Endoplasmic reticulum stress induces up-regulation of hepatic β-Klotho expression through ATF4 signaling pathway

Biochemical and Biophysical Research Communications

Volumn 459, Issue 2, 2015, Pages 300-305

  Dong, Kun ^a   Li, Huating ^a   Zhang, Mingliang ^a   Jiang, Shan ^a   Chen, Shuqin ^a   Zhou, Jian ^b   Dai, Zhi ^b   Fang, Qichen ^a   Jia, Weiping ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Endoplasmic reticulum stress; Fibroblast growth factor 21; Non alcoholic fatty liver disease; Klotho

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; BETA KLOTHO PROTEIN; FIBROBLAST GROWTH FACTOR 21; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; KLOTHO PROTEIN; THAPSIGARGIN; TRIACYLGLYCEROL; TUNICAMYCIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; ATF4 PROTEIN, HUMAN; ATF4 PROTEIN, MOUSE; FIBROBLAST GROWTH FACTOR; KLB PROTEIN, HUMAN; KLB PROTEIN, MOUSE; MEMBRANE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET INDUCED OBESITY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; FATTY LIVER; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VIVO STUDY; LIPID DIET; LIVER CELL; LOW FAT DIET; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; DRUG EFFECTS; GENETICS; LIVER; METABOLISM; MOUSE MUTANT; OBESITY;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; DIET, HIGH-FAT; ENDOPLASMIC RETICULUM STRESS; FATTY LIVER; FIBROBLAST GROWTH FACTORS; HEP G2 CELLS; HUMANS; LIVER; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; SIGNAL TRANSDUCTION; TUNICAMYCIN; UP-REGULATION;

EID: 84925491637     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.02.104     Document Type: Article

References (35)

1. A. Kharitonenkov, T.L. Shiyanova, and A. Koester FGF-21 as a novel metabolic regulator J. Clin. Invest 115 2005 1627 1635
2. T. Inagaki, P. Dutchak, and G. Zhao Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21 Cell. Metab. 5 2007 415 425
3. M.J. Potthoff, T. Inagaki, and S. Satapati FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response Proc. Natl. Acad. Sci. U S A 106 2009 10853 10858
4. M.K. Badman, P. Pissios, and A.R. Kennedy Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states Cell. Metab. 5 2007 426 437
5. H. Li, K. Dong, and Q. Fang High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: a 3-year prospective study in China J. Hepatol. 58 2013 557 563
6. H. Li, Q. Fang, and F. Gao Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride J. Hepatol. 53 2010 934 940
7. M. Mraz, M. Bartlova, and Z. Lacinova Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity Clin. Endocrinol. (Oxf) 71 2009 369 375
8. A.O. Chavez, M. Molina-Carrion, and M.A. Abdul-Ghani Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance Diabetes Care 32 2009 1542 1546
9. W. Chen, R.L. Hoo, and M. Konishi Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes J. Biol. Chem. 286 2011 34559 34566
10. Y. Hotta, H. Nakamura, and M. Konishi Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver Endocrinology 150 2009 4625 4633
11. F.M. Fisher, S. Kleiner, and N. Douris FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis Genes. Dev. 26 2012 271 281
12. X. Ding, J. Boney-Montoya, and B.M. Owen betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism Cell. Metab. 16 2012 387 393
13. Y. Ogawa, H. Kurosu, and M. Yamamoto BetaKlotho is required for metabolic activity of fibroblast growth factor 21 Proc. Natl. Acad. Sci. U S A 104 2007 7432 7437
14. S. Ito, S. Kinoshita, and N. Shiraishi Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel klotho family protein Mech. Dev. 98 2000 115 119
15. J.M. Gallego-Escuredo, J. Gomez-Ambrosi, and V. Catalan Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients Int. J. Obes. (Lond) 39 2015 121 129
16. F.M. Fisher, P.C. Chui, and P.J. Antonellis Obesity is a fibroblast growth factor 21 (FGF21)-resistant state Diabetes 59 2010 2781 2789
17. I. Braakman, and D.N. Hebert Protein folding in the endoplasmic reticulum Cold Spring Harb. Perspect. Biol. 5 2013 a013201
18. G.S. Hotamisligil Endoplasmic reticulum stress and the inflammatory basis of metabolic disease Cell 140 2010 900 917
19. L. Ozcan, and I. Tabas Role of endoplasmic reticulum stress in metabolic disease and other disorders Annu Rev. Med. 63 2012 317 328
20. X.Z. Wang, B. Lawson, and J.W. Brewer Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153) Mol. Cell. Biol. 16 1996 4273 4280
21. D.T. Rutkowski, J. Wu, and S.H. Back UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators Dev. Cell. 15 2008 829 840
22. F.G. Schaap, A.E. Kremer, and W.H. Lamers Fibroblast growth factor 21 is induced by endoplasmic reticulum stress Biochimie 95 2013 692 699
23. X.S. Wan, X.H. Lu, and Y.C. Xiao ATF4- and CHOP-dependent induction of FGF21 through endoplasmic reticulum stress Biomed. Res. Int. 2014 2014 807874
24. S. Jiang, C. Yan, and Q.C. Fang Fibroblast growth factor 21 is regulated by the IRE1alpha-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis J. Biol. Chem. 289 2014 29751 29765
25. D.E. Kleiner, E.M. Brunt, and M. Van Natta Design and validation of a histological scoring system for nonalcoholic fatty liver disease Hepatology 41 2005 1313 1321
26. S. Chitturi, G.C. Farrell, and E. Hashimoto Non-alcoholic fatty liver disease in the Asia-Pacific region: definitions and overview of proposed guidelines J. Gastroenterol. Hepatol. 22 2007 778 787
27. A. Chatzigeorgiou, A. Halapas, and K. Kalafatakis The use of animal models in the study of diabetes mellitus In Vivo 23 2009 245 258
28. U. Ozcan, Q. Cao, and E. Yilmaz Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes Science 306 2004 457 461
29. R. Goetz, M. Ohnishi, and X. Ding Klotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligands Mol. Cell. Biol. 32 2012 1944 1954
30. H. Kurosu, M. Choi, and Y. Ogawa Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21 J. Biol. Chem. 282 2007 26687 26695
31. A. Kharitonenkov, J.D. Dunbar, and H.A. Bina FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho J. Cell. Physiol. 215 2008 1 7
32. F.M. Fisher, J.L. Estall, and A.C. Adams Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo Endocrinology 152 2011 2996 3004
33. J. Diaz-Delfin, E. Hondares, and R. Iglesias TNF-alpha represses beta-klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway Endocrinology 153 2012 4238 4245
34. M. Suzuki, Y. Uehara, and K. Motomura-Matsuzaka betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c Mol. Endocrinol. 22 2008 1006 1014
35. C. Yang, C. Jin, and X. Li Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB PLoS One 7 2012 e33870