-
1
-
-
33750042335
-
-
Cold Spring Harbor Monograph Series 48, Cold Spring Harbor, NY
-
Mathews, M.B., Sonenberg, N. and Hershey, J. (2007) Translation Control in Biology and Medicine. Cold Spring Harbor Monograph Series 48, Cold Spring Harbor, NY
-
(2007)
Translation Control in Biology and Medicine
-
-
Mathews, M.B.1
Sonenberg, N.2
Hershey, J.3
-
2
-
-
17744399963
-
Study of translational control of eukaryotic gene expression using yeast
-
CrossRef PubMed
-
Hinnebusch, A.G., Asano, K., Olsen, D.S., Phan, L., Nielsen, K.H. and Valasek, L. (2004) Study of translational control of eukaryotic gene expression using yeast. Ann. N.Y. Acad. Sci. 1038, 60-74 CrossRef PubMed
-
(2004)
Ann. N.Y. Acad. Sci.
, vol.1038
, pp. 60-74
-
-
Hinnebusch, A.G.1
Asano, K.2
Olsen, D.S.3
Phan, L.4
Nielsen, K.H.5
Valasek, L.6
-
3
-
-
84863904349
-
The elongation, termination, and recycling phases of translation in eukaryotes
-
CrossRef PubMed
-
Dever, T.E. and Green, R. (2012) The elongation, termination, and recycling phases of translation in eukaryotes. Cold Spring Harb. Perspect. Biol. 4, a013706 CrossRef PubMed
-
(2012)
Cold Spring Harb. Perspect. Biol.
, vol.4
, pp. a013706
-
-
Dever, T.E.1
Green, R.2
-
4
-
-
75149196287
-
The mechanism of eukaryotic translation initiation and principles of its regulation
-
CrossRef
-
Jackson, R.J., Hellen, C.U. and Pestova, T.V. (2010) The mechanism of eukaryotic translation initiation and principles of its regulation. N. Rev. Mol. Cell Biol. 11, 113-127 CrossRef
-
(2010)
N. Rev. Mol. Cell Biol.
, vol.11
, pp. 113-127
-
-
Jackson, R.J.1
Hellen, C.U.2
Pestova, T.V.3
-
5
-
-
60149091189
-
Regulation of translation initiation in eukaryotes: Mechanisms and biological targets
-
CrossRef PubMed
-
Sonenberg, N. and Hinnebusch, A.G. (2009) Regulation of translation initiation in eukaryotes: Mechanisms and biological targets. Cell 136, 731-745 CrossRef PubMed
-
(2009)
Cell
, vol.136
, pp. 731-745
-
-
Sonenberg, N.1
Hinnebusch, A.G.2
-
6
-
-
79959324681
-
Cap and cap-binding proteins in the control of gene expression
-
CrossRef PubMed
-
Topisirovic, I., Svitkin, Y.V., Sonenberg, N. and Shatkin, A.J. (2011) Cap and cap-binding proteins in the control of gene expression. Wiley Interdiscip. Rev. RNA 2, 277-298 CrossRef PubMed
-
(2011)
Wiley Interdiscip. Rev. RNA
, vol.2
, pp. 277-298
-
-
Topisirovic, I.1
Svitkin, Y.V.2
Sonenberg, N.3
Shatkin, A.J.4
-
7
-
-
0032834055
-
EIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
-
CrossRef PubMed
-
Gingras, A.C., Raught, B. and Sonenberg, N. (1999) eIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 68, 913-963 CrossRef PubMed
-
(1999)
Annu. Rev. Biochem.
, vol.68
, pp. 913-963
-
-
Gingras, A.C.1
Raught, B.2
Sonenberg, N.3
-
8
-
-
79953052296
-
mRNA helicases: The tacticians of translational control
-
CrossRef PubMed
-
Parsyan, A., Svitkin, Y., Shahbazian, D., Gkogkas, C., Lasko, P., Merrick, W.C. and Sonenberg, N. (2011) mRNA helicases: The tacticians of translational control. Nat. Rev. Mol. Cell Biol. 12, 235-245 CrossRef PubMed
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.12
, pp. 235-245
-
-
Parsyan, A.1
Svitkin, Y.2
Shahbazian, D.3
Gkogkas, C.4
Lasko, P.5
Merrick, W.C.6
Sonenberg, N.7
-
9
-
-
84902193122
-
The scanning mechanism of eukaryotic translation initiation
-
CrossRef PubMed
-
Hinnebusch, A.G. (2014) The scanning mechanism of eukaryotic translation initiation. Annu. Rev. Biochem. 83, 779-812 CrossRef PubMed
-
(2014)
Annu. Rev. Biochem.
, vol.83
, pp. 779-812
-
-
Hinnebusch, A.G.1
-
10
-
-
12644303224
-
Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G
-
PubMed
-
Tarun, Jr, S.Z. and Sachs, A.B. (1996) Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G. EMBO J. 15, 7168-7177 PubMed
-
(1996)
EMBO J.
, vol.15
, pp. 7168-7177
-
-
Tarun, S.Z.1
Sachs, A.B.2
-
11
-
-
11844281461
-
Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms
-
CrossRef PubMed
-
Kahvejian, A., Svitkin, Y.V., Sukarieh, R., M'Boutchou, M.N. and Sonenberg, N. (2005) Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms. Genes Dev. 19, 104-113 CrossRef PubMed
-
(2005)
Genes Dev.
, vol.19
, pp. 104-113
-
-
Kahvejian, A.1
Svitkin, Y.V.2
Sukarieh, R.3
M'Boutchou, M.N.4
Sonenberg, N.5
-
12
-
-
84926409849
-
Targeting the translation machinery in cancer
-
CrossRef PubMed
-
Bhat, M., Robichaud, N., Hulea, L., Sonenberg, N., Pelletier, J. and Topisirovic, I. (2015) Targeting the translation machinery in cancer. Nat. Rev. Drug Discov. 14, 261-278 CrossRef PubMed
-
(2015)
Nat. Rev. Drug Discov.
, vol.14
, pp. 261-278
-
-
Bhat, M.1
Robichaud, N.2
Hulea, L.3
Sonenberg, N.4
Pelletier, J.5
Topisirovic, I.6
-
13
-
-
38849180436
-
Targeting the eukaryotic translation initiation factor 4E for cancer therapy
-
CrossRef PubMed
-
Graff, J.R., Konicek, B.W., Carter, J.H. and Marcusson, E.G. (2008) Targeting the eukaryotic translation initiation factor 4E for cancer therapy. Cancer Res. 68, 631-634 CrossRef PubMed
-
(2008)
Cancer Res.
, vol.68
, pp. 631-634
-
-
Graff, J.R.1
Konicek, B.W.2
Carter, J.H.3
Marcusson, E.G.4
-
14
-
-
0021112625
-
5'-Conformation of capped alfalfa mosaic virus ribonucleic acid 4 may reflect its independence of the cap structure or of cap-binding protein for efficient translation
-
CrossRef PubMed
-
Gehrke, L., Auron, P.E., Quigley, G.J., Rich, A. and Sonenberg, N. (1983) 5'-Conformation of capped alfalfa mosaic virus ribonucleic acid 4 may reflect its independence of the cap structure or of cap-binding protein for efficient translation. Biochemistry 22, 5157-5164 CrossRef PubMed
-
(1983)
Biochemistry
, vol.22
, pp. 5157-5164
-
-
Gehrke, L.1
Auron, P.E.2
Quigley, G.J.3
Rich, A.4
Sonenberg, N.5
-
15
-
-
0018801281
-
Methylmercury hydroxide enhancement of translation and transcription of ovalbumin and conalbumin mRNA's
-
PubMed
-
Payvar, F. and Schimke, R.T. (1979) Methylmercury hydroxide enhancement of translation and transcription of ovalbumin and conalbumin mRNA's. J. Biol. Chem. 254, 7636-7642 PubMed
-
(1979)
J. Biol. Chem.
, vol.254
, pp. 7636-7642
-
-
Payvar, F.1
Schimke, R.T.2
-
16
-
-
0021799353
-
Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency
-
CrossRef PubMed
-
Pelletier, J. and Sonenberg, N. (1985) Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency. Cell 40, 515-526 CrossRef PubMed
-
(1985)
Cell
, vol.40
, pp. 515-526
-
-
Pelletier, J.1
Sonenberg, N.2
-
17
-
-
0025089002
-
Translational repression by a complex between the iron-responsive element of ferritin mRNA and its specific cytoplasmic binding protein is position-dependent in vivo
-
PubMed
-
Goossen, B., Caughman, S.W., Harford, J.B., Klausner, R.D. and Hentze, M.W. (1990) Translational repression by a complex between the iron-responsive element of ferritin mRNA and its specific cytoplasmic binding protein is position-dependent in vivo. EMBO J. 9, 4127-4133 PubMed
-
(1990)
EMBO J.
