-
1
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov, D.D., Ali, S.M., Sengupta, S., Sheen, J.H., Hsu, P.P., Bagley, A.F., Markhard, A.L. and Sabatini, D.M. (2006) Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol. Cell 22, 159-168
-
(2006)
Mol. Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
2
-
-
77952967459
-
MTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs
-
Dowling, R.J., Topisirovic, I., Alain, T., Bidinosti, M., Fonseca, B.D., Petroulakis, E., Wang, X., Larsson, O., Selvaraj, A., Liu, Y. et al. (2010) mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science 328, 1172-1176
-
(2010)
Science
, vol.328
, pp. 1172-1176
-
-
Dowling, R.J.1
Topisirovic, I.2
Alain, T.3
Bidinosti, M.4
Fonseca, B.D.5
Petroulakis, E.6
Wang, X.7
Larsson, O.8
Selvaraj, A.9
Liu, Y.10
-
3
-
-
0032843917
-
Drosophila S6 kinase: A regulator of cell size
-
DOI 10.1126/science.285.5436.2126
-
Montagne, J., Stewart, M.J., Stocker, H., Hafen, E., Kozma, S.C. and Thomas, G. (1999) Drosophila S6 kinase: a regulator of cell size. Science 285, 2126-2129 (Pubitemid 29451430)
-
(1999)
Science
, vol.285
, Issue.5436
, pp. 2126-2129
-
-
Montagne, J.1
Stewart, M.J.2
Stocker, H.3
Hafen, E.4
Kozma, S.C.5
Thomas, G.6
-
6
-
-
33745570504
-
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity
-
DOI 10.1038/sj.emboj.7601166, PII 7601166
-
Shahbazian, D., Roux, P.P., Mieulet, V., Cohen, M.S., Raught, B., Taunton, J., Hershey, J.W., Blenis, J., Pende, M. and Sonenberg, N. (2006) The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J. 25, 2781-2791 (Pubitemid 43980385)
-
(2006)
EMBO Journal
, vol.25
, Issue.12
, pp. 2781-2791
-
-
Shahbazian, D.1
Roux, P.P.2
Mieulet, V.3
Cohen, M.S.4
Raught, B.5
Taunton, J.6
Hershey, J.W.B.7
Blenis, J.8
Pende, M.9
Sonenberg, N.10
-
7
-
-
37549028779
-
Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function
-
Jastrzebski, K., Hannan, K.M., Tchoubrieva, E.B., Hannan, R.D. and Pearson, R.B. (2007) Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function. Growth Factors 25, 209-226
-
(2007)
Growth Factors
, vol.25
, pp. 209-226
-
-
Jastrzebski, K.1
Hannan, K.M.2
Tchoubrieva, E.B.3
Hannan, R.D.4
Pearson, R.B.5
-
8
-
-
50649084799
-
All translation elongation factors and the e, f, and h subunits of translation initiation factor 3 are encoded by 5′-terminal oligopyrimidine (TOP) mRNAs
-
Iadevaia, V., Caldarola, S., Tino, E., Amaldi, F. and Loreni, F. (2008) All translation elongation factors and the e, f, and h subunits of translation initiation factor 3 are encoded by 5′-terminal oligopyrimidine (TOP) mRNAs. RNA 14, 1730-1736
-
(2008)
RNA
, vol.14
, pp. 1730-1736
-
-
Iadevaia, V.1
Caldarola, S.2
Tino, E.3
Amaldi, F.4
Loreni, F.5
-
9
-
-
0036889291
-
Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation
-
DOI 10.1128/MCB.22.23.8101-8113.2002
-
Stolovich, M., Tang, H., Hornstein, E., Levy, G., Cohen, R., Bae, S.S., Birnbaum, M.J. and Meyuhas, O. (2002) Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation. Mol. Cell. Biol. 22, 8101-8113 (Pubitemid 35304044)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.23
, pp. 8101-8113
-
-
Stolovich, M.1
Tang, H.2
Hornstein, E.3
Levy, G.4
Cohen, R.5
Bae, S.S.6
Birnbaum, M.J.7
Meyuhas, O.8
-
10
-
-
0028207001
-
Rapamycin selectively represses translation of the 'polypyrimidine tract'mRNA family
-
Jefferies, H.B.J., Reinhard, G., Kozma, S.C. and Thomas, G. (1994) Rapamycin selectively represses translation of the 'polypyrimidine tract'mRNA family. Proc. Natl. Acad. Sci. U.S.A. 91, 4441-4445
-
(1994)
Proc. Natl. Acad. Sci. U.S.A.
