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Volumn 6, Issue , 2015, Pages

Research Perspectives on the Regulation and Physiological Functions of FGF21 and its Association with NAFLD

Author keywords

chronic inflammation; epigenetic regulation; ER stress; FGF21; NAFLD; NASH

Indexed keywords


EID: 85006185441     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2015.00147     Document Type: Review
Times cited : (44)

References (75)
  • 1
    • 0035081241 scopus 로고    scopus 로고
    • Fibroblast growth factors
    • REVIEWS3005, 11276432
    • Ornitz DM Itoh N. Fibroblast growth factors. Genome Biol (2001) 2:REVIEWS3005.10.1186/gb-2001-2-3-reviews300511276432
    • (2001) Genome Biol , vol.2
    • Ornitz, D.M.1    Itoh, N.2
  • 2
    • 84870568785 scopus 로고    scopus 로고
    • Circulating fibroblast growth factors as metabolic regulators – a critical appraisal
    • 23217254
    • Angelin B Larsson TE Rudling M. Circulating fibroblast growth factors as metabolic regulators – a critical appraisal. Cell Metab (2012) 16:693–705.10.1016/j.cmet.2012.11.00123217254
    • (2012) Cell Metab , vol.16 , pp. 693-705
    • Angelin, B.1    Larsson, T.E.2    Rudling, M.3
  • 3
    • 77957376253 scopus 로고    scopus 로고
    • Research resource: comprehensive expression atlas of the fibroblast growth factor system in adult mouse
    • 20667984
    • Fon Tacer K Bookout AL Ding X Kurosu H John GB Wang L et al. Research resource: comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Mol Endocrinol (2010) 24:2050–64.10.1210/me.2010-014220667984
    • (2010) Mol Endocrinol , vol.24 , pp. 2050-2064
    • Fon Tacer, K.1    Bookout, A.L.2    Ding, X.3    Kurosu, H.4    John, G.B.5    Wang, L.6
  • 4
    • 34247565954 scopus 로고    scopus 로고
    • Molecular insights into the Klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members
    • 17339340
    • Goetz R Beenken A Ibrahimi OA Kalinina J Olsen SK Eliseenkova AV et al. Molecular insights into the Klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol Cell Biol (2007) 27:3417–28.10.1128/MCB.02249-0617339340
    • (2007) Mol Cell Biol , vol.27 , pp. 3417-3428
    • Goetz, R.1    Beenken, A.2    Ibrahimi, O.A.3    Kalinina, J.4    Olsen, S.K.5    Eliseenkova, A.V.6
  • 5
    • 84911917697 scopus 로고    scopus 로고
    • Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding
    • 25008183
    • Markan KR Naber MC Ameka MK Anderegg MD Mangelsdorf DJ Kliewer SA et al. Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding. Diabetes (2014) 63:4057–63.10.2337/db14-059525008183
    • (2014) Diabetes , vol.63 , pp. 4057-4063
    • Markan, K.R.1    Naber, M.C.2    Ameka, M.K.3    Anderegg, M.D.4    Mangelsdorf, D.J.5    Kliewer, S.A.6
  • 6
    • 34249686631 scopus 로고    scopus 로고
    • Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    • 17550777
    • Inagaki T Dutchak P Zhao G Ding X Gautron L Parameswara V et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab (2007) 5:415–25.10.1016/j.cmet.2007.05.00317550777
    • (2007) Cell Metab , vol.5 , pp. 415-425
    • Inagaki, T.1    Dutchak, P.2    Zhao, G.3    Ding, X.4    Gautron, L.5    Parameswara, V.6
  • 7
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
    • 17550778
    • Badman MK Pissios P Kennedy AR Koukos G Flier JS Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab (2007) 5:426–37.10.1016/j.cmet.2007.05.00217550778
    • (2007) Cell Metab , vol.5 , pp. 426-437
    • Badman, M.K.1    Pissios, P.2    Kennedy, A.R.3    Koukos, G.4    Flier, J.S.5    Maratos-Flier, E.6
  • 9
  • 10
    • 84874664386 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 is induced by endoplasmic reticulum stress
    • 23123503
    • Schaap FG Kremer AE Lamers WH Jansen PL Gaemers IC. Fibroblast growth factor 21 is induced by endoplasmic reticulum stress. Biochimie (2013) 95:692–9.10.1016/j.biochi.2012.10.01923123503
