Lung endothelial barrier protection by resveratrol involves inhibition of HMGB1 release and HMGB1-induced mitochondrial oxidative damage via an Nrf2-dependent mechanism

Free Radical Biology and Medicine

Volumn 88, Issue Part B, 2015, Pages 404-416

  Dong, Wen Wen ^a,b   Liu, Yu Jian ^b   Lv, Zhou ^a   Mao, Yan Fei ^a   Wang, Ying Wei ^a   Zhu, Xiao Yan ^c   Jiang, Lai ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI UNIVERSITY OF SPORT   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Free radicals; HMGB1; Lung endothelial barrier; Mitochondrial oxidative damage; Nrf2; Resveratrol; Ventilator induced lung injury

Indexed keywords

ADENOSINE TRIPHOSPHATE; HIGH MOBILITY GROUP B1 PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; MITOCHONDRIAL DNA; RESVERATROL; SUPEROXIDE; TRANSCRIPTION FACTOR NRF2; VASCULAR ENDOTHELIAL CADHERIN; ANTIOXIDANT; NFE2L2 PROTEIN, MOUSE; SMALL INTERFERING RNA; STILBENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PERMEABILIZATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; GENE EXPRESSION; IN VIVO STUDY; LUNG BLOOD VESSEL; LUNG ENDOTHELIUM; LUNG PARENCHYMA; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TIDAL VOLUME; VENTILATOR INDUCED LUNG INJURY; ANIMAL; DISEASE MODEL; DRUG EFFECTS; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE SILENCING; GENETIC TRANSFECTION; INSTITUTE FOR CANCER RESEARCH MOUSE; LUNG; MECHANICAL STRESS; METABOLISM; MITOCHONDRION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE KNOCKDOWN TECHNIQUES; HMGB1 PROTEIN; LUNG; MALE; MICE; MICE, INBRED ICR; MITOCHONDRIA; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; STILBENES; STRESS, MECHANICAL; TRANSFECTION; VENTILATOR-INDUCED LUNG INJURY;

EID: 84969835759     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.05.004     Document Type: Article

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