SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 9, 2015, Pages 2817-2822

  Douda, David Nobuhiro ^a,b,d   Khan, Meraj A ^a   Grasemann, Hartmut ^c   Palaniyar, Nades ^a,b,c  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

NADPH oxidase; NETosis; Neutrophil extracellular traps; Neutrophils; SK channels

Indexed keywords

CALCIUM; CALCIUM ACTIVATED POTASSIUM CHANNEL; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; POTASSIUM CHANNEL SK3; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; UNCLASSIFIED DRUG; CYBB PROTEIN, HUMAN; KCNN3 PROTEIN, HUMAN; MEMBRANE PROTEIN;

ARTICLE; CALCIUM TRANSPORT; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR TRAP; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRION; NEUTROPHIL; PRIORITY JOURNAL; CALCIUM SIGNALING; CELL DEATH; CLINICAL TRIAL; CYTOLOGY; FEMALE; MALE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

CALCIUM SIGNALING; CELL DEATH; EXTRACELLULAR TRAPS; FEMALE; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MEMBRANE GLYCOPROTEINS; MITOCHONDRIA; NADPH OXIDASE; NEUTROPHILS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS;

EID: 84924059048     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1414055112     Document Type: Article

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