-
1
-
-
77956224494
-
Oxygen in stem cell biology: A critical component of the stem cell niche
-
Mohyeldin, A., Garzon-Muvdi, T. & Quinones-Hinojosa, A. Oxygen in stem cell biology: A critical component of the stem cell niche. Cell Stem Cell 7, 150-161 (2010
-
(2010)
Cell Stem Cell
, vol.7
, pp. 150-161
-
-
Mohyeldin, A.1
Garzon-Muvdi, T.2
Quinones-Hinojosa, A.3
-
2
-
-
33645863768
-
Transcriptional regulation of metabolism
-
Desvergne, B., Michalik, L. & Wahli, W. Transcriptional regulation of metabolism. Physiol. Rev. 86, 465-514 (2006
-
(2006)
Physiol. Rev
, vol.86
, pp. 465-514
-
-
Desvergne, B.1
Michalik, L.2
Wahli, W.3
-
3
-
-
84867906972
-
Gatekeepers of chromatin: Small metabolites elicit big changes in gene expression
-
Kaochar, S. & Tu, B. P. Gatekeepers of chromatin: Small metabolites elicit big changes in gene expression. Trends. Biochem. Sci. 37, 477-483 (2012
-
(2012)
Trends. Biochem. Sci
, vol.37
, pp. 477-483
-
-
Kaochar, S.1
Tu, B.P.2
-
4
-
-
77953169046
-
Cellular bioenergetics as a target for obesity therapy
-
Tseng, Y. H., Cypess, A. M. & Kahn, C. R. Cellular bioenergetics as a target for obesity therapy. Nat. Rev. Drug. Discov. 9, 465-482 (2010
-
(2010)
Nat. Rev. Drug. Discov
, vol.9
, pp. 465-482
-
-
Tseng, Y.H.1
Cypess, A.M.2
Kahn, C.R.3
-
5
-
-
84858604270
-
Metabolic reprogramming: A cancer hallmark even warburg did not anticipate
-
Ward, P. S. & Thompson, C. B. Metabolic reprogramming: A cancer hallmark even warburg did not anticipate. Cancer cell 21, 297-308 (2012
-
(2012)
Cancer cell
, vol.21
, pp. 297-308
-
-
Ward, P.S.1
Thompson, C.B.2
-
6
-
-
38449116576
-
Developmental origins of health and disease: New insights
-
Hanson, M. A. & Gluckman, P. D. Developmental origins of health and disease: New insights. Basic. Clin. Pharmacol. Toxicol. 102, 90-93 (2008
-
(2008)
Basic. Clin. Pharmacol. Toxicol
, vol.102
, pp. 90-93
-
-
Hanson, M.A.1
Gluckman, P.D.2
-
7
-
-
84867398818
-
The role of nutrition on epigenetic modifications and their implications on health
-
Jimenez-Chillaron, J. C., Diaz, R., Martinez, D., Pentinat, T., Ramon-Krauel, M., Ribo, S. et al. The role of nutrition on epigenetic modifications and their implications on health. Biochimie 94, 2242-2263 (2012
-
(2012)
Biochimie
, vol.94
, pp. 2242-2263
-
-
Jimenez-Chillaron, J.C.1
Diaz, R.2
Martinez, D.3
Pentinat, T.4
Ramon-Krauel, M.5
Ribo, S.6
-
8
-
-
84875537133
-
Epigenetic reprogramming in cancer
-
Suva, M. L., Riggi, N. & Bernstein, B. E. Epigenetic reprogramming in cancer. Science 339, 1567-1570 (2013
-
(2013)
Science
, vol.339
, pp. 1567-1570
-
-
Suva, M.L.1
Riggi, N.2
Bernstein, B.E.3
-
9
-
-
84858796263
-
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
-
Turcan, S., Rohle, D., Goenka, A., Walsh, L. A., Fang, F., Yilmaz, E. et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 483, 479-483 (2012
-
(2012)
Nature
, vol.483
, pp. 479-483
-
-
Turcan, S.1
Rohle, D.2
Goenka, A.3
Walsh, L.A.4
Fang, F.5
Yilmaz, E.6
-
10
-
-
84862632865
-
Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
-