, vol.9
, pp. 4127-4133
-
-
Goossen, B.1
Caughman, S.W.2
Harford, J.B.3
Klausner, R.D.4
Hentze, M.W.5
-
18
-
-
0027380401
-
The influence of 5'-secondary structures upon ribosome binding to mRNA during translation in yeast
-
PubMed
-
Sagliocco, F.A., Vega Laso, M.R., Zhu, D., Tuite, M.F., McCarthy, J.E. and Brown, A.J. (1993) The influence of 5'-secondary structures upon ribosome binding to mRNA during translation in yeast. J. Biol. Chem. 268, 26522-26530 PubMed
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 26522-26530
-
-
Sagliocco, F.A.1
Vega Laso, M.R.2
Zhu, D.3
Tuite, M.F.4
McCarthy, J.E.5
Brown, A.J.6
-
19
-
-
33646193306
-
Control of mammalian translation by mRNA structure near caps
-
CrossRef PubMed
-
Babendure, J.R., Babendure, J.L., Ding, J.H. and Tsien, R.Y. (2006) Control of mammalian translation by mRNA structure near caps. RNA 12, 851-861 CrossRef PubMed
-
(2006)
RNA
, vol.12
, pp. 851-861
-
-
Babendure, J.R.1
Babendure, J.L.2
Ding, J.H.3
Tsien, R.Y.4
-
20
-
-
0005218668
-
Influences of mRNA secondary structure on initiation by eukaryotic ribosomes
-
CrossRef PubMed
-
Kozak, M. (1986) Influences of mRNA secondary structure on initiation by eukaryotic ribosomes. Proc. Natl. Acad. Sci. U.S.A. 83, 2850-2854 CrossRef PubMed
-
(1986)
Proc. Natl. Acad. Sci. U.S.A.
, vol.83
, pp. 2850-2854
-
-
Kozak, M.1
-
21
-
-
0026723117
-
MRNAs containing extensive secondary structure in their 5' non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E
-
PubMed
-
Koromilas, A.E., Lazaris-Karatzas, A. and Sonenberg, N. (1992) mRNAs containing extensive secondary structure in their 5' non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E. EMBO J. 11, 4153-4158 PubMed
-
(1992)
EMBO J.
, vol.11
, pp. 4153-4158
-
-
Koromilas, A.E.1
Lazaris-Karatzas, A.2
Sonenberg, N.3
-
22
-
-
0035032444
-
The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure
-
CrossRef PubMed
-
Svitkin, Y.V., Pause, A., Haghighat, A., Pyronnet, S., Witherell, G., Belsham, G.J. and Sonenberg, N. (2001) The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure. RNA 7, 382-394 CrossRef PubMed
-
(2001)
RNA
, vol.7
, pp. 382-394
-
-
Svitkin, Y.V.1
Pause, A.2
Haghighat, A.3
Pyronnet, S.4
Witherell, G.5
Belsham, G.J.6
Sonenberg, N.7
-
23
-
-
84882291342
-
Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity
-
CrossRef PubMed
-
Feoktistova, K., Tuvshintogs, E., Do, A. and Fraser, C.S. (2013) Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity. Proc. Natl. Acad. Sci. U.S.A. 110, 13339-13344 CrossRef PubMed
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 13339-13344
-
-
Feoktistova, K.1
Tuvshintogs, E.2
Do, A.3
Fraser, C.S.4
-
24
-
-
84860527756
-
A unifying model for mTORC1-mediated regulation of mRNA translation
-
CrossRef PubMed
-
Thoreen, C.C., Chantranupong, L., Keys, H.R., Wang, T., Gray, N.S. and Sabatini, D.M. (2012) A unifying model for mTORC1-mediated regulation of mRNA translation. Nature 485, 109-113 CrossRef PubMed
-
(2012)
Nature
, vol.485
, pp. 109-113
-
-
Thoreen, C.C.1
Chantranupong, L.2
Keys, H.R.3
Wang, T.4
Gray, N.S.5
Sabatini, D.M.6
-
25
-
-
84862777192
-
The translational landscape of mTOR signalling steers cancer initiation and metastasis
-
CrossRef PubMed
-
Hsieh, A.C., Liu, Y., Edlind, M.P., Ingolia, N.T., Janes, M.R., Sher, A., Shi, E.Y., Stumpf, C.R., Christensen, C., Bonham, M.J. et al. (2012) The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature 485, 55-61 CrossRef PubMed
-
(2012)
Nature
, vol.485
, pp. 55-61
-
-
Hsieh, A.C.1
Liu, Y.2
Edlind, M.P.3
Ingolia, N.T.4
Janes, M.R.5
Sher, A.6
Shi, E.Y.7
Stumpf, C.R.8
Christensen, C.9
Bonham, M.J.10
-
26
-
-
84901700198
-
Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner
-
CrossRef PubMed
-
Miloslavski, R., Cohen, E., Avraham, A., Iluz, Y., Hayouka, Z., Kasir, J., Mudhasani, R., Jones, S.N., Cybulski, N., Ruegg, M.A. et al. (2014) Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner. J. Mol. Cell Biol. 6, 255-266 CrossRef PubMed
-
(2014)
J. Mol. Cell Biol.
, vol.6
, pp. 255-266
-
-
Miloslavski, R.1
Cohen, E.2
Avraham, A.3
Iluz, Y.4
Hayouka, Z.5
Kasir, J.6
Mudhasani, R.7
Jones, S.N.8
Cybulski, N.9
Ruegg, M.A.10
-
27
-
-
84930959981
-
The race to decipher the top secrets of TOP mRNAs
-
CrossRef PubMed
-
Meyuhas, O. and Kahan, T. (2014) The race to decipher the top secrets of TOP mRNAs. Biochim. Biophys. Acta. 1849, 801-811 CrossRef PubMed
-
(2014)
Biochim. Biophys. Acta.
, vol.1849
, pp. 801-811
-
-
Meyuhas, O.1
Kahan, T.2
-
28
-
-
0029166687
-
The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins
-
PubMed
-
Mader, S., Lee, H., Pause, A. and Sonenberg, N. (1995) The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Mol. Cell. Biol. 15, 4990-4997 PubMed
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 4990-4997
-
-
Mader, S.1
Lee, H.2
Pause, A.3
Sonenberg, N.4
-
29
-
-
0028034233
-
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function
-
CrossRef PubMed
-
Pause, A., Belsham, G.J., Gingras, A.C., Donze, O., Lin, T.A., Lawrence, Jr, J.C. and Sonenberg, N. (1994) Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature 371, 762-767 CrossRef PubMed
-
(1994)
Nature
, vol.371
, pp. 762-767
-
-
Pause, A.1
Belsham, G.J.2
Gingras, A.C.3
Donze, O.4
Lin, T.A.5
Lawrence, J.C.6
Sonenberg, N.7
-
30
-
-
0032577691
-
4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family
-
CrossRef PubMed
-
Poulin, F., Gingras, A.C., Olsen, H., Chevalier, S. and Sonenberg, N. (1998) 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. J. Biol. Chem. 273, 14002-14007 CrossRef PubMed
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14002-14007
-
-
Poulin, F.1
Gingras, A.C.2
Olsen, H.3
Chevalier, S.4
Sonenberg, N.5
-
31
-
-
4043171462
-
Upstream and downstream of mTOR
-
CrossRef PubMed
-
Hay, N. and Sonenberg, N. (2004) Upstream and downstream of mTOR. Genes Dev. 18, 1926-1945 CrossRef PubMed
-
(2004)
Genes Dev.
