Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans

Journal of Experimental Medicine

Volumn 208, Issue 12, 2011, Pages 2357-2366

  Caskey, Marina ^a   Lefebvre, François ^b   Filali Mouhim, Abdelali ^b   Cameron, Mark J ^c   Goulet, Jean Philippe ^b   Haddad, Elias K ^b,c   Breton, Gaëlle ^a   Trumpfheller, Christine ^a   Pollak, Sarah ^a   Shimeliovich, Irina ^a   Duque Alarcon, Angela ^c   Pan, Li ^c   Nelkenbaum, Annette ^a   Salazar, Andres M ^d   Schlesinger, Sarah J ^a   Steinman, Ralph M ^a   Sékaly, Rafick P ^b,c  

^a ROCKEFELLER UNIVERSITY   (United States)

^b CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^c Vaccine and Gene Therapy Institute of Florida   (United States)

^d Oncovir Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYMETHYLCELLULOSE POLYCYTIDYLIC POLYINOSINIC ACID POLYLYSINE; DOUBLE STRANDED RNA; IMMUNOLOGICAL ADJUVANT; INFLAMMASOME; INTERFERON; INTERFERON RECEPTOR; LIVE VACCINE; PATTERN RECOGNITION RECEPTOR; PLACEBO; RNA HELICASE; TOLL LIKE RECEPTOR AGONIST; VIRUS VACCINE; YELLOW FEVER VACCINE;

ADULT; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG SAFETY; DRUG TOLERABILITY; ERYTHEMA; EX VIVO STUDY; FEMALE; FEVER; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEADACHE; HUMAN; HUMAN EXPERIMENT; INJECTION SITE ERYTHEMA; INJECTION SITE INDURATION; INJECTION SITE PAIN; INNATE IMMUNITY; MALAISE; MALE; MYALGIA; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE;

ADJUVANTS, IMMUNOLOGIC; CARBOXYMETHYLCELLULOSE SODIUM; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; INJECTIONS, SUBCUTANEOUS; INTERFERONS; MICROARRAY ANALYSIS; POLY I-C; POLYLYSINE; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VIRAL VACCINES;

EID: 84855486511     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20111171     Document Type: Article

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