-
1
-
-
0036384262
-
The origins of a concept: The protease-antiprotease imbalance hypothesis
-
PubMed PMID: 12226052
-
Turino GM. The origins of a concept: the protease-antiprotease imbalance hypothesis. Chest 2002; 122(3):1058-1060. PubMed PMID: 12226052.
-
(2002)
Chest
, vol.122
, Issue.3
, pp. 1058-1060
-
-
Turino, G.M.1
-
2
-
-
75449140353
-
Photographic reconstruction of a three-dimensional model of the lung, with special reference to centrilobular emphysema
-
PubMed PMID: 14023527
-
Cowdrey CR, Kleinerman J, Wright GW. Photographic reconstruction of a three-dimensional model of the lung, with special reference to centrilobular emphysema. Am Rev Respir Dis. 1963; 87:239-244. PubMed PMID: 14023527.
-
(1963)
Am Rev Respir Dis.
, vol.87
, pp. 239-244
-
-
Cowdrey, C.R.1
Kleinerman, J.2
Wright, G.W.3
-
3
-
-
0007442571
-
Enzymatically produced pulmonary emphysema; A preliminary report
-
Epub 1964/12/01. PubMed PMID: 14241128
-
Gross P, Babyak MA, Tolker E, Kaschak M. Enzymatically produced pulmonary emphysema; a preliminary report. J Occup Med 1964; 6:481-484. Epub 1964/12/01. PubMed PMID: 14241128.
-
(1964)
J Occup Med
, vol.6
, pp. 481-484
-
-
Gross, P.1
Babyak, M.A.2
Tolker, E.3
Kaschak, M.4
-
4
-
-
0016107545
-
Relationship between elastolytic acitivity and experimental emphysema-induced properties of papain preparations
-
PubMed PMID: 4415535
-
Snider GL, Hayes JA, Franzblau C, Kagan HM, Stone PS, Korthy AL. Relationship between elastolytic acitivity and experimental emphysema-induced properties of papain preparations. Am Rev Respir Dis 1974; 110(3):254-262. PubMed PMID: 4415535.
-
(1974)
Am Rev Respir Dis
, vol.110
, Issue.3
, pp. 254-262
-
-
Snider, G.L.1
Hayes, J.A.2
Franzblau, C.3
Kagan, H.M.4
Stone, P.S.5
Korthy, A.L.6
-
5
-
-
0016811228
-
The pathology of elastaseinduced panacinar emphysema in hamsters
-
doi: 10.1002/path.1711170102. PubMed PMID: 1195057
-
Hayes JA, Korthy A, Snider GL. The pathology of elastaseinduced panacinar emphysema in hamsters. J Pathol 1975; 117(1):1-14. doi: 10.1002/path. 1711170102. PubMed PMID: 1195057.
-
(1975)
J Pathol
, vol.117
, Issue.1
, pp. 1-14
-
-
Hayes, J.A.1
Korthy, A.2
Snider, G.L.3
-
6
-
-
0015086978
-
Proteolytic mechanisms and pulmonary emphysema
-
PubMed PMID: 4107042
-
Turino GM. Proteolytic mechanisms and pulmonary emphysema. Bull Physiopathol Respir 1971; 7(4):719-727. PubMed PMID: 4107042.
-
(1971)
Bull Physiopathol Respir
, vol.7
, Issue.4
, pp. 719-727
-
-
Turino, G.M.1
-
7
-
-
0017646163
-
Experimental emphysema: Concepts and questions
-
PubMed PMID: 334287
-
Chrzanowski PJ, Turino GM. Experimental emphysema: concepts and questions. Bull Eur Physiopathol Respir 1977; 13(4):471-477. PubMed PMID: 334287.
-
(1977)
Bull Eur Physiopathol Respir
, vol.13
, Issue.4
, pp. 471-477
-
-
Chrzanowski, P.J.1
Turino, G.M.2
-
8
-
-
0014678424
-
Serum elastase inhibitor deficiency and alpha-1 antitrypsin deficiency in patients with obstructive emphysema
-
PubMed PMID: 5793975
-
Turino GM, Senior RM, Garg BD, Keller S, Levi MM, Mandl I. Serum elastase inhibitor deficiency and alpha-1 antitrypsin deficiency in patients with obstructive emphysema. Science 1969; 165(3894):709-711. PubMed PMID: 5793975.