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
32
-
-
84859778293
-
MTOR signaling in growth control and disease
-
CrossRef PubMed
-
Laplante, M. and Sabatini, D.M. (2012) mTOR signaling in growth control and disease. Cell 149, 274-293 CrossRef PubMed
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
33
-
-
78650647490
-
A comprehensive map of the mTOR signaling network
-
CrossRef PubMed
-
Caron, E., Ghosh, S., Matsuoka, Y., Ashton-Beaucage, D., Therrien, M., Lemieux, S., Perreault, C., Roux, P.P. and Kitano, H. (2010) A comprehensive map of the mTOR signaling network. Mol. Syst. Biol. 6, 453 CrossRef PubMed
-
(2010)
Mol. Syst. Biol.
, vol.6
, pp. 453
-
-
Caron, E.1
Ghosh, S.2
Matsuoka, Y.3
Ashton-Beaucage, D.4
Therrien, M.5
Lemieux, S.6
Perreault, C.7
Roux, P.P.8
Kitano, H.9
-
34
-
-
32044465506
-
TOR signaling in growth and metabolism
-
CrossRef PubMed
-
Wullschleger, S., Loewith, R. and Hall, M.N. (2006) TOR signaling in growth and metabolism. Cell 124, 471-484 CrossRef PubMed
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
35
-
-
0037623417
-
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
-
CrossRef PubMed
-
Kim, D.H., Sarbassov, D.D., Ali, S.M., Latek, R.R., Guntur, K.V., Erdjument-Bromage, H., Tempst, P. and Sabatini, D.M. (2003) GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol. Cell 11, 895-904 CrossRef PubMed
-
(2003)
Mol. Cell
, vol.11
, pp. 895-904
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
Latek, R.R.4
Guntur, K.V.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
36
-
-
67349217986
-
Molecular mechanisms of mTOR-mediated translational control
-
CrossRef PubMed
-
Ma, X.M. and Blenis, J. (2009) Molecular mechanisms of mTOR-mediated translational control. Nat. Rev. Mol. Cell. Biol. 10, 307-318 CrossRef PubMed
-
(2009)
Nat. Rev. Mol. Cell. Biol.
, vol.10
, pp. 307-318
-
-
Ma, X.M.1
Blenis, J.2
-
37
-
-
84903158167
-
Regulation of mTORC1 by amino acids
-
CrossRef PubMed
-
Bar-Peled, L. and Sabatini, D.M. (2014) Regulation of mTORC1 by amino acids. Trends Cell Biol. 24, 400-406 CrossRef PubMed
-
(2014)
Trends Cell Biol.
, vol.24
, pp. 400-406
-
-
Bar-Peled, L.1
Sabatini, D.M.2
-
38
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
CrossRef PubMed
-
Cantley, L.C. (2002) The phosphoinositide 3-kinase pathway. Science 296, 1655-1657 CrossRef PubMed
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
39
-
-
51849111556
-
PI3K pathway alterations in cancer: Variations on a theme
-
CrossRef PubMed
-
Yuan, T.L. and Cantley, L.C. (2008) PI3K pathway alterations in cancer: Variations on a theme. Oncogene 27, 5497-5510 CrossRef PubMed
-
(2008)
Oncogene
, vol.27
, pp. 5497-5510
-
-
Yuan, T.L.1
Cantley, L.C.2
-
40
-
-
34347210090
-
Identification of Protor as a novel Rictor-binding component of mTOR complex-2
-
CrossRef PubMed
-
Pearce, L.R., Huang, X., Boudeau, J., Pawlowski, R., Wullschleger, S., Deak, M., Ibrahim, A.F., Gourlay, R., Magnuson, M.A. and Alessi, D.R. (2007) Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem. J. 405, 513-522 CrossRef PubMed
-
(2007)
Biochem. J.
, vol.405
, pp. 513-522
-
-
Pearce, L.R.1
Huang, X.2
Boudeau, J.3
Pawlowski, R.4
Wullschleger, S.5
Deak, M.6
Ibrahim, A.F.7
Gourlay, R.8
Magnuson, M.A.9
Alessi, D.R.10
-
41
-
-
0033604585
-
The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
-
CrossRef PubMed
-
Kandel, E.S. and Hay, N. (1999) The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp. Cell Res. 253, 210-229 CrossRef PubMed
-
(1999)
Exp. Cell Res.
, vol.253
, pp. 210-229
-
-
Kandel, E.S.1
Hay, N.2
-
42
-
-
0035499454
-
Ten years of protein kinase B signalling: A hard Akt to follow
-
CrossRef PubMed
-
Brazil, D.P. and Hemmings, B.A. (2001) Ten years of protein kinase B signalling: A hard Akt to follow. Trends Biochem. Sci. 26, 657-664 CrossRef PubMed
-
(2001)
Trends Biochem. Sci.
, vol.26
, pp. 657-664
-
-
Brazil, D.P.1
Hemmings, B.A.2
-
43
-
-
0035235458
-
Phosphatidylinositol 3' kinase signaling in mammary tumorigenesis
-
CrossRef PubMed
-
Scheid, M.P. and Woodgett, J.R. (2001) Phosphatidylinositol 3' kinase signaling in mammary tumorigenesis. J. Mammary Gland Biol. Neoplasia 6, 83-99 CrossRef PubMed
-
(2001)
J. Mammary Gland Biol. Neoplasia
, vol.6
, pp. 83-99
-
-
Scheid, M.P.1
Woodgett, J.R.2
-
44
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
CrossRef PubMed
-
Sarbassov, D.D., Ali, S.M., Sengupta, S., Sheen, J.H., Hsu, P.P., Bagley, A.F., Markhard, A.L. and Sabatini, D.M. (2006) Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol. Cell 22, 159-168 CrossRef PubMed
-
(2006)
Mol. Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
45
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
CrossRef PubMed
-
Inoki, K., Li, Y., Zhu, T., Wu, J. and Guan, K.L. (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4, 648-657 CrossRef PubMed
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
46
-
-
0036085555
-
Upregulation of renal BSC1 and TSC in prenatally programmed hypertension
-
CrossRef PubMed
-
Manning, J., Beutler, K., Knepper, M.A. and Vehaskari, V.M. (2002) Upregulation of renal BSC1 and TSC in prenatally programmed hypertension. Am. J. Physiol. Renal Physiol. 283, F202-F206 CrossRef PubMed
-
(2002)
Am. J. Physiol. Renal Physiol.
, vol.283
, pp. F202-F206
-
-
Manning, J.1
Beutler, K.2
Knepper, M.A.3
Vehaskari, V.M.4
-
47
-
-
84865371057
-
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1
-
CrossRef PubMed
-
Dibble, C.C., Elis, W., Menon, S., Qin, W., Klekota, J., Asara, J.M., Finan, P.M., Kwiatkowski, D.J., Murphy, L.O. and Manning, B.D. (2012) TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol. Cell 47, 535-546 CrossRef PubMed
-
(2012)
Mol. Cell
, vol.47
, pp. 535-546
-
-
Dibble, C.C.1
Elis, W.2
Menon, S.3
Qin, W.4
Klekota, J.5
Asara, J.M.6
Finan, P.M.7
Kwiatkowski, D.J.8
Murphy, L.O.9
Manning, B.D.10
-
48
-
-
0033153166
-
Regulation of 4E-BP1 phosphorylation: A novel two-step mechanism
-
CrossRef PubMed
-
Gingras, A.C., Gygi, S.P., Raught, B., Polakiewicz, R.D., Abraham, R.T., Hoekstra, M.F., Aebersold, R. and Sonenberg, N. (1999) Regulation of 4E-BP1 phosphorylation: A novel two-step mechanism. Genes Dev. 13, 1422-1437 CrossRef PubMed
-
(1999)
Genes Dev.
, vol.13
, pp. 1422-1437
-
-
Gingras, A.C.1
Gygi, S.P.2
Raught, B.3
Polakiewicz, R.D.4
Abraham, R.T.5
Hoekstra, M.F.6
Aebersold, R.7
Sonenberg, N.8
-
49
-
-
0032520009
-
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway
-
CrossRef PubMed
-
Gingras, A.C., Kennedy, S.G., O'Leary, M.A., Sonenberg, N. and Hay, N. (1998) 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev. 12, 502-513 CrossRef PubMed
-
(1998)
Genes Dev.
