-
2
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
3
-
-
77649193013
-
Immune infiltration in human tumors: A prognostic factor that should not be ignored
-
Pages F, Galon J, Dieu-Nosjean MC, Tartour E, Sautes-Fridman C, Fridman WH. Immune infiltration in human tumors: a prognostic factor that should not be ignored. Oncogene 2010; 29:1093-1102.
-
(2010)
Oncogene
, vol.29
, pp. 1093-1102
-
-
Pages, F.1
Galon, J.2
Dieu-Nosjean, M.C.3
Tartour, E.4
Sautes-Fridman, C.5
Fridman, W.H.6
-
4
-
-
79952093380
-
Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction
-
Mlecnik B, Tosolini M, Kirilovsky A, et al. Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction. J Clin Oncol 2011; 29:610-618.
-
(2011)
J Clin Oncol
, vol.29
, pp. 610-618
-
-
Mlecnik, B.1
Tosolini, M.2
Kirilovsky, A.3
-
5
-
-
84864059882
-
Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanoma
-
Azimi F, Scolyer RA, Rumcheva P, et al. Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanoma. J Clin Oncol 2012; 30:2678-2683.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2678-2683
-
-
Azimi, F.1
Scolyer, R.A.2
Rumcheva, P.3
-
6
-
-
79956329617
-
Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer
-
Mahmoud SM, Paish EC, Powe DG, et al. Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer. J Clin Oncol 2011; 29:1949-1955.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1949-1955
-
-
Mahmoud, S.M.1
Paish, E.C.2
Powe, D.G.3
-
7
-
-
84879100801
-
Immune infiltrates are prognostic factors in localized gastrointestinal stromal tumors
-
Rusakiewicz S, Semeraro M, Sarabi M, et al. Immune infiltrates are prognostic factors in localized gastrointestinal stromal tumors. Cancer Res 2013; 73:3499-3510.
-
(2013)
Cancer Res
, vol.73
, pp. 3499-3510
-
-
Rusakiewicz, S.1
Semeraro, M.2
Sarabi, M.3
-
8
-
-
84856021596
-
Prognostic significance of tumor-infiltrating T cells in ovarian cancer: A meta-analysis
-
Hwang WT, Adams SF, Tahirovic E, Hagemann IS, Coukos G. Prognostic significance of tumor-infiltrating T cells in ovarian cancer: a meta-analysis. Gynecol Oncol 2012; 124:192-198.
-
(2012)
Gynecol Oncol
, vol.124
, pp. 192-198
-
-
Hwang, W.T.1
Adams, S.F.2
Tahirovic, E.3
Hagemann, I.S.4
Coukos, G.5
-
9
-
-
77958012775
-
Gene signature in melanoma associated with clinical activity: A potential clue to unlock cancer immunotherapy
-
Gajewski TF, Louahed J, Brichard VG. Gene signature in melanoma associated with clinical activity: a potential clue to unlock cancer immunotherapy. Cancer J 2010; 16:399-403.
-
(2010)
Cancer J
, vol.16
, pp. 399-403
-
-
Gajewski, T.F.1
Louahed, J.2
Brichard, V.G.3
-
10
-
-
82155168544
-
A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma
-
Hamid O, Schmidt H, Nissan A, et al. A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma. J Transl Med 2011; 9:204.
-
(2011)
J Transl Med
, vol.9
, pp. 204
-
-
Hamid, O.1
Schmidt, H.2
Nissan, A.3
-
11
-
-
73349142719
-
In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer
-
Pages F, Kirilovsky A, Mlecnik B, et al. In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer. J Clin Oncol 2009; 27:5944-5951.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5944-5951
-
-
Pages, F.1
Kirilovsky, A.2
Mlecnik, B.3
-
12
-
-
84890280907
-
Towards the introduction of the 'Immunoscore' in the classification of malignant tumours
-
Galon J, Mlecnik B, Bindea G, et al. Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. J Pathol 2014; 232:199-209.
-
(2014)
J Pathol
, vol.232
, pp. 199-209
-
-
Galon, J.1
Mlecnik, B.2
Bindea, G.3
-
13
-
-
70349569569
-
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
-
Ahmadzadeh M, Johnson LA, Heemskerk B, et al. Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 2009; 114:1537-1544.
-
(2009)
Blood
, vol.114
, pp. 1537-1544
-
-
Ahmadzadeh, M.1
Johnson, L.A.2
Heemskerk, B.3
-
14
-
-
4344671644
-
Effector function of human tumor-specific CD8 T cells in melanoma lesions: A state of local functional tolerance
-
Zippelius A, Batard P, Rubio-Godoy V, et al. Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance. Cancer Res 2004; 64:2865-2873.
-
(2004)
Cancer Res
, vol.64
, pp. 2865-2873
-
-
Zippelius, A.1
Batard, P.2
Rubio-Godoy, V.3
-
15
-
-
84920956732
-
PD-1 blockade induces responses by inhibiting adaptive immune resistance
-
Tumeh PC, Harview CL, Yearley JH, et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 2014; 515:568-571.
-
(2014)
Nature
, vol.515
, pp. 568-571
-
-
Tumeh, P.C.1
Harview, C.L.2
Yearley, J.H.3
-
16
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012; 366:2443-2454.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
17
-
-
84898973055
-
Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
-
Topalian SL, Sznol M, McDermott DF, et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol 2014; 32:1020-1030.
-
(2014)
J Clin Oncol
, vol.32
, pp. 1020-1030
-
-
Topalian, S.L.1
Sznol, M.2
McDermott, D.F.3
-
18
-
-
84929481480
-
Pembrolizumab for the treatment of non-small-cell lung cancer
-
Garon EB, Rizvi NA, Hui R, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med 2015; 372:2018-2028.
-
(2015)
N Engl J Med
, vol.372
, pp. 2018-2028
-
-
Garon, E.B.1
Rizvi, N.A.2
Hui, R.3
-
19
-
-
84944937210
-
Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
-
Borghaei H, Paz-Ares L, Horn L, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med 2015; 373:1627-1639.