, vol.91
, pp. 4441-4445
-
-
Jefferies, H.B.J.1
Reinhard, G.2
Kozma, S.C.3
Thomas, G.4
-
11
-
-
11144356304
-
- /- mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway
-
- /- mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol. Cell. Biol. 24, 3112-3124
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 3112-3124
-
-
Pende, M.1
Um, S.H.2
Mieulet, V.3
Sticker, M.4
Goss, V.L.5
Mestan, J.6
Mueller, M.7
Fumagalli, S.8
Kozma, S.C.9
Thomas, G.10
-
12
-
-
24944464482
-
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis
-
DOI 10.1101/gad.351605
-
Ruvinsky, I., Sharon, N., Lerer, T., Cohen, H., Stolovich-Rain, M., Nir, T., Dor, Y., Zisman, P. and Meyuhas, O. (2005) Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev. 19, 2199-2211 (Pubitemid 41330321)
-
(2005)
Genes and Development
, vol.19
, Issue.18
, pp. 2199-2211
-
-
Ruvinsky, I.1
Sharon, N.2
Lerer, T.3
Cohen, H.4
Stolovich-Rain, M.5
Nir, T.6
Dor, Y.7
Zisman, P.8
Meyuhas, O.9
-
13
-
-
33750044901
-
Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases
-
DOI 10.1038/sj.onc.1209883, PII 1209883
-
Mayer, C. and Grummt, I. (2006) Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases. Oncogene 25, 6384-6391 (Pubitemid 44582283)
-
(2006)
Oncogene
, vol.25
, Issue.48
, pp. 6384-6391
-
-
Mayer, C.1
Grummt, I.2
-
14
-
-
77955287244
-
MTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1
-
Kantidakis, T., Ramsbottom, B.A., Birch, J.L., Dowding, S.N. and White, R.J. (2010) mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1. Proc. Natl. Acad. Sci. U.S.A. 107, 11823-11828
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 11823-11828
-
-
Kantidakis, T.1
Ramsbottom, B.A.2
Birch, J.L.3
Dowding, S.N.4
White, R.J.5
-
15
-
-
1542343973
-
mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability
-
DOI 10.1101/gad.285504
-
Mayer, C., Zhao, J., Yuan, X. and Grummt, I. (2004) mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. Genes Dev. 18, 423-434 (Pubitemid 38316349)
-
(2004)
Genes and Development
, vol.18
, Issue.4
, pp. 423-434
-
-
Mayer, C.1
Zhao, J.2
Yuan, X.3
Grummt, I.4
-
16
-
-
0242637318
-
mTOR-Dependent Regulation of Ribosomal Gene Transcription Requires S6K1 and Is Mediated by Phosphorylation of the Carboxy-Terminal Activation Domain of the Nucleolar Transcription Factor UBF
-
DOI 10.1128/MCB.23.23.8862-8877.2003
-
Hannan, K.M., Brandenburger, Y., Jenkins, A., Sharkey, K., Cavanaugh, A., Rothblum, L., Moss, T., Poortinga, G., McArthur, G.A., Pearson, R.B. and Hannan, R.D. (2003) mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. Mol. Cell. Biol. 23, 8862-8877 (Pubitemid 37433385)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.23
, pp. 8862-8877
-
-
Hannan, K.M.1
Brandenburger, Y.2
Jenkins, A.3
Sharkey, K.4
Cavanaugh, A.5
Rothblum, L.6
Moss, T.7
Poortinga, G.8
McArthur, G.A.9
Pearson, R.B.10
Hannan, R.D.11
-
17
-
-
78649712949
-
MTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
-
Oh, W.J., Wu, C.C., Kim, S.J., Facchinetti, V., Julien, L.A., Finlan, M., Roux, P.P., Su, B. and Jacinto, E. (2010) mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 29, 3939-3951
-
(2010)
EMBO J.
