Architecture of human mTOR complex 1

Science

Volumn 351, Issue 6268, 2016, Pages 48-52

  Aylett, Christopher H S ^a   Sauer, Evelyn ^b   Imseng, Stefan ^b   Boehringer, Daniel ^a   Hall, Michael N ^b   Ban, Nenad ^a   Maier, Timm ^b  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

FK 506 BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MLST8 PROTEIN, HUMAN; MULTIPROTEIN COMPLEX; PROTEIN BINDING; RPTOR PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

CANCER; DIABETES; ENZYME; NERVOUS SYSTEM DISORDER; PATHOLOGY;

ALPHA HELIX; ARTICLE; CHAETOMIUM; CHAETOMIUM THERMOPHILUM; COMPLEX FORMATION; CRYOELECTRON MICROSCOPY; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY; CHEMISTRY; ENZYME SPECIFICITY; HUMAN; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

CHAETOMIUM THERMOPHILUM; MAMMALIA; RAPTORES;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CATALYTIC DOMAIN; CRYOELECTRON MICROSCOPY; HUMANS; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; TACROLIMUS BINDING PROTEINS; TOR SERINE-THREONINE KINASES;

EID: 84952950121     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaa3870     Document Type: Article

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