Testosterone supplementation improves anemia in aging male mice

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 69 A, Issue 5, 2014, Pages 505-513

  Guo, Wen ^a   Li, Michelle ^a   Bhasin, Shalender ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Aging; Anemia; Erythropoiesis; Iron bioavailability.; Testosterone

Indexed keywords

ANDROGEN; TESTOSTERONE;

AGING; ANEMIA; ANIMAL; ARTICLE; C57BL MOUSE; DIET SUPPLEMENTATION; ERYTHROCYTE; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; IRON BIOAVAILABILITY.; MALE; MEAN CORPUSCULAR VOLUME; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; SPLEEN;

AGING; ANEMIA; ERYTHROPOIESIS; IRON BIOAVAILABILITY.; TESTOSTERONE;

AGING; ANDROGENS; ANEMIA; ANIMALS; DIETARY SUPPLEMENTS; ERYTHROCYTE INDICES; ERYTHROCYTES; ERYTHROID PRECURSOR CELLS; ERYTHROPOIESIS; MALE; MICE; MICE, INBRED C57BL; SPLEEN; TESTOSTERONE;

EID: 84899045860     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glt127     Document Type: Article

References (38)

1. Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: Evidence for a high rate of unexplained anemia. Blood. 2004;104:2263-2268
2. Patel KV, Harris TB, Faulhaber M, et al. Racial variation in the relationship of anemia with mortality and mobility disability among older adults. Blood. 2007;109:4663-4670
3. Patel KV, Longo DL, Ershler WB, Yu B, Semba RD, Ferrucci L, Guralnik JM. Haemoglobin concentration and the risk of death in older adults: Differences by race/ethnicity in the NHANES III followup. Br J Haematol. 2009;145:514-523
4. Chaves PH, Ashar B, Guralnik JM, Fried LP. Looking at the relationship between hemoglobin concentration and prevalent mobility difficulty in older women. Should the criteria currently used to define anemia in older people be reevaluated? J Am Geriatr Soc. 2002;50:1257-1264
5. Balducci L. Anemia, fatigue and aging. Transfus Clin Biol. 2010;17: 375-381
6. Penninx BW, Guralnik JM, Onder G, Ferrucci L, Wallace RB, Pahor M. Anemia and decline in physical performance among older persons. Am J Med. 2003;115:104-110
7. Penninx BW, Pahor M, Cesari M, et al. Anemia is associated with disability and decreased physical performance and muscle strength in the elderly. J Am Geriatr Soc. 2004;52:719-724
8. Millot S, Andrieu V, Letteron P, et al. Erythropoietin stimulates spleen BMP4-dependent stress erythropoiesis and partially corrects anemia in a mouse model of generalized inflammation. Blood. 2010;116:6072-6081
9. Saitoh T, Morimoto K, Kumagai T, Tsuboi I, Aikawa S, Horie T. Comparison of erythropoietic response to androgen in young and old senescence accelerated mice. Mech Ageing Dev. 1999;109:125-139
10. Ferrucci L, Maggio M, Bandinelli S, et al. Low testosterone levels and the risk of anemia in older men and women. Arch Intern Med. 2006;166:1380-1388
11. Shahidi NT. Androgens and erythropoiesis. N Engl J Med. 1973;289: 72-80
12. Guo W, Bachman E, Li M, et al. Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells. Aging Cell. 2013;12:280-291
13. Chen K, Liu J, Heck S, Chasis JA, An X, Mohandas N. Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis. Proc Natl Acad Sci USA. 2009;106:17413-17418
14. Ponka P. Tissue-specific regulation of iron metabolism and heme synthesis: Distinct control mechanisms in erythroid cells. Blood. 1997;89:1-25
15. Coviello AD, Kaplan B, Lakshman KM, Chen T, Singh AB, Bhasin S. Effects of graded doses of testosterone on erythropoiesis in healthy young and older men. J Clin Endocrinol Metab. 2008;93:914-919
16. Adamson JW, Longo DN. Anemia and Polycythemia. New York, NY: McGraw-Hill; 2001
17. Magnani M, Rossi L, Stocchi V, Cucchiarini L, Piacentini G, Fornaini G. Effect of age on some properties of mice erythrocytes. Mech Ageing Dev. 1988;42:37-47
18. Shiga T, Maeda N, Kon K. Erythrocyte rheology. Crit Rev Oncol Hematol. 1990;10:9-48
19. N emeth E, Ganz T. The role of hepcidin in iron metabolism. Acta Haematol. 2009;122:78-86
20. Powers JS, Krantz SB, Collins JC, et al. Erythropoietin response to anemia as a function of age. J Am Geriatr Soc. 1991;39:30-32
21. Benderro GF, LaManna JC. Kidney EPO expression during chronic hypoxia in aged mice. Adv Exp Med Biol. 2013;765:9-14
22. Maggio M, Snyder PJ, Ceda GP, et al. Is the haematopoietic effect of testosterone mediated by erythropoietin? The results of a clinical trial in older men. Andrology. 2013;1:24-28
23. Ershler WB, Sheng S, McKelvey J, et al. Serum erythropoietin and aging: A longitudinal analysis. J Am Geriatr Soc. 2005;53:1360-1365
24. Lowry JA, Mackay JP. GATA-1: One protein, many partners. Int J Biochem Cell Biol. 2006;38:6-11
25. Tsiftsoglou AS, Vizirianakis IS, Strouboulis J. Erythropoiesis: Model systems, molecular regulators, and developmental programs. IUBMB Life. 2009;61:800-830
26. Cantor AB, Orkin SH. Transcriptional regulation of erythropoiesis: An affair involving multiple partners. Oncogene. 2002;21:3368-3376
27. Mancini E, Sanjuan-Pla A, Luciani L, et al. FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors. EMBO J. 2012;31:351-365
28. Cao A, Moi P. Regulation of the globin genes. Pediatr Res. 2002;51: 415-421
29. Shivdasani RA, Orkin SH. Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2. Proc Natl Acad Sci USA. 1995;92:8690-8694
30. Capron C, Lacout C, Lécluse Y, et al. LYL-1 deficiency induces a stress erythropoiesis. Exp Hematol. 2011;39:629-642
31. Poss KD, Tonegawa S. Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci USA. 1997;94:10919-10924
32. Koulnis M, Pop R, Porpiglia E, Shearstone JR, Hidalgo D, Socolovsky M. Identification and analysis of mouse erythroid progenitors using the CD71/TER119 flow-cytometric assay. J Vis Exp. 2011; Aug 5;(54). pii: 2809. doi:10.3791/2809
33. Schofield R, Dexter TM, Lord BI, Testa NG. Comparison of haemopoiesis in young and old mice. Mech Ageing Dev. 1986;34:1-12
34. Rothman IK, Zanjani ED, Gordon AS, Silber R. Nucleoside deaminase: An enzymatic marker for stress erythropoiesis in the mouse. J Clin Invest. 1970;49:2051-2067
35. Page DL, Glenner GG. Social interaction and wounding in the genesis of 'spontaneous' murine amyloidosis. Am J Pathol. 1972;67:555-567
36. Williams LH, Udupa KB, Lipshitz DA. Evaluation of the effect of age on hematopoiesis in the C57BL/6 mouse. Exp Hematol. 1986;14:827-832
37. Lee P, Gelbart T, Waalen J, Beutler E. The anemia of ageing is not associated with increased plasma hepcidin levels. Blood Cells Mol Dis. 2008;41:252-254
38. Udupa KB, Lipschitz DA. Erythropoiesis in the aged mouse: I. Response to stimulation in vivo. J Lab Clin Med. 1984;103: 574-580.