Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice

Translational Research

Volumn 172, Issue , 2016, Pages 18-29.e2

  Liu, Zhiping ^a   Wang, Jiaojiao ^a   Huang, Xiaoyang ^a   Li, Zhuoming ^a   Liu, Peiqing ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Abbreviations ApoE apolipoprotein E deficient; GAPDH glyceraldehyde 3 phosphate dehydrogenase; HCD high cholesterol diet; HDL high density lipoprotein; HUVEC human umbilical vein endothelial cells; ICAM 1 intracellular adhesion molecule 1; LDL low density lipoprotein; MAECs mouse aortic endothelial cells; MCP 1 monocyte chemotactic protein 1; mRNA messenger RNA; NF B nuclear factor B; ORO Oil Red O; shRNA small hairpin RNA; siRNA small interfering RNA; SIRT6 sirtuin 6; VCAM 1 vascular cellular adhesion molecule 1

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; SHORT HAIRPIN RNA; SIRTUIN 6; APOLIPOPROTEIN E; CHOLESTEROL; SIRT6 PROTEIN, MOUSE; SIRTUIN; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ENDOTHELIUM; AORTA ROOT; AORTA SINUS; ARTICLE; ATHEROSCLEROSIS; CELL ADHESION; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; MACROPHAGE; MALE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; UPREGULATION; VASODILATATION; ANIMAL; ATHEROSCLEROTIC PLAQUE; BLOOD; C57BL MOUSE; DEFICIENCY; DIET; GENE DELETION; LENTIVIRINAE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CELL ADHESION; CHOLESTEROL; DIET; ENDOTHELIUM, VASCULAR