Non-invasive diagnosis of non-alcoholic steatohepatitis by combined serum biomarkers

Journal of Hepatology

Volumn 56, Issue 6, 2012, Pages 1363-1370

  Shen, Jiayun ^a,b   Chan, Henry Lik Yuen ^a,b   Wong, Grace Lai Hung ^a,b   Choi, Paul Cheung Lung ^b   Chan, Anthony Wing Hung ^b   Chan, Hoi Yun ^a,b   Chim, Angel Mei Ling ^a,b   Yeung, David Ka Wai ^b   Chan, Francis Ka Leung ^a,b   Woo, Jean ^a   Yu, Jun ^a,b   Chu, Winnie Chiu Wing ^b   Wong, Vincent Wai Sun ^a,b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Adipocyte fatty acid binding protein; Cytokeratin 18; Fatty liver; Fibroblast growth factor 21; Liver biopsy

Indexed keywords

CYTOKERATIN 18; FATTY ACID BINDING PROTEIN 4; FIBROBLAST GROWTH FACTOR 21;

ADULT; ARTICLE; CLINICAL ASSESSMENT; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DIAGNOSTIC TEST ACCURACY STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FATTY LIVER; FEMALE; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER HISTOLOGY; MAJOR CLINICAL STUDY; MALE; NON INVASIVE MEASUREMENT; NONALCOHOLIC FATTY LIVER; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY; VALIDATION STUDY;

ADULT; BIOLOGICAL MARKERS; FATTY ACID-BINDING PROTEINS; FATTY LIVER; FEMALE; FIBROBLAST GROWTH FACTORS; HUMANS; KERATIN-18; LOGISTIC MODELS; MALE; MIDDLE AGED;

EID: 84862795311     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2011.12.025     Document Type: Article

References (30)