, vol.12
, pp. 502-513
-
-
Gingras, A.C.1
Kennedy, S.G.2
O'Leary, M.A.3
Sonenberg, N.4
Hay, N.5
-
50
-
-
34250755685
-
Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation
-
CrossRef PubMed
-
Mamane, Y., Petroulakis, E., Martineau, Y., Sato, T.A., Larsson, O., Rajasekhar, V.K. and Sonenberg, N. (2007) Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation. PLoS One 2, e242 CrossRef PubMed
-
(2007)
PLoS One
, vol.2
, pp. e242
-
-
Mamane, Y.1
Petroulakis, E.2
Martineau, Y.3
Sato, T.A.4
Larsson, O.5
Rajasekhar, V.K.6
Sonenberg, N.7
-
51
-
-
78650723802
-
Identification of differential translation in genome wide studies
-
CrossRef PubMed
-
Larsson, O., Sonenberg, N. and Nadon, R. (2010) Identification of differential translation in genome wide studies. Proc. Natl. Acad. Sci. U.S.A. 107, 21487-21492 CrossRef PubMed
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 21487-21492
-
-
Larsson, O.1
Sonenberg, N.2
Nadon, R.3
-
52
-
-
0025314596
-
Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap
-
CrossRef PubMed
-
Lazaris-Karatzas, A., Montine, K.S. and Sonenberg, N. (1990) Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap. Nature 345, 544-547 CrossRef PubMed
-
(1990)
Nature
, vol.345
, pp. 544-547
-
-
Lazaris-Karatzas, A.1
Montine, K.S.2
Sonenberg, N.3
-
53
-
-
0026583874
-
The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts
-
PubMed
-
Lazaris-Karatzas, A. and Sonenberg, N. (1992) The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts. Mol. Cell. Biol. 12, 1234-1238 PubMed
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 1234-1238
-
-
Lazaris-Karatzas, A.1
Sonenberg, N.2
-
54
-
-
2942544833
-
Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells
-
CrossRef PubMed
-
Avdulov, S., Li, S., Michalek, V., Burrichter, D., Peterson, M., Perlman, D.M., Manivel, J.C., Sonenberg, N., Yee, D., Bitterman, P.B. and Polunovsky, V.A. (2004) Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell 5, 553-563 CrossRef PubMed
-
(2004)
Cancer Cell
, vol.5
, pp. 553-563
-
-
Avdulov, S.1
Li, S.2
Michalek, V.3
Burrichter, D.4
Peterson, M.5
Perlman, D.M.6
Manivel, J.C.7
Sonenberg, N.8
Yee, D.9
Bitterman, P.B.10
Polunovsky, V.A.11
-
55
-
-
0030041884
-
Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E
-
CrossRef PubMed
-
Rousseau, D., Kaspar, R., Rosenwald, I., Gehrke, L. and Sonenberg, N. (1996) Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. Proc. Natl. Acad. Sci. U.S.A. 93, 1065-1070 CrossRef PubMed
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 1065-1070
-
-
Rousseau, D.1
Kaspar, R.2
Rosenwald, I.3
Gehrke, L.4
Sonenberg, N.5
-
57
-
-
0027362742
-
Decreasing the level of translation initiation factor 4E with antisense RNA causes reversal of ras-mediated transformation and tumorigenesis of cloned rat embryo fibroblasts
-
CrossRef PubMed
-
Rinker-Schaeffer, C.W., Graff, J.R., De Benedetti, A., Zimmer, S.G. and Rhoads, R.E. (1993) Decreasing the level of translation initiation factor 4E with antisense RNA causes reversal of ras-mediated transformation and tumorigenesis of cloned rat embryo fibroblasts. Int. J. Cancer 55, 841-847 CrossRef PubMed
-
(1993)
Int. J. Cancer
, vol.55
, pp. 841-847
-
-
Rinker-Schaeffer, C.W.1
Graff, J.R.2
De Benedetti, A.3
Zimmer, S.G.4
Rhoads, R.E.5
-
58
-
-
1642586272
-
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
-
CrossRef PubMed
-
Wendel, H.G., De Stanchina, E., Fridman, J.S., Malina, A., Ray, S., Kogan, S., Cordon-Cardo, C., Pelletier, J. and Lowe, S.W. (2004) Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 428, 332-337 CrossRef PubMed
-
(2004)
Nature
, vol.428
, pp. 332-337
-
-
Wendel, H.G.1
De Stanchina, E.2
Fridman, J.S.3
Malina, A.4
Ray, S.5
Kogan, S.6
Cordon-Cardo, C.7
Pelletier, J.8
Lowe, S.W.9
-
59
-
-
2442648845
-
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
-
CrossRef PubMed
-
Ruggero, D., Montanaro, L., Ma, L., Xu, W., Londei, P., Cordon-Cardo, C. and Pandolfi, P.P. (2004) The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat. Med. 10, 484-486 CrossRef PubMed
-
(2004)
Nat. Med.
, vol.10
, pp. 484-486
-
-
Ruggero, D.1
Montanaro, L.2
Ma, L.3
Xu, W.4
Londei, P.5
Cordon-Cardo, C.6
Pandolfi, P.P.7
-
60
-
-
0032981328
-
Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo
-
PubMed
-
Waskiewicz, A.J., Johnson, J.C., Penn, B., Mahalingam, M., Kimball, S.R. and Cooper, J.A. (1999) Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. Mol. Cell. Biol. 19, 1871-1880 PubMed
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 1871-1880
-
-
Waskiewicz, A.J.1
Johnson, J.C.2
Penn, B.3
Mahalingam, M.4
Kimball, S.R.5
Cooper, J.A.6
-
61
-
-
0030977270
-
MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates
-
CrossRef PubMed
-
Fukunaga, R. and Hunter, T. (1997) MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J. 16, 1921-1933 CrossRef PubMed
-
(1997)
EMBO J.
, vol.16
, pp. 1921-1933
-
-
Fukunaga, R.1
Hunter, T.2
-
62
-
-
9244228003
-
Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities
-
CrossRef PubMed
-
Topisirovic, I., Ruiz-Gutierrez, M. and Borden, K.L. (2004) Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities. Cancer Res. 64, 8639-8642 CrossRef PubMed
-
(2004)
Cancer Res.
, vol.64
, pp. 8639-8642
-
-
Topisirovic, I.1
Ruiz-Gutierrez, M.2
Borden, K.L.3
-
63
-
-
37249042829
-
Dissecting eIF4E action in tumorigenesis
-
CrossRef PubMed
-
Wendel, H.G., Silva, R.L., Malina, A., Mills, J.R., Zhu, H., Ueda, T., Watanabe-Fukunaga, R., Fukunaga, R., Teruya-Feldstein, J., Pelletier, J. and Lowe, S.W. (2007) Dissecting eIF4E action in tumorigenesis. Genes Dev. 21, 3232-3237 CrossRef PubMed
-
(2007)
Genes Dev.
, vol.21
, pp. 3232-3237
-
-
Wendel, H.G.1
Silva, R.L.2
Malina, A.3
Mills, J.R.4
Zhu, H.5
Ueda, T.6
Watanabe-Fukunaga, R.7
Fukunaga, R.8
Teruya-Feldstein, J.9
Pelletier, J.10
Lowe, S.W.11
-
64
-
-
77956275419
-
EIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
-
CrossRef PubMed
-
Furic, L., Rong, L., Larsson, O., Koumakpayi, I.H., Yoshida, K., Brueschke, A., Petroulakis, E., Robichaud, N., Pollak, M., Gaboury, L.A. et al. (2010) eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proc. Natl. Acad. Sci. U.S.A. 107, 14134-14139 CrossRef PubMed
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 14134-14139
-
-
Furic, L.1
Rong, L.2
Larsson, O.3
Koumakpayi, I.H.4
Yoshida, K.5
Brueschke, A.6
Petroulakis, E.7
Robichaud, N.8
Pollak, M.9
Gaboury, L.A.10
-
65
-
-
84929372129
-
Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3
-
CrossRef PubMed
-
Robichaud, N., Del Rincon, S.V., Huor, B., Alain, T., Petruccelli, L.A., Hearnden, J., Goncalves, C., Grotegut, S., Spruck, C.H., Furic, L. et al. (2014) Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3. Oncogene 34, 2032-2042 CrossRef PubMed
-
(2014)
Oncogene
, vol.34
, pp. 2032-2042
-
-
Robichaud, N.1
Del Rincon, S.V.2
Huor, B.3
Alain, T.4
Petruccelli, L.A.5
Hearnden, J.6
Goncalves, C.7
Grotegut, S.8
Spruck, C.H.9
Furic, L.10
-
66
-
-
4243110417
-
Pten dose dictates cancer progression in the prostate
-
CrossRef
-
Trotman, L.C., Niki, M., Dotan, Z.A., Koutcher, J.A., Cristofano, A., Xiao, A., Khoo, A.S., Roy-Burman, P., Greenberg, N.M., Dyke, T. et al. (2003) Pten dose dictates cancer progression in the prostate. PLoS Biol. 1, CrossRef
-
(2003)
PLoS Biol.