-
(2015)
N Engl J Med
, vol.373
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
-
20
-
-
84946607195
-
Nivolumab versus everolimus in advanced renal-cell carcinoma
-
Motzer RJ, Escudier B, McDermott DF, et al. Nivolumab versus everolimus in advanced renal-cell carcinoma. N Engl JMed 2015; 373:1803-1813.
-
(2015)
N Engl JMed
, vol.373
, pp. 1803-1813
-
-
Motzer, R.J.1
Escudier, B.2
McDermott, D.F.3
-
21
-
-
84925221855
-
Pd-1 blockade with nivolumab in relapsed or refractory hodgkin's lymphoma
-
Ansell SM, Lesokhin AM, Borrello I, et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N Engl J Med 2015; 372:311-319.
-
(2015)
N Engl J Med
, vol.372
, pp. 311-319
-
-
Ansell, S.M.1
Lesokhin, A.M.2
Borrello, I.3
-
22
-
-
84923078390
-
Mpdl3280a (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
-
Powles T, Eder JP, Fine GD, et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 2014; 515:558-562.
-
(2014)
Nature
, vol.515
, pp. 558-562
-
-
Powles, T.1
Eder, J.P.2
Fine, G.D.3
-
23
-
-
66149156276
-
Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment
-
Harlin H, Meng Y, Peterson AC, et al. Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment. Cancer Res 2009; 69:3077-3085.
-
(2009)
Cancer Res
, vol.69
, pp. 3077-3085
-
-
Harlin, H.1
Meng, Y.2
Peterson, A.C.3
-
24
-
-
84932646690
-
Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints
-
Mikucki ME, Fisher DT, Matsuzaki J, et al. Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints. Nat Commun 2015; 6:7458.
-
(2015)
Nat Commun
, vol.6
, pp. 7458
-
-
Mikucki, M.E.1
Fisher, D.T.2
Matsuzaki, J.3
-
26
-
-
0021070204
-
Injection of mice with antibody to interferon enhances the growth of transplantable murine tumors
-
Gresser I, Belardelli F, Maury C, Maunoury MT, Tovey MG. Injection of mice with antibody to interferon enhances the growth of transplantable murine tumors. J Exp Med 1983; 158:2095-2107.
-
(1983)
J Exp Med
, vol.158
, pp. 2095-2107
-
-
Gresser, I.1
Belardelli, F.2
Maury, C.3
Maunoury, M.T.4
Tovey, M.G.5
-
27
-
-
0015949913
-
Interferon and cell division. IX. Interferon-resistant L1210 cells: Characteristics and origin
-
Gresser I, Bandu MT, Brouty-Boye D. Interferon and cell division. IX. Interferon-resistant L1210 cells: characteristics and origin. J Natl Cancer Inst 1974; 52:553-559.
-
(1974)
J Natl Cancer Inst
, vol.52
, pp. 553-559
-
-
Gresser, I.1
Bandu, M.T.2
Brouty-Boye, D.3
-
28
-
-
0023440840
-
Molecular mechanisms of action of interferons in the Friend virus-induced leukemia cell system
-
Affabris E, Romeo G, Federico M, et al. Molecular mechanisms of action of interferons in the Friend virus-induced leukemia cell system. Haematologica 1987; 72:76-78.
-
(1987)
Haematologica
, vol.72
, pp. 76-78
-
-
Affabris, E.1
Romeo, G.2
Federico, M.3
-
29
-
-
0014828095
-
Antitumor effects of interferon preparations in mice
-
Gresser I, Bourali C. Antitumor effects of interferon preparations in mice. J Natl Cancer Inst 1970; 45:365-376.
-
(1970)
J Natl Cancer Inst
, vol.45
, pp. 365-376
-
-
Gresser, I.1
Bourali, C.2
-
30
-
-
22144465860
-
A critical function for type i interferons in cancer immunoediting
-
Dunn GP, Bruce AT, Sheehan KC, et al. A critical function for type I interferons in cancer immunoediting. Nat Immunol 2005; 6:722-729.
-
(2005)
Nat Immunol
, vol.6
, pp. 722-729
-
-
Dunn, G.P.1
Bruce, A.T.2
Sheehan, K.C.3
-
31
-
-
80355136945
-
Host type i ifn signals are required for antitumor cd8+ t cell responses through cd8+ dendritic cells
-
Fuertes MB, Kacha AK, Kline J, et al. Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8+ dendritic cells. J Exp Med 2011; 208:2005-2016.
-
(2011)
J Exp Med
, vol.208
, pp. 2005-2016
-
-
Fuertes, M.B.1
Kacha, A.K.2
Kline, J.3
-
32
-
-
80355147292
-
Type i interferon is selectively required by dendritic cells for immune rejection of tumors
-
Diamond MS, Kinder M, Matsushita H, et al. Type I interferon is selectively required by dendritic cells for immune rejection of tumors. J Exp Med 2011; 208:1989-2003.
-
(2011)
J Exp Med
, vol.208
, pp. 1989-2003
-
-
Diamond, M.S.1
Kinder, M.2
Matsushita, H.3
-
33
-
-
0034684659
-
CD8(+) but not CD8 (-) dendritic cells cross-prime cytotoxic T cells in vivo
-
den Haan JM, Lehar SM, Bevan MJ. CD8(+) but not CD8 (-) dendritic cells cross-prime cytotoxic T cells in vivo. J Exp Med 2000; 192:1685-1696.
-
(2000)
J Exp Med
, vol.192
, pp. 1685-1696
-
-
Den Haan, J.M.1
Lehar, S.M.2
Bevan, M.J.3
-
34
-
-
0035340499
-
Cutting edge: Intravenous soluble antigen is presented to CD4 T cells by CD8-dendritic cells, but cross-presented to CD8 T cells by CD8+ dendritic cells
-
Pooley JL, Heath WR, Shortman K. Cutting edge: intravenous soluble antigen is presented to CD4 T cells by CD8-dendritic cells, but cross-presented to CD8 T cells by CD8+ dendritic cells. J Immunol 2001; 166:5327-5330.
