The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Dowling, David J ^a,b   Tan, Zhen ^a,b,c   Prokopowicz, Zofia M ^a,b   Palmer, Christine D ^a,b   Matthews, Maura Ann H ^d   Dietsch, Gregory N ^d   Hershberg, Robert M ^d   Levy, Ofer ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d VentiRx Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZAZEPINE DERIVATIVE; CD14 ANTIGEN; CD209 ANTIGEN; CD86 ANTIGEN; CL 075; COLONY STIMULATING FACTOR; HLA DR ANTIGEN; IMIDAZOQUINOLINE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOSTIMULATING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHORYL LIPID A; RESIQUIMOD; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VTX 087; VTX 217; VTX 294; VTX 744;

ADULT; ARTICLE; BLOOD SAMPLING; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG POTENCY; DRUG STRUCTURE; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOSTIMULATION; LEUKOCYTE ACTIVATION; MONOCYTE; NEWBORN; PROTEIN EXPRESSION;

ADULT; ANALYSIS OF VARIANCE; BENZAZEPINES; DENDRITIC CELLS; FLOW CYTOMETRY; HEK293 CELLS; HUMANS; IMIDAZOLES; INFANT, NEWBORN; LEUKOCYTES; LIPID A; QUINOLINES; THIAZOLES; TOLL-LIKE RECEPTOR 8;

EID: 84874614617     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058164     Document Type: Article

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