The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia

Leukemia

Volumn 26, Issue 6, 2012, Pages 1195-1202

  Willems, L ^a,b   Chapuis, N ^a,b   Puissant, A ^c   MacIel, T T ^d   Green, A S ^a,e   Jacque, N ^a   Vignon, C ^f   Park, S ^a,b   Guichard, S ^g   Herault, O ^f   Fricot, A ^d   Hermine, O ^h   Moura, I C ^d   Auberger, P ^c   Ifrah, N ^i,j   Dreyfus, F ^a,b,j   Bonnet, D ^k   Lacombe, C ^a,b   Mayeux, P ^a   Bouscary, D ^a,b,j   Tamburini, J ^a,b   more..

^a INSTITUT COCHIN   (France)

^b Inserm U1016 ^*  (France)

^c UNIVERSITY HOSPITAL OF NICE   (France)

^d INSERM   (France)

^e HÔPITAL CHARLES NICOLLE   (France)

^f UNIVERSITÉ DE TOURS   (France)

^g ASTRAZENECA   (United Kingdom)

^h HÔPITAL NECKER ENFANTS MALADES   (France)

ⁱ ANGERS UNIVERSITY HOSPITAL   (France)

^j CHU BRETONNEAU   (France)

^k IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

more..

Author keywords

AML; apoptosis; autophagy; AZD8055; mTOR; protein translation

Indexed keywords

AZD 8055; CASPASE; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAPAMYCIN;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL CYCLE PROGRESSION; CELL DEATH; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUMOR GROWTH;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; LEUKEMIA, MYELOID, ACUTE; MICE; MICE, NUDE; MORPHOLINES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEINS; SURVIVAL RATE; TRANSCRIPTION FACTORS; TREATMENT OUTCOME; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84862012594     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.339     Document Type: Article

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