-
(2001)
J Immunol
, vol.166
, pp. 5327-5330
-
-
Pooley, J.L.1
Heath, W.R.2
Shortman, K.3
-
35
-
-
77349083495
-
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8+ conventional dendritic cells
-
Edelson BT, Kc W, Juang R, et al. Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8+ conventional dendritic cells. J Exp Med 2010; 207:823-836.
-
(2010)
J Exp Med
, vol.207
, pp. 823-836
-
-
Edelson, B.T.1
Kc, W.2
Juang, R.3
-
37
-
-
0037011021
-
ICSBP is essential for the development of mouse type i interferon-producing cells and for the generation and activation of CD8(+) dendritic cells
-
Schiavoni G, Mattei F, Sestili P, et al. ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8(+) dendritic cells. J Exp Med 2002; 196:1415-1425.
-
(2002)
J Exp Med
, vol.196
, pp. 1415-1425
-
-
Schiavoni, G.1
Mattei, F.2
Sestili, P.3
-
38
-
-
0037220671
-
Essential role for ICSBP in the in vivo development of murine CD8 + dendritic cells
-
Aliberti J, Schulz O, Pennington DJ, et al. Essential role for ICSBP in the in vivo development of murine CD8 + dendritic cells. Blood 2003; 101:305-310.
-
(2003)
Blood
, vol.101
, pp. 305-310
-
-
Aliberti, J.1
Schulz, O.2
Pennington, D.J.3
-
39
-
-
56449097442
-
Batf3 deficiency reveals a critical role for CD8+ dendritic cells in cytotoxic T cell immunity
-
Hildner K, Edelson BT, Purtha WE, et al. Batf3 deficiency reveals a critical role for CD8+ dendritic cells in cytotoxic T cell immunity. Science 2008; 322:1097-1100.
-
(2008)
Science
, vol.322
, pp. 1097-1100
-
-
Hildner, K.1
Edelson, B.T.2
Purtha, W.E.3
-
40
-
-
84867884822
-
Compensatory dendritic cell development mediated by batf-irf interactions
-
Tussiwand R, Lee WL, Murphy TL, et al. Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature 2012; 490:502-507.
-
(2012)
Nature
, vol.490
, pp. 502-507
-
-
Tussiwand, R.1
Lee, W.L.2
Murphy, T.L.3
-
41
-
-
45749120843
-
Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling
-
Robbins SH, Walzer T, Dembele D, et al. Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling. Genome Biol 2008; 9:R17.
-
(2008)
Genome Biol
, vol.9
, pp. R17
-
-
Robbins, S.H.1
Walzer, T.2
Dembele, D.3
-
42
-
-
67249158956
-
Identification of a dendritic cell receptor that couples sensing of necrosis to immunity
-
Sancho D, Joffre OP, Keller AM, et al. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 2009; 458:899-903.
-
(2009)
Nature
, vol.458
, pp. 899-903
-
-
Sancho, D.1
Joffre, O.P.2
Keller, A.M.3
-
43
-
-
0033068180
-
CD8+ and CD8-subclasses of dendritic cells direct the development of distinct T helper cells in vivo
-
Maldonado-Lopez R, De Smedt T, Michel P, et al. CD8+ and CD8-subclasses of dendritic cells direct the development of distinct T helper cells in vivo. J Exp Med 1999; 189:587-592.
-
(1999)
J Exp Med
, vol.189
, pp. 587-592
-
-
Maldonado-Lopez, R.1
De Smedt, T.2
Michel, P.3
-
44
-
-
80051915459
-
CD8(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites
-
Mashayekhi M, Sandau MM, Dunay IR, et al. CD8(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites. Immunity 2011; 35:249-259.
-
(2011)
Immunity
, vol.35
, pp. 249-259
-
-
Mashayekhi, M.1
Sandau, M.M.2
Dunay, I.R.3
-
45
-
-
84912120595
-
Sting-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors
-
Woo SR, Fuertes MB, Corrales L, et al. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity 2014; 41:830-842.
-
(2014)
Immunity
, vol.41
, pp. 830-842
-
-
Woo, S.R.1
Fuertes, M.B.2
Corrales, L.3
-
46
-
-
84964344569
-
Expansion and activation of cd103(+) dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic pd-l1 and braf inhibition
-
Salmon H, Idoyaga J, Rahman A, et al. Expansion and activation of CD103(+) dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition. Immunity 2016; 44:924-938.
-
(2016)
Immunity
, vol.44
, pp. 924-938
-
-
Salmon, H.1
Idoyaga, J.2
Rahman, A.3
-
47
-
-
84961656295
-
Visualization of immediate immune responses to pioneer metastatic cells in the lung
-
Headley MB, Bins A, Nip A, et al. Visualization of immediate immune responses to pioneer metastatic cells in the lung. Nature 2016; 531:513-517.
-
(2016)
Nature
, vol.531
, pp. 513-517
-
-
Headley, M.B.1
Bins, A.2
Nip, A.3
-
48
-
-
77955389719
-
Tumor masses support naive T cell infiltration, activation, and differentiation into effectors
-
Thompson ED, Enriquez HL, Fu YX, Engelhard VH. Tumor masses support naive T cell infiltration, activation, and differentiation into effectors. J Exp Med 2010; 207:1791-1804.
-
(2010)
J Exp Med
, vol.207
, pp. 1791-1804
-
-
Thompson, E.D.1
Enriquez, H.L.2
Fu, Y.X.3
Engelhard, V.H.4
-
49
-
-
84929379918
-
Effector lymphocyte-induced lymph nodelike vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity
-
Peske JD, Thompson ED, Gemta L, Baylis RA, Fu YX, Engelhard VH. Effector lymphocyte-induced lymph nodelike vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity. Nat Commun 2015; 6:7114.
-
(2015)
Nat Commun
, vol.6
, pp. 7114
-
-
Peske, J.D.1
Thompson, E.D.2
Gemta, L.3
Baylis, R.A.4
Fu, Y.X.5
Engelhard, V.H.6
-
50
-
-
0036293726
-
An innate sense of danger
-
Matzinger P. An innate sense of danger. Ann NY Acad Sci 2002; 961:341-342.
