aylett, C.H.1
Sauer, E.2
Imseng, S.3
-
22
-
-
84960117201
-
Structural insights of mTOR complex 1
-
Yuan HX, Guan KL: Structural insights of mTOR complex 1. Cell Res. 2016; 26(3): 267-8.
-
(2016)
Cell Res
, vol.26
, Issue.3
, pp. 267-268
-
-
Yuan, H.X.1
Guan, K.L.2
-
23
-
-
77952967459
-
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs
-
Dowling RJ, Topisirovic I, Alain T, et al.: mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science. 2010; 328(5982): 1172-6.
-
(2010)
Science
, vol.328
, Issue.5982
, pp. 1172-1176
-
-
Dowling, R.J.1
Topisirovic, I.2
Alain, T.3
-
24
-
-
62049084546
-
Rapamycin induces transactivation of the EGFR and increases cell survival
-
Chaturvedi D, Gao X, Cohen MS, et al.: Rapamycin induces transactivation of the EGFR and increases cell survival. Oncogene. 2009; 28(9): 1187-96.
-
(2009)
Oncogene
, vol.28
, Issue.9
, pp. 1187-1196
-
-
Chaturvedi, D.1
Gao, X.2
Cohen, M.S.3
-
25
-
-
80655126355
-
mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling
-
Rodrik-Outmezguine VS, Chandarlapaty S, Pagano NC, et al.: mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling. Cancer Discov. 2011; 1(3): 248-59.
-
(2011)
Cancer Discov
, vol.1
, Issue.3
, pp. 248-259
-
-
Rodrik-Outmezguine, V.S.1
Chandarlapaty, S.2
Pagano, N.C.3
-
26
-
-
84896692038
-
Rapamycin: one drug, many effects
-
Li J, Kim SG, Blenis J: Rapamycin: one drug, many effects. Cell Metab. 2014; 19(3): 373-9.
-
(2014)
Cell Metab
, vol.19
, Issue.3
, pp. 373-379
-
-
Li, J.1
Kim, S.G.2
Blenis, J.3
-
27
-
-
84959520989
-
Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases
-
Liu R, Proud CG: Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases. Acta Pharmacol Sin. 2016; 37(3): 285-94.
-
(2016)
Acta Pharmacol Sin
, vol.37
, Issue.3
, pp. 285-294
-
-
Liu, R.1
Proud, C.G.2
-
28
-
-
67650228579
-
Rapamycin inhibits mTORC1, but not completely
-
Thoreen CC, Sabatini DM: Rapamycin inhibits mTORC1, but not completely. Autophagy. 2009; 5(5): 725-6.
-
(2009)
Autophagy
, vol.5
, Issue.5
, pp. 725-726
-
-
Thoreen, C.C.1
Sabatini, D.M.2
-
29
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov DD, Ali SM, Sengupta S, et al.: Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell. 2006; 22(2): 159-68.
-
(2006)
Mol Cell
, vol.22
, Issue.2
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
-
30
-
-
75749105049
-
mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling
-
Julien LA, Carriere A, Moreau J, et al.: mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol Cell Biol. 2010; 30(4): 908-21.
-
(2010)
Mol Cell Biol
, vol.30
, Issue.4
, pp. 908-921
-
-
Julien, L.A.1
Carriere, A.2
Moreau, J.3
-
31
-
-
84929209716
-
Signaling crosstalk between the mTOR complexes
-
Xie J, Proud CG: Signaling crosstalk between the mTOR complexes. Translation (Austin). 2014; 2(1): e28174.
-
(2014)
Translation (Austin)
, vol.2
, Issue.1
-
-
Xie, J.1
Proud, C.G.2
-
32
-
-
0030832514
-
SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo
-
Schuler W, Sedrani R, Cottens S, et al.: SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo. Transplantation. 1997; 64(1): 36-42.