Xiao, M., Yang, H., Xu, W., Ma, S., Lin, H., Zhu, H. et al. Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 26, 1326-1338 (2012
-
(2012)
Genes Dev
, vol.26
, pp. 1326-1338
-
-
Xiao, M.1
Yang, H.2
Xu, W.3
Ma, S.4
Lin, H.5
Zhu, H.6
-
11
-
-
0034610814
-
The language of covalent histone modifications
-
Strahl, B. D. & Allis, C. D. The language of covalent histone modifications. Nature 403, 41-45 (2000
-
(2000)
Nature
, vol.403
, pp. 41-45
-
-
Strahl, B.D.1
Allis, C.D.2
-
13
-
-
84864010293
-
Nutrition and epigenetics: An interplay of dietary methyl donors, one-carbon metabolism and DNA methylation
-
Anderson, O. S., Sant, K. E. & Dolinoy, D. C. Nutrition and epigenetics: An interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. J. Nutr. Biochem. 23, 853-859 (2012
-
(2012)
J. Nutr. Biochem
, vol.23
, pp. 853-859
-
-
Anderson, O.S.1
Sant, K.E.2
Dolinoy, D.C.3
-
14
-
-
79952202310
-
Epigenomic disruption: The effects of early developmental exposures
-
Bernal, A. J. & Jirtle, R. L. Epigenomic disruption: The effects of early developmental exposures. Birth Defects Res. A Clin. Mol. Teratol. 88, 938-944 (2010
-
(2010)
Birth Defects Res. A Clin. Mol. Teratol
, vol.88
, pp. 938-944
-
-
Bernal, A.J.1
Jirtle, R.L.2
-
15
-
-
0031873353
-
Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice
-
Wolff, G. L., Kodell, R. L., Moore, S. R. & Cooney, C. A. Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. Faseb J. 12, 949-957 (1998
-
(1998)
Faseb J.
, vol.12
, pp. 949-957
-
-
Wolff, G.L.1
Kodell, R.L.2
Moore, S.R.3
Cooney, C.A.4
-
16
-
-
78049286684
-
Histone demethylases in development and disease
-
Pedersen, M. T. & Helin, K. Histone demethylases in development and disease. Trends. Cell. Biol. 20, 662-671 (2010
-
(2010)
Trends. Cell. Biol
, vol.20
, pp. 662-671
-
-
Pedersen, M.T.1
Helin, K.2
-
17
-
-
11144332565
-
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
-
Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J R., Cole, P. A. et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119, 941-953 (2004
-
(2004)
Cell
, vol.119
, pp. 941-953
-
-
Shi, Y.1
Lan, F.2
Matson, C.3
Mulligan, P.4
Whetstine, J.R.5
Cole, P.A.6
-
18
-
-
67650522886
-
A novel mammalian flavin-dependent histone demethylase
-
Karytinos, A., Forneris, F., Profumo, A., Ciossani, G., Battaglioli, E., Binda, C. et al. A novel mammalian flavin-dependent histone demethylase. J. Biol. Chem. 284, 17775-17782 (2009
-
(2009)
J. Biol. Chem
, vol.284
, pp. 17775-17782
-
-
Karytinos, A.1
Forneris, F.2
Profumo, A.3
Ciossani, G.4
Battaglioli, E.5
Binda, C.6
-
19
-
-
0033854585
-
The riboflavin/FAD cycle in rat liver mitochondria
-
Barile, M., Brizio, C., Valenti, D., De Virgilio, C. & Passarella, S. The riboflavin/FAD cycle in rat liver mitochondria. Eur. J. Biochem. 267, 4888-4900 (2000
-
(2000)
Eur. J. Biochem
, vol.267
, pp. 4888-4900
-
-
Barile, M.1
Brizio, C.2
Valenti, D.3
De Virgilio, C.4
Passarella, S.5
-
20
-
-
32844454603
-
Histone demethylation by a family of JmjC domain-containing proteins
-
Tsukada, Y., Fang, J., Erdjument-Bromage, H., Warren, M. E., Borchers, C. H., Tempst, P. et al. Histone demethylation by a family of JmjC domain-containing proteins. Nature 439, 811-816 (2006