-
(2002)
Ann NY Acad Sci
, vol.961
, pp. 341-342
-
-
Matzinger, P.1
-
51
-
-
84950141423
-
Sting activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
-
Demaria O, De Gassart A, Coso S, et al. STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity. Proc Natl Acad Sci USA 2015; 112:15408-15413.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. 15408-15413
-
-
Demaria, O.1
De Gassart, A.2
Coso, S.3
-
52
-
-
33947663623
-
The role of the purinergic P2X7 receptor in inflammation
-
Lister MF, Sharkey J, Sawatzky DA, et al. The role of the purinergic P2X7 receptor in inflammation. J Inflamm 2007; 4:5.
-
(2007)
J Inflamm
, vol.4
, pp. 5
-
-
Lister, M.F.1
Sharkey, J.2
Sawatzky, D.A.3
-
53
-
-
84916894965
-
Sting-mediated DNA sensing promotes antitumor and autoimmune responses to dying cells
-
Klarquist J, Hennies CM, Lehn MA, Reboulet RA, Feau S, Janssen EM. STING-mediated DNA sensing promotes antitumor and autoimmune responses to dying cells. J Immunol 2014; 193:6124-6134.
-
(2014)
J Immunol
, vol.193
, pp. 6124-6134
-
-
Klarquist, J.1
Hennies, C.M.2
Lehn, M.A.3
Reboulet, R.A.4
Feau, S.5
Janssen, E.M.6
-
54
-
-
84943663898
-
Diverse roles of STING-dependent signaling on the development of cancer
-
Ahn J, Konno H, Barber GN. Diverse roles of STING-dependent signaling on the development of cancer. Oncogene 2015; 34:5302-5308.
-
(2015)
Oncogene
, vol.34
, pp. 5302-5308
-
-
Ahn, J.1
Konno, H.2
Barber, G.N.3
-
55
-
-
84868615556
-
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
-
Huber S, Gagliani N, Zenewicz LA, et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature 2012; 491:259-263.
-
(2012)
Nature
, vol.491
, pp. 259-263
-
-
Huber, S.1
Gagliani, N.2
Zenewicz, L.A.3
-
56
-
-
77955350419
-
MyD88-mediated signaling prevents development of adenocarcinomas of the colon: Role of interleukin 18
-
Salcedo R, Worschech A, Cardone M, et al. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J Exp Med 2010; 207:1625-1636.
-
(2010)
J Exp Med
, vol.207
, pp. 1625-1636
-
-
Salcedo, R.1
Worschech, A.2
Cardone, M.3
-
57
-
-
84964698449
-
Sting contributes to antiglioma immunity via triggering type i ifn signals in the tumor microenvironment
-
Ohkuri T, Ghosh A, Kosaka A, et al. STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment. Cancer Immunol Res 2014; 2:1199-1208.
-
(2014)
Cancer Immunol Res
, vol.2
, pp. 1199-1208
-
-
Ohkuri, T.1
Ghosh, A.2
Kosaka, A.3
-
58
-
-
84873711885
-
Cyclic gmp-amp synthase is a cytosolic DNA sensor that activates the type i interferon pathway
-
Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 2013; 339:786-791.
-
(2013)
Science
, vol.339
, pp. 786-791
-
-
Sun, L.1
Wu, J.2
Du, F.3
Chen, X.4
Chen, Z.J.5
-
59
-
-
84880508067
-
Cyclic gmp-amp containing mixed phosphodiester linkages is an endogenous high-affinity ligand for sting
-
Zhang X, Shi H, Wu J, et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell 2013; 51:226-235.
-
(2013)
Mol Cell
, vol.51
, pp. 226-235
-
-
Zhang, X.1
Shi, H.2
Wu, J.3
-
60
-
-
70349943834
-
Sting regulates intracellular DNA-mediated, type i interferon-dependent innate immunity
-
Ishikawa H, Ma Z, Barber GN. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 2009; 461:788-792.
-
(2009)
Nature
, vol.461
, pp. 788-792
-
-
Ishikawa, H.1
Ma, Z.2
Barber, G.N.3
-
61
-
-
84924778328
-
Phosphorylation of innate immune adaptor proteins mavs, sting, and trif induces irf3 activation
-
Liu S, Cai X, Wu J, et al. Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 2015; 347:aaa2630.
-
(2015)
Science
, vol.347
, pp. aaa2630
-
-
Liu, S.1
Cai, X.2
Wu, J.3
-
62
-
-
84888637695
-
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cgamp
-
Ablasser A, Schmid-Burgk JL, Hemmerling I, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature 2013; 503:530-534.
-
(2013)
Nature
, vol.503
, pp. 530-534
-
-
Ablasser, A.1
Schmid-Burgk, J.L.2
Hemmerling, I.3
-
63
-
-
84971237993
-
Carcinoma-astrocyte gap junctions promote brain metastasis by cgamp transfer
-
Chen Q, Boire A, Jin X, et al. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature 2016; 533:493-498.
-
(2016)
Nature
, vol.533
, pp. 493-498
-
-
Chen, Q.1
Boire, A.2
Jin, X.3
-
64
-
-
84910031744
-
Inflammation-driven carcinogenesis is mediated through sting
-
Ahn J, Xia T, Konno H, Konno K, Ruiz P, Barber GN. Inflammation-driven carcinogenesis is mediated through STING. Nat Commun 2014; 5:5166.
-
(2014)
Nat Commun
, vol.5
, pp. 5166
-
-
Ahn, J.1
Xia, T.2
Konno, H.3
Konno, K.4
Ruiz, P.5
Barber, G.N.6
-
65
-
-
84965032473
-
Sting promotes the growth of tumors characterized by low antigenicity via ido activation
-
Lemos H, Mohamed E, Huang L, et al. STING promotes the growth of tumors characterized by low antigenicity via IDO activation. Cancer Res 2016; 76:2076-2081.
