Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase

Journal of Medicinal Chemistry

Volumn 56, Issue 15, 2013, Pages 6259-6272

  Crocetti, Letizia ^a   Schepetkin, Igor A ^b   Cilibrizzi, Agostino ^a   Graziano, Alessia ^a   Vergelli, Claudia ^a   Giomi, Donatella ^a   Khlebnikov, Andrei I ^c   Quinn, Mark T ^b   Giovannoni, Maria Paola ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b MONTANA STATE UNIVERSITY   (United States)

^c ALTAI STATE TECHNICAL UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

CHYMOTRYPSIN; INDAZOLE DERIVATIVE; KALLIKREIN; LEUKOCYTE ELASTASE; SERINE PROTEINASE INHIBITOR; THROMBIN;

ARTICLE; CHEMICAL STRUCTURE; DRUG HALF LIFE; ENZYME ACTIVE SITE; HUMAN; HYDROLYSIS; MOLECULAR DOCKING; PROTON TRANSPORT; SPECTROPHOTOMETRY; STRUCTURE ACTIVITY RELATION;

BENZENE DERIVATIVES; BENZOATES; DRUG STABILITY; HUMANS; HYDROLYSIS; INDAZOLES; KINETICS; LEUKOCYTE ELASTASE; MOLECULAR DOCKING SIMULATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84881450780     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400742j     Document Type: Article

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