-
(2006)
Nature
, vol.439
, pp. 811-816
-
-
Tsukada, Y.1
Fang, J.2
Erdjument-Bromage, H.3
Warren, M.E.4
Borchers, C.H.5
Tempst, P.6
-
21
-
-
82955207588
-
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation
-
Wu, H. & Zhang, Y. Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev. 25, 2436-2452 (2011
-
(2011)
Genes Dev
, vol.25
, pp. 2436-2452
-
-
Wu, H.1
Zhang, Y.2
-
22
-
-
84858797950
-
Sirtuins as regulators of metabolism and healthspan
-
Houtkooper, R. H., Pirinen, E. & Auwerx, J. Sirtuins as regulators of metabolism and healthspan. Nat. Rev. Mol. Cell. Biol. 13, 225-238 (2012
-
(2012)
Nat. Rev. Mol. Cell. Biol
, vol.13
, pp. 225-238
-
-
Houtkooper, R.H.1
Pirinen, E.2
Auwerx, J.3
-
23
-
-
66249105703
-
ATP-citrate lyase links cellular metabolism to histone acetylation
-
Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R. & Thompson, C. B. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 324, 1076-1080 (2009
-
(2009)
Science
, vol.324
, pp. 1076-1080
-
-
Wellen, K.E.1
Hatzivassiliou, G.2
Sachdeva, U.M.3
Bui, T.V.4
Cross, J.R.5
Thompson, C.B.6
-
24
-
-
0038054341
-
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
-
Mootha, V. K., Lindgren, C. M., Eriksson, K. F., Subramanian, A., Sihag, S., Lehar, J. et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 34, 267-273 (2003
-
(2003)
Nat. Genet
, vol.34
, pp. 267-273
-
-
Mootha, V.K.1
Lindgren, C.M.2
Eriksson, K.F.3
Subramanian, A.4
Sihag, S.5
Lehar, J.6
-
25
-
-
0037477855
-
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
-
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S. et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc. Natl Acad. Sci. USA 100, 8466-8471 (2003
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 8466-8471
-
-
Patti, M.E.1
Butte, A.J.2
Crunkhorn, S.3
Cusi, K.4
Berria, R.5
Kashyap, S.6
-
26
-
-
0036788293
-
Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
-
Kelley, D. E., He, J., Menshikova, E. V. & Ritov, V. B. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51, 2944-2950 (2002
-
(2002)
Diabetes
, vol.51
, pp. 2944-2950
-
-
Kelley, D.E.1
He, J.2
Menshikova, E.V.3
Ritov, V.B.4
-
27
-
-
0026772772
-
Type 2 (non-insulin-dependent) diabetes mellitus: The thrifty phenotype hypothesis
-
Hales, C. N. & Barker, D. J. Type 2 (non-insulin-dependent) diabetes mellitus: The thrifty phenotype hypothesis. Diabetologia 35, 595-601 (1992
-
(1992)
Diabetologia
, vol.35
, pp. 595-601
-
-
Hales, C.N.1
Barker, D.J.2
-
28
-
-
69449093363
-
Epigenetic mechanisms that underpin metabolic and cardiovascular diseases
-
Gluckman, P. D., Hanson, M. A., Buklijas, T., Low, F. M. & Beedle, A. S. Epigenetic mechanisms that underpin metabolic and cardiovascular diseases. Nat. Rev. Endocrinol. 5, 401-408 (2009
-
(2009)
Nat. Rev. Endocrinol
, vol.5
, pp. 401-408
-
-
Gluckman, P.D.1
Hanson, M.A.2
Buklijas, T.3
Low, F.M.4
Beedle, A.S.5
-
29
-
-
53649083550
-
Is mitochondrial dysfunction a cause of insulin resistance? Trends Endocrinol
-