1. G.C. Farrell, and C.Z. Larter Nonalcoholic fatty liver disease: from steatosis to cirrhosis Hepatology 43 2006 S99 S112
2. V.W. Wong, H.L. Chan, A.Y. Hui, K.F. Chan, C.T. Liew, and F.K. Chan Clinical and histological features of non-alcoholic fatty liver disease in Hong Kong Chinese Aliment Pharmacol Ther 20 2004 45 49 (Pubitemid 38938718)
3. V.W. Wong, A.Y. Hui, S.W. Tsang, J.L. Chan, A.M. Tse, and K.F. Chan Metabolic and adipokine profile of Chinese patients with nonalcoholic fatty liver disease Clin Gastroenterol Hepatol 4 2006 1154 1161 (Pubitemid 44311653)
4. A.E. Feldstein, P. Charatcharoenwitthaya, S. Treeprasertsuk, J.T. Benson, F.B. Enders, and P. Angulo The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years Gut 58 2009 1538 1544
5. J.L. Newton, D.E. Jones, E. Henderson, L. Kane, K. Wilton, and A.D. Burt Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance Gut 57 2008 807 813 (Pubitemid 351716975)
6. L.A. Adams, J.F. Lymp, J. St Sauver, S.O. Sanderson, K.D. Lindor, and A. Feldstein The natural history of nonalcoholic fatty liver disease: a population-based cohort study Gastroenterology 129 2005 113 121 (Pubitemid 41002048)
7. V.W. Wong, G.L. Wong, P.C. Choi, A.W. Chan, M.K. Li, and H.Y. Chan Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years Gut 59 2010 969 974
8. M. Ekstedt, L.E. Franzen, U.L. Mathiesen, L. Thorelius, M. Holmqvist, and G. Bodemar Long-term follow-up of patients with NAFLD and elevated liver enzymes Hepatology 44 2006 865 873 (Pubitemid 46489550)
9. A.E. Feldstein, A. Wieckowska, A.R. Lopez, Y.C. Liu, N.N. Zein, and A.J. McCullough Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study Hepatology 50 2009 1072 1078
10. K.L. Milner, D. van der Poorten, A. Xu, E. Bugianesi, J.G. Kench, and K.S. Lam Adipocyte fatty acid binding protein levels relate to inflammation and fibrosis in nonalcoholic fatty liver disease Hepatology 49 2009 1926 1934
11. H. Li, Q. Fang, F. Gao, J. Fan, J. Zhou, and X. Wang Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride J Hepatol 53 2010 934 940
12. N. Assy, S. Schlesinger, and O. Hussein Elevated plasma protein C levels correlate with the presence of fatty liver (NASH and NAFLD) Gut 54 2005 729 (Pubitemid 40559265)
13. D. Bonnefont-Rousselot, V. Ratziu, P. Giral, F. Charlotte, I. Beucler, and T. Poynard Blood oxidative stress markers are unreliable markers of hepatic steatosis Aliment Pharmacol Ther 23 2006 91 98 (Pubitemid 43381171)
14. J.W. Haukeland, J.K. Damas, Z. Konopski, E.M. Loberg, T. Haaland, and I. Goverud Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2 J Hepatol 44 2006 1167 1174
15. M. Shimada, H. Kawahara, K. Ozaki, M. Fukura, H. Yano, and M. Tsuchishima Usefulness of a combined evaluation of the serum adiponectin level, HOMA-IR, and serum type IV collagen 7S level to predict the early stage of nonalcoholic steatohepatitis Am J Gastroenterol 102 2007 1931 1938 (Pubitemid 47301507)
16. M. Charlton, P. Angulo, N. Chalasani, R. Merriman, K. Viker, and P. Charatcharoenwitthaya Low circulating levels of dehydroepiandrosterone in histologically advanced nonalcoholic fatty liver disease Hepatology 47 2008 484 492 (Pubitemid 351280716)
17. N. Alkhouri, R. Lopez, M. Berk, and A.E. Feldstein Serum retinol-binding protein 4 levels in patients with nonalcoholic fatty liver disease J Clin Gastroenterol 43 2009 985 989
18. Y. Li, C. Xu, C. Yu, L. Xu, and M. Miao Association of serum uric acid level with non-alcoholic fatty liver disease: a cross-sectional study J Hepatol 50 2009 1029 1034
19. D.L. Diab, L. Yerian, P. Schauer, S.R. Kashyap, R. Lopez, and S.L. Hazen Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients Clin Gastroenterol Hepatol 6 2008 1249 1254
20. J. Dushay, P.C. Chui, G.S. Gopalakrishnan, M. Varela-Rey, M. Crawley, and F.M. Fisher Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease Gastroenterology 139 2010 456 463
21. T.I. Tamimi, H.M. Elgouhari, N. Alkhouri, L.M. Yerian, M.P. Berk, and R. Lopez An apoptosis panel for nonalcoholic steatohepatitis diagnosis J Hepatol 54 2011 1224 1229
22. L.N. Bell, J.L. Theodorakis, R. Vuppalanchi, R. Saxena, K.G. Bemis, and M. Wang Serum proteomics and biomarker discovery across the spectrum of nonalcoholic fatty liver disease Hepatology 51 2010 111 120
23. V.W. Wong, J. Vergniol, G.L. Wong, J. Foucher, H.L. Chan, and B. Le Bail Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease Hepatology 51 2010 454 462
24. V.W. Wong, G.L. Wong, S.W. Tsang, T. Fan, W.C. Chu, and J. Woo High prevalence of colorectal neoplasm in patients with non-alcoholic steatohepatitis Gut 60 2011 829 836
25. R. Ali, and K. Cusi New diagnostic and treatment approaches in non-alcoholic fatty liver disease (NAFLD) Ann Med 41 2009 265 278
26. L.S. Szczepaniak, P. Nurenberg, D. Leonard, J.D. Browning, J.S. Reingold, and S. Grundy Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population Am J Physiol Endocrinol Metab 288 2005 E462 468
27. K.G. Alberti, R.H. Eckel, S.M. Grundy, P.Z. Zimmet, J.I. Cleeman, and K.A. Donato Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity Circulation 120 2009 1640 1645
28. D.E. Kleiner, E.M. Brunt, M. Van Natta, C. Behling, M.J. Contos, and O.W. Cummings Design and validation of a histological scoring system for nonalcoholic fatty liver disease Hepatology 41 2005 1313 1321 (Pubitemid 40770284)
29. C.A. Matteoni, Z.M. Younossi, T. Gramlich, N. Boparai, Y.C. Liu, and A.J. McCullough Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity Gastroenterology 116 1999 1413 1419 (Pubitemid 29258890)
30. A.J. Sanyal, E.M. Brunt, D.E. Kleiner, K.V. Kowdley, N. Chalasani, and J.E. Lavine Endpoints and clinical trial design for nonalcoholic steatohepatitis Hepatology 54 2011 344 353