-
(1969)
Science
, vol.165
, Issue.3894
, pp. 709-711
-
-
Turino, G.M.1
Senior, R.M.2
Garg, B.D.3
Keller, S.4
Levi, M.M.5
Mandl, I.6
-
9
-
-
0014349683
-
Mediators of inflammation in leukocyte lysosomes. IX. Elastinolytic activity in granules of human polymorphonuclear leukocytes
-
PubMed PMID: 5303065; PubMed Central PMCID: PMC2138566
-
Janoff A, Scherer J. Mediators of inflammation in leukocyte lysosomes. IX. Elastinolytic activity in granules of human polymorphonuclear leukocytes. J Exp Med 1968; 128(5):1137- 1155. PubMed PMID: 5303065; PubMed Central PMCID: PMC2138566.
-
(1968)
J Exp Med
, vol.128
, Issue.5
, pp. 1137-1155
-
-
Janoff, A.1
Scherer, J.2
-
10
-
-
0017669252
-
The induction of pulmonary emphysema with human leukocyte elastase
-
PubMed PMID: 900634
-
Senior RM, Tegner H, Kuhn C, Ohlsson K, Starcher BC, Pierce JA. The induction of pulmonary emphysema with human leukocyte elastase. Am Rev Respir Dis 1977; 116(3):469-75. PubMed PMID: 900634.
-
(1977)
Am Rev Respir Dis
, vol.116
, Issue.3
, pp. 469-475
-
-
Senior, R.M.1
Tegner, H.2
Kuhn, C.3
Ohlsson, K.4
Starcher, B.C.5
Pierce, J.A.6
-
11
-
-
0020427797
-
Elastase-induced emphysema: Retention of instilled proteinase in the rat
-
Epub 1982/11/01. PubMed PMID: 6756234
-
Sandhaus RA, Janoff A. Elastase-induced emphysema: retention of instilled proteinase in the rat. Am Rev Respir Dis 1982; 126(5):914-920. Epub 1982/11/01. PubMed PMID: 6756234.
-
(1982)
Am Rev Respir Dis
, vol.126
, Issue.5
, pp. 914-920
-
-
Sandhaus, R.A.1
Janoff, A.2
-
12
-
-
0017755313
-
Studies on the fate of pancreatic elastase in the hamster lung: 14C-guanidinated elastase
-
PubMed PMID: 879599
-
Stone PJ, Pereira W, Jr., Biles D, Snider GL, Kagan HM, Franzblau C. Studies on the fate of pancreatic elastase in the hamster lung: 14C-guanidinated elastase. Am Rev Respir Dis 1977; 116(1):49-56. PubMed PMID: 879599.
-
(1977)
Am Rev Respir Dis
, vol.116
, Issue.1
, pp. 49-56
-
-
Stone, P.J.1
Pereira Jr., W.2
Biles, D.3
Snider, G.L.4
Kagan, H.M.5
Franzblau, C.6
-
13
-
-
0017420709
-
Comparison of the elastolytic effects of human leukocyte elastase and porcine pancreatic elastase
-
PubMed PMID: 868639
-
Senior RM, Bielefeld DR, Starcher BC. Comparison of the elastolytic effects of human leukocyte elastase and porcine pancreatic elastase. Adv Exp Med Biol 1977; 79:249-261. PubMed PMID: 868639
-
(1977)
Adv Exp Med Biol
, vol.79
, pp. 249-261
-
-
Senior, R.M.1
Bielefeld, D.R.2
Starcher, B.C.3
-
14
-
-
0015261220
-
Inhibition of human granulocyte elastase by serum alpha-1 antitrypsin
-
PubMed PMID: 5007608
-
Janoff A. Inhibition of human granulocyte elastase by serum alpha-1 antitrypsin. Am Rev Respir Dis 1972; 105(1):121-122. PubMed PMID: 5007608.
-
(1972)
Am Rev Respir Dis
, vol.105
, Issue.1
, pp. 121-122
-
-
Janoff, A.1
-
15
-
-
0018689889
-
Alpha-1 antitrypsin deficiency and increased susceptibility to elastase-induced experimental emphysema in a rat model
-
PubMed PMID: 316297
-
Blackwood RA, Cerreta JM, Mandl I, Turino GM. Alpha-1 antitrypsin deficiency and increased susceptibility to elastase-induced experimental emphysema in a rat model. Am Rev Respir Dis 1979; 120(6):1375-1379. PubMed PMID: 316297.
