Nrf2 Knockdown Disrupts the Protective Effect of Curcumin on Alcohol-Induced Hepatocyte Necroptosis

Molecular Pharmaceutics

Volumn 13, Issue 12, 2016, Pages 4043-4053

  Lu, Chunfeng ^a   Xu, Wenxuan ^a   Zhang, Feng ^a   Shao, Jiangjuan ^a   Zheng, Shizhong ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

alcoholic liver disease; curcumin; necroptosis; Nrf2; p53

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; CURCUMIN; CYTOPROTECTIVE AGENT; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1ALPHA; LIVER PROTECTIVE AGENT; MESSENGER RNA; MIXED LINEAGE KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN P53; RECEPTOR INTERACTING PROTEIN 1; RECEPTOR INTERACTING PROTEIN 3; SHORT HAIRPIN RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; NFE2L2 PROTEIN, MOUSE; TOPICAL ANTIINFECTIVE AGENT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL LIVER CIRRHOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL PROTECTION; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LENTIVIRINAE; LIVER CELL; LIVER PROTECTION; LIVER TOXICITY; MOUSE; NECROPTOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANIMAL; DRUG EFFECTS; KNOCKOUT MOUSE; LIVER DISEASES, ALCOHOLIC; METABOLISM; NECROSIS; OXIDATIVE STRESS; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; ANTINEOPLASTIC AGENTS; CURCUMIN; ETHANOL; HEPATOCYTES; LIVER DISEASES, ALCOHOLIC; MICE; MICE, KNOCKOUT; NECROSIS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHOSPHORYLATION;

EID: 85002879717     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.6b00562     Document Type: Article

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