P2Y6 receptor antagonist MRS2578 inhibits neutrophil activation and aggregated neutrophil extracellular trap formation induced by gout-associated monosodium urate crystals

Journal of Immunology

Volumn 198, Issue 1, 2017, Pages 428-442

  Sil, Payel ^a   Hayes, Craig P ^a   Reaves, Barbara J ^a   Breen, Patrick ^a   Quinn, Shannon ^a   Sokolove, Jeremy ^b,c   Rada, Balázs ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; INTERLEUKIN 8; LEUKOCYTE ELASTASE; MRS 2578; MYELOPEROXIDASE; PURINERGIC P2Y RECEPTOR; PURINERGIC P2Y RECEPTOR ANTAGONIST; PURINERGIC P2Y6 RECEPTOR; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; SURAMIN; UNCLASSIFIED DRUG; URATE; ISOTHIOCYANIC ACID DERIVATIVE; N,N''-1,4-BUTANEDIYLBIS(N'-(3-ISOTHIOCYANATOPHENYL))THIOUREA; PURINERGIC P2 RECEPTOR; THIOUREA; URIC ACID;

CALCIUM CELL LEVEL; CALCIUM SIGNALING; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CRYSTAL; DRUG MECHANISM; ENZYME ACTIVITY; EXTRACELLULAR TRAP; GOUT; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; LEUKOCYTE MIGRATION; NEUTROPHIL; OSTEOARTHRITIS; PHAGOCYTOSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVIEW; SYNOVIAL FLUID; ANALOGS AND DERIVATIVES; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HIGH THROUGHPUT SCREENING; IMMUNOLOGY; IN VITRO STUDY; METABOLISM; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; SIGNAL TRANSDUCTION;

CHEMOTAXIS, LEUKOCYTE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR TRAPS; FLUORESCENT ANTIBODY TECHNIQUE; GOUT; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IN VITRO TECHNIQUES; ISOTHIOCYANATES; MICROSCOPY, CONFOCAL; NEUTROPHIL ACTIVATION; NEUTROPHILS; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION; SYNOVIAL FLUID; THIOUREA; URIC ACID;

EID: 85006968381     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1600766     Document Type: Review

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