-
(1979)
Am Rev Respir Dis
, vol.120
, Issue.6
, pp. 1375-1379
-
-
Blackwood, R.A.1
Cerreta, J.M.2
Mandl, I.3
Turino, G.M.4
-
16
-
-
0017755314
-
Possible mechanisms of emphysema in smokers: Cigarette smoke condensate suppresses protease inhibition in vitro
-
Epub 1977/07/01. PubMed PMID: 301725
-
Janoff A, Carp H. Possible mechanisms of emphysema in smokers: cigarette smoke condensate suppresses protease inhibition in vitro. Am Rev Respir Dis 1977; 116(1):65-72. Epub 1977/07/01. PubMed PMID: 301725.
-
(1977)
Am Rev Respir Dis
, vol.116
, Issue.1
, pp. 65-72
-
-
Janoff, A.1
Carp, H.2
-
17
-
-
0018129815
-
Possible mechanisms of emphysema in smokers. in vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants
-
PubMed PMID: 101105
-
Carp H, Janoff A. Possible mechanisms of emphysema in smokers. In vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants. Am Rev Respir Dis 1978; 118(3):617-621. PubMed PMID: 101105.
-
(1978)
Am Rev Respir Dis
, vol.118
, Issue.3
, pp. 617-621
-
-
Carp, H.1
Janoff, A.2
-
18
-
-
0018579538
-
Cigarette smoke inhalation decreases alpha-1 antitrypsin activity in rat lung
-
PubMed PMID: 316187
-
Janoff A, Carp H, Lee DK, Drew RT. Cigarette smoke inhalation decreases alpha-1 antitrypsin activity in rat lung. Science 1979; 206(4424):1313-1314. PubMed PMID: 316187.
-
(1979)
Science
, vol.206
, Issue.4424
, pp. 1313-1314
-
-
Janoff, A.1
Carp, H.2
Lee, D.K.3
Drew, R.T.4
-
19
-
-
0018800894
-
The oxidative inactivation of human alpha-1 proteinase inhibitor. Further evidence for methionine at the reactive center
-
PubMed PMID: 312289
-
Johnson D, Travis J. The oxidative inactivation of human alpha-1 proteinase inhibitor. Further evidence for methionine at the reactive center. J Biol Chem 1979; 254(10):4022-4026. PubMed PMID: 312289.
-
(1979)
J Biol Chem
, vol.254
, Issue.10
, pp. 4022-4026
-
-
Johnson, D.1
Travis, J.2
-
20
-
-
0021919760
-
Elastases and emphysema. Current assessment of the protease-antiprotease hypothesis
-
Epub 1985/08/01. PubMed PMID: 3896082
-
Janoff A. Elastases and emphysema. Current assessment of the protease-antiprotease hypothesis. Am Rev Respir Dis 1985; 132(2):417-433. Epub 1985/08/01. PubMed PMID: 3896082.
-
(1985)
Am Rev Respir Dis
, vol.132
, Issue.2
, pp. 417-433
-
-
Janoff, A.1
-
21
-
-
0034118160
-
Lung neutrophil burden correlates with increased proinfl ammatory cytokines and decreased lung function in individuals with alpha (1)-antitrypsin deficiency
-
PubMed PMID: 0010843938
-
Rouhani F, Paone G, Smith NK, Krein P, Barnes P, Brantly ML. Lung neutrophil burden correlates with increased proinfl ammatory cytokines and decreased lung function in individuals with alpha(1)-antitrypsin deficiency. Chest 2000; 117(5 Suppl 1):250S-251S. PubMed PMID: 0010843938.
-
(2000)
Chest
, vol.117
, Issue.5 SUPPL. 1
-
-
Rouhani, F.1
Paone, G.2
Smith, N.K.3
Krein, P.4
Barnes, P.5
Brantly, M.L.6
-
22
-
-
0032110436
-
Survival and FEV1 decline in individuals with severe deficiency of alpha-1 antitrypsin
-
The Alpha-1-Antitrypsin Deficiency Registry Study Group PubMed PMID: 9655706
-
Survival and FEV1 decline in individuals with severe deficiency of alpha-1 antitrypsin. The Alpha-1-Antitrypsin Deficiency Registry Study Group. Am J Respir Crit Care Med 1998; 158(1):49-59. PubMed PMID: 9655706.