    • (2013) Biochimie , vol.95 , pp. 692-699
    • Schaap, F.G.1    Kremer, A.E.2    Lamers, W.H.3    Jansen, P.L.4    Gaemers, I.C.5
  • 11
    • 84858311217 scopus 로고    scopus 로고
    • Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation
    • 22233381
    • De Sousa-Coelho AL Marrero PF Haro D. Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation. Biochem J (2012) 443:165–71.10.1042/BJ2011174822233381
    • (2012) Biochem J , vol.443 , pp. 165-171
    • De Sousa-Coelho, A.L.1    Marrero, P.F.2    Haro, D.3
  • 12
    • 84872057896 scopus 로고    scopus 로고
    • Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
    • 23202295
    • Kim KH Jeong YT Oh H Kim SH Cho JM Kim YN et al. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med (2013) 19:83–92.10.1038/nm.301423202295
    • (2013) Nat Med , vol.19 , pp. 83-92
    • Kim, K.H.1    Jeong, Y.T.2    Oh, H.3    Kim, S.H.4    Cho, J.M.5    Kim, Y.N.6
  • 13
    • 84877149547 scopus 로고    scopus 로고
    • Acute exercise induces FGF21 expression in mice and in healthy humans
    • 23667629
    • Kim KH Kim SH Min YK Yang HM Lee JB Lee MS. Acute exercise induces FGF21 expression in mice and in healthy humans. PLoS One (2013) 8:e63517.10.1371/journal.pone.006351723667629
    • (2013) PLoS One , vol.8 , pp. e63517
    • Kim, K.H.1    Kim, S.H.2    Min, Y.K.3    Yang, H.M.4    Lee, J.B.5    Lee, M.S.6
  • 14
    • 79960110157 scopus 로고    scopus 로고
    • The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism
    • 21666694
    • Lee JH Giannikopoulos P Duncan SA Wang J Johansen CT Brown JD et al. The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. Nat Med (2011) 17:812–5.10.1038/nm.234721666694
    • (2011) Nat Med , vol.17 , pp. 812-815
    • Lee, J.H.1    Giannikopoulos, P.2    Duncan, S.A.3    Wang, J.4    Johansen, C.T.5    Brown, J.D.6
  • 15
    • 69249238074 scopus 로고    scopus 로고
    • Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes
    • 19660458
    • Iizuka K Takeda J Horikawa Y. Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes. FEBS Lett (2009) 583:2882–6.10.1016/j.febslet.2009.07.05319660458
    • (2009) FEBS Lett , vol.583 , pp. 2882-2886
    • Iizuka, K.1    Takeda, J.2    Horikawa, Y.3
  • 16
    • 37549052177 scopus 로고    scopus 로고
    • Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes
    • 17954559
    • Wang H Qiang L Farmer SR. Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes. Mol Cell Biol (2008) 28:188–200.10.1128/MCB.00992-0717954559
    • (2008) Mol Cell Biol , vol.28 , pp. 188-200
    • Wang, H.1    Qiang, L.2    Farmer, S.R.3
  • 17
    • 33845407972 scopus 로고    scopus 로고
    • Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling
    • 17063460
    • Moyers JS Shiyanova TL Mehrbod F Dunbar JD Noblitt TW Otto KA et al. Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling. J Cell Physiol (2007) 210:1–6.10.1002/jcp.2084717063460
    • (2007) J Cell Physiol , vol.210 , pp. 1-6
    • Moyers, J.S.1    Shiyanova, T.L.2    Mehrbod, F.3    Dunbar, J.D.4    Noblitt, T.W.5    Otto, K.A.6
  • 18
    • 84864105994 scopus 로고    scopus 로고
    • Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21
    • 22661717
    • Cyphert HA Ge X Kohan AB Salati LM Zhang Y Hillgartner FB. Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21. J Biol Chem (2012) 287:25123–38.10.1074/jbc.M112.37590722661717
    • (2012) J Biol Chem , vol.287 , pp. 25123-25138
    • Cyphert, H.A.1    Ge, X.2    Kohan, A.B.3    Salati, L.M.4    Zhang, Y.5    Hillgartner, F.B.6
  • 19
    • 84862323517 scopus 로고    scopus 로고
    • Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet
    • 21889884
    • Uebanso T Taketani Y Yamamoto H Amo K Tanaka S Arai H et al. Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet. J Nutr Biochem (2012) 23:785–90.10.1016/j.jnutbio.2011.03.02321889884
    • (2012) J Nutr Biochem , vol.23 , pp. 785-790