Turner, N. & Heilbronn, L. K. Is mitochondrial dysfunction a cause of insulin resistance? Trends Endocrinol. Metab. 19, 324-330 (2008
-
(2008)
Metab
, vol.19
, pp. 324-330
-
-
Turner, N.1
Heilbronn, L.K.2
-
30
-
-
69149087790
-
Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density
-
Barres, R., Osler, M. E., Yan, J., Rune, A., Fritz, T., Caidahl, K. et al. Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. Cell. Metab. 10, 189-198 (2009
-
(2009)
Cell. Metab
, vol.10
, pp. 189-198
-
-
Barres, R.1
Osler, M.E.2
Yan, J.3
Rune, A.4
Fritz, T.5
Caidahl, K.6
-
31
-
-
5344247243
-
PGC-1alpha turbocharging mitochondria
-
Houten, S. M. & Auwerx, J. PGC-1alpha: Turbocharging mitochondria. Cell 119, 5-7 (2004
-
(2004)
Cell
, vol.119
, pp. 5-7
-
-
Houten, S.M.1
Auwerx, J.2
-
32
-
-
77954523386
-
Deoxyribonucleic acid methylation and gene expression of PPARGC1A in human muscle is influenced by high-fat overfeeding in a birth-weight-dependent manner
-
Brons, C., Jacobsen, S., Nilsson, E., Ronn, T., Jensen, C. B., Storgaard, H. et al. Deoxyribonucleic acid methylation and gene expression of PPARGC1A in human muscle is influenced by high-fat overfeeding in a birth-weight-dependent manner. J. Clin. Endocrinol. Metab. 95, 3048-3056 (2010
-
(2010)
J. Clin. Endocrinol. Metab
, vol.95
, pp. 3048-3056
-
-
Brons, C.1
Jacobsen, S.2
Nilsson, E.3
Ronn, T.4
Jensen, C.B.5
Storgaard, H.6
-
33
-
-
0035084699
-
Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
-
Sanyal, A. J., Campbell-Sargent, C., Mirshahi, F., Rizzo, W. B., Contos, M. J., Sterling, R. K. et al. Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities. Gastroenterology 120, 1183-1192 (2001
-
(2001)
Gastroenterology
, vol.120
, pp. 1183-1192
-
-
Sanyal, A.J.1
Campbell-Sargent, C.2
Mirshahi, F.3
Rizzo, W.B.4
Contos, M.J.5
Sterling, R.K.6
-
34
-
-
78649568544
-
Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: Impact of liver methylation of the peroxisome proliferatoractivated receptor gamma coactivator 1alpha promoter
-
Sookoian, S., Rosselli, M. S., Gemma, C., Burgueno, A. L., Fernandez Gianotti, T., Castano, G. O. et al. Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: Impact of liver methylation of the peroxisome proliferatoractivated receptor gamma coactivator 1alpha promoter. Hepatology 52, 1992-2000 (2010
-
(2010)
Hepatology
, vol.52
, pp. 1992-2000
-
-
Sookoian, S.1
Rosselli, M.S.2
Gemma, C.3
Burgueno, A.L.4
Fernandez Gianotti, T.5
Castano, G.O.6
-
35
-
-
0141719852
-
Gene-diet interactions in brain aging and neurodegenerative disorders
-
Mattson, M. P. Gene-diet interactions in brain aging and neurodegenerative disorders. Ann. Intern. Med. 139, 441-444 (2003
-
(2003)
Ann. Intern. Med
, vol.139
, pp. 441-444
-
-
Mattson, M.P.1
-
36
-
-
77958072667
-
PGC-1alpha, a potential therapeutic target for early intervention in Parkinson's disease
-
Zheng, B., Liao, Z., Locascio, J. J., Lesniak, K. A., Roderick, S. S., Watt, M. L. et al. PGC-1alpha, a potential therapeutic target for early intervention in Parkinson's disease. Sci. Transl. Med. 2, 52ra73 (2010
-
(2010)
Sci. Transl. Med
, vol.2
, pp. 52-73