-
(1998)
Am J Respir Crit Care Med
, vol.158
, Issue.1
, pp. 49-59
-
-
-
23
-
-
0032724157
-
A randomized clinical trial of alpha-1 antitrypsin augmentation therapy
-
PubMed PMID: 10556107
-
Dirksen A, Dijkman JH, Madsen F, Stoel B, Hutchison DC, Ulrik CS, et al. A randomized clinical trial of alpha-1 antitrypsin augmentation therapy. Am J Respir Crit Care Med 1999; 160(5 Pt 1):1468-1472. PubMed PMID: 10556107.
-
(1999)
Am J Respir Crit Care Med
, vol.160
, Issue.5 PART 1
, pp. 1468-1472
-
-
Dirksen, A.1
Dijkman, J.H.2
Madsen, F.3
Stoel, B.4
Hutchison, D.C.5
Ulrik, C.S.6
-
24
-
-
77957273246
-
Therapeutic efficacy of alpha-1 antitrypsin augmentation therapy on the loss of lung tissue: An integrated analysis of 2 randomised clinical trials using computed tomography densitometry
-
Epub 2010/10/06. doi: 10.1186/1465-9921-11-136. PubMed PMID: 20920370; PubMed Central PMCID: PMC2964614
-
Stockley RA, Parr DG, Piitulainen E, Stolk J, Stoel BC, Dirksen A. Therapeutic efficacy of alpha-1 antitrypsin augmentation therapy on the loss of lung tissue: an integrated analysis of 2 randomised clinical trials using computed tomography densitometry. Respir Res 2010; 11:136. Epub 2010/10/06. doi: 10.1186/1465-9921-11-136. PubMed PMID: 20920370; PubMed Central PMCID: PMC2964614.
-
(2010)
Respir Res
, vol.11
, pp. 136
-
-
Stockley, R.A.1
Parr, D.G.2
Piitulainen, E.3
Stolk, J.4
Stoel, B.C.5
Dirksen, A.6
-
25
-
-
0031242842
-
Does alpha-1 antitrypsin augmentation therapy slow the annual decline in FEV1 in patients with severe hereditary alpha1-antitrypsin deficiency?
-
Wissenschaftliche Arbeitsgemeinschaft zur Therapie von Lungenerkrankungen (WATL) alpha1-AT study group PubMed PMID: 9387950
-
Seersholm N, Wencker M, Banik N, Viskum K, Dirksen A, Kok-Jensen A, et al. Does alpha-1 antitrypsin augmentation therapy slow the annual decline in FEV1 in patients with severe hereditary alpha1-antitrypsin deficiency? Wissenschaftliche Arbeitsgemeinschaft zur Therapie von Lungenerkrankungen (WATL) alpha1-AT study group. Eur Respir J 1997; 10(10):2260-2263. PubMed PMID: 9387950.
-
(1997)
Eur Respir J
, vol.10
, Issue.10
, pp. 2260-2263
-
-
Seersholm, N.1
Wencker, M.2
Banik, N.3
Viskum, K.4
Dirksen, A.5
Kok-Jensen, A.6
-
26
-
-
0030823772
-
Requirement for macrophage elastase for cigarette smokeinduced emphysema in mice
-
PubMed PMID: 9302297
-
Hautamaki RD, Kobayashi DK, Senior RM, Shapiro SD. Requirement for macrophage elastase for cigarette smokeinduced emphysema in mice. Science 1997; 277(5334):2002- 2004. PubMed PMID: 9302297.
-
(1997)
Science
, vol.277
, Issue.5334
, pp. 2002-2004
-
-
Hautamaki, R.D.1
Kobayashi, D.K.2
Senior, R.M.3
Shapiro, S.D.4
-
27
-
-
34547563344
-
Alpha-1 antitrypsin (AAT) anomalies are associated with lung disease due to rapidly growing mycobacteria and AAT inhibits Mycobacterium abscessus infection of macrophages
-
doi: 10.1080/00365540701225744. PubMed PMID: 17654345
-
Chan ED, Kaminska AM, Gill W, Chmura K, Feldman NE, Bai X, et al. Alpha-1 antitrypsin (AAT) anomalies are associated with lung disease due to rapidly growing mycobacteria and AAT inhibits Mycobacterium abscessus infection of macrophages. Scand J Infect Dis 2007; 39(8):690-696. doi: 10.1080/ 00365540701225744. PubMed PMID: 17654345.