    • Uebanso, T.1    Taketani, Y.2    Yamamoto, H.3    Amo, K.4    Tanaka, S.5    Arai, H.6
  • 20
    • 84870312300 scopus 로고    scopus 로고
    • Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 corepressor complex in mice
    • 23073827
    • Archer A Venteclef N Mode A Pedrelli M Gabbi C Clement K et al. Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 corepressor complex in mice. Mol Endocrinol (2012) 26:1980–90.10.1210/me.2012-115123073827
    • (2012) Mol Endocrinol , vol.26 , pp. 1980-1990
    • Archer, A.1    Venteclef, N.2    Mode, A.3    Pedrelli, M.4    Gabbi, C.5    Clement, K.6
  • 21
    • 84920483737 scopus 로고    scopus 로고
    • Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21
    • 25476453
    • Owen BM Mangelsdorf DJ Kliewer SA. Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21. Trends Endocrinol Metab (2015) 26:22–9.10.1016/j.tem.2014.10.00225476453
    • (2015) Trends Endocrinol Metab , vol.26 , pp. 22-29
    • Owen, B.M.1    Mangelsdorf, D.J.2    Kliewer, S.A.3
  • 23
    • 79953886306 scopus 로고    scopus 로고
    • Thermogenic activation induces FGF21 expression and release in brown adipose tissue
    • 21317437
    • Hondares E Iglesias R Giralt A Gonzalez FJ Giralt M Mampel T et al. Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J Biol Chem (2011) 286:12983–90.10.1074/jbc.M110.21588921317437
    • (2011) J Biol Chem , vol.286 , pp. 12983-12990
    • Hondares, E.1    Iglesias, R.2    Giralt, A.3    Gonzalez, F.J.4    Giralt, M.5    Mampel, T.6
  • 24
    • 84863012459 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones
    • 22304921
    • Dutchak PA Katafuchi T Bookout AL Choi JH Yu RT Mangelsdorf DJ et al. Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones. Cell (2012) 148:556–67.10.1016/j.cell.2011.11.06222304921
    • (2012) Cell , vol.148 , pp. 556-567
    • Dutchak, P.A.1    Katafuchi, T.2    Bookout, A.L.3    Choi, J.H.4    Yu, R.T.5    Mangelsdorf, D.J.6
  • 25
    • 33750110683 scopus 로고    scopus 로고
    • Fuel metabolism in starvation
    • Cahill GF Jr. Fuel metabolism in starvation. Annu Rev Nutr (2006) 26:1–22.10.1146/annurev.nutr.26.061505.111258
    • (2006) Annu Rev Nutr , vol.26 , pp. 1-22
    • Cahill, G.F.1
  • 26
    • 58749117235 scopus 로고    scopus 로고
    • Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2
    • 19187775
    • Sakakibara I Fujino T Ishii M Tanaka T Shimosawa T Miura S et al. Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. Cell Metab (2009) 9:191–202.10.1016/j.cmet.2008.12.00819187775
    • (2009) Cell Metab , vol.9 , pp. 191-202
    • Sakakibara, I.1    Fujino, T.2    Ishii, M.3    Tanaka, T.4    Shimosawa, T.5    Miura, S.6
  • 27
    • 67649823642 scopus 로고    scopus 로고
    • FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
    • 19541642
    • Potthoff MJ Inagaki T Satapati S Ding X He T Goetz R et al. FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci U S A (2009) 106:10853–8.10.1073/pnas.090418710619541642
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 10853-10858
    • Potthoff, M.J.1    Inagaki, T.2    Satapati, S.3    Ding, X.4    He, T.5    Goetz, R.6
  • 29
    • 33750587755 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways
    • 16936195
    • Wente W Efanov AM Brenner M Kharitonenkov A Koster A Sandusky GE et al. Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways. Diabetes (2006) 55:2470–8.10.2337/db05-143516936195
    • (2006) Diabetes , vol.55 , pp. 2470-2478
    • Wente, W.1    Efanov, A.M.2    Brenner, M.3    Kharitonenkov, A.4    Koster, A.5    Sandusky, G.E.6
  • 30
    • 84908018672 scopus 로고    scopus 로고
    • FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss
    • 25130400
    • Owen BM Ding X Morgan DA Coate KC Bookout AL Rahmouni K et al. FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss. Cell Metab (2014) 20:670–7.10.1016/j.cmet.2014.07.01225130400
