HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

EMBO Molecular Medicine

Volumn 9, Issue 2, 2017, Pages 181-197

  Myant, Kevin B ^a,b   Cammareri, Patrizia ^a   Hodder, Michael C ^a   Wills, Jimi ^b   Von Kriegsheim, Alex ^b   Győrffy, Balázs ^c,d   Rashid, Mamun ^e   Polo, Simona ^f   Maspero, Elena ^f   Vaughan, Lynsey ^g   Gurung, Basanta ^h   Barry, Evan ^h   Malliri, Angeliki ^g   Camargo, Fernando ^h   Adams, David J ^e   Iavarone, Antonio ⁱ   Lasorella, Anna ⁱ   Sansom, Owen J ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^d SEMMELWEIS UNIVERSITY   (Hungary)

^e WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^f FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^g UNIVERSITY OF MANCHESTER   (United Kingdom)

^h BOSTON CHILDREN S HOSPITAL   (United States)

ⁱ Department of Medicine   (United States)

Author keywords

colorectal cancer; DNA damage; HUWE1; MCL1; MYC

Indexed keywords

PROTEIN MCL 1; HUWE1 PROTEIN, MOUSE; MUTANT PROTEIN; MYC PROTEIN; MYC PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APC GENE; ARTICLE; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GENE DELETION; GENE FUNCTION; GENE MUTATION; HUWE1 GENE; MOUSE; NONHUMAN; ONCOGENE MYC; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; ANIMAL; CARCINOGENESIS; COLORECTAL TUMOR; GENETICS; METABOLISM; PATHOLOGY;

ANIMALS; CARCINOGENESIS; COLORECTAL NEOPLASMS; DNA DAMAGE; GENE DELETION; GENES, TUMOR SUPPRESSOR; MICE; MUTANT PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES;

EID: 85007039831     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201606684     Document Type: Article

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