-
-
Zheng, B.1
Liao, Z.2
Locascio, J.J.3
Lesniak, K.A.4
Roderick, S.S.5
Watt, M.L.6
-
37
-
-
70149093436
-
Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
-
Yao, J., Irwin, R. W., Zhao, L., Nilsen, J., Hamilton, R. T. & Brinton, R. D. Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc. Natl Acad. Sci. USA 106, 14670-14675 (2009
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 14670-14675
-
-
Yao, J.1
Irwin, R.W.2
Zhao, L.3
Nilsen, J.4
Hamilton, R.T.5
Brinton, R.D.6
-
38
-
-
35348874911
-
Developmental origin of fat: Tracking obesity to its source
-
Gesta, S., Tseng, Y. H. & Kahn, C. R. Developmental origin of fat: Tracking obesity to its source. Cell 131, 242-256 (2007
-
(2007)
Cell
, vol.131
, pp. 242-256
-
-
Gesta, S.1
Tseng, Y.H.2
Kahn, C.R.3
-
39
-
-
0036478904
-
Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice
-
Yamauchi, T., Oike, Y., Kamon, J., Waki, H., Komeda, K., Tsuchida, A. et al. Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice. Nat. Genet. 30, 221-226 (2002
-
(2002)
Nat. Genet
, vol.30
, pp. 221-226
-
-
Yamauchi, T.1
Oike, Y.2
Kamon, J.3
Waki, H.4
Komeda, K.5
Tsuchida, A.6
-
40
-
-
64749111074
-
Role of Jhdm2a in regulating metabolic gene expression and obesity resistance
-
Tateishi, K., Okada, Y., Kallin, E. M. & Zhang, Y. Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature 458, 757-761 (2009
-
(2009)
Nature
, vol.458
, pp. 757-761
-
-
Tateishi, K.1
Okada, Y.2
Kallin, E.M.3
Zhang, Y.4
-
41
-
-
68049095260
-
Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice
-
Inagaki, T., Tachibana, M., Magoori, K., Kudo, H., Tanaka, T., Okamura, M. et al. Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice. Genes Cells 14, 991-1001 (2009
-
(2009)
Genes Cells
, vol.14
, pp. 991-1001
-
-
Inagaki, T.1
Tachibana, M.2
Magoori, K.3
Kudo, H.4
Tanaka, T.5
Okamura, M.6
-
42
-
-
75749127447
-
Increased expression of DNA methyltransferase 3a in obese adipose tissue: Studies with transgenic mice
-
Kamei, Y., Suganami, T., Ehara, T., Kanai, S., Hayashi, K., Yamamoto, Y. et al. Increased expression of DNA methyltransferase 3a in obese adipose tissue: Studies with transgenic mice. Obesity (Silver Spring) 18, 314-321 (2010
-
(2010)
Obesity (Silver Spring
, vol.18
, pp. 314-321
-
-
Kamei, Y.1
Suganami, T.2
Ehara, T.3
Kanai, S.4
Hayashi, K.5
Yamamoto, Y.6
-
43
-
-
84866098641
-
Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver
-
Ehara, T., Kamei, Y., Takahashi, M., Yuan, X., Kanai, S., Tamura, E. et al. Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver. Diabetes 61, 2442-2450 (2012
-
(2012)
Diabetes
, vol.61
, pp. 2442-2450
-
-
Ehara, T.1
Kamei, Y.2
Takahashi, M.3
Yuan, X.4
Kanai, S.5
Tamura, E.6
-
44
-
-
65549170303
-
Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-Activating epigenetic marks that coexist on the lysine tail
-
Brasacchio, D., Okabe, J., Tikellis, C., Balcerczyk, A., George, P., Baker, E. K. et al. Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-Activating epigenetic marks that coexist on the lysine tail. Diabetes 58, 1229-1236 (2009
-
(2009)
Diabetes
, vol.58