-
(2007)
Scand J Infect Dis
, vol.39
, Issue.8
, pp. 690-696
-
-
Chan, E.D.1
Kaminska, A.M.2
Gill, W.3
Chmura, K.4
Feldman, N.E.5
Bai, X.6
-
28
-
-
80155145248
-
Phase 2 clinical trial of a recombinant adenoassociated viral vector expressing alpha-1 antitrypsin: Interim results
-
doi: 10.1089/hum.2011.053. PubMed PMID: 21609134; PubMed Central PMCID: PMC3205788
-
Flotte TR, Trapnell BC, Humphries M, Carey B, Calcedo R, Rouhani F, et al. Phase 2 clinical trial of a recombinant adenoassociated viral vector expressing alpha-1 antitrypsin: interim results. Hum Gene Ther 2011; 22(10):1239-1247. doi: 10.1089/hum.2011.053. PubMed PMID: 21609134; PubMed Central PMCID: PMC3205788.
-
(2011)
Hum Gene Ther
, vol.22
, Issue.10
, pp. 1239-1247
-
-
Flotte, T.R.1
Trapnell, B.C.2
Humphries, M.3
Carey, B.4
Calcedo, R.5
Rouhani, F.6
-
29
-
-
0742307402
-
Phase i trial of intramuscular injection of a recombinant adeno-associated virus alpha-1 antitrypsin (rAAV2-CBhAAT) gene vector to AAT-deficient adults
-
doi: 10.1089/10430340460732490. PubMed PMID: 14965381
-
Flotte TR, Brantly ML, Spencer LT, Byrne BJ, Spencer CT, Baker DJ, et al. Phase I trial of intramuscular injection of a recombinant adeno-associated virus alpha-1 antitrypsin (rAAV2-CBhAAT) gene vector to AAT-deficient adults. Hum Gene Ther 2004; 15(1):93-128. doi: 10.1089/10430340460732490. PubMed PMID: 14965381.
-
(2004)
Hum Gene Ther
, vol.15
, Issue.1
, pp. 93-128
-
-
Flotte, T.R.1
Brantly, M.L.2
Spencer, L.T.3
Byrne, B.J.4
Spencer, C.T.5
Baker, D.J.6
-
30
-
-
1242306798
-
Role of human neutrophil peptides in lung inflammation associated with alpha-1 antitrypsin deficiency
-
Epub 2003/11/05. doi: 10.1152/ajplung.00099.2003 00099.2003 [ii] PubMed: PMID: 14594730
-
Spencer LT, Paone G, Krein PM, Rouhani FN, Rivera-Nieves J, Brantly ML. Role of human neutrophil peptides in lung inflammation associated with alpha-1 antitrypsin deficiency. Am J Physiol Lung Cell Mol Physiol 2004; 286(3):L514-520. Epub 2003/11/05. doi: 10.1152/ajplung.00099.2003 00099.2003 [pii]. PubMed PMID: 14594730.
-
(2004)
Am J Physiol Lung Cell Mol Physiol
, vol.286
, Issue.3
-
-
Spencer, L.T.1
Paone, G.2
Krein, P.M.3
Rouhani, F.N.4
Rivera-Nieves, J.5
Brantly, M.L.6
-
31
-
-
0018893350
-
Chemotactic activity of elastin-derived peptides
-
doi: 10.1172/JCI109926. PubMed PMID: 6903189 PubMed Central PMCID PMC371663
-
Senior RM, Griffin GL, Mecham RP. Chemotactic activity of elastin-derived peptides. J Clin Invest 1980; 66(4):859-862. doi: 10.1172/JCI109926. PubMed PMID: 6903189; PubMed Central PMCID: PMC371663
-
(1980)
J Clin Invest
, vol.66
, Issue.4
, pp. 859-862
-
-
Senior, R.M.1
Griffin, G.L.2
Mecham, R.P.3
-
32
-
-
84875668547
-
Alpha-1 antitrypsin augmentation therapy
-
Wewers M, Crystal R. Alpha-1 antitrypsin augmentation therapy. 2013 COPD, 10:S1; 64-67.
-
(2013)
COPD
, vol.10
, Issue.S1
, pp. 64-67
-
-
Wewers, M.1
Crystal, R.2
|