-
(1997)
Transplantation
, vol.64
, Issue.1
, pp. 36-42
-
-
Schuler, W.1
Sedrani, R.2
Cottens, S.3
-
33
-
-
0030814696
-
SDZ RAD, a new rapamycin derivative: synergism with cyclosporine
-
Schuurman HJ, Cottens S, Fuchs S, et al.: SDZ RAD, a new rapamycin derivative: synergism with cyclosporine. Transplantation. 1997; 64(1): 32-5.
-
(1997)
Transplantation
, vol.64
, Issue.1
, pp. 32-35
-
-
Schuurman, H.J.1
Cottens, S.2
Fuchs, S.3
-
34
-
-
67651155960
-
Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
-
Raynaud FI, Eccles SA, Patel S, et al.: Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941. Mol Cancer Ther. 2009; 8(7): 1725-38.
-
(2009)
Mol Cancer Ther
, vol.8
, Issue.7
, pp. 1725-1738
-
-
Raynaud, F.I.1
Eccles, S.A.2
Patel, S.3
-
35
-
-
51049109033
-
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
-
Maira S, Stauffer F, Brueggen J, et al.: Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther. 2008; 7(7): 1851-63.
-
(2008)
Mol Cancer Ther
, vol.7
, Issue.7
, pp. 1851-1863
-
-
Maira, S.1
Stauffer, F.2
Brueggen, J.3
-
36
-
-
78650322376
-
Vertical targeting of the phosphatidylinositol-3 kinase pathway as a strategy for treating melanoma
-
Aziz SA, Jilaveanu LB, Zito C, et al.: Vertical targeting of the phosphatidylinositol-3 kinase pathway as a strategy for treating melanoma. Clin Cancer Res. 2010; 16(24): 6029-39.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.24
, pp. 6029-6039
-
-
Aziz, S.A.1
Jilaveanu, L.B.2
Zito, C.3
-
37
-
-
57349194139
-
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
-
Engelman JA, Chen L, Tan X, et al.: Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med. 2008; 14(12): 1351-6.
-
(2008)
Nat Med
, vol.14
, Issue.12
, pp. 1351-1356
-
-
Engelman, J.A.1
Chen, L.2
Tan, X.3
-
38
-
-
77954638677
-
Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin
-
Knight SD, Adams ND, Burgess JL, et al.: Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin. ACS Med Chem Lett. 2010; 1(1): 39-43.
-
(2010)
ACS Med Chem Lett
, vol.1
, Issue.1
, pp. 39-43
-
-
Knight, S.D.1
Adams, N.D.2
Burgess, J.L.3
-
39
-
-
84899711229
-
Characterization of the activity of the PI3K/mTOR inhibitor XL765 (SAR245409) in tumor models with diverse genetic alterations affecting the PI3K pathway
-
Yu P, Laird AD, Du X, et al.: Characterization of the activity of the PI3K/mTOR inhibitor XL765 (SAR245409) in tumor models with diverse genetic alterations affecting the PI3K pathway. Mol Cancer Ther. 2014; 13(5): 1078-91.
-
(2014)
Mol Cancer Ther
, vol.13
, Issue.5
, pp. 1078-1091
-
-
Yu, P.1
Laird, A.D.2
Du, X.3
-
40
-
-
39149123820
-
A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity
-
Garlich JR, De P, Dey N, et al.: A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity. Cancer Res. 2008; 68(1): 206-15.
-
(2008)
Cancer Res
, vol.68
, Issue.1
, pp. 206-215
-
-
Garlich, J.R.1
De, P.2
Dey, N.3
-
41
-
-
54249162351
-
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
-
Apsel B, Blair JA, Gonzalez B, et al.: Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008; 4(11): 691-9.
-
(2008)
Nat Chem Biol
, vol.4
, Issue.11
, pp. 691-699
-
-
Apsel, B.1
Blair, J.A.2
Gonzalez, B.3
-
42
-
-
61349141302
-
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
-
Feldman ME, Apsel B, Uotila A, et al.: Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 2009; 7(2): e38.