    • (2014) Cell Metab , vol.20 , pp. 670-677
    • Owen, B.M.1    Ding, X.2    Morgan, D.A.3    Coate, K.C.4    Bookout, A.L.5    Rahmouni, K.6
  • 31
    • 45649085226 scopus 로고    scopus 로고
    • Inhibition of growth hormone signaling by the fasting-induced hormone FGF21
    • 18585098
    • Inagaki T Lin VY Goetz R Mohammadi M Mangelsdorf DJ Kliewer SA. Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. Cell Metab (2008) 8:77–83.10.1016/j.cmet.2008.05.00618585098
    • (2008) Cell Metab , vol.8 , pp. 77-83
    • Inagaki, T.1    Lin, V.Y.2    Goetz, R.3    Mohammadi, M.4    Mangelsdorf, D.J.5    Kliewer, S.A.6
  • 32
    • 84883763046 scopus 로고    scopus 로고
    • FGF21 contributes to neuroendocrine control of female reproduction
    • 23933983
    • Owen BM Bookout AL Ding X Lin VY Atkin SD Gautron L et al. FGF21 contributes to neuroendocrine control of female reproduction. Nat Med (2013) 19:1153–6.10.1038/nm.325023933983
    • (2013) Nat Med , vol.19 , pp. 1153-1156
    • Owen, B.M.1    Bookout, A.L.2    Ding, X.3    Lin, V.Y.4    Atkin, S.D.5    Gautron, L.6
  • 33
    • 84863116228 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor gamma
    • 22315431
    • Wei W Dutchak PA Wang X Ding X Wang X Bookout AL et al. Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor gamma. Proc Natl Acad Sci U S A (2012) 109:3143–8.10.1073/pnas.120079710922315431
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 3143-3148
    • Wei, W.1    Dutchak, P.A.2    Wang, X.3    Ding, X.4    Wang, X.5    Bookout, A.L.6
  • 34
    • 84907046103 scopus 로고    scopus 로고
    • FGF-21 and skeletal remodeling during and after lactation in C57BL/6J mice
    • 24914939
    • Bornstein S Brown SA Le PT Wang X DeMambro V Horowitz MC et al. FGF-21 and skeletal remodeling during and after lactation in C57BL/6J mice. Endocrinology (2014) 155:3516–26.10.1210/en.2014-108324914939
    • (2014) Endocrinology , vol.155 , pp. 3516-3526
    • Bornstein, S.1    Brown, S.A.2    Le, P.T.3    Wang, X.4    DeMambro, V.5    Horowitz, M.C.6
  • 35
    • 31144434817 scopus 로고    scopus 로고
    • Constant darkness is a circadian metabolic signal in mammals
    • 16421573
    • Zhang J Kaasik K Blackburn MR Lee CC. Constant darkness is a circadian metabolic signal in mammals. Nature (2006) 439:340–3.10.1038/nature0436816421573
    • (2006) Nature , vol.439 , pp. 340-343
    • Zhang, J.1    Kaasik, K.2    Blackburn, M.R.3    Lee, C.C.4
  • 36
    • 84881508008 scopus 로고    scopus 로고
    • The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
    • 23066506
    • Zhang Y Xie Y Berglund ED Coate KC He TT Katafuchi T et al. The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. Elife (2012) 1:e00065.10.7554/eLife.0006523066506
    • (2012) Elife , vol.1 , pp. e00065
    • Zhang, Y.1    Xie, Y.2    Berglund, E.D.3    Coate, K.C.4    He, T.T.5    Katafuchi, T.6
  • 37
    • 84883778996 scopus 로고    scopus 로고
    • FGF21 regulates metabolism and circadian behavior by acting on the nervous system
    • 23933984
    • Bookout AL de Groot MH Owen BM Lee S Gautron L Lawrence HL et al. FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat Med (2013) 19:1147–52.10.1038/nm.324923933984
    • (2013) Nat Med , vol.19 , pp. 1147-1152
    • Bookout, A.L.1    de Groot, M.H.2    Owen, B.M.3    Lee, S.4    Gautron, L.5    Lawrence, H.L.6
  • 38
    • 84871784780 scopus 로고    scopus 로고
    • Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor
    • 23301087
    • Nelson BT Ding X Boney-Montoya J Gerard RD Kliewer SA Andrews MT. Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor. PLoS One (2013) 8:e53574.10.1371/journal.pone.005357423301087
    • (2013) PLoS One , vol.8 , pp. e53574
    • Nelson, B.T.1    Ding, X.2    Boney-Montoya, J.3    Gerard, R.D.4    Kliewer, S.A.5    Andrews, M.T.6
  • 39
    • 84863012022 scopus 로고    scopus 로고
    • FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis
    • 22302939
    • Fisher FM Kleiner S Douris N Fox EC Mepani RJ Verdeguer F et al. FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis. Genes Dev (2012) 26:271–81.10.1101/gad.177857.11122302939
    • (2012) Genes Dev , vol.26 , pp. 271-281
    • Fisher, F.M.1    Kleiner, S.2    Douris, N.3    Fox, E.C.4    Mepani, R.J.5    Verdeguer, F.6
  • 40
    • 84869233588 scopus 로고    scopus 로고
    • Human BAT possesses molecular signatures that resemble beige/brite cells
    • 23166672
    • Sharp LZ Shinoda K Ohno H Scheel DW Tomoda E Ruiz L et al. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS One (2012) 7:e49452.10.1371/journal.pone.004945223166672
    • (2012) PLoS One , vol.7 , pp. e49452
    • Sharp, L.Z.1    Shinoda, K.2    Ohno, H.3    Scheel, D.W.4    Tomoda, E.5    Ruiz, L.6
  • 41
    • 84893452569 scopus 로고    scopus 로고
    • Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans
    • 24506871
    • Lee P Linderman JD Smith S Brychta RJ Wang J Idelson C et al. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metab (2014) 19:302–9.10.1016/j.cmet.2013.12.01724506871
    • (2014) Cell Metab , vol.19 , pp. 302-309
    • Lee, P.1    Linderman, J.D.2    Smith, S.3    Brychta, R.J.4    Wang, J.5    Idelson, C.6
  • 43
    • 84905679771 scopus 로고    scopus 로고
    • The breadth of FGF21’s metabolic actions are governed by FGFR1 in adipose tissue
    • 24024127
    • Adams AC Yang C Coskun T Cheng CC Gimeno RE Luo Y et al. The breadth of FGF21’s metabolic actions are governed by FGFR1 in adipose tissue. Mol Metab (2012) 2:31–7.10.1016/j.molmet.2012.08.00724024127
    • (2012) Mol Metab , vol.2 , pp. 31-37
    • Adams, A.C.1    Yang, C.2    Coskun, T.3    Cheng, C.C.4    Gimeno, R.E.5    Luo, Y.6
  • 44
    • 84893849860 scopus 로고    scopus 로고
    • Interplay between FGF21 and insulin action in the liver regulates metabolism
    • 24401271
    • Emanuelli B Vienberg SG Smyth G Cheng C Stanford KI Arumugam M et al. Interplay between FGF21 and insulin action in the liver regulates metabolism. J Clin Invest (2014) 124:515–27.10.1172/JCI6735324401271
    • (2014) J Clin Invest , vol.124 , pp. 515-527
    • Emanuelli, B.1    Vienberg, S.G.2    Smyth, G.3    Cheng, C.4    Stanford, K.I.5    Arumugam, M.6
  • 45
    • 84896710569 scopus 로고    scopus 로고
    • Functional thermogenic beige adipogenesis is inducible in human neck fat
    • 23736373
    • Lee P Werner CD Kebebew E Celi FS. Functional thermogenic beige adipogenesis is inducible in human neck fat. Int J Obes (Lond) (2014) 38:170–6.10.1038/ijo.2013.8223736373
    • (2014) Int J Obes (Lond) , vol.38 , pp. 170-176
    • Lee, P.1    Werner, C.D.2    Kebebew, E.3    Celi, F.S.4
  • 46
    • 84930579383 scopus 로고    scopus 로고
    • Pharmacologic effects of FGF21 are independent of the “browning” of white adipose tissue
    • 25955208
    • Veniant MM Sivits G Helmering J Komorowski R Lee J Fan W et al. Pharmacologic effects of FGF21 are independent of the “browning” of white adipose tissue. Cell Metab (2015) 21:731–8.10.1016/j.cmet.2015.04.01925955208
    • (2015) Cell Metab , vol.21 , pp. 731-738
    • Veniant, M.M.1    Sivits, G.2    Helmering, J.3    Komorowski, R.4    Lee, J.5    Fan, W.6
  • 48
    • 84921771693 scopus 로고    scopus 로고
    • The role of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fatty liver disease and implications for therapy
    • 25516477
    • Liu J Xu Y Hu Y Wang G. The role of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fatty liver disease and implications for therapy. Metabolism (2015) 64:380–90.10.1016/j.metabol.2014.11.00925516477
    • (2015) Metabolism , vol.64 , pp. 380-390
    • Liu, J.1    Xu, Y.2    Hu, Y.3    Wang, G.4
  • 49
    • 84907766271 scopus 로고    scopus 로고
    • Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet
    • 25178843