, vol.1
-
-
Trotman, L.C.1
Niki, M.2
Dotan, Z.A.3
Koutcher, J.A.4
Cristofano, A.5
Xiao, A.6
Khoo, A.S.7
Roy-Burman, P.8
Greenberg, N.M.9
Dyke, T.10
-
67
-
-
79952223149
-
Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases
-
CrossRef PubMed
-
Konicek, B.W., Stephens, J.R., McNulty, A.M., Robichaud, N., Peery, R.B., Dumstorf, C.A., Dowless, M.S., Iversen, P.W., Parsons, S., Ellis, K.E. et al. (2011) Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases. Cancer Res. 71, 1849-1857 CrossRef PubMed
-
(2011)
Cancer Res.
, vol.71
, pp. 1849-1857
-
-
Konicek, B.W.1
Stephens, J.R.2
McNulty, A.M.3
Robichaud, N.4
Peery, R.B.5
Dumstorf, C.A.6
Dowless, M.S.7
Iversen, P.W.8
Parsons, S.9
Ellis, K.E.10
-
68
-
-
84874106479
-
EIF4F suppression in breast cancer affects maintenance and progression
-
CrossRef PubMed
-
Nasr, Z., Robert, F., Jr, J.A., Muller, W.J. and Pelletier, J. (2013) eIF4F suppression in breast cancer affects maintenance and progression. Oncogene 32, 861-871 CrossRef PubMed
-
(2013)
Oncogene
, vol.32
, pp. 861-871
-
-
Nasr, Z.1
Robert, F.J.A.2
Muller, W.J.3
Pelletier, J.4
-
69
-
-
81855169565
-
Cancer invasion and the microenvironment: Plasticity and reciprocity
-
CrossRef PubMed
-
Friedl, P. and Alexander, S. (2011) Cancer invasion and the microenvironment: Plasticity and reciprocity. Cell 147, 992-1009 CrossRef PubMed
-
(2011)
Cell
, vol.147
, pp. 992-1009
-
-
Friedl, P.1
Alexander, S.2
-
70
-
-
59449090107
-
TGF-beta-induced epithelial to mesenchymal transition
-
CrossRef PubMed
-
Xu, J., Lamouille, S. and Derynck, R. (2009) TGF-beta-induced epithelial to mesenchymal transition. Cell Res. 19, 156-172 CrossRef PubMed
-
(2009)
Cell Res.
, vol.19
, pp. 156-172
-
-
Xu, J.1
Lamouille, S.2
Derynck, R.3
-
71
-
-
84930823150
-
Mnks, eIF4E phosphorylation and cancer
-
Proud, C.G. (2014) Mnks, eIF4E phosphorylation and cancer. Biochim. Biophys. Acta 766-773
-
(2014)
Biochim. Biophys. Acta
, pp. 766-773
-
-
Proud, C.G.1
-
72
-
-
34548028705
-
Funnel factor
-
CrossRef PubMed
-
Armengol, G., Rojo, F., Castellvi, J., Iglesias, C., Cuatrecasas, M., Pons, B., Baselga, J. and Cajal, S. (2007) funnel factor. Cancer Res. 67, 7551-7555 CrossRef PubMed
-
(2007)
Cancer Res.
, vol.67
, pp. 7551-7555
-
-
Armengol, G.1
Rojo, F.2
Castellvi, J.3
Iglesias, C.4
Cuatrecasas, M.5
Pons, B.6
Baselga, J.7
Cajal, S.8
-
73
-
-
84920987074
-
Targeting the eIF4F translation initiation complex: A critical nexus for cancer development
-
CrossRef PubMed
-
Pelletier, J., Graff, J., Ruggero, D. and Sonenberg, N. (2015) Targeting the eIF4F translation initiation complex: A critical nexus for cancer development. Cancer Res. 75, 250-263 CrossRef PubMed
-
(2015)
Cancer Res.
, vol.75
, pp. 250-263
-
-
Pelletier, J.1
Graff, J.2
Ruggero, D.3
Sonenberg, N.4
-
74
-
-
84555195333
-
Development of ATP-competitive mTOR inhibitors
-
CrossRef PubMed
-
Liu, Q., Kang, S.A., Thoreen, C.C., Hur, W., Wang, J., Chang, J.W., Markhard, A., Zhang, J., Sim, T., Sabatini, D.M. and Gray, N.S. (2012) Development of ATP-competitive mTOR inhibitors. Methods Mol. Biol. 821, 447-460 CrossRef PubMed
-
(2012)
Methods Mol. Biol.
, vol.821
, pp. 447-460
-
-
Liu, Q.1
Kang, S.A.2
Thoreen, C.C.3
Hur, W.4
Wang, J.5
Chang, J.W.6
Markhard, A.7
Zhang, J.8
Sim, T.9
Sabatini, D.M.10
Gray, N.S.11
-
75
-
-
61349141302
-
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
-
CrossRef
-
Feldman, M.E., Apsel, B., Uotila, A., Loewith, R., Knight, Z.A., Ruggero, D. and Shokat, K.M. (2009) Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 7, CrossRef
-
(2009)
PLoS Biol.
, pp. 7
-
-
Feldman, M.E.1
Apsel, B.2
Uotila, A.3
Loewith, R.4
Knight, Z.A.5
Ruggero, D.6
Shokat, K.M.7
-
76
-
-
80053070033
-
PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis
-
CrossRef PubMed
-
Ilic, N., Utermark, T., Widlund, H.R. and Roberts, T.M. (2011) PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis. Proc. Natl. Acad. Sci. U.S.A. 108, E699-E708 CrossRef PubMed
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. E699-E708
-
-
Ilic, N.1
Utermark, T.2
Widlund, H.R.3
Roberts, T.M.4
-
77
-
-
84894095058
-
Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation
-
CrossRef PubMed
-
Cope, C.L., Gilley, R., Balmanno, K., Sale, M.J., Howarth, K.D., Hampson, M., Smith, P.D., Guichard, S.M. and Cook, S.J. (2014) Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation. J. Cell Sci. 127, 788-800 CrossRef PubMed
-
(2014)