-
(2009)
PLoS Biol
, vol.7
, Issue.2
-
-
Feldman, M.E.1
Apsel, B.2
Uotila, A.3
-
43
-
-
77649286736
-
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBPeIF4E
-
Hsieh AC, Costa M, Zollo O, et al.: Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBPeIF4E. Cancer Cell. 2010; 17(3): 249-61.
-
(2010)
Cancer Cell
, vol.17
, Issue.3
, pp. 249-261
-
-
Hsieh, A.C.1
Costa, M.2
Zollo, O.3
-
44
-
-
84862777192
-
The translational landscape of mTOR signalling steers cancer initiation and metastasis
-
Hsieh AC, Liu Y, Edlind MP, et al.: The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 2012; 485(7396): 55-61.
-
(2012)
Nature
, vol.485
, Issue.7396
, pp. 55-61
-
-
Hsieh, A.C.1
Liu, Y.2
Edlind, M.P.3
-
45
-
-
65549145048
-
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
-
Thoreen CC, Kang SA, Chang JW, et al.: An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem. 2009; 284(12): 8023-32.
-
(2009)
J Biol Chem
, vol.284
, Issue.12
, pp. 8023-8032
-
-
Thoreen, C.C.1
Kang, S.A.2
Chang, J.W.3
-
46
-
-
84876950862
-
Characterization of Torin2, an ATPcompetitive inhibitor of mTOR, ATM, and ATR
-
Liu Q, Xu C, Kirubakaran S, et al.: Characterization of Torin2, an ATPcompetitive inhibitor of mTOR, ATM, and ATR. Cancer Res. 2013; 73(8): 2574-86.
-
(2013)
Cancer Res
, vol.73
, Issue.8
, pp. 2574-2586
-
-
Liu, Q.1
Xu, C.2
Kirubakaran, S.3
-
47
-
-
67650312583
-
Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
-
García-Martínez JM, Moran J, Clarke RG, et al.: Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem J. 2009; 421(1): 29-42.
-
(2009)
Biochem J
, vol.421
, Issue.1
, pp. 29-42
-
-
García-Martínez, J.M.1
Moran, J.2
Clarke, R.G.3
-
48
-
-
70349256453
-
The discovery and optimisation of pyrido[2, 3-d]pyrimidine-2, 4-diamines as potent and selective inhibitors of mTOR kinase
-
Malagu K, Duggan H, Menear K, et al.: The discovery and optimisation of pyrido[2, 3-d]pyrimidine-2, 4-diamines as potent and selective inhibitors of mTOR kinase. Bioorg Med Chem Lett. 2009; 19(20): 5950-3.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, Issue.20
, pp. 5950-5953
-
-
Malagu, K.1
Duggan, H.2
Menear, K.3
-
49
-
-
68049137608
-
Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin
-
Yu K, Toral-Barza L, Shi C, et al.: Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009; 69(15): 6232-40.
-
(2009)
Cancer Res
, vol.69
, Issue.15
, pp. 6232-6240
-
-
Yu, K.1
Toral-Barza, L.2
Shi, C.3
-
50
-
-
75149112670
-
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
-
Chresta CM, Davies BR, Hickson I, et al.: AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. Cancer Res. 2010; 70(1): 288-98.
-
(2010)
Cancer Res
, vol.70
, Issue.1
, pp. 288-298
-
-
Chresta, C.M.1
Davies, B.R.2
Hickson, I.3
-
51
-
-
84873731572
-
Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014
-
Pike KG, Malagu K, Hummersone MG, et al.: Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014. Bioorg Med Chem Lett. 2013; 23(5): 1212-6.
-
(2013)
Bioorg Med Chem Lett
, vol.23
, Issue.5
, pp. 1212-1216
-
-
Pike, K.G.1
Malagu, K.2
Hummersone, M.G.3
-
52
-
-
0034721255
-
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
-
Shapiro AM, Lakey JR, Ryan EA, et al.: Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000; 343(4): 230-8.
