Antagonism of the STING pathway via activation of the AIM2 inflammasome by intracellular DNA

Journal of Immunology

Volumn 196, Issue 7, 2016, Pages 3191-3198

  Corrales, Leticia ^a   Woo, Seng Ryong ^a   Williams, Jason B ^a   McWhirter, Sarah M ^b   Dubensky, Thomas W ^b   Gajewski, Thomas F ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b Aduro BioTech Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSENT IN MELANOMA 2 PROTEIN; APOPTOSIS ASSOCIATED SPECKLIKE PROTEIN; BETA INTERFERON; CELL DNA; CELL PROTEIN; CYCLIC AMP; CYCLIC GMP; INFLAMMASOME; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 1BETA CONVERTING ENZYME; MEMBRANE PROTEIN; STIMULATOR OF INTERFERON GENES PROTEIN; TANK BINDING KINASE 1; UNCLASSIFIED DRUG; AIM2 PROTEIN, MOUSE; DNA; DNA BINDING PROTEIN; GAMMA INTERFERON; MB21D1 PROTEIN, MOUSE; MPYS PROTEIN, MOUSE; NUCLEOTIDYLTRANSFERASE;

ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; DENDRITIC CELL; ENZYME INHIBITION; FEMALE; IN VITRO STUDY; INTERFERON PRODUCTION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEFICIENCY; PROTEIN PHOSPHORYLATION; PYROPTOSIS; ANIMAL; ANTIGEN PRESENTING CELL; BIOSYNTHESIS; DEFICIENCY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; NEOPLASM; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGEN-PRESENTING CELLS; CASPASE 1; DNA; DNA-BINDING PROTEINS; FEMALE; INFLAMMASOMES; INTERFERON-GAMMA; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NEOPLASMS; NUCLEOTIDYLTRANSFERASES; PYROPTOSIS; SIGNAL TRANSDUCTION;

EID: 84962590036     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1502538     Document Type: Article

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