Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway

Blood

Volumn 107, Issue 7, 2006, Pages 2936-2942

  Khine, Aye Aye ^b   Del Sorbo, Lorenzo ^b   Vaschetto, Rosanna ^b   Voglis, Stefanos ^b   Tullis, Elizabeth ^b   Slutsky, Arthur S ^b   Downey, Gregory P ^b   Zhang, Haibo ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA DEFENSIN; ANTISENSE OLIGONUCLEOTIDE; CIBACRON BLUE F3GA; INTERLEUKIN 8; LIGAND; NUCLEOTIDE; PURINE P2X RECEPTOR; PURINE P2Y6 RECEPTOR; RECEPTOR BLOCKING AGENT; SURAMIN; TUMOR NECROSIS FACTOR ALPHA; URIDINE TRIPHOSPHATE;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOSE RESPONSE; DRUG BINDING; DRUG EFFECT; DRUG INHIBITION; EPITHELIUM CELL; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; LUNG ALVEOLUS EPITHELIUM; NEUTROPHIL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 33645523777     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2005-06-2314     Document Type: Article

References (49)

1. Faurschou M, Borregaard N. Neutrophil granules and secretory vesicles in inflammation. Microbes Infect. 2003;5:1317-1327.
2. Gabay JE, Almeida RP. Antibiotic peptides and serine protease homologs in human polymorphonuclear leukocytes: defensins and azurocidin. Curr Opin Immunol. 1993;5:97-102.
3. Ganz T, Lehrer RI. Defensins. Curr Opin Immunol. 1994;6:584-589.
4. Zhang XL, Selsted ME, Pardi A. NMR studies of defensin antimicrobial peptides, I: resonance assignment and secondary structure determination of rabbit NP-2 and human HNP-1. Biochemistry. 1992;31:11348-11356.
5. Pardi A, Zhang XL, Selsted ME, Skalicky JJ, Yip PF. NMR studies of defensin antimicrobial peptides, II: three-dimensional structures of rabbit NP-2 and human HNP-1. Biochemistry. 1992;31:11357-11364.
6. Ihi T, Nakazato M, Mukae H, Matsukura S. Elevated concentrations of human neutrophil peptides in plasma, blood, and body fluids from patients with infections. Clin Infect Dis. 1997;25:1134-1140.
7. Ashitani J, Mukae H, Ihiboshi H, et al. Defensin in plasma and in bronchoalveolar lavage fluid from patients with acute respiratory distress syndrome. Nihon Kyobu Shikkan Gakkai Zasshi. 1996;34:1349-1353.
8. Ashitani J, Mukae H, Nakazato M, et al. Elevated concentrations of defensins in bronchoalveolar lavage fluid in diffuse panbronchiolitis. Eur Respir J. 1998;11:104-111.
9. Voglis S, Downey G, Grinstein S, Slutsky AS, Zhang H. HNP can impair PMN phagocytic function [abstract]. Am J Respir Crit Care Med. 2002;165:A533.
10. Panyutich AV, Panyutich EA, Krapivin VA, Baturevich EA, Ganz T. Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis. J Lab Clin Med. 1993;122:202-207.
11. Soong LB, Ganz T, Ellison A, Caughey GH. Purification and characterization of defensins from cystic fibrosis sputum. Inflamm Res. 1997;46:98-102.
12. Hiemstra PS, van Wetering S, Stolk J. Neutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: effects on pulmonary epithelium. Eur Respir J. 1998;12:1200-1208.
13. Yang D, Chen Q, Chertov O, Oppenheim JJ. Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells. J Leukoc Biol. 2000;68:9-14.
14. Territo MC, Ganz T, Selsted ME, Lehrer R. Monocyte-chemotactic activity of defensins from human neutrophils. J Clin Invest. 1989;84:2017-2020.
15. Van Wetering S, Mannesse-Lazeroms SP, van Sterkenburg MA, Hiemstra PS. Neutrophil defensins stimulate the release of cytokines by airway epithelial cells: modulation by dexamethasone. Inflamm Res. 2002;51:8-15.
16. Mahalingam S, Karupiah G. Chemokines and chemokine receptors in infectious diseases. Immunol Cell Biol. 1999;77:469-475.
17. Kanegasaki S, Nomura Y, Nitta N, et al. A novel optical assay system for the quantitative measurement of chemotaxis. J Immunol Methods. 2003;282:1-11.
18. Durr M, Peschel A. Chemokines meet defensins: the merging concepts of chemoattractants and antimicrobial peptides in host defense. Infect Immun. 2002;70:6515-6517.
19. Cole AM, Ganz T, Liese AM, Burdick MD, Liu L, Strieter RM. IFN-inducible ELR - CXC chemokines display defensin-like antimicrobial activity. J Immunol. 2001;167:623-627.
20. Hoover DM, Boulegue C, Yang D, et al. The structure of human macrophage inflammatory protein-3alpha/CCL20: linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins. J Biol Chem. 2002;277:37647-37654.
21. North RA. Molecular physiology of P2X receptors. Physiol Rev. 2002;82:1013-1067.
22. von Kugelgen I, Wetter A. Molecular pharmacology of P2Y-receptors. Naunyn Schmiedebergs Arch Pharmacol. 2000;362:310-323.