-
(2000)
N Engl J Med
, vol.343
, Issue.4
, pp. 230-238
-
-
Shapiro, A.M.1
Lakey, J.R.2
Ryan, E.A.3
-
53
-
-
21344462346
-
Five-year follow-up after clinical islet transplantation
-
Ryan EA, Paty BW, Senior PA, et al.: Five-year follow-up after clinical islet transplantation. Diabetes. 2005; 54(7): 2060-9.
-
(2005)
Diabetes
, vol.54
, Issue.7
, pp. 2060-2069
-
-
Ryan, E.A.1
Paty, B.W.2
Senior, P.A.3
-
54
-
-
10744228630
-
Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets
-
Bell E, Cao X, Moibi JA, et al.: Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets. Diabetes. 2003; 52(11): 2731-9.
-
(2003)
Diabetes
, vol.52
, Issue.11
, pp. 2731-2739
-
-
Bell, E.1
Cao, X.2
Moibi, J.A.3
-
55
-
-
33750583959
-
Sirolimus is associated with reduced islet engraftment and impaired beta-cell function
-
Zhang N, Su D, Qu S, et al.: Sirolimus is associated with reduced islet engraftment and impaired beta-cell function. Diabetes. 2006; 55(9): 2429-36.
-
(2006)
Diabetes
, vol.55
, Issue.9
, pp. 2429-2436
-
-
Zhang, N.1
Su, D.2
Qu, S.3
-
56
-
-
84862528153
-
Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)
-
Barlow AD, Xie J, Moore CE, et al.: Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2). Diabetologia. 2012; 55(5): 1355-65.
-
(2012)
Diabetologia
, vol.55
, Issue.5
, pp. 1355-1365
-
-
Barlow, A.D.1
Xie, J.2
Moore, C.E.3
-
57
-
-
81155132211
-
Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and down-regulation of p62/sequestosome 1
-
Huang S, Yang ZJ, Yu C, et al.: Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and down-regulation of p62/sequestosome 1. J Biol Chem. 2011; 286(46): 40002-12.
-
(2011)
J Biol Chem
, vol.286
, Issue.46
, pp. 40002-40012
-
-
Huang, S.1
Yang, Z.J.2
Yu, C.3
-
58
-
-
84862012594
-
The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia
-
Willems L, Chapuis N, Puissant A, et al.: The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia. Leukemia. 2012; 26(6): 1195-202.
-
(2012)
Leukemia
, vol.26
, Issue.6
, pp. 1195-1202
-
-
Willems, L.1
Chapuis, N.2
Puissant, A.3
-
59
-
-
79955398591
-
Otto Warburg's contributions to current concepts of cancer metabolism
-
Koppenol WH, Bounds PL, Dang CV: Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer. 2011; 11(5): 325-37.
-
(2011)
Nat Rev Cancer
, vol.11
, Issue.5
, pp. 325-337
-
-
Koppenol, W.H.1
Bounds, P.L.2
Dang, C.V.3
-
60
-
-
84871233832
-
eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies
-
Alain T, Morita M, Fonseca BD, et al.: eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies. Cancer Res. 2012; 72(24): 6468-76.
-
(2012)
Cancer Res
, vol.72
, Issue.24
, pp. 6468-6476
-
-
Alain, T.1
Morita, M.2
Fonseca, B.D.3
-
61
-
-
84894136566
-
Targeting eukaryotic translation in mesothelioma cells with an eIF4E-specific antisense oligonucleotide
-
Jacobson BA, Thumma SC, Jay-Dixon J, et al.: Targeting eukaryotic translation in mesothelioma cells with an eIF4E-specific antisense oligonucleotide. PLoS One. 2013; 8(11): e81669.
-
(2013)
PLoS One
, vol.8
, Issue.11
-
-
Jacobson, B.A.1
Thumma, S.C.2
Jay-Dixon, J.3
-
62
-
-
33846449110
-
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G
-
Moerke NJ, Aktas H, Chen H, et al.: Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell. 2007; 128(2): 257-67.
-
(2007)
Cell
, vol.128
, Issue.2
, pp. 257-267
-
-
Moerke, N.J.1
Aktas, H.2
Chen, H.3
-
63
-
-
59749098906
-
mTORC1 signalling and mRNA translation
-
Proud CG: mTORC1 signalling and mRNA translation. Biochem Soc Trans. 2009; 37(Pt 1): 227-31.
