Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

Nature Immunology

Volumn 13, Issue 9, 2012, Pages 832-842

  Chiba, Shigeki ^a   Baghdadi, Muhammad ^a,b   Akiba, Hisaya ^c   Yoshiyama, Hironori ^a   Kinoshita, Ichiro ^b   Dosaka Akita, Hirotoshi ^b   Fujioka, Yoichiro ^b   Ohba, Yusuke ^b   Gorman, Jacob V ^d   Colgan, John D ^d   Hirashima, Mitsuomi ^e   Uede, Toshimitsu ^a   Takaoka, Akinori ^a   Yagita, Hideo ^c   Jinushi, Masahisa ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF IOWA   (United States)

^e KAGAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON 4; BETA1 INTERFERON; CISPLATIN; CPG OLIGODEOXYNUCLEOTIDE; CYTOKINE; DNA VACCINE; ECALECTIN; GLYCOPROTEIN GP 100; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 6; MESSENGER RNA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY RMT3 23; NUCLEIC ACID; PLASMID DNA; PROTEIN TIM 3; RECEPTOR PROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CHEMOTHERAPY; CANCER PATIENT; CELL DEATH; CONTROLLED STUDY; CYTOSOL; DENDRITIC CELL; DNA IMMUNIZATION; EFFECTOR CELL; ENDOSOME; HUMAN; HUMAN CELL; IMMUNOGENICITY; IMMUNOMODULATION; IMMUNOREGULATION; INNATE IMMUNITY; MACROPHAGE; MELANOMA; MOLECULAR RECOGNITION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STROMA CELL; TUMOR CELL; TUMOR IMMUNITY; TUMOR INFILTRATING DENDRITIC CELL; TUMOR MICROENVIRONMENT;

ANIMALS; DENDRITIC CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HMGB1 PROTEIN; HUMANS; IMMUNITY, INNATE; IMMUNOBLOTTING; IMMUNOLOGIC SURVEILLANCE; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; NEOPLASMS; NUCLEIC ACIDS; RECEPTORS, PATTERN RECOGNITION; RECEPTORS, VIRUS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR MICROENVIRONMENT;

EID: 84865422909     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2376     Document Type: Article

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