    • Tanaka N Takahashi S Fang ZZ Matsubara T Krausz KW Qu A et al. Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet. Biochim Biophys Acta (2014) 1841:1596–607.10.1016/j.bbalip.2014.08.01525178843
    • (2014) Biochim Biophys Acta , vol.1841 , pp. 1596-1607
    • Tanaka, N.1    Takahashi, S.2    Fang, Z.Z.3    Matsubara, T.4    Krausz, K.W.5    Qu, A.6
  • 50
    • 84908291960 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets
    • 25083607
    • Fisher FM Chui PC Nasser IA Popov Y Cunniff JC Lundasen T et al. Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets. Gastroenterology (2014) 147:1073–83e6.10.1053/j.gastro.2014.07.04425083607
    • (2014) Gastroenterology , vol.147 , pp. 1073-1836
    • Fisher, F.M.1    Chui, P.C.2    Nasser, I.A.3    Popov, Y.4    Cunniff, J.C.5    Lundasen, T.6
  • 51
    • 84897422306 scopus 로고    scopus 로고
    • Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH)
    • 24594481
    • Jha P Knopf A Koefeler H Mueller M Lackner C Hoefler G et al. Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH). Biochim Biophys Acta (2014) 1842:959–70.10.1016/j.bbadis.2014.02.01224594481
    • (2014) Biochim Biophys Acta , vol.1842 , pp. 959-970
    • Jha, P.1    Knopf, A.2    Koefeler, H.3    Mueller, M.4    Lackner, C.5    Hoefler, G.6
  • 52
    • 84874117479 scopus 로고    scopus 로고
    • High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: a 3-year prospective study in China
    • 23142063
    • Li H Dong K Fang Q Hou X Zhou M Bao Y et al. High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: a 3-year prospective study in China. J Hepatol (2013) 58:557–63.10.1016/j.jhep.2012.10.02923142063
    • (2013) J Hepatol , vol.58 , pp. 557-563
    • Li, H.1    Dong, K.2    Fang, Q.3    Hou, X.4    Zhou, M.5    Bao, Y.6
  • 53
    • 84862795311 scopus 로고    scopus 로고
    • Non-invasive diagnosis of non-alcoholic steatohepatitis by combined serum biomarkers
    • 22314419
    • Shen J Chan HL Wong GL Choi PC Chan AW Chan HY et al. Non-invasive diagnosis of non-alcoholic steatohepatitis by combined serum biomarkers. J Hepatol (2012) 56:1363–70.10.1016/j.jhep.2011.12.02522314419
    • (2012) J Hepatol , vol.56 , pp. 1363-1370
    • Shen, J.1    Chan, H.L.2    Wong, G.L.3    Choi, P.C.4    Chan, A.W.5    Chan, H.Y.6
  • 54
    • 77955474305 scopus 로고    scopus 로고
    • Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease
    • 20451522
    • Dushay J Chui PC Gopalakrishnan GS Varela-Rey M Crawley M Fisher FM et al. Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology (2010) 139:456–63.10.1053/j.gastro.2010.04.05420451522
    • (2010) Gastroenterology , vol.139 , pp. 456-463
    • Dushay, J.1    Chui, P.C.2    Gopalakrishnan, G.S.3    Varela-Rey, M.4    Crawley, M.5    Fisher, F.M.6
  • 55
    • 77956519052 scopus 로고    scopus 로고
    • Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease
    • 20624171
    • Yilmaz Y Eren F Yonal O Kurt R Aktas B Celikel CA et al. Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease. Eur J Clin Invest (2010) 40:887–92.10.1111/j.1365-2362.2010.02338.x20624171
    • (2010) Eur J Clin Invest , vol.40 , pp. 887-892
    • Yilmaz, Y.1    Eren, F.2    Yonal, O.3    Kurt, R.4    Aktas, B.5    Celikel, C.A.6
  • 56
    • 77957359658 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride
    • 20675007
    • Li H Fang Q Gao F Fan J Zhou J Wang X et al. Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. J Hepatol (2010) 53:934–40.10.1016/j.jhep.2010.05.01820675007
    • (2010) J Hepatol , vol.53 , pp. 934-940
    • Li, H.1    Fang, Q.2    Gao, F.3    Fan, J.4    Zhou, J.5    Wang, X.6
  • 57
    • 84880909811 scopus 로고    scopus 로고
    • Metabolism-epigenome crosstalk in physiology and diseases
    • 23719186
    • Hino S Nagaoka K Nakao M. Metabolism-epigenome crosstalk in physiology and diseases. J Hum Genet (2013) 58:410–5.10.1038/jhg.2013.5723719186
    • (2013) J Hum Genet , vol.58 , pp. 410-415