-
(2009)
Biochem Soc Trans
, vol.37
, pp. 227-231
-
-
Proud, C.G.1
-
64
-
-
84555189440
-
Regulation and function of the RSK family of protein kinases
-
Romeo Y, Zhang X, Roux PP: Regulation and function of the RSK family of protein kinases. Biochem J. 2012; 441(12): 553-69.
-
(2012)
Biochem J
, vol.441
, Issue.12
, pp. 553-569
-
-
Romeo, Y.1
Zhang, X.2
Roux, P.P.3
-
65
-
-
0032843917
-
Drosophila S6 kinase: a regulator of cell size
-
Montagne J, Stewart MJ, Stocker H, et al.: Drosophila S6 kinase: a regulator of cell size. Science. 1999; 285(5436): 2126-9.
-
(1999)
Science
, vol.285
, Issue.5436
, pp. 2126-2129
-
-
Montagne, J.1
Stewart, M.J.2
Stocker, H.3
-
66
-
-
0032538890
-
Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase
-
Shima H, Pende M, Chen Y, et al.: Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J. 1998; 17(22): 6649-59.
-
(1998)
EMBO J
, vol.17
, Issue.22
, pp. 6649-6659
-
-
Shima, H.1
Pende, M.2
Chen, Y.3
-
67
-
-
84896629473
-
Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program
-
Chauvin C, Koka V, Nouschi A, et al.: Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program. Oncogene. 2014; 33(4): 474-83.
-
(2014)
Oncogene
, vol.33
, Issue.4
, pp. 474-483
-
-
Chauvin, C.1
Koka, V.2
Nouschi, A.3
-
68
-
-
0242637318
-
mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF
-
Hannan KM, Brandenburger Y, Jenkins A, et al.: mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. Mol Cell Biol. 2003; 23(23): 8862-77.
-
(2003)
Mol Cell Biol
, vol.23
, Issue.23
, pp. 8862-8877
-
-
Hannan, K.M.1
Brandenburger, Y.2
Jenkins, A.3
-
69
-
-
84912533536
-
mTORC1 signaling controls multiple steps in ribosome biogenesis
-
Iadevaia V, Liu R, Proud CG: mTORC1 signaling controls multiple steps in ribosome biogenesis. Semin Cell Dev Biol. 2014; 36: 113-20.
-
(2014)
Semin Cell Dev Biol
, vol.36
, pp. 113-120
-
-
Iadevaia, V.1
Liu, R.2
Proud, C.G.3
-
70
-
-
84863736613
-
Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53
-
Bywater MJ, Poortinga G, Sanij E, et al.: Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53. Cancer Cell. 2012; 22(1): 51-65.
-
(2012)
Cancer Cell
, vol.22
, Issue.1
, pp. 51-65
-
-
Bywater, M.J.1
Poortinga, G.2
Sanij, E.3
-
71
-
-
84954064847
-
Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma
-
Devlin JR, Hannan KM, Hein N, et al.: Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma. Cancer Discov. 2016; 6(1): 59-70.
-
(2016)
Cancer Discov
, vol.6
, Issue.1
, pp. 59-70
-
-
Devlin, J.R.1
Hannan, K.M.2
Hein, N.3
-
72
-
-
84938570135
-
Point mutations of the mTOR-RHEB pathway in renal cell carcinoma
-
Ghosh AP, Marshall CB, Coric T, et al.: Point mutations of the mTOR-RHEB pathway in renal cell carcinoma. Oncotarget. 2015; 6(20): 17895-910.
-
(2015)
Oncotarget
, vol.6
, Issue.20
, pp. 17895-17910
-
-
Ghosh, A.P.1
Marshall, C.B.2
Coric, T.3
-
73
-
-
84899678098
-
A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity
-
Grabiner BC, Nardi V, Birsoy K, et al.: A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discov. 2014; 4(5): 554-63.