, vol.29
, pp. 3939-3951
-
-
Oh, W.J.1
Wu, C.C.2
Kim, S.J.3
Facchinetti, V.4
Julien, L.A.5
Finlan, M.6
Roux, P.P.7
Su, B.8
Jacinto, E.9
-
18
-
-
79952293503
-
Activation of mTORC2 by association with the ribosome
-
Zinzalla, V., Stracka, D., Oppliger, W. and Hall, M.N. (2011) Activation of mTORC2 by association with the ribosome. Cell 144, 757-768
-
(2011)
Cell
, vol.144
, pp. 757-768
-
-
Zinzalla, V.1
Stracka, D.2
Oppliger, W.3
Hall, M.N.4
-
19
-
-
61349141302
-
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
-
Feldman, M.E., Apsel, B., Uotila, A., Loewith, R., Knight, Z.A., Ruggero, D. and Shokat, K.M. (2009) Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 7, e38
-
(2009)
PLoS Biol.
, vol.7
-
-
Feldman, M.E.1
Apsel, B.2
Uotila, A.3
Loewith, R.4
Knight, Z.A.5
Ruggero, D.6
Shokat, K.M.7
-
20
-
-
75149112670
-
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
-
Chresta, C.M., Davies, B.R., Hickson, I., Harding, T., Cosulich, S., Critchlow, S.E., Vincent, J.P., Ellston, R., Jones, D., Sini, P. et al. (2010) AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. Cancer Res. 70, 288-298
-
(2010)
Cancer Res.
, vol.70
, pp. 288-298
-
-
Chresta, C.M.1
Davies, B.R.2
Hickson, I.3
Harding, T.4
Cosulich, S.5
Critchlow, S.E.6
Vincent, J.P.7
Ellston, R.8
Jones, D.9
Sini, P.10
-
21
-
-
15044340650
-
Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins
-
DOI 10.1128/MCB.25.7.2558-2572.2005
-
Wang, X., Beugnet, A., Murakami, M., Yamanaka, S. and Proud, C.G. (2005) Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins Mol. Cell. Biol. 25, 2558-2572 (Pubitemid 40381622)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.7
, pp. 2558-2572
-
-
Wang, X.1
Beugnet, A.2
Murakami, M.3
Yamanaka, S.4
Proud, C.G.5
-
22
-
-
59249097362
-
The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- Or rictor-independent manner
-
Patursky-Polischuk, I., Stolovich-Rain, M., Hausner-Hanochi, M., Kasir, J., Cybulski, N., Avruch, J., Ruegg, M.A., Hall, M.N. and Meyuhas, O. (2009) The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner. Mol. Cell. Biol. 29, 640-649
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 640-649
-
-
Patursky-Polischuk, I.1
Stolovich-Rain, M.2
Hausner-Hanochi, M.3
Kasir, J.4
Cybulski, N.5
Avruch, J.6
Ruegg, M.A.7
Hall, M.N.8
Meyuhas, O.9
-
23
-
-
0029831167
-
Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002
-
Brunn, G.J., Williams, J., Sabers, C., Weiderrecht, G., Lawrence, J.C. and Abraham, R.T. (1996) Direct inhibition of the signalling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J. 15, 5256-5267 (Pubitemid 26336209)
-
(1996)
EMBO Journal
, vol.15
, Issue.19
, pp. 5256-5267
-
-
Brunn, G.J.1
Williams, J.2
Sabers, C.3
Wiederrecht, G.4
Lawrence Jr., J.C.5
Abraham, R.T.6
-
24
-
-
46349099804
-
Comprehensive detection of human terminal oligo-pyrimidine (TOP) genes and analysis of their characteristics
-
DOI 10.1093/nar/gkn248
-
Yamashita, R., Suzuki, Y., Takeuchi, N., Wakaguri, H., Ueda, T., Sugano, S. and Nakai, K. (2008) Comprehensive detection of human terminal oligo-pyrimidine (TOP) genes and analysis of their characteristics. Nucleic Acids Res. 36, 3707-3715 (Pubitemid 351917532)
