Necroptosis: An emerging type of cell death in liver diseases

World Journal of Gastroenterology

Volumn 20, Issue 35, 2014, Pages 12526-12532

  Saeed, Waqar Khalid ^a   Jun, Dae Won ^a  

^a Hanyang University   (South Korea)

Author keywords

Apoptosis; Cell death; Liver disease; Necroptosis; Programmed necrosis

Indexed keywords

PHOSPHOTRANSFERASE; RIP1 KINASE; RIP3 KINASE; UNCLASSIFIED DRUG; PROTEIN KINASE INHIBITOR; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE;

APOPTOSIS; CELL LOSS; CELL PROTECTION; CELL SURVIVAL; HUMAN; LIVER DISEASE; NECROPTOSIS; NECROSIS; NONHUMAN; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SHORT SURVEY; UBIQUITINATION; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; LIVER; LIVER DISEASES; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; HUMANS; LIVER; LIVER DISEASES; MOLECULAR TARGETED THERAPY; NECROSIS; PROTEIN KINASE INHIBITORS; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 84909594692     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i35.12526     Document Type: Short Survey

References (51)

1. Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH, Blagosklonny MV, El-Deiry WS, Golstein P, Green DR, Hengartner M, Knight RA, Kumar S, Lipton SA, Malorni W, Nuñez G, Peter ME, Tschopp J, Yuan J, Piacentini M, Zhivotovsky B, Melino G. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ 2009; 16: 3-11 [PMID: 18846107 DOI: 10.1038/cdd.2008.150]
2. Degterev A, Yuan J. Expansion and evolution of cell death programmes. Nat Rev Mol Cell Biol 2008; 9: 378-390 [PMID: 18414491 DOI: 10.1038/nrm2393]
3. Majno G, Joris I. Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 1995; 146: 3-15 [PMID: 7856735]
4. Hotchkiss RS, Strasser A, McDunn JE, Swanson PE. Cell death. N Engl J Med 2009; 361: 1570-1583 [PMID: 19828534 DOI: 10.1056/NEJMra0901217]
5. Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 2005; 1: 112-119 [PMID: 16408008 DOI: 10.1038/nchembio711]
6. Meylan E, Tschopp J. The RIP kinases: crucial integrators of cellular stress. Trends Biochem Sci 2005; 30: 151-159 [PMID: 15752987 DOI: 10.1016/j.tibs.2005.01.003]
7. Chan FK, Shisler J, Bixby JG, Felices M, Zheng L, Appel M, Orenstein J, Moss B, Lenardo MJ. A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. J Biol Chem 2003; 278: 51613-51621 [PMID: 14532286 DOI: 10.1074/jbc.M305633200]
8. Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 2009; 137: 1112-1123 [PMID: 19524513 DOI: 10.1016/j.cell.2009.05.037]
9. Fulda S. The mechanism of necroptosis in normal and cancer cells. Cancer Biol Ther 2013; 14: 999-1004 [PMID: 24025353 DOI: 10.4161/cbt.26428]
10. Wu W, Liu P, Li J. Necroptosis: an emerging form of programmed cell death. Crit Rev Oncol Hematol 2012; 82: 249-258 [PMID: 21962882 DOI: 10.1016/j.critrevonc.2011.08.004]
11. Sun X, Yin J, Starovasnik MA, Fairbrother WJ, Dixit VM. Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. J Biol Chem 2002; 277: 9505-9511 [PMID: 11734559 DOI: 10.1074/jbc.M109488200]
12. Festjens N, Vanden Berghe T, Cornelis S, Vandenabeele P. RIP1, a kinase on the crossroads of a cell's decision to live or die. Cell Death Differ 2007; 14: 400-410 [PMID: 17301840 DOI: 10.1038/sj.cdd.4402085]
13. Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S, Bodmer JL, Schneider P, Seed B, Tschopp J. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol 2000; 1: 489-495 [PMID: 11101870 DOI: 10.1038/82732]
14. Moriwaki K, Chan FK. RIP3: a molecular switch for necrosis and inflammation. Genes Dev 2013; 27: 1640-1649 [PMID: 23913919 DOI: 10.1101/gad.223321.113]
15. An J, Mehrhof F, Harms C, Lättig-Tünnemann G, Lee SL, Endres M, Li M, Sellge G, Mandić AD, Trautwein C, Donath S. ARC is a novel therapeutic approach against acetamin-ophen-induced hepatocellular necrosis. J Hepatol 2013; 58: 297-305 [PMID: 23046676 DOI: 10.1016/j.jhep.2012.10.002]
16. Roychowdhury S, McMullen MR, Pisano SG, Liu X, Nagy LE. Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury. Hepatology 2013; 57: 1773-1783 [PMID: 23319235 DOI: 10.1002/hep.26200]