, pp. 1229-1236
-
-
Brasacchio, D.1
Okabe, J.2
Tikellis, C.3
Balcerczyk, A.4
George, P.5
Baker, E.K.6
-
45
-
-
53349101264
-
Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
-
El-Osta, A., Brasacchio, D., Yao, D., Pocai, A., Jones, P. L., Roeder, R. G. et al. Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J. Exp. Med. 205, 2409-2417 (2008
-
(2008)
J. Exp. Med
, vol.205
, pp. 2409-2417
-
-
El-Osta, A.1
Brasacchio, D.2
Yao, D.3
Pocai, A.4
Jones, P.L.5
Roeder, R.G.6
-
46
-
-
84859176881
-
FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure
-
Hino, S., Sakamoto, A., Nagaoka, K., Anan, K., Wang, Y., Mimasu, S. et al. FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure. Nat. Commun. 3, 758 (2012
-
(2012)
Nat. Commun
, vol.3
, Issue.758
-
-
Hino, S.1
Sakamoto, A.2
Nagaoka, K.3
Anan, K.4
Wang, Y.5
Mimasu, S.6
-
47
-
-
78449244155
-
The epigenetic basis of the Warburg effect
-
Wang, X. & Jin, H. The epigenetic basis of the Warburg effect. Epigenetics 5, 566-568 (2010
-
(2010)
Epigenetics
, vol.5
, pp. 566-568
-
-
Wang, X.1
Jin, H.2
-
48
-
-
80054776840
-
Promoter hypermethylation mediated downregulation of FBP1 in human hepatocellular carcinoma and colon cancer
-
Chen, M., Zhang, J., Li, N., Qian, Z., Zhu, M., Li, Q. et al. Promoter hypermethylation mediated downregulation of FBP1 in human hepatocellular carcinoma and colon cancer. PLoS One 6, e25564 (2011
-
(2011)
PLoS One
, vol.6
-
-
Chen, M.1
Zhang, J.2
Li, N.3
Qian, Z.4
Zhu, M.5
Li, Q.6
-
49
-
-
84870874690
-
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism
-
Sebastian, C., Zwaans, B. M., Silberman, D. M., Gymrek, M., Goren, A., Zhong, L. et al. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell 151, 1185-1199 (2012
-
(2012)
Cell
, vol.151
, pp. 1185-1199
-
-
Sebastian, C.1
Zwaans, B.M.2
Silberman, D.M.3
Gymrek, M.4
Goren, A.5
Zhong, L.6
-
50
-
-
79955579989
-
The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
-
Donohoe, D. R., Garge, N., Zhang, X., Sun, W., O'Connell, T. M., Bunger, M. K. et al. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell. Metab. 13, 517-526 (2011
-
(2011)
Cell. Metab
, vol.13
, pp. 517-526
-
-
Donohoe, D.R.1
Garge, N.2
Zhang, X.3
Sun, W.4
O'Connell, T.M.5
Bunger, M.K.6
-
51
-
-
0038676409
-
Inhibition of histone deacetylase activity by butyrate
-
Davie, J. R. Inhibition of histone deacetylase activity by butyrate. J. Nutr. 133, 2485S-2493S (2003
-
(2003)
J. Nutr
, vol.133
-
-
Davie, J.R.1
-
52
-
-
58149145317
-
Butyrate metabolism in human colon carcinoma cells: Implications concerning its growth-inhibitory effect
-
Andriamihaja, M., Chaumontet, C., Tome, D. & Blachier, F. Butyrate metabolism in human colon carcinoma cells: Implications concerning its growth-inhibitory effect. J. Cell. Physiol. 218, 58-65 (2009
-
(2009)
J. Cell. Physiol
, vol.218
, pp. 58-65
-
-
Andriamihaja, M.1
Chaumontet, C.2
Tome, D.3
Blachier, F.4
-
53
-
-
0942301264
-
Microbial degradation products influence colon cancer risk: The butyrate controversy
-
Lupton, J. R. Microbial degradation products influence colon cancer risk: The butyrate controversy. J. Nutr. 134, 479-482 (2004