    • Hino, S.1    Nagaoka, K.2    Nakao, M.3
  • 58
    • 84863534997 scopus 로고    scopus 로고
    • Metabolic regulation of epigenetics
    • Lu C Thompson CB. Metabolic regulation of epigenetics. Cell Metab (2012) 16:9–17.10.1016/j.cmet.2012.06.001
    • (2012) Cell Metab , vol.16 , pp. 9-17
    • Lu, C.1    Thompson, C.B.2
  • 59
    • 84901784272 scopus 로고    scopus 로고
    • ATF4- and CHOP-dependent induction of FGF21 through endoplasmic reticulum stress
    • 24900988
    • Wan XS Lu XH Xiao YC Lin Y Zhu H Ding T et al. ATF4- and CHOP-dependent induction of FGF21 through endoplasmic reticulum stress. Biomed Res Int (2014) 2014:807874.10.1155/2014/80787424900988
    • (2014) Biomed Res Int , vol.2014 , pp. 807874
    • Wan, X.S.1    Lu, X.H.2    Xiao, Y.C.3    Lin, Y.4    Zhu, H.5    Ding, T.6
  • 60
    • 84925513492 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress
    • 25537833
    • Kim SH Kim KH Kim HK Kim MJ Back SH Konishi M et al. Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress. Diabetologia (2015) 58:809–18.10.1007/s00125-014-3475-625537833
    • (2015) Diabetologia , vol.58 , pp. 809-818
    • Kim, S.H.1    Kim, K.H.2    Kim, H.K.3    Kim, M.J.4    Back, S.H.5    Konishi, M.6
  • 61
    • 84908200877 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 is regulated by the IRE1alpha-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis
    • 25170079
    • Jiang S Yan C Fang QC Shao ML Zhang YL Liu Y et al. Fibroblast growth factor 21 is regulated by the IRE1alpha-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis. J Biol Chem (2014) 289:29751–65.10.1074/jbc.M114.56596025170079
    • (2014) J Biol Chem , vol.289 , pp. 29751-29765
    • Jiang, S.1    Yan, C.2    Fang, Q.C.3    Shao, M.L.4    Zhang, Y.L.5    Liu, Y.6
  • 62
    • 84930699176 scopus 로고    scopus 로고
    • Selective regulation of FGF19 and FGF21 expression by cellular and nutritional stress
    • 26052146
    • Shimizu M Morimoto H Maruyama R Inoue J Sato R. Selective regulation of FGF19 and FGF21 expression by cellular and nutritional stress. J Nutr Sci Vitaminol (Tokyo) (2015) 61:154–60.10.3177/jnsv.61.15426052146
    • (2015) J Nutr Sci Vitaminol (Tokyo) , vol.61 , pp. 154-160
    • Shimizu, M.1    Morimoto, H.2    Maruyama, R.3    Inoue, J.4    Sato, R.5
  • 63
    • 84925491637 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induces up-regulation of hepatic beta-Klotho expression through ATF4 signaling pathway
    • 25727012
    • Dong K Li H Zhang M Jiang S Chen S Zhou J et al. Endoplasmic reticulum stress induces up-regulation of hepatic beta-Klotho expression through ATF4 signaling pathway. Biochem Biophys Res Commun (2015) 459:300–5.10.1016/j.bbrc.2015.02.10425727012
    • (2015) Biochem Biophys Res Commun , vol.459 , pp. 300-305
    • Dong, K.1    Li, H.2    Zhang, M.3    Jiang, S.4    Chen, S.5    Zhou, J.6
  • 64
    • 84856493734 scopus 로고    scopus 로고
    • Increased circulating and epicardial adipose tissue mRNA expression of fibroblast growth factor-21 after cardiac surgery: possible role in postoperative inflammatory response and insulin resistance
    • Kotulak T Drapalova J Kopecky P Lacinova Z Kramar P Riha H et al. Increased circulating and epicardial adipose tissue mRNA expression of fibroblast growth factor-21 after cardiac surgery: possible role in postoperative inflammatory response and insulin resistance. Physiol Res (2011) 60:757–67.
    • (2011) Physiol Res , vol.60 , pp. 757-767
    • Kotulak, T.1    Drapalova, J.2    Kopecky, P.3    Lacinova, Z.4    Kramar, P.5    Riha, H.6
  • 65
  • 66
    • 85117317397 scopus 로고    scopus 로고
    • The effect of fibroblast growth factor 21 on type 2 diabetic inflammation biomarkers
    • Chi O Wei L Kun L Mingyan C Jianping L. The effect of fibroblast growth factor 21 on type 2 diabetic inflammation biomarkers. J Hunan Norm Univ (Med Sci) (2012) 2:004.