-
(2016)
Cancer Res
, vol.76
, pp. 2076-2081
-
-
Lemos, H.1
Mohamed, E.2
Huang, L.3
-
66
-
-
84885169498
-
Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses
-
Huang L, Li L, Lemos H, et al. Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses. J Immunol 2013; 191:3509-3513.
-
(2013)
J Immunol
, vol.191
, pp. 3509-3513
-
-
Huang, L.1
Li, L.2
Lemos, H.3
-
67
-
-
0037062934
-
Release of chromatin protein hmgb1 by necrotic cells triggers inflammation
-
Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002; 418:191-195.
-
(2002)
Nature
, vol.418
, pp. 191-195
-
-
Scaffidi, P.1
Misteli, T.2
Bianchi, M.E.3
-
68
-
-
34948820602
-
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
-
Apetoh L, Ghiringhelli F, Tesniere A, et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med 2007; 13:1050-1059.
-
(2007)
Nat Med
, vol.13
, pp. 1050-1059
-
-
Apetoh, L.1
Ghiringhelli, F.2
Tesniere, A.3
-
69
-
-
84865422909
-
Tumor-infiltrating dcs suppress nucleic acid-mediated innate immune responses through interactions between the receptor tim-3 and the alarmin hmgb1
-
Chiba S, Baghdadi M, Akiba H, et al. Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. Nat Immunol 2012; 13:832-842.
-
(2012)
Nat Immunol
, vol.13
, pp. 832-842
-
-
Chiba, S.1
Baghdadi, M.2
Akiba, H.3
-
70
-
-
84866378556
-
Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release
-
Venereau E, Casalgrandi M, Schiraldi M, et al. Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release. J Exp Med 2012; 209:1519-1528.
-
(2012)
J Exp Med
, vol.209
, pp. 1519-1528
-
-
Venereau, E.1
Casalgrandi, M.2
Schiraldi, M.3
-
71
-
-
84860862890
-
Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1)
-
Yang H, Lundback P, Ottosson L, et al. Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1). Mol Med 2012; 18:250-259.
-
(2012)
Mol Med
, vol.18
, pp. 250-259
-
-
Yang, H.1
Lundback, P.2
Ottosson, L.3
-
72
-
-
33845893860
-
Pivotal advance: Analysis of proinflammatory activity of highly purified eukaryotic recombinant HMGB1 (amphoterin)
-
Rouhiainen A, Tumova S, Valmu L, Kalkkinen N, Rauvala H. Pivotal advance: analysis of proinflammatory activity of highly purified eukaryotic recombinant HMGB1 (amphoterin). J Leukoc Biol 2007; 81:49-58.
-
(2007)
J Leukoc Biol
, vol.81
, pp. 49-58
-
-
Rouhiainen, A.1
Tumova, S.2
Valmu, L.3
Kalkkinen, N.4
Rauvala, H.5
-
74
-
-
84864503916
-
Micrornas bind to tolllike receptors to induce prometastatic inflammatory response
-
Fabbri M, Paone A, Calore F, et al. MicroRNAs bind to tolllike receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci USA 2012; 109:E2110-E2116.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. E2110-E2116
-
-
Fabbri, M.1
Paone, A.2
Calore, F.3
-
75
-
-
33746581694
-
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus
-
Crow YJ, Hayward BE, Parmar R, et al. Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus. Nat Genet 2006; 38:917-920.
-
(2006)
Nat Genet
, vol.38
, pp. 917-920
-
-
Crow, Y.J.1
Hayward, B.E.2
Parmar, R.3
-
76
-
-
34548327158
-
Mutations in the gene encoding the 3'-5' DNA exonuclease trex1 are associated with systemic lupus erythematosus
-
Lee-Kirsch MA, Gong M, Chowdhury D, et al. Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet 2007; 39:1065-1067.
-
(2007)
Nat Genet
, vol.39
, pp. 1065-1067
-
-
Lee-Kirsch, M.A.1
Gong, M.2
Chowdhury, D.3
-
78
-
-
84886789626
-
Cyclic dinucleotides trigger ulk1 (atg1) phosphorylation of sting to prevent sustained innate immune signaling
-
Konno H, Konno K, Barber GN. Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell 2013; 155:688-698.
-
(2013)
Cell
, vol.155
, pp. 688-698
-
-
Konno, H.1
Konno, K.2
Barber, G.N.3
-
79
-
-
77950362382
-
The inflammasomes
-
Schroder K, Tschopp J. The inflammasomes. Cell 2010; 140:821-832.
-
(2010)
Cell
, vol.140
, pp. 821-832
-
-
Schroder, K.1
Tschopp, J.2
-
80
-
-
84927745897
-
Pyroptotic cell death defends against intracellular pathogens
-
Jorgensen I, Miao EA. Pyroptotic cell death defends against intracellular pathogens. Immunol Rev 2015; 265:130-142.
-
(2015)
Immunol Rev
, vol.265
, pp. 130-142
-
-
Jorgensen, I.1
Miao, E.A.2
-
81
-
-
84962590036
-
Antagonism of the STING pathway via activation of the AIM2 inflammasome by intracellular DNA
-
Corrales L, Woo SR, Williams JB, McWhirter SM, Dubensky TW Jr, Gajewski TF. Antagonism of the STING pathway via activation of the AIM2 inflammasome by intracellular DNA. J Immunol 2016; 196:3191-3198.
-
(2016)
J Immunol
, vol.196
, pp. 3191-3198
-
-
Corrales, L.1
Woo, S.R.2
Williams, J.B.3
McWhirter, S.M.4
Gajewski, T.F.5
-
83
-
-
84979518723
-
Nk cells restrain spontaneous antitumor cd8+ t cell priming through pd-1/pd-l1 interactions with dendritic cells
-
Iraolagoitia XL, Spallanzani RG, Torres NI, et al. NK cells restrain spontaneous antitumor CD8+ T cell priming through PD-1/PD-L1 interactions with dendritic cells. J Immunol 2016; 197:953-961.
