PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling

European Journal of Immunology

Volumn 46, Issue 1, 2016, Pages 223-229

  Desai, Jyaysi ^a   Kumar, Santhosh V ^a   Mulay, Shrikant R ^a   Konrad, Lukas ^a   Romoli, Simone ^a   Schauer, Christine ^b   Herrmann, Martin ^b   Bilyy, Rostyslav ^c   Müller, Susanna ^d   Popper, Bastian ^d   Nakazawa, Daigo ^a   Weidenbusch, Marc ^a   Thomasova, Dana ^a   Krautwald, Stefan ^e   Linkermann, Andreas ^e   Anders, Hans Joachim ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY   (Ukraine)

^d UNIVERSITY OF MUNICH   (Germany)

^e UNIVERSITY OF KIEL   (Germany)

Author keywords

Necroptosis; Necrosis; Neutrophil; Neutrophil extracellular trap formation; Receptor interacting protein kinase

Indexed keywords

MIXED LINEAGE KINASE DOMAIN LIKE 1; PHOSPHOTRANSFERASE; REACTIVE OXYGEN METABOLITE; RECEPTOR INTERACTING PROTEIN KINASE 1; RECEPTOR INTERACTING PROTEIN KINASE 3; UNCLASSIFIED DRUG; URATE; MLKL PROTEIN, HUMAN; MLKL PROTEIN, MOUSE; PHOSPHORYLCHOLINE; POLY(MPC-CO-MA); POLYMETHACRYLIC ACID DERIVATIVE; PROTEIN KINASE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK1 PROTEIN, HUMAN; RIPK1 PROTEIN, MOUSE; RIPK3 PROTEIN, HUMAN; RIPK3 PROTEIN, MOUSE; URIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; AUTOIMMUNE DISEASE; CHRONIC GRANULOMATOUS DISEASE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EXTRACELLULAR TRAP; FEMALE; GOUT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MOUSE; NECROPTOSIS; NONHUMAN; PRIORITY JOURNAL; THROMBOSIS; VASCULITIS; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CONFOCAL MICROSCOPY; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; NEUTROPHIL; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; EXTRACELLULAR TRAPS; FEMALE; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; NEUTROPHILS; PHOSPHORYLCHOLINE; POLYMETHACRYLIC ACIDS; PROTEIN KINASES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; URIC ACID;

EID: 84953778857     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201545605     Document Type: Article

References (24)

1. Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y. et al., Neutrophil extracellular traps kill bacteria. Science 2004. 303: 1532-1535.
2. Fuchs, T. A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., Weinrauch, Y. et al., Novel cell death program leads to neutrophil extracellular traps. J. Cell Biol. 2007. 176: 231-241.
3. Kessenbrock, K., Krumbholz, M., Schonermarck, U., Back, W., Gross, W. L., Werb, Z., Grone, H. J. et al., Netting neutrophils in autoimmune small-vessel vasculitis. Nat. Med. 2009. 15: 623-625.
4. Phillipson, M. and Kubes, P., The neutrophil in vascular inflammation. Nat. Med. 2011. 17: 1381-1390.
5. Allam, R., Kumar, S. V., Darisipudi, M. N. and Anders, H. J., Extracellular histones in tissue injury and inflammation. J. Mol. Med. 2014. 92: 465-472.
6. Khandpur, R., Carmona-Rivera, C., Vivekanandan-Giri, A., Gizinski, A., Yalavarthi, S., Knight, J. S., Friday, S. et al., NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis. Sci. Transl. Med. 2013. 5: 178ra140.
7. Villanueva, E., Yalavarthi, S., Berthier, C. C., Hodgin, J. B., Khandpur, R., Lin, A. M., Rubin, C. J. et al., Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus. J. Immunol. 2011. 187: 538-552.
8. Schauer, C., Janko, C., Munoz, L. E., Zhao, Y., Kienhofer, D., Frey, B., Lell, M. et al., Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. Nat. Med. 2014. 20: 511-517.
9. Schorn, C., Janko, C., Latzko, M., Chaurio, R., Schett, G. and Herrmann, M., Monosodium urate crystals induce extracellular DNA traps in neutrophils, eosinophils, and basophils but not in mononuclear cells. Front Immunol. 2012. 3: 277.
10. Metzler, K. D., Fuchs, T. A., Nauseef, W. M., Reumaux, D., Roesler, J., Schulze, I., Wahn, V. et al., Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity. Blood 2011. 117: 953-959.
11. Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M. et al., Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 2012. 19: 107-120.
12. Vanden Berghe, T., Linkermann, A., Jouan-Lanhouet, S., Walczak, H. and Vandenabeele, P., Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat. Rev. Mol. Cell. Biol. 2014. 15: 135-147.
13. Li, J., McQuade, T., Siemer, A. B., Napetschnig, J., Moriwaki, K., Hsiao, Y. S., Damko, E. et al., The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell 2012. 150: 339-350.
14. Zhao, J., Jitkaew, S., Cai, Z., Choksi, S., Li, Q., Luo, J. and Liu, Z. G., Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. Proc. Natl. Acad. Sci. USA 2012. 109: 5322-5327.
15. Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G. D. et al., Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat. Chem. Biol. 2005. 1: 112-119.
16. Linkermann, A. and Green, D. R., Necroptosis. The New England journal of medicine. 2014. 370: (5) 455-465.
17. Amulic, B., Cazalet, C., Hayes, G. L., Metzler, K. D. and Zychlinsky, A., Neutrophil function: from mechanisms to disease. Annu. Rev. Immunol. 2012. 30: 459-489.
18. Greenlee-Wacker, M. C., Rigby, K. M., Kobayashi, S. D., Porter, A. R., DeLeo, F. R. and Nauseef, W. M., Phagocytosis of Staphylococcus aureus by human neutrophils prevents macrophage efferocytosis and induces programmed necrosis. J. Immunol. 2014. 192: 4709-4717.
19. Remijsen, Q., Vanden Berghe, T., Wirawan, E., Asselbergh, B., Parthoens, E., De Rycke, R., Noppen, S. et al., Neutrophil extracellular trap cell death requires both autophagy and superoxide generation. Cell Res. 2011. 21: 290-304.
20. Yipp, B. G. and Kubes, P. NETosis: how vital is it? Blood 2013. 122: 2784-2794.
21. Basit, F., Cristofanon, S. and Fulda, S., Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes. Cell Death Differ. 2013. 20: 1161-1173.
22. Mitroulis, I., Kambas, K., Chrysanthopoulou, A., Skendros, P., Apostolidou, E., Kourtzelis, I., Drosos, G. I. et al., Neutrophil extracellular trap formation is associated with IL-1beta and autophagy-related signaling in gout. PLoS One 2011. 6: e29318.
23. Chen, X., Li, W., Ren, J., Huang, D., He, W. T., Song, Y. et al., Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death. Cell Res. 2014. 24: 105-121.
24. Wang, H., Sun, L., Su, L., Rizo, J., Liu, L., Wang, L. F., et al., Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Mol. Cell 2014. 54: 133-146.