17. Ramachandran A, McGill MR, Xie Y, Ni HM, Ding WX, Jaeschke H. Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice. Hepatology 2013; 58: 2099-2108 [PMID: 23744808 DOI: 10.1002/hep.26547]
18. Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009; 325: 332-336 [PMID: 19498109 DOI: 10.1126/science.1172308]
19. Mannon RB. Necroptosis in solid organ transplantation: a missing link to immune activation? Am J Transplant 2013; 13: 2785-2786 [PMID: 24103049 DOI: 10.1111/ajt.12450]
20. Lau A, Wang S, Jiang J, Haig A, Pavlosky A, Linkermann A, Zhang ZX, Jevnikar AM. RIPK3-mediated necroptosis promotes donor kidney inflammatory injury and reduces allograft survival. Am J Transplant 2013; 13: 2805-2818 [PMID: 24103001 DOI: 10.1111/ajt.12447]
21. Vandenabeele P, Vanden Berghe T, Festjens N. Caspase inhibitors promote alternative cell death pathways. Sci STKE 2006; 2006: pe44 [PMID: 17062895 DOI: 10.1126/stke.3582006pe44]
22. Cho Y, McQuade T, Zhang H, Zhang J, Chan FK. RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. PLoS One 2011; 6: e23209 [PMID: 21853090 DOI: 10.1371/journal.pone.0023209]
23. Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 2008; 4: 313-321 [PMID: 18408713 DOI: 10.1038/nchembio.83]
24. He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 2009; 137: 1100-1111 [PMID: 19524512 DOI: 10.1016/j.cell.2009.05.021]
25. McNeal SI, LeGolvan MP, Chung CS, Ayala A. The dual functions of receptor interacting protein 1 in fas-induced hepatocyte death during sepsis. Shock 2011; 35: 499-505 [PMID: 21263386 DOI: 10.1097/SHK.0b013e31820b2db1]
26. Los M, Mozoluk M, Ferrari D, Stepczynska A, Stroh C, Renz A, Herceg Z, Wang ZQ, Schulze-Osthoff K. Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Mol Biol Cell 2002; 13: 978-988 [PMID: 11907276 DOI: 10.1091/mbc.01-05-0272]
27. Meurette O, Huc L, Rebillard A, Le Moigne G, Lagadic-Gossmann D, Dimanche-Boitrel MT. TRAIL (TNF-related apoptosis-inducing ligand) induces necrosis-like cell death in tumor cells at acidic extracellular pH. Ann N Y Acad Sci 2005; 1056: 379-387 [PMID: 16387703 DOI: 10.1196/annals.1352.018]
28. Linkermann A, Bräsen JH, Himmerkus N, Liu S, Huber TB, Kunzendorf U, Krautwald S. Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury. Kidney Int 2012; 81: 751-761 [PMID: 22237751 DOI: 10.1038/ki.2011.450]
29. Rosenbaum DM, Degterev A, David J, Rosenbaum PS, Roth S, Grotta JC, Cuny GD, Yuan J, Savitz SI. Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J Neurosci Res 2010; 88: 1569-1576 [PMID: 20025059 DOI: 10.1002/jnr.22314]
30. Wang YQ, Wang L, Zhang MY, Wang T, Bao HJ, Liu WL, Dai DK, Zhang L, Chang P, Dong WW, Chen XP, Tao LY. Necrostatin-1 suppresses autophagy and apoptosis in mice traumatic brain injury model. Neurochem Res 2012; 37: 1849-1858 [PMID: 22736198 DOI: 10.1007/s11064-012-0791-4]
31. Roychowdhury S, Chiang DJ, Mandal P, McMullen MR, Liu X, Cohen JI, Pollard J, Feldstein AE, Nagy LE. Inhibition of Apoptosis Protects Mice from Ethanol-Mediated Acceleration of Early Markers of CCl4-Induced Fibrosis but not Steatosis or Inflammation. Alcohol Clin Exp Res 2012; 36: 1139-1147 [PMID: 22273278 DOI: 10.1111/j.1530-0277.2011.01720.x]
32. Sharma M, Gadang V, Jaeschke A. Critical role for mixed-lineage kinase 3 in acetaminophen-induced hepatotoxicity. Mol Pharmacol 2012; 82: 1001-1007 [PMID: 22918968 DOI: 10.1124/mol.112.079863]
33. Jouan-Lanhouet S, Arshad MI, Piquet-Pellorce C, Martin-Chouly C, Le Moigne-Muller G, Van Herreweghe F, Takahashi N, Sergent O, Lagadic-Gossmann D, Vandenabeele P, Samson M, Dimanche-Boitrel MT. TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation. Cell Death Differ 2012; 19: 2003-2014 [PMID: 22814620 DOI: 10.1038/cdd.2012.90]
34. Zhou Y, Dai W, Lin C, Wang F, He L, Shen M, Chen P, Wang C, Lu J, Xu L, Xu X, Guo C. Protective effects of necrostatin-1 against concanavalin A-induced acute hepatic injury in mice. Mediators Inflamm 2013; 2013: 706156 [PMID: 24198446 DOI: 10.1155/2013/706156]
35. Vanlangenakker N, Bertrand MJ, Bogaert P, Vandenabeele P, Vanden Berghe T. TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members. Cell Death Dis 2011; 2: e230 [PMID: 22089168 DOI: 10.1038/cddis.2011.111]
36. Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, Gottlieb E, Green DR, Hengartner MO, Kepp O, Knight RA, Kumar S, Lipton SA, Lu X, Madeo F, Malorni W, Mehlen P, Nuñez G, Peter ME, Piacentini M, Rubinsztein DC, Shi Y, Simon HU, Vandenabeele P, White E, Yuan J, Zhivotovsky B, Melino G, Kroemer G. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012; 19: 107-120 [PMID: 21760595 DOI: 10.1038/cdd.2011.96]
37. Sosna J, Voigt S, Mathieu S, Lange A, Thon L, Davarnia P, Herdegen T, Linkermann A, Rittger A, Chan FK, Kabelitz D, Schütze S, Adam D. TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. Cell Mol Life Sci 2014; 71: 331-348 [PMID: 23760205 DOI: 10.1007/s00018-013-1381-6]
38. Linkermann A, Bräsen JH, Darding M, Jin MK, Sanz AB, Heller JO, De Zen F, Weinlich R, Ortiz A, Walczak H, Weinberg JM, Green DR, Kunzendorf U, Krautwald S. Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury. Proc Natl Acad Sci USA 2013; 110: 12024-12029 [PMID: 23818611 DOI: 10.1073/pnas.1305538110]
39. Chang P, Dong W, Zhang M, Wang Z, Wang Y, Wang T, Gao Y, Meng H, Luo B, Luo C, Chen X, Tao L. Anti-necroptosis chemical necrostatin-1 can also suppress apoptotic and autophagic pathway to exert neuroprotective effect in mice intracerebral hemorrhage model. J Mol Neurosci 2014; 52: 242-249 [PMID: 24122153 DOI: 10.1007/s12031-013-0132-3]
40. Tamura Y, Chiba Y, Tanioka T, Shimizu N, Shinozaki S, Yamada M, Kaneki K, Mori S, Araki A, Ito H, Kaneki M. NO donor induces Nec-1-inhibitable, but RIP1-independent, necrotic cell death in pancreatic β-cells. FEBS Lett 2011; 585: 3058-3064 [PMID: 21888904 DOI: 10.1016/j.febslet.2011.08.028]
41. Biton S, Ashkenazi A. NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling. Cell 2011; 145: 92-103 [PMID: 21458669 DOI: 10.1016/j.cell.2011.02.023]
42. Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B, Stockwell BR. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 2012; 149: 1060-1072 [PMID: 22632970 DOI: 10.1016/j.cell.2012.03.042]
43. Zhou Z, Han V, Han J. New components of the necroptotic pathway. Protein Cell 2012; 3: 811-817 [PMID: 23073834 DOI: 10.1007/s13238-012-2083-9]
44. Wang Z, Jiang H, Chen S, Du F, Wang X. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 2012; 148: 228-243 [PMID: 22265414 DOI: 10.1016/j.cell.2011.11.030]
45. Tait SW, Oberst A, Quarato G, Milasta S, Haller M, Wang R, Karvela M, Ichim G, Yatim N, Albert ML, Kidd G, Wakefield R, Frase S, Krautwald S, Linkermann A, Green DR. Widespread mitochondrial depletion via mitophagy does not compromise necroptosis. Cell Rep 2013; 5: 878-885 [PMID: 24268776 DOI: 10.1016/j.celrep.2013.10.034]
46. Zhao J, Jitkaew S, Cai Z, Choksi S, Li Q, Luo J, Liu ZG. Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. Proc Natl Acad Sci USA 2012; 109: 5322-5327 [PMID: 22421439 DOI: 10.1073/pnas.1200012109]
47. Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X, Wang X. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 2012; 148: 213-227 [PMID: 22265413 DOI: 10.1016/j.cell.2011.11.031]
48. Wu J, Huang Z, Ren J, Zhang Z, He P, Li Y, Ma J, Chen W, Zhang Y, Zhou X, Yang Z, Wu SQ, Chen L, Han J. Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res 2013; 23: 994-1006 [PMID: 23835476 DOI: 10.1038/cr.2013.91]
49. Upton JW, Kaiser WJ, Mocarski ES. Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe 2010; 7: 302-313 [PMID: 20413098 DOI: 10.1016/j.chom.2010.03.006]
50. Linkermann A, Bräsen JH, De Zen F, Weinlich R, Schwendener RA, Green DR, Kunzendorf U, Krautwald S. Dichotomy between RIP1- and RIP3-mediated necroptosis in tumor necrosis factor-α-induced shock. Mol Med 2012; 18: 577-586 [PMID: 22371307 DOI: 10.2119/molmed.2011.00423]
51. Takahashi N, Duprez L, Grootjans S, Cauwels A, Nerinckx W, DuHadaway JB, Goossens V, Roelandt R, Van Hauwermeiren F, Libert C, Declercq W, Callewaert N, Prendergast GC, Degterev A, Yuan J, Vandenabeele P. Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models. Cell Death Dis 2012; 3: e437 [PMID: 23190609 DOI: 10.1038/cddis.2012.176]