Risk factors for bronchiectasis in children with cystic fibrosis

New England Journal of Medicine

Volumn 368, Issue 21, 2013, Pages 1963-1970

  Sly, Peter D ^a   Gangell, Catherine L ^a   Chen, Linping ^a   Ware, Robert S ^a   Ranganathan, Sarath ^b,c   Mott, Lauren S ^d,e   Murray, Conor P ^d   Stick, Stephen M ^d,e  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d PRINCESS MARGARET HOSPITAL FOR CHILDREN   (Australia)

^e UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

LEUKOCYTE ELASTASE;

AGE DISTRIBUTION; ARTICLE; BRONCHIECTASIS; CHILD; COMPUTER ASSISTED TOMOGRAPHY; CYSTIC FIBROSIS; ENZYME ACTIVITY; FEMALE; HUMAN; INFANT; LONGITUDINAL STUDY; LUNG INFECTION; LUNG LAVAGE; MAJOR CLINICAL STUDY; MALE; MECONIUM ILEUS; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RESPIRATORY TRACT DISEASE; RESPIRATORY TRACT INFLAMMATION; RISK ASSESSMENT; RISK FACTOR; STAPHYLOCOCCUS AUREUS;

EID: 84878000440     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1301725     Document Type: Article

References (28)

1. de Jong PA, Nakano Y, Hop WC, et al. Changes in airway dimensions on computed tomography scans of children with cystic fibrosis. Am J Respir Crit Care Med 2005;172:218-24. (Pubitemid 40981197)
2. de Jong PA, Nakano Y, Lequin MH, et al. Progressive damage on high resolution computed tomography despite stable lung function in cystic fibrosis. Eur Respir J 2004;23:93-7. (Pubitemid 38088503)
3. Mott LS, Park J, Murray CP, et al. Progression of early structural lung disease in young children with cystic fibrosis assessed using CT. Thorax 2012;67:509-16.
4. Sly PD, Brennan S, Gangell C, et al. Lung disease at diagnosis in infants with cystic fibrosis detected by newborn screening. Am J Respir Crit Care Med 2009;180:146-52.
5. Stick SM, Brennan S, Murray C, et al. Bronchiectasis in infants and preschool children diagnosed with cystic fibrosis after newborn screening. J Pediatr 2009;155:623-8.
6. Davis SD, Fordham LA, Brody AS, et al. Computed tomography reflects lower airway inflammation and tracks changes in early cystic fibrosis. Am J Respir Crit Care Med 2007;175:943-50. (Pubitemid 46684705)
7. Long FR, Williams RS, Castile RG. Structural airway abnormalities in infants and young children with cystic fibrosis. J Pediatr 2004;144:154-61. (Pubitemid 38869388)
8. Martinez TM, Llapur CJ, Williams TH, et al. High-resolution computed tomography imaging of airway disease in infants with cystic fibrosis. Am J Respir Crit Care Med 2005;172:1133-8. (Pubitemid 43066649)
9. Wainwright CE, Vidmar S, Armstrong DS, et al. Effect of bronchoalveolar lavagedirected therapy on Pseudomonas aeruginosa infection and structural lung injury in children with cystic fibrosis: a randomized trial. JAMA 2011;306:163-71.
10. Ranganathan SC, Parsons F, Gangell C, et al. Evolution of pulmonary inflammation and nutritional status in infants and young children with cystic fibrosis. Thorax 2011;66:408-13.
11. Pillarisetti N, Williamson E, Linnane B, et al. Infection, inflammation, and lung function decline in infants with cystic fibrosis. Am J Respir Crit Care Med 2011;184:75-81.
12. Armstrong DS, Hook SM, Jamsen KM, et al. Lower airway inflammation in infants with cystic fibrosis detected by newborn screening. Pediatr Pulmonol 2005;40:500-10. (Pubitemid 41720706)
13. Khan TZ, Wagener JS, Bost T, Martinez J, Accurso FJ, Riches DW. Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med 1995;151:1075-82.
14. Brennan S, Hall GL, Horak F, et al. Correlation of forced oscillation technique in preschool children with cystic fibrosis with pulmonary inflammation. Thorax 2005;60:159-63. (Pubitemid 40222900)
15. Mott LS, Park J, Gangell CL, et al. Distribution of early structural lung changes due to cystic fibrosis detected with chest computed tomography. J Pediatr 2013 January 25 (Epub ahead of print).
16. Gangell C, Gard S, Douglas T, et al. Inflammatory responses to individual microorganisms in the lungs of children with cystic fibrosis. Clin Infect Dis 2011;53:425-32.
17. Stockley RA. Neutrophils and protease/ antiprotease imbalance. Am J Respir Crit Care Med 1999;160:S49-S52.
18. Papayannopoulos V, Metzler K, Hakkim A, Zychlinsky A. Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J Cell Biol 2010;191:677-91.
19. Owen CA, Campbell MA, Sannes PL, Boukedes SS, Campbell EJ. Cell surfacebound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteases. J Cell Biol 1995;131:775-89.
20. Kapur N, Masel JP, Watson D, Masters IB, Chang AB. Bronchoarterial ratio on high-resolution CT scan of the chest in children without pulmonary pathology: need to redefine bronchial dilatation. Chest 2011;139:1445-50.
21. Laguna TA, Wagner BD, Starcher B, et al. Urinary desmosine: a biomarker of structural lung injury during CF pulmonary exacerbation. Pediatr Pulmonol 2012;47:856-63.
22. Reeves EP, Bergin DA, Fitzgerald S, et al. A novel neutrophil derived inflammatory biomarker of pulmonary exacerbation in cystic fibrosis. J Cyst Fibros 2012;11:100-7.
23. Létuvé S, Kozhich A, Arouche N, et al. YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages. J Immunol 2008;181:5167-73.
24. Elborn JS, Perrett J, Forsman-Semb K, Marks-Konczalik J, Gunawardena K, Entwistle N. Efficacy, safety and effect on biomarkers of AZD9668 in cystic fibrosis. Eur Respir J 2012;40:969-76.
25. Kuraki T, Ishibashi M, Takayama M, Shiraishi M, Yoshida M. A novel oral neutrophil elastase inhibitor (ONO-6818) inhibits human neutrophil elastase-induced emphysema in rats. Am J Respir Crit Care Med 2002;166:496-500.
26. Tremblay GM, Janelle MF, Bourbonnais Y. Anti-inflammatory activity of neutrophil elastase inhibitors. Curr Opin Investig Drugs 2003;4:556-65. (Pubitemid 36717201)
27. Konstan MW, Byard PJ, Hoppel CL, Davis PB. Effect of high-dose ibuprofen in patients with cystic fibrosis. N Engl J Med 1995;332:848-54.
28. Lands LC, Stanojevic S. Oral nonsteroidal anti-inflammatory drug therapy for cystic fibrosis. Cochrane Database Syst Rev 2007;4:CD001505.