-
(2016)
J Immunol
, vol.197
, pp. 953-961
-
-
Iraolagoitia, X.L.1
Spallanzani, R.G.2
Torres, N.I.3
-
84
-
-
34548024379
-
Tumor-infiltrating gammadelta T cells suppress T and dendritic cell function via mechanisms controlled by a unique toll-like receptor signaling pathway
-
Peng G, Wang HY, Peng W, Kiniwa Y, Seo KH, Wang RF. Tumor-infiltrating gammadelta T cells suppress T and dendritic cell function via mechanisms controlled by a unique toll-like receptor signaling pathway. Immunity 2007; 27:334-348.
-
(2007)
Immunity
, vol.27
, pp. 334-348
-
-
Peng, G.1
Wang, H.Y.2
Peng, W.3
Kiniwa, Y.4
Seo, K.H.5
Wang, R.F.6
-
86
-
-
84955561954
-
Cancer immunosurveillance by tissue-resident innate lymphoid cells and innate-like T cells
-
Dadi S, Chhangawala S, Whitlock BM, et al. Cancer immunosurveillance by tissue-resident innate lymphoid cells and innate-like T cells. Cell 2016; 164:365-377.
-
(2016)
Cell
, vol.164
, pp. 365-377
-
-
Dadi, S.1
Chhangawala, S.2
Whitlock, B.M.3
-
87
-
-
78650647326
-
Has the microbiota played a critical role in the evolution of the adaptive immune system
-
Lee YK, Mazmanian SK. Has the microbiota played a critical role in the evolution of the adaptive immune system Science 2010; 330:1768-1773.
-
(2010)
Science
, vol.330
, pp. 1768-1773
-
-
Lee, Y.K.1
Mazmanian, S.K.2
-
88
-
-
84861980130
-
Interactions between the microbiota and the immune system
-
Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science 2012; 336:1268-1273.
-
(2012)
Science
, vol.336
, pp. 1268-1273
-
-
Hooper, L.V.1
Littman, D.R.2
Macpherson, A.J.3
-
89
-
-
33748588423
-
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
-
Ivanov, II, McKenzie BS, Zhou L, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006; 126:1121-1133.
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
McKenzie, B.S.2
Zhou, L.3
-
90
-
-
84948451779
-
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy
-
Sivan A, Corrales L, Hubert N, et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science 2015; 350:1084-1089.
-
(2015)
Science
, vol.350
, pp. 1084-1089
-
-
Sivan, A.1
Corrales, L.2
Hubert, N.3
-
91
-
-
84927741155
-
Consecutive oral administration of Bifidobacterium longum MM-2 improves the defense system against influenza virus infection by enhancing natural killer cell activity in a murine model
-
Kawahara T, Takahashi T, Oishi K, et al. Consecutive oral administration of Bifidobacterium longum MM-2 improves the defense system against influenza virus infection by enhancing natural killer cell activity in a murine model. Microbiol Immunol 2015; 59:1-12.
-
(2015)
Microbiol Immunol
, vol.59
, pp. 1-12
-
-
Kawahara, T.1
Takahashi, T.2
Oishi, K.3
-
92
-
-
84864322646
-
Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota
-
Ganal SC, Sanos SL, Kallfass C, et al. Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota. Immunity 2012; 37:171-186.
-
(2012)
Immunity
, vol.37
, pp. 171-186
-
-
Ganal, S.C.1
Sanos, S.L.2
Kallfass, C.3
-
93
-
-
84864311450
-
Commensal bacteria calibrate the activation threshold of innate antiviral immunity
-
Abt MC, Osborne LC, Monticelli LA, et al. Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity 2012; 37:158-170.
-
(2012)
Immunity
, vol.37
, pp. 158-170
-
-
Abt, M.C.1
Osborne, L.C.2
Monticelli, L.A.3
-
94
-
-
84948461699
-
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
-
Vetizou M, Pitt JM, Daillere R, et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science 2015; 350:1079-1084.
-
(2015)
Science
, vol.350
, pp. 1079-1084
-
-
Vetizou, M.1
Pitt, J.M.2
Daillere, R.3
-
95
-
-
84888049920
-
Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment
-
Iida N, Dzutsev A, Stewart CA, et al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science 2013; 342:967-970.
-
(2013)
Science
, vol.342
, pp. 967-970
-
-
Iida, N.1
Dzutsev, A.2
Stewart, C.A.3
-
96
-
-
84888059687
-
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
-
Viaud S, Saccheri F, Mignot G, et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science 2013; 342:971-976.
-
(2013)
Science
, vol.342
, pp. 971-976
-
-
Viaud, S.1
Saccheri, F.2
Mignot, G.3
-
97
-
-
84886698315
-
Innate and adaptive immune cells in the tumor microenvironment
-
Gajewski TF, Schreiber H, Fu YX. Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol 2013; 14:1014-1022.
-
(2013)
Nat Immunol
, vol.14
, pp. 1014-1022
-
-
Gajewski, T.F.1
Schreiber, H.2
Fu, Y.X.3
-
98
-
-
84887865311
-
T cells in the human metastatic melanoma microenvironment express site-specific homing receptors and retention integrins
-
Salerno EP, Olson WC, McSkimming C, Shea S, Slingluff CL Jr. T cells in the human metastatic melanoma microenvironment express site-specific homing receptors and retention integrins. Int J Cancer 2014; 134:563-574.
-
(2014)
Int J Cancer
, vol.134
, pp. 563-574
-
-
Salerno, E.P.1
Olson, W.C.2
McSkimming, C.3
Shea, S.4
Slingluff, C.L.J.R.5
-
99
-
-
84857746620
-
Immunotype and immunohistologic characteristics of tumor-infiltrating immune cells are associated with clinical outcome in metastatic melanoma
-
Erdag G, Schaefer JT, Smolkin ME, et al. Immunotype and immunohistologic characteristics of tumor-infiltrating immune cells are associated with clinical outcome in metastatic melanoma. Cancer Res 2012; 72:1070-1080.