J. Cell Sci.
, vol.127
, pp. 788-800
-
-
Cope, C.L.1
Gilley, R.2
Balmanno, K.3
Sale, M.J.4
Howarth, K.D.5
Hampson, M.6
Smith, P.D.7
Guichard, S.M.8
Cook, S.J.9
-
78
-
-
84874725307
-
MTOR inhibitor efficacy is determined by the eIF4E/4E-BP ratio
-
PubMed
-
Alain, T., Sonenberg, N. and Topisirovic, I. (2012) mTOR inhibitor efficacy is determined by the eIF4E/4E-BP ratio. Oncotarget 3, 1491-1492 PubMed
-
(2012)
Oncotarget
, vol.3
, pp. 1491-1492
-
-
Alain, T.1
Sonenberg, N.2
Topisirovic, I.3
-
79
-
-
77952967459
-
MTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs
-
CrossRef PubMed
-
Dowling, R.J., Topisirovic, I., Alain, T., Bidinosti, M., Fonseca, B.D., Petroulakis, E., Wang, X., Larsson, O., Selvaraj, A., Liu, Y. et al. (2010) mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science 328, 1172-1176 CrossRef PubMed
-
(2010)
Science
, vol.328
, pp. 1172-1176
-
-
Dowling, R.J.1
Topisirovic, I.2
Alain, T.3
Bidinosti, M.4
Fonseca, B.D.5
Petroulakis, E.6
Wang, X.7
Larsson, O.8
Selvaraj, A.9
Liu, Y.10
-
80
-
-
34848901974
-
Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity
-
CrossRef PubMed
-
Graff, J.R., Konicek, B.W., Vincent, T.M., Lynch, R.L., Monteith, D., Weir, S.N., Schwier, P., Capen, A., Goode, R.L., Dowless, M.S. et al. (2007) Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity. J. Clin. Invest. 117, 2638-2648 CrossRef PubMed
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2638-2648
-
-
Graff, J.R.1
Konicek, B.W.2
Vincent, T.M.3
Lynch, R.L.4
Monteith, D.5
Weir, S.N.6
Schwier, P.7
Capen, A.8
Goode, R.L.9
Dowless, M.S.10
-
81
-
-
84862979524
-
Translational homeostasis via the mRNA cap-binding protein, EIF4E
-
CrossRef PubMed
-
Yanagiya, A., Suyama, E., Adachi, H., Svitkin, Y.V., Aza-Blanc, P., Imataka, H., Mikami, S., Martineau, Y., Ronai, Z.A. and Sonenberg, N. (2012) Translational homeostasis via the mRNA cap-binding protein, eIF4E. Mol. Cell 46, 847-858 CrossRef PubMed
-
(2012)
Mol. Cell
, vol.46
, pp. 847-858
-
-
Yanagiya, A.1
Suyama, E.2
Adachi, H.3
Svitkin, Y.V.4
Aza-Blanc, P.5
Imataka, H.6
Mikami, S.7
Martineau, Y.8
Ronai, Z.A.9
Sonenberg, N.10
-
82
-
-
84863803532
-
Targeting Mnks for cancer therapy
-
PubMed
-
Hou, J., Lam, F., Proud, C. and Wang, S. (2012) Targeting Mnks for cancer therapy. Oncotarget 3, 118-131 PubMed
-
(2012)
Oncotarget
, vol.3
, pp. 118-131
-
-
Hou, J.1
Lam, F.2
Proud, C.3
Wang, S.4
-
83
-
-
0034928792
-
Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2
-
CrossRef PubMed
-
Knauf, U., Tschopp, C. and Gram, H. (2001) Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. Mol. Cell Biol. 21, 5500-5511 CrossRef PubMed
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 5500-5511
-
-
Knauf, U.1
Tschopp, C.2
Gram, H.3
-
84
-
-
49749125291
-
Targeting the eIF4F translation initiation complex for cancer therapy
-
CrossRef PubMed
-
Konicek, B.W., Dumstorf, C.A. and Graff, J.R. (2008) Targeting the eIF4F translation initiation complex for cancer therapy. Cell Cycle 7, 2466-2471 CrossRef PubMed
-
(2008)
Cell Cycle
, vol.7
, pp. 2466-2471
-
-
Konicek, B.W.1
Dumstorf, C.A.2
Graff, J.R.3
-
85
-
-
84899994001
-
Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: Syn thesis, SAR analysis and biological evaluation
-
CrossRef PubMed
-
Diab, S., Teo, T., Kumarasiri, M., Li, P., Yu, M., Lam, F., Basnet, S.K., Sykes, M.J., Albrecht, H., Milne, R. and Wang, S. (2014) Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: Synthesis, SAR analysis and biological evaluation. ChemMedChem 9, 962-972 CrossRef PubMed
-
(2014)
ChemMedChem
, vol.9
, pp. 962-972
-
-
Diab, S.1
Teo, T.2
Kumarasiri, M.3
Li, P.4
Yu, M.5
Lam, F.6
Basnet, S.K.7
Sykes, M.J.8
Albrecht, H.9
Milne, R.10
Wang, S.11
-
86
-
-
77956271160
-
Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development
-
CrossRef PubMed
-
Ueda, T., Sasaki, M., Elia, A.J., Chio, II, Hamada, K., Fukunaga, R. and Mak, T.W. (2010) Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development. Proc. Natl. Acad. Sci. U.S.A. 107, 13984-13990 CrossRef PubMed
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 13984-13990
-
-
Ueda, T.1
Sasaki, M.2
Elia, A.J.3
Chio, I.I.4
Hamada, K.5
Fukunaga, R.6
Mak, T.W.7
-
87
-
-
84905653296
-
Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G
-
CrossRef PubMed
-
Papadopoulos, E., Jenni, S., Kabha, E., Takrouri, K.J., Yi, T., Salvi, N., Luna, R.E., Gavathiotis, E., Mahalingam, P., Arthanari, H. et al. (2014) Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G. Proc. Natl. Acad. Sci. U.S.A. 111, E3187-E3195 CrossRef PubMed
-
(2014)
Proc. Natl. Acad. Sci. U.S.A.
, vol.111
, pp. E3187-E3195
-
-
Papadopoulos, E.1
Jenni, S.2
Kabha, E.3
Takrouri, K.J.4
Yi, T.5
Salvi, N.6
Luna, R.E.7
Gavathiotis, E.8
Mahalingam, P.9
Arthanari, H.10
-
88
-
-
77951671938
-
The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation
-
CrossRef PubMed
-
Fan, S., Li, Y., Yue, P., Khuri, F.R. and Sun, S.Y. (2010) The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation. Neoplasia 12, 346-356 CrossRef PubMed
-
(2010)
Neoplasia
, vol.12
, pp. 346-356
-
-
Fan, S.1
Li, Y.2
Yue, P.3
Khuri, F.R.4
Sun, S.Y.5
-
89
-
-
84868622977
-
Tumor suppression by small molecule inhibitors of translation initiation
-
PubMed
-
Chen, L., Aktas, B.H., Wang, Y., He, X., Sahoo, R., Zhang, N., Denoyelle, S., Kabha, E., Yang, H., Freedman, R.Y. et al. (2012) Tumor suppression by small molecule inhibitors of translation initiation. Oncotarget 3, 869-881 PubMed
-
(2012)
Oncotarget
, vol.3
, pp. 869-881
-
-
Chen, L.1
Aktas, B.H.2
Wang, Y.3
He, X.4
Sahoo, R.5
Zhang, N.6
Denoyelle, S.7
Kabha, E.8
Yang, H.9
Freedman, R.Y.10
-
90
-
-
84860729291
-
The cap-translation inhibitor 4EGI-1 induces apoptosis in multiple myeloma through Noxa induction
-
CrossRef PubMed
-
Descamps, G., Gomez-Bougie, P., Tamburini, J., Green, A., Bouscary, D., Maiga, S., Moreau, P., Gouill, S., Pellat-Deceunynck, C. and Amiot, M. (2012) The cap-translation inhibitor 4EGI-1 induces apoptosis in multiple myeloma through Noxa induction. Br. J. Cancer 106, 1660-1667 CrossRef PubMed
-
(2012)
Br. J. Cancer
, vol.106
, pp. 1660-1667
-
-
Descamps, G.1
Gomez-Bougie, P.2
Tamburini, J.3
Green, A.4
Bouscary, D.5
Maiga, S.6
Moreau, P.7
Gouill, S.8
Pellat-Deceunynck, C.9
Amiot, M.10
-
91
-
-
84901801991
-
Targeting eIF4GI translation initiation factor affords an attractive therapeutic strategy in multiple myeloma
-
CrossRef PubMed
-
Attar-Schneider, O., Drucker, L., Zismanov, V., Tartakover-Matalon, S. and Lishner, M. (2014) Targeting eIF4GI translation initiation factor affords an attractive therapeutic strategy in multiple myeloma. Cell. Signal. 26, 1878-1887 CrossRef PubMed
-
(2014)
Cell. Signal.