    • (2012) J Hunan Norm Univ (Med Sci) , vol.2 , pp. 004
    • Chi, O.1    Wei, L.2    Kun, L.3    Mingyan, C.4    Jianping, L.5
  • 67
    • 84865422329 scopus 로고    scopus 로고
    • TNF-alpha represses beta-Klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway
    • 22778214
    • Diaz-Delfin J Hondares E Iglesias R Giralt M Caelles C Villarroya F. TNF-alpha represses beta-Klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway. Endocrinology (2012) 153:4238–45.10.1210/en.2012-119322778214
    • (2012) Endocrinology , vol.153 , pp. 4238-4245
    • Diaz-Delfin, J.1    Hondares, E.2    Iglesias, R.3    Giralt, M.4    Caelles, C.5    Villarroya, F.6
  • 68
    • 84861324386 scopus 로고    scopus 로고
    • FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis
    • 22474187
    • Feingold KR Grunfeld C Heuer JG Gupta A Cramer M Zhang T et al. FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis. Endocrinology (2012) 153:2689–700.10.1210/en.2011-149622474187
    • (2012) Endocrinology , vol.153 , pp. 2689-2700
    • Feingold, K.R.1    Grunfeld, C.2    Heuer, J.G.3    Gupta, A.4    Cramer, M.5    Zhang, T.6
  • 69
    • 84883481988 scopus 로고    scopus 로고
    • The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
    • 24011069
    • Gaich G Chien JY Fu H Glass LC Deeg MA Holland WL et al. The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. Cell Metab (2013) 18:333–40.10.1016/j.cmet.2013.08.00524011069
    • (2013) Cell Metab , vol.18 , pp. 333-340
    • Gaich, G.1    Chien, J.Y.2    Fu, H.3    Glass, L.C.4    Deeg, M.A.5    Holland, W.L.6
  • 70
    • 48349127924 scopus 로고    scopus 로고
    • The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man
    • 18680716
    • Galman C Lundasen T Kharitonenkov A Bina HA Eriksson M Hafstrom I et al. The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man. Cell Metab (2008) 8:169–74.10.1016/j.cmet.2008.06.01418680716
    • (2008) Cell Metab , vol.8 , pp. 169-174
    • Galman, C.1    Lundasen, T.2    Kharitonenkov, A.3    Bina, H.A.4    Eriksson, M.5    Hafstrom, I.6
  • 71
    • 68149091653 scopus 로고    scopus 로고
    • Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance
    • 19487637
    • Chavez AO Molina-Carrion M Abdul-Ghani MA Folli F Defronzo RA Tripathy D. Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance. Diabetes Care (2009) 32:1542–6.10.2337/dc09-068419487637
    • (2009) Diabetes Care , vol.32 , pp. 1542-1546
    • Chavez, A.O.1    Molina-Carrion, M.2    Abdul-Ghani, M.A.3    Folli, F.4    Defronzo, R.A.5    Tripathy, D.6
  • 72
    • 79956113302 scopus 로고    scopus 로고
    • Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans
    • 21325103
    • Yu H Xia F Lam KS Wang Y Bao Y Zhang J et al. Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans. Clin Chem (2011) 57:691–700.10.1373/clinchem.2010.15518421325103
    • (2011) Clin Chem , vol.57 , pp. 691-700
    • Yu, H.1    Xia, F.2    Lam, K.S.3    Wang, Y.4    Bao, Y.5    Zhang, J.6
  • 73
    • 84901821975 scopus 로고    scopus 로고
    • FGF21-based pharmacotherapy – potential utility for metabolic disorders
    • 24709036
    • Gimeno RE Moller DE. FGF21-based pharmacotherapy – potential utility for metabolic disorders. Trends Endocrinol Metab (2014) 25:303–11.10.1016/j.tem.2014.03.00124709036
    • (2014) Trends Endocrinol Metab , vol.25 , pp. 303-311
    • Gimeno, R.E.1    Moller, D.E.2
  • 74
    • 84930178522 scopus 로고    scopus 로고
    • The role of fibroblast growth factor 21 in diabetes and its complications: a review from clinical perspective
    • 25796513
    • Liu JJ Foo JP Liu S Lim SC. The role of fibroblast growth factor 21 in diabetes and its complications: a review from clinical perspective. Diabetes Res Clin Pract (2015) 108:382–9.10.1016/j.diabres.2015.02.03225796513
    • (2015) Diabetes Res Clin Pract , vol.108 , pp. 382-389
    • Liu, J.J.1    Foo, J.P.2    Liu, S.3    Lim, S.C.4
  • 75
    • 84864388774 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate
    • 22696219
    • Wu S Levenson A Kharitonenkov A De Luca F. Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate. J Biol Chem (2012) 287:26060–7.10.1074/jbc.M112.34370722696219
    • (2012) J Biol Chem , vol.287 , pp. 26060-26067
    • Wu, S.1    Levenson, A.2    Kharitonenkov, A.3    De Luca, F.4


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