-
(2012)
Cancer Res
, vol.72
, pp. 1070-1080
-
-
Erdag, G.1
Schaefer, J.T.2
Smolkin, M.E.3
-
100
-
-
84936821508
-
Association of response to programmed death receptor 1 (PD-1) blockade with pembrolizumab (MK-3475) with an interferon-inflammatory immune gene signature
-
Ribas A, Robert C, Hodi S, et al. Association of response to programmed death receptor 1 (PD-1) blockade with pembrolizumab (MK-3475) with an interferon-inflammatory immune gene signature. J Clin Oncol 2015; 33:(suppl; abstr 3001).
-
(2015)
J Clin Oncol
, vol.33
-
-
Ribas, A.1
Robert, C.2
Hodi, S.3
-
101
-
-
84941108977
-
Inflamed-phenotype gene expression signatures to predict benefit from the anti-PD-1 antibody pembrolizumab in PD-L1+ head and neck cancer patients
-
suppl; abstr 6017
-
Seiwert TY, Burtness B, Weiss J, et al. Inflamed-phenotype gene expression signatures to predict benefit from the anti-PD-1 antibody pembrolizumab in PD-L1+ head and neck cancer patients. J Clin Oncol 2015; 33:(suppl; abstr 6017).
-
(2015)
J Clin Oncol
, vol.33
-
-
Seiwert, T.Y.1
Burtness, B.2
Weiss, J.3
-
102
-
-
84936953099
-
Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity
-
Spranger S, Bao RY, Gajewski TF. Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity. Nature 2015; 523:231-U261.
-
(2015)
Nature
, vol.523
, pp. 231-261
-
-
Spranger, S.1
Bao, R.Y.2
Gajewski, T.F.3
-
103
-
-
84877795529
-
Mouse, but not human sting, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid
-
Conlon J, Burdette DL, Sharma S, et al. Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid. J Immunol 2013; 190:5216-5225.
-
(2013)
J Immunol
, vol.190
, pp. 5216-5225
-
-
Conlon, J.1
Burdette, D.L.2
Sharma, S.3
-
104
-
-
84882815198
-
Structure-function analysis of sting activation by c[g(2',5')pa(3',5')p] and targeting by antiviral dmxaa
-
Gao P, Ascano M, Zillinger T, et al. Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell 2013; 154:748-762.
-
(2013)
Cell
, vol.154
, pp. 748-762
-
-
Gao, P.1
Ascano, M.2
Zillinger, T.3
-
105
-
-
84880522115
-
Anticancer flavonoids are mouse-selective sting agonists
-
Kim S, Li L, Maliga Z, Yin Q, Wu H, Mitchison TJ. Anticancer flavonoids are mouse-selective STING agonists. ACS Chem Biol 2013; 8:1396-1401.
-
(2013)
ACS Chem Biol
, vol.8
, pp. 1396-1401
-
-
Kim, S.1
Li, L.2
Maliga, Z.3
Yin, Q.4
Wu, H.5
Mitchison, T.J.6
-
106
-
-
84869208004
-
5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential
-
Prantner D, Perkins DJ, Lai W, et al. 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential. J Biol Chem 2012; 287:39776-39788.
-
(2012)
J Biol Chem
, vol.287
, pp. 39776-39788
-
-
Prantner, D.1
Perkins, D.J.2
Lai, W.3
-
107
-
-
84929705879
-
Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity
-
Corrales L, Glickman LH, McWhirter SM, et al. Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep 2015; 11:1018-1030.
-
(2015)
Cell Rep
, vol.11
, pp. 1018-1030
-
-
Corrales, L.1
Glickman, L.H.2
McWhirter, S.M.3
-
108
-
-
80051638135
-
Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (asa404) in advanced non-small-cell lung cancer
-
Lara PN Jr, Douillard JY, Nakagawa K, et al. Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (ASA404) in advanced non-small-cell lung cancer. J Clin Oncol 2011; 29:2965-2971.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2965-2971
-
-
Douillard, J.Y.1
Nakagawa, K.2
-
109
-
-
85016317140
-
-
Aduro Biotech Inc. Novartis Pharmaceuticals Study of the Safety and Efficacy of MIW815 (ADU-S100) in Patients with Advanced/Metastatic Solid Tumors or Lymphomas. 2020. ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). Identifier: NCT02675439. Available from
-
Aduro Biotech Inc, Novartis Pharmaceuticals. Study of the Safety and Efficacy of MIW815 (ADU-S100) in Patients with Advanced/Metastatic Solid Tumors or Lymphomas. 2020. ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). Identifier: NCT02675439. Available from: https://ClinicalTrials.gov/show/NCT02675439. (citedJuly 2016).
-
-
-
-
110
-
-
78049420571
-
Situ Vaccination with A TLR9 Agonist Induces Systemic Lymphoma Regression: A Phase I/II Study
-
Brody JD, Ai WZ, Czerwinski DK, et al. In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: a phase I/II study. J Clin Oncol 2010; 28:4324-4332.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4324-4332
-
-
Brody, J.D.1
Ai, W.Z.2
Czerwinski, D.K.3
-
111
-
-
84855486511
-
Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans
-
Caskey M, Lefebvre F, Filali-Mouhim A, et al. Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans. J Exp Med 2011; 208:2357-2366.
-
(2011)
J Exp Med
, vol.208
, pp. 2357-2366
-
-
Caskey, M.1
Lefebvre, F.2
Filali-Mouhim, A.3
-
112
-
-
84874614617
-
The ultra-potent and selective tlr8 agonist vtx-294 activates human newborn and adult leukocytes
-
Dowling DJ, Tan Z, Prokopowicz ZM, et al. The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes. PLoS One 2013; 8:e58164.