, vol.26
, pp. 1878-1887
-
-
Attar-Schneider, O.1
Drucker, L.2
Zismanov, V.3
Tartakover-Matalon, S.4
Lishner, M.5
-
92
-
-
84906265523
-
4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis
-
PubMed
-
Yi, T., Kabha, E., Papadopoulos, E. and Wagner, G. (2014) 4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis. Oncotarget 5, 6028-6037 PubMed
-
(2014)
Oncotarget
, vol.5
, pp. 6028-6037
-
-
Yi, T.1
Kabha, E.2
Papadopoulos, E.3
Wagner, G.4
-
93
-
-
84903523080
-
Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction
-
CrossRef PubMed
-
Mahalingam, P., Takrouri, K., Chen, T., Sahoo, R., Papadopoulos, E., Chen, L., Wagner, G., Aktas, B.H., Halperin, J.A. and Chorev, M. (2014) Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction. J. Med. Chem. 57, 5094-5111 CrossRef PubMed
-
(2014)
J. Med. Chem.
, vol.57
, pp. 5094-5111
-
-
Mahalingam, P.1
Takrouri, K.2
Chen, T.3
Sahoo, R.4
Papadopoulos, E.5
Chen, L.6
Wagner, G.7
Aktas, B.H.8
Halperin, J.A.9
Chorev, M.10
-
94
-
-
84897080920
-
Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors
-
CrossRef PubMed
-
Takrouri, K., Chen, T., Papadopoulos, E., Sahoo, R., Kabha, E., Chen, H., Cantel, S., Wagner, G., Halperin, J.A., Aktas, B.H. and Chorev, M. (2014) Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors. Eur. J. Med. Chem. 77, 361-377 CrossRef PubMed
-
(2014)
Eur. J. Med. Chem.
, vol.77
, pp. 361-377
-
-
Takrouri, K.1
Chen, T.2
Papadopoulos, E.3
Sahoo, R.4
Kabha, E.5
Chen, H.6
Cantel, S.7
Wagner, G.8
Halperin, J.A.9
Aktas, B.H.10
Chorev, M.11
-
95
-
-
84896709524
-
3-substituted indazoles as configurationally locked 4EGI-1 mimetics and inhibitors of the eIF4E/eIF4G interaction
-
CrossRef PubMed
-
Yefidoff-Freedman, R., Chen, T., Sahoo, R., Chen, L., Wagner, G., Halperin, J.A., Aktas, B.H. and Chorev, M. (2014) 3-substituted indazoles as configurationally locked 4EGI-1 mimetics and inhibitors of the eIF4E/eIF4G interaction. Chembiochem 15, 595-611 CrossRef PubMed
-
(2014)
Chembiochem
, vol.15
, pp. 595-611
-
-
Yefidoff-Freedman, R.1
Chen, T.2
Sahoo, R.3
Chen, L.4
Wagner, G.5
Halperin, J.A.6
Aktas, B.H.7
Chorev, M.8
-
96
-
-
84889564693
-
Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface
-
CrossRef PubMed
-
Lukhele, S., Bah, A., Lin, H., Sonenberg, N. and Forman-Kay, J.D. (2013) Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface. Structure 21, 2186-2196 CrossRef PubMed
-
(2013)
Structure
, vol.21
, pp. 2186-2196
-
-
Lukhele, S.1
Bah, A.2
Lin, H.3
Sonenberg, N.4
Forman-Kay, J.D.5
-
97
-
-
84907303445
-
4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation
-
CrossRef PubMed
-
Igreja, C., Peter, D., Weiler, C. and Izaurralde, E. (2014) 4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation. Nat. Commun. 5, 4790 CrossRef PubMed
-
(2014)
Nat. Commun.
, vol.5
, pp. 4790
-
-
Igreja, C.1
Peter, D.2
Weiler, C.3
Izaurralde, E.4
-
98
-
-
84925269956
-
Molecular architecture of 4E-BP translational inhibitors bound to eIF4E
-
CrossRef PubMed
-
Peter, D., Igreja, C., Weber, R., Wohlbold, L., Weiler, C., Ebertsch, L., Weichenrieder, O. and Izaurralde, E. (2015) Molecular architecture of 4E-BP translational inhibitors bound to eIF4E. Mol. Cell 57, 1074-1087 CrossRef PubMed
-
(2015)
Mol. Cell
, vol.57
, pp. 1074-1087
-
-
Peter, D.1
Igreja, C.2
Weber, R.3
Wohlbold, L.4
Weiler, C.5
Ebertsch, L.6
Weichenrieder, O.7
Izaurralde, E.8
-
99
-
-
84925538272
-
Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch
-
CrossRef PubMed
-
Bah, A., Vernon, R.M., Siddiqui, Z., Krzeminski, M., Muhandiram, R., Zhao, C., Sonenberg, N., Kay, L.E. and Forman-Kay, J.D. (2015) Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch. Nature 519, 106-109 CrossRef PubMed
-
(2015)
Nature
, vol.519
, pp. 106-109
-
-
Bah, A.1
Vernon, R.M.2
Siddiqui, Z.3
Krzeminski, M.4
Muhandiram, R.5
Zhao, C.6
Sonenberg, N.7
Kay, L.E.8
Forman-Kay, J.D.9
-
100
-
-
84863838830
-
Cap-dependent translation initiation factor eIF4E: An emerging anticancer drug target
-
CrossRef PubMed
-
Jia, Y., Polunovsky, V., Bitterman, P.B. and Wagner, C.R. (2012) Cap-dependent translation initiation factor eIF4E: An emerging anticancer drug target. Med. Res. Rev. 32, 786-814 CrossRef PubMed
-
(2012)
Med. Res. Rev.
, vol.32
, pp. 786-814
-
-
Jia, Y.1
Polunovsky, V.2
Bitterman, P.B.3
Wagner, C.R.4
-
101
-
-
84873396333
-
Treatment of breast and lung cancer cells with a N-7 benzyl guanosine monophosphate tryptamine phosphoramidate pronucleotide (4Ei-1) results in chemosensitization to gemcitabine and induced eIF4E proteasomal degradation
-
CrossRef PubMed
-
Li, S., Jia, Y., Jacobson, B., McCauley, J., Kratzke, R., Bitterman, P.B. and Wagner, C.R. (2013) Treatment of breast and lung cancer cells with a N-7 benzyl guanosine monophosphate tryptamine phosphoramidate pronucleotide (4Ei-1) results in chemosensitization to gemcitabine and induced eIF4E proteasomal degradation. Mol. Pharm. 10, 523-531 CrossRef PubMed
-
(2013)
Mol. Pharm.
, vol.10
, pp. 523-531
-
-
Li, S.1
Jia, Y.2
Jacobson, B.3
McCauley, J.4
Kratzke, R.5
Bitterman, P.B.6
Wagner, C.R.7
-
102
-
-
65749084524
-
Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation
-
CrossRef PubMed
-
Ghosh, B., Benyumov, A.O., Ghosh, P., Jia, Y., Avdulov, S., Dahlberg, P.S., Peterson, M., Smith, K., Polunovsky, V.A., Bitterman, P.B. and Wagner, C.R. (2009) Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation. ACS Chem. Biol. 4, 367-377 CrossRef PubMed
-
(2009)
ACS Chem. Biol.
, vol.4
, pp. 367-377
-
-
Ghosh, B.1
Benyumov, A.O.2
Ghosh, P.3
Jia, Y.4
Avdulov, S.5
Dahlberg, P.S.6
Peterson, M.7
Smith, K.8
Polunovsky, V.A.9
Bitterman, P.B.10
Wagner, C.R.11
-
103
-
-
84904556518
-
Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells
-
CrossRef PubMed
-
Chen, E.Z., Jacobson, B.A., Patel, M.R., Okon, A.M., Li, S., Xiong, K., Vaidya, A.J., Bitterman, P.B., Wagner, C.R. and Kratzke, R.A. (2014) Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells. Invest. New Drugs 32, 598-603 CrossRef PubMed
-
(2014)
Invest. New Drugs
, vol.32
, pp. 598-603
-
-
Chen, E.Z.1
Jacobson, B.A.2
Patel, M.R.3
Okon, A.M.4
Li, S.5
Xiong, K.6
Vaidya, A.J.7
Bitterman, P.B.8
Wagner, C.R.9
Kratzke, R.A.10
-
104
-
-
84860267772
-
Structure-guided design, syn thesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction
-
CrossRef PubMed
-
Chen, X., Kopecky, D.J., Mihalic, J., Jeffries, S., Min, X., Heath, J., Deignan, J., Lai, S., Fu, Z., Guimaraes, C. et al. (2012) Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction. J. Med. Chem. 55, 3837-3851 CrossRef PubMed
-
(2012)
J. Med. Chem.
, vol.55
, pp. 3837-3851
-
-
Chen, X.1
Kopecky, D.J.2
Mihalic, J.3
Jeffries, S.4
Min, X.5
Heath, J.6
Deignan, J.7
Lai, S.8
Fu, Z.9
Guimaraes, C.10
-
105
-
-
84930960339
-
Targeting the eIF4A RNA helicase as an anti-neoplastic approach
-
Chu, J. and Pelletier, J. (2014) Targeting the eIF4A RNA helicase as an anti-neoplastic approach. Biochim. Biophys. Acta 781-791
-
(2014)
Biochim. Biophys. Acta
, pp. 781-791
-
-
Chu, J.1
Pelletier, J.2
-
106
-
-
84860214990
-
Intra-tumour heterogeneity: A looking glass for cancer?