23. Lee BC, Cheng T, Adams GB, et al. P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells. Genes Dev. 2003;17:1592-1604.
24. 2+ and IL-8 secretion. Am J Respir Cell Mol Biol. 2005;33:601-609.
25. Di Virgilio F, Chiozzi P, Ferrari D, et al. Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood. 2001;97:587-600.
26. Idzko M, Panther E, Bremer HC, et al. Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils. Br J Pharmacol. 2003;138:1244-1250.
27. Warny M, Aboudola S, Robson SC, et al. P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide. J Biol Chem. 2001;276:26051-26056.
28. Idzko M, Panther E, Sorichter S, et al. Characterization of the biological activities of uridine diphosphate in human dendritic cells: influence on chemotaxis and CXCL8 release. J Cell Physiol. 2004;201:286-293.
29. Lazarowski ER, Boucher RC, Harden TK. Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrations. J Biol Chem. 2000;275:31061-31068.
30. Burvall K, Palmberg L, Larsson K. Effects by 8-bromo-cyclicAMP on basal and organic dust-induced release of interleukin-6 and interleukin-8 in A549 human airway epithelial cells. Respir Med. 2003;97:46-50.
31. Meade CJ, Worrall L, Hayes D, Protin U. Induction of interleukin 8 release from the HMC-1 mast cell line: synergy between stem cell factor and activators of the adenosine A(2b) receptor. Biochem Pharmacol. 2002;64:317-325.
32. Porro JA, Lee J-H, de Azavedo J, et al. Direct and indirect bacterial killing functions of neutrophil defensins in lung explants. Am J Physiol Lung Cell Mol Physiol. 2001;281:L1240-L1247.
33. Zhang H, Porro G, Orzech N, Mullen B, Liu M, Slutsky AS. Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion. Am J Physiol Lung Cell Mol Physiol. 2001;280:L947-L954.
34. Lee JH, Del Sorbo L, Uhlig S, et al. Intercellular adhesion molecule-1 mediates cellular cross-talk between parenchymal and immune cells after lipopolysaccharide neutralization. J Immunol. 2004;172:608-616.
35. Zhao DM, Xue HH, Chida K, et al. Effect of erythromycin on ATP-induced intracellular calcium response in A549 cells. Am J Physiol Lung Cell Mol Physiol. 2000;278:L726-L736.
36. Chertov O, Michiel DF, Xu L, et al. Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils. J Biol Chem. 1996;271:2935-2940.
37. Lillard JW Jr, Boyaka PN, Chertov O, Oppenheim JJ, McGhee JR. Mechanisms for induction of acquired host immunity by neutrophil peptide defensins. Proc Natl Acad Sci U S A. 1999;96:651-656.
38. Ishii H, Fujii T, Hogg JC, et al. Contribution of IL-1 beta and TNF-alpha to the initiation of the peripheral lung response to atmospheric particulates (PM10). Am J Physiol Lung Cell Mol Physiol. 2004;287:L176-L183.
39. Sparkes RS, Kronenberg M, Heinzmann C, et al. Assignment of defensin gene(s) to human chromosome 8p23. Genomics. 1989;5:240-244.
40. Linzmeier R, Michaelson D, Liu L, Ganz T. The structure of neutrophil defensin genes. FEBS Lett. 1993;321:267-273.
41. Aarbiou J, Rabe KF, Hiemstra PS. Role of defensins in inflammatory lung disease. Ann Med. 2002;34:96-101.
42. Van Wetering S, Mannesse-Lazeroms SP, Van Sterkenburg MA, Daha MR, Dijkman JH, Hiemstra PS. Effect of defensins on interleukin-8 synthesis in airway epithelial cells. Am J Physiol. 1997;272:L888-L896.
43. Sakamoto N, Mukae H, Fujii T, et al. Differential effects of α- and β-defensin on cytokine production by cultured human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2005;288:L508-L513.
44. Chaly YV, Paleolog EM, Kolesnikova TS, Tikhonov II, Petratchenko EV, Voitenok NN. Neutrophil alpha-defensin human neutrophil peptide modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells. Eur Cytokine Netw. 2000;11:257-266.
45. Crane JK, Olson RA, Jones HM, Duffey ME. Release of ATP during host cell killing by enteropathogenic E. coli and its role as a secretory mediator. Am J Physiol Gastrointest Liver Physiol. 2002;283:G74-G86.
46. Elssner A, Duncan M, Gavrilin M, Wewers MD. A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release. J Immunol. 2004;172:4987-4994.
47. 4 nucleotide receptors. Biochem Pharmacol. 2003;65:923-931.
48. 6 nucleotide receptor activates PKC to protect 1321N1 astrocytoma cells against tumor necrosis factor-induced apoptosis. Cell Mol Neurobiol. 2003;23:401-418.
49. 14) and increase intracellular calcium in response to its agonist, uridine diphosphoglucose. J Immunol. 2003;171:1941-1949.