-
(2013)
PLoS One
, vol.8
, pp. e58164
-
-
Dowling, D.J.1
Tan, Z.2
Prokopowicz, Z.M.3
-
113
-
-
85016240873
-
-
Dynavax Technologies Corporation Study of SD-101 in Combination with Localized Low-dose Radiation in Patients with Untreated Low-grade B-cell Lymphoma. 2016. ClinicalTrials. gov [Internet]. Bethesda (MD): National Library of Medicine (US). Identifier: NCT02266147. Available from: https://ClinicalTrials.gov/show/NCT02266147. (cited 01 Jul 2016
-
Dynavax Technologies Corporation. Study of SD-101 in Combination with Localized Low-dose Radiation in Patients with Untreated Low-grade B-cell Lymphoma. 2016. ClinicalTrials. gov [Internet]. Bethesda (MD): National Library of Medicine (US). Identifier: NCT02266147. Available from: https://ClinicalTrials.gov/show/NCT02266147. (cited 01 Jul 2016).
-
-
-
-
114
-
-
85016318879
-
-
Immune Design, Merck Sharp & Dohme Corp Study of Intratumoral G100 with or without Pembrolizumab in Patients with Follicular Non-Hodgkin's Lymphoma. 2017. ClinicalTrials. gov [Internet]. Bethesda (MD): National Library of Medicine (US). Identifier: NCT02501473. Available from: https:// ClinicalTrials.gov/show/NCT02501473. (cited 01 July 2016
-
Immune Design, Merck Sharp & Dohme Corp. Study of Intratumoral G100 with or without Pembrolizumab in Patients with Follicular Non-Hodgkin's Lymphoma. 2017. ClinicalTrials. gov [Internet]. Bethesda (MD): National Library of Medicine (US). Identifier: NCT02501473. Available from: https:// ClinicalTrials.gov/show/NCT02501473. (cited 01 July 2016).
-
-
-
-
115
-
-
85016314575
-
-
MedImmune LLC A Study of MEDI9197 Administered in Subjects with a Solid Tumor Cancer. 2018. ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). Identifier: NCT02556463. Available from: https://ClinicalTrials. gov/show/NCT02556463. (cited 01 Jul 2016
-
MedImmune LLC. A Study of MEDI9197 Administered in Subjects with a Solid Tumor Cancer. 2018. ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). Identifier: NCT02556463. Available from: https://ClinicalTrials. gov/show/NCT02556463. (cited 01 Jul 2016).
-
-
-
-
116
-
-
85016334989
-
-
Oncovir Inc, National Institutes of Health, Icahn School of Medicine at Mount Sinai, Bay Hematology Oncology, Emory University, University of Pittsburgh, National Cancer Institute
-
Oncovir Inc, National Institutes of Health, Icahn School of Medicine at Mount Sinai, Bay Hematology Oncology, Emory University, University of Pittsburgh, National Cancer Institute. In Situ, Autologous Therapeutic Vaccination Against Solid Cancers with Intratumoral Hiltonol. 2018. ClinicalTrials. gov [Internet]. Bethesda (MD): National Library of Medicine (US). Identifier: NCT02423863. Available from: https:// ClinicalTrials.gov/show/NCT02423863. (cited 01 Jul 2016).
-
In Situ, Autologous Therapeutic Vaccination Against Solid Cancers with Intratumoral Hiltonol. 2018. ClinicalTrials. Gov [Internet]. Bethesda (MD): National Library of Medicine (US). Identifier: NCT02423863. Available from: Https:// ClinicalTrials.gov/show/NCT02423863. (cited 01 Jul 2016
-
-
-
117
-
-
84912128872
-
Sting-dependent cytosolic DNA sensing promotes radiation-induced type i interferon-dependent antitumor immunity in immunogenic tumors
-
Deng L, Liang H, Xu M, et al. STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity 2014; 41:843-852.
-
(2014)
Immunity
, vol.41
, pp. 843-852
-
-
Deng, L.1
Liang, H.2
Xu, M.3
-
118
-
-
85016308306
-
-
University of Chicago Study of PD1 Blockade by Pembrolizumab with Stereotactic Body Radiotherapy in Advanced Solid Tumors. 2017. ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). Identifier: NCT02608385. Available from: https://ClinicalTrials.gov/ show/NCT02608385. (cited 01 July 2016
-
University of Chicago. Study of PD1 Blockade by Pembrolizumab with Stereotactic Body Radiotherapy in Advanced Solid Tumors. 2017. ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). Identifier: NCT02608385. Available from: https://ClinicalTrials.gov/ show/NCT02608385. (cited 01 July 2016).
-
-
-
-
119
-
-
85010889847
-
Correlation of wnt/-catenin pathway activation with immune exclusion across most human cancers
-
suppl; abstr 3004
-
Luke JJ, Bao R, Spranger S, Sweis RF, Gajewski T. Correlation of WNT/-catenin pathway activation with immune exclusion across most human cancers. J Clin Oncol 2016; 34:(suppl; abstr 3004).
-
(2016)
J Clin Oncol
, vol.34
-
-
Luke, J.J.1
Bao, R.2
Spranger, S.3
Sweis, R.F.4
Gajewski, T.5
-
120
-
-
84957093642
-
Loss of pten promotes resistance to t cell-mediated immunotherapy
-
Peng W, Chen JQ, Liu C, et al. Loss of PTEN promotes resistance to T cell-mediated immunotherapy. Cancer Discov 2016; 6:202-216.
-
(2016)
Cancer Discov
, vol.6
, pp. 202-216
-
-
Peng, W.1
Chen, J.Q.2
Liu, C.3
-
121
-
-
84979763259
-
Molecular drivers of the non-T-cell-inflamed tumor microenvironment in urothelial bladder cancer
-
Sweis RF, Spranger S, Bao R, et al. Molecular drivers of the non-T-cell-inflamed tumor microenvironment in urothelial bladder cancer. Cancer Immunol Res 2016; 4:563-568.
-
(2016)
Cancer Immunol Res
, vol.4
, pp. 563-568
-
-
Sweis, R.F.1
Spranger, S.2
Bao, R.3
-
122
-
-
84960842480
-
MYC regulates the antitumor immune response through CD47 and PD-L1
-
Casey SC, Tong L, Li Y, et al. MYC regulates the antitumor immune response through CD47 and PD-L1. Science 2016; 352:227-231.
-
(2016)
Science
, vol.352
, pp. 227-231
-
-
Casey, S.C.1
Tong, L.2
Li, Y.3
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