The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Hansen, Ashleigh ^a   Alston, Laurie ^a   Tulk, Sarah E ^b   Schenck, L Patrick ^b   Grassie, Michael E ^b   Alhassan, Basmah F ^b   Veermalla, Arun Teja ^a   Al Bashir, Samir ^c   Gendron, Fernand Pierre ^d   Altier, Christophe ^a   MacDonald, Justin A ^b   Beck, Paul L ^b   Hirota, Simon A ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c JORDAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Jordan)

^d UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; INTERLEUKIN 8; MSR 2578; PURINERGIC P2Y6 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE; APYRASE; ENTEROTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PURINERGIC P2 RECEPTOR; PURINERGIC P2 RECEPTOR ANTAGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL POLARITY; CELL STRAIN CACO 2; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXICITY; DIGESTIVE SYSTEM FUNCTION DISORDER; DRUG MECHANISM; ENTERITIS; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA PERMEABILITY; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BLOCKING; ANIMAL; BIOSYNTHESIS; CACO 2 CELL LINE; DISEASE MODEL; GENETICS; INFLAMMATION; INTESTINE MUCOSA; METABOLISM; MICROBIOLOGY; PEPTOCLOSTRIDIUM DIFFICILE; PSEUDOMEMBRANOUS COLITIS; SIGNAL TRANSDUCTION;

ANIMALS; APYRASE; CACO-2 CELLS; CLOSTRIDIUM DIFFICILE; DISEASE MODELS, ANIMAL; ENTEROCOLITIS, PSEUDOMEMBRANOUS; ENTEROTOXINS; HUMANS; INFLAMMATION; INTERLEUKIN-8; INTESTINAL MUCOSA; MALE; MICE; NF-KAPPA B; PURINERGIC P2 RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION;

EID: 84896738465     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0081491     Document Type: Article

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