-
CrossRef
-
Marusyk, A., Almendro, V. and Polyak, K. (2012) Intra-tumour heterogeneity: A looking glass for cancer? Rev. Cancer 12, 323-334 CrossRef
-
(2012)
Rev. Cancer
, vol.12
, pp. 323-334
-
-
Marusyk, A.1
Almendro, V.2
Polyak, K.3
-
107
-
-
84898033361
-
Tumor heterogeneity confounds and illuminates: A case for Darwinian tumor evolution
-
CrossRef PubMed
-
Polyak, K. (2014) Tumor heterogeneity confounds and illuminates: A case for Darwinian tumor evolution. Nat. Med. 20, 344-346 CrossRef PubMed
-
(2014)
Nat. Med.
, vol.20
, pp. 344-346
-
-
Polyak, K.1
-
108
-
-
84884514632
-
Single-cell quantitative HER2 measurement identifies heterogeneity and distinct subgroups within traditionally defined HER2-positive patients
-
CrossRef PubMed
-
Onsum, M.D., Geretti, E., Paragas, V., Kudla, A.J., Moulis, S.P., Luus, L., Wickham, T.J., McDonagh, C.F., Macbeath, G. and Hendriks, B.S. (2013) Single-cell quantitative HER2 measurement identifies heterogeneity and distinct subgroups within traditionally defined HER2-positive patients. Am. J. Pathol. 183, 1446-1460 CrossRef PubMed
-
(2013)
Am. J. Pathol.
, vol.183
, pp. 1446-1460
-
-
Onsum, M.D.1
Geretti, E.2
Paragas, V.3
Kudla, A.J.4
Moulis, S.P.5
Luus, L.6
Wickham, T.J.7
McDonagh, C.F.8
Macbeath, G.9
Hendriks, B.S.10
-
109
-
-
84879978653
-
Immunohistochemical profile and morphology in triple - negative breast cancers
-
PubMed
-
Rao, C., Shetty, J. and Prasad, K.H. (2013) Immunohistochemical profile and morphology in triple - negative breast cancers. J. Clin. Diagn. Res. 7, 1361-1365 PubMed
-
(2013)
J. Clin. Diagn. Res.
, vol.7
, pp. 1361-1365
-
-
Rao, C.1
Shetty, J.2
Prasad, K.H.3
-
110
-
-
33847147313
-
American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer
-
CrossRef PubMed
-
Wolff, A.C., Hammond, M.E., Schwartz, J.N., Hagerty, K.L., Allred, D.C., Cote, R.J., Dowsett, M., Fitzgibbons, P.L., Hanna, W.M., Langer, A. et al. (2007) American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J. Clin. Oncol. 25, 118-145 CrossRef PubMed
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 118-145
-
-
Wolff, A.C.1
Hammond, M.E.2
Schwartz, J.N.3
Hagerty, K.L.4
Allred, D.C.5
Cote, R.J.6
Dowsett, M.7
Fitzgibbons, P.L.8
Hanna, W.M.9
Langer, A.10
-
111
-
-
38049025794
-
Review: Side effects of approved molecular targeted therapies in solid cancers
-
CrossRef PubMed
-
Widakowich, C., de Castro, G., de Azambuja, E., Dinh, P. and Awada, A. (2007) Review: Side effects of approved molecular targeted therapies in solid cancers. Oncologist 12, 1443-1455 CrossRef PubMed
-
(2007)
Oncologist
, vol.12
, pp. 1443-1455
-
-
Widakowich, C.1
De Castro, G.2
De Azambuja, E.3
Dinh, P.4
Awada, A.5
-
112
-
-
84908245075
-
Combined vemurafenib and cobimetinib in BRAF-mutated melanoma
-
CrossRef PubMed
-
Larkin, J., Ascierto, P.A., Dreno, B., Atkinson, V., Liszkay, G., Maio, M., Mandala, M., Demidov, L., Stroyakovskiy, D., Thomas, L. et al. (2014) Combined vemurafenib and cobimetinib in BRAF-mutated melanoma. N. Engl. J. Med. 371, 1867-1876 CrossRef PubMed
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 1867-1876
-
-
Larkin, J.1
Ascierto, P.A.2
Dreno, B.3
Atkinson, V.4
Liszkay, G.5
Maio, M.6
Mandala, M.7
Demidov, L.8
Stroyakovskiy, D.9
Thomas, L.10
-
113
-
-
84919844789
-
The intra-tumor heterogeneity of cell signaling factors in breast cancer: P4E-BP1 and peIF4E are diffusely expressed and are real potential targets
-
CrossRef PubMed
-
Ramon, Y.C.S., De Mattos-Arruda, L., Sonenberg, N., Cortes, J. and Peg, V. (2014) The intra-tumor heterogeneity of cell signaling factors in breast cancer: P4E-BP1 and peIF4E are diffusely expressed and are real potential targets. Clin. Transl. Oncol. 16, 937-941 CrossRef PubMed
-
(2014)
Clin. Transl. Oncol.
, vol.16
, pp. 937-941
-
-
Ramon, Y.C.S.1
De Mattos-Arruda, L.2
Sonenberg, N.3
Cortes, J.4
Peg, V.5
-
114
-
-
84907216956
-
EIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies
-
CrossRef PubMed
-
Boussemart, L., Malka-Mahieu, H., Girault, I., Allard, D., Hemmingsson, O., Tomasic, G., Thomas, M., Basmadjian, C., Ribeiro, N., Thuaud, F. et al. (2014) eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies. Nature 513, 105-109 CrossRef PubMed
-
(2014)
Nature
, vol.513
, pp. 105-109
-
-
Boussemart, L.1
Malka-Mahieu, H.2
Girault, I.3
Allard, D.4
Hemmingsson, O.5
Tomasic, G.6
Thomas, M.7
Basmadjian, C.8
Ribeiro, N.9
Thuaud, F.10
-
115
-
-
84872595085
-
Autism-related deficits via dysregulated eIF4E-dependent translational control
-
CrossRef PubMed
-
Gkogkas, C.G., Khoutorsky, A., Ran, I., Rampakakis, E., Nevarko, T., Weatherill, D.B., Vasuta, C., Yee, S., Truitt, M., Dallaire, P. et al. (2013) Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature 493, 371-377 CrossRef PubMed
-
(2013)
Nature
, vol.493
, pp. 371-377
-
-
Gkogkas, C.G.1
Khoutorsky, A.2
Ran, I.3
Rampakakis, E.4
Nevarko, T.5
Weatherill, D.B.6
Vasuta, C.7
Yee, S.8
Truitt, M.9
Dallaire, P.10
-
116
-
-
84915750890
-
Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes
-
CrossRef PubMed
-
Gkogkas, C.G., Khoutorsky, A., Cao, R., Jafarnejad, S.M., Prager-Khoutorsky, M., Giannakas, N., Kaminari, A., Fragkouli, A., Nader, K., Price, T.J. et al. (2014) Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes. Cell Rep. 9, 1742-1755 CrossRef PubMed
-
(2014)
Cell Rep.
, vol.9
, pp. 1742-1755
-
-
Gkogkas, C.G.1
Khoutorsky, A.2
Cao, R.3
Jafarnejad, S.M.4
Prager-Khoutorsky, M.5
Giannakas, N.6
Kaminari, A.7
Fragkouli, A.8
Nader, K.9
Price, T.J.10
|