-
(2004)
J. Nutr
, vol.134
, pp. 479-482
-
-
Lupton, J.R.1
-
54
-
-
84870389262
-
The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation
-
Donohoe, D. R., Collins, L. B., Wali, A., Bigler, R., Sun, W. & Bultman, S. J. The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. Mol. Cell. 48, 612-626 (2012
-
(2012)
Mol. Cell
, vol.48
, pp. 612-626
-
-
Donohoe, D.R.1
Collins, L.B.2
Wali, A.3
Bigler, R.4
Sun, W.5
Bultman, S.J.6
-
55
-
-
84865218876
-
Molecular pathogenesis of IDH mutations in gliomas
-
Ichimura, K. Molecular pathogenesis of IDH mutations in gliomas. Brain. Tumor. Pathol. 29, 131-139 (2012
-
(2012)
Brain. Tumor. Pathol
, vol.29
, pp. 131-139
-
-
Ichimura, K.1
-
56
-
-
84866479450
-
IDH mutations in acute myeloid leukemia
-
Rakheja, D., Konoplev, S., Medeiros, L. J. & Chen, W. IDH mutations in acute myeloid leukemia. Hum. Pathol. 43, 1541-1551 (2012
-
(2012)
Hum. Pathol
, vol.43
, pp. 1541-1551
-
-
Rakheja, D.1
Konoplev, S.2
Medeiros, L.J.3
Chen, W.4
-
57
-
-
72049125350
-
Cancer-Associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M. et al. Cancer-Associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462, 739-744 (2009
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
Bennett, B.D.4
Bittinger, M.A.5
Driggers, E.M.6
-
58
-
-
79955547561
-
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
-
Chowdhury, R., Yeoh, K. K., Tian, Y. M., Hillringhaus, L., Bagg, E. A., Rose, N. R. et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO. Rep. 12, 463-469 (2011
-
(2011)
EMBO. Rep
, vol.12
, pp. 463-469
-
-
Chowdhury, R.1
Yeoh, K.K.2
Tian, Y.M.3
Hillringhaus, L.4
Bagg, E.A.5
Rose, N.R.6
-
59
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
-
Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S. H. et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer cell 19, 17-30 (2011
-
(2011)
Cancer cell
, vol.19
, pp. 17-30
-
-
Xu, W.1
Yang, H.2
Liu, Y.3
Yang, Y.4
Wang, P.5
Kim, S.H.6
-
60
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Figueroa, M. E., Abdel-Wahab, O., Lu, C., Ward, P. S., Patel, J., Shih, A. et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer cell 18, 553-567 (2010
-
(2010)
Cancer cell
, vol.18
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
Ward, P.S.4
Patel, J.5
Shih, A.6
-
61
-
-
84866419591
-
Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
-
Lian, C. G., Xu, Y., Ceol, C., Wu, F., Larson, A., Dresser, K. et al. Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell 150, 1135-1146 (2012
-
(2012)
Cell
, vol.150
, pp. 1135-1146
-
-
Lian, C.G.1
Xu, Y.2
Ceol, C.3
Wu, F.4
Larson, A.5
Dresser, K.6
-
62
-
-
84875496294
-
R-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible
-
Losman, J. A., Looper, R. E., Koivunen, P., Lee, S., Schneider, R. K., McMahon, C. et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science 339, 1621-1625 (2013
-
(2013)
Science
, vol.339
, pp. 1621-1625
-
-
Losman, J.A.1
Looper, R.E.2
Koivunen, P.3
Lee, S.4
Schneider, R.K.5
McMahon, C.6
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