-
(2008)
Nucleic Acids Research
, vol.36
, Issue.11
, pp. 3707-3715
-
-
Yamashita, R.1
Suzuki, Y.2
Takeuchi, N.3
Wakaguri, H.4
Ueda, T.5
Sugano, S.6
Nakai, K.7
-
25
-
-
77953512889
-
MTOR binds to the promoters of RNA polymerase I- And III-transcribed genes
-
Tsang, C.K., Liu, H. and Zheng, X.F. (2010) mTOR binds to the promoters of RNA polymerase I- and III-transcribed genes. Cell Cycle 9, 953-957
-
(2010)
Cell Cycle
, vol.9
, pp. 953-957
-
-
Tsang, C.K.1
Liu, H.2
Zheng, X.F.3
-
26
-
-
77952036652
-
Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells
-
Shor, B., Wu, J., Shakey, Q., Toral-Barza, L., Shi, C., Follettie, M. and Yu, K. (2010) Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells. J. Biol. Chem. 285, 15380-15392
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 15380-15392
-
-
Shor, B.1
Wu, J.2
Shakey, Q.3
Toral-Barza, L.4
Shi, C.5
Follettie, M.6
Yu, K.7
-
27
-
-
74849122022
-
TORC1 association with rDNA chromatin as a mechanism to co-regulate Pol I and Pol III
-
Wei, Y. and Zheng, X.F. (2009) TORC1 association with rDNA chromatin as a mechanism to co-regulate Pol I and Pol III. Cell Cycle 8, 3802-3803
-
(2009)
Cell Cycle
, vol.8
, pp. 3802-3803
-
-
Wei, Y.1
Zheng, X.F.2
-
28
-
-
68249159982
-
Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1
-
Wei, Y., Tsang, C.K. and Zheng, X.F. (2009) Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1. EMBO J. 28, 2220-2230
-
(2009)
EMBO J.
, vol.28
, pp. 2220-2230
-
-
Wei, Y.1
Tsang, C.K.2
Zheng, X.F.3
-
29
-
-
74849135206
-
Sch9 partially mediates TORC1 signaling to control ribosomal RNA synthesis
-
Wei, Y. and Zheng, X.F. (2009) Sch9 partially mediates TORC1 signaling to control ribosomal RNA synthesis. Cell Cycle 8, 4085-4090
-
(2009)
Cell Cycle
, vol.8
, pp. 4085-4090
-
-
Wei, Y.1
Zheng, X.F.2
-
30
-
-
69249240179
-
Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis
-
Huber, A., Bodenmiller, B., Uotila, A., Stahl, M., Wanka, S., Gerrits, B., Aebersold, R. and Loewith, R. (2009) Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. Genes Dev. 23, 1929-1943
-
(2009)
Genes Dev.
, vol.23
, pp. 1929-1943
-
-
Huber, A.1
Bodenmiller, B.2
Uotila, A.3
Stahl, M.4
Wanka, S.5
Gerrits, B.6
Aebersold, R.7
Loewith, R.8
-
31
-
-
67649827419
-
Regulation of RNA polymerase III transcription involves SCH9-dependent and SCH9-independent branches of the target of rapamycin (TOR) pathway
-
Lee, J., Moir, R.D. and Willis, I.M. (2009) Regulation of RNA polymerase III transcription involves SCH9-dependent and SCH9-independent branches of the target of rapamycin (TOR) pathway. J. Biol. Chem. 284, 12604-12608
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 12604-12608
-
-
Lee, J.1
Moir, R.D.2
Willis, I.M.3
-
32
-
-
77955292162
-
MTORC1 directly phosphorylates and regulates human MAF1
-
Michels, A.A., Robitaille, A.M., Buczynski-Ruchonnet, D., Hodroj, W., Reina, J.H., Hall, M.N. and Hernandez, N. (2010) mTORC1 directly phosphorylates and regulates human MAF1. Mol. Cell Biol. 30, 3749-3757
-
(2010)
Mol. Cell Biol.
, vol.30
, pp. 3749-3757
-
-
Michels, A.A.1
Robitaille, A.M.2
Buczynski-Ruchonnet, D.3
Hodroj, W.4
Reina, J.H.5
Hall, M.N.6
Hernandez, N.7
|