-
(2014)
Cancer Discov
, vol.4
, Issue.5
, pp. 554-563
-
-
Grabiner, B.C.1
Nardi, V.2
Birsoy, K.3
-
74
-
-
84969872786
-
Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor
-
Rodrik-Outmezguine VS, Okaniwa M, Yao Z, et al.: Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor. Nature. 2016; 534(7606): 272-6.
-
(2016)
Nature
, vol.534
, Issue.7606
, pp. 272-276
-
-
Rodrik-Outmezguine, V.S.1
Okaniwa, M.2
Yao, Z.3
-
75
-
-
77952243626
-
Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer
-
Sato T, Nakashima A, Guo L, et al.: Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer. Oncogene. 2010; 29(18): 2746-52.
-
(2010)
Oncogene
, vol.29
, Issue.18
, pp. 2746-2752
-
-
Sato, T.1
Nakashima, A.2
Guo, L.3
-
76
-
-
84899680978
-
Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib
-
Wagle N, Grabiner BC, van Allen EM, et al.: Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib. Cancer Discov. 2014; 4(5): 546-53.
-
(2014)
Cancer Discov
, vol.4
, Issue.5
, pp. 546-553
-
-
Wagle, N.1
Grabiner, B.C.2
van Allen, E.M.3
-
77
-
-
0018101547
-
Rapamycin (AY-22, 989), a new antifungal antibiotic. III. In vitro and in vivo evaluation
-
Baker H, Sidorowicz A, Sehgal SN, et al.: Rapamycin (AY-22, 989), a new antifungal antibiotic. III. In vitro and in vivo evaluation. J Antibiot (Tokyo). 1978; 31(6): 539-45.
-
(1978)
J Antibiot (Tokyo)
, vol.31
, Issue.6
, pp. 539-545
-
-
Baker, H.1
Sidorowicz, A.2
Sehgal, S.N.3
-
78
-
-
0016713286
-
Rapamycin (AY-22, 989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
-
Sehgal SN, Baker H, Vézina C: Rapamycin (AY-22, 989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J Antibiot (Tokyo). 1975; 28(10): 727-32.
-
(1975)
J Antibiot (Tokyo)
, vol.28
, Issue.10
, pp. 727-732
-
-
Sehgal, S.N.1
Baker, H.2
Vézina, C.3
-
79
-
-
0018606537
-
Rapamycin (AY-22, 989), a new antifungal antibiotic. IV. Mechanism of action
-
Singh K, Sun S, Vézina C: Rapamycin (AY-22, 989), a new antifungal antibiotic. IV. Mechanism of action. J Antibiot (Tokyo). 1979; 32(6): 630-45.
-
(1979)
J Antibiot (Tokyo)
, vol.32
, Issue.6
, pp. 630-645
-
-
Singh, K.1
Sun, S.2
Vézina, C.3
-
80
-
-
0016724057
-
Rapamycin (AY-22, 989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
-
Vézina C, Kudelski A, Sehgal SN: Rapamycin (AY-22, 989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo). 1975; 28(10): 721-6.
-
(1975)
J Antibiot (Tokyo)
, vol.28
, Issue.10
, pp. 721-726
-
-
Vézina, C.1
Kudelski, A.2
Sehgal, S.N.3
-
81
-
-
0035866358
-
Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy
-
Geoerger B, Kerr K, Tang CB, et al.: Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy. Cancer Res. 2001; 61(4): 1527-32.
-
(2001)
Cancer Res
, vol.61
, Issue.4
, pp. 1527-1532
-
-
Geoerger, B.1
Kerr, K.2
Tang, C.B.3
-
82
-
-
77955443001
-
Critical roles for mTORC2-and rapamycininsensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells
-
Carayol N, Vakana E, Sassano A, et al.: Critical roles for mTORC2-and rapamycininsensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells. Proc Natl Acad Sci U S A. 2010; 107(28): 12469-74.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.28
, pp. 12469-12474
-
-
Carayol, N.1
Vakana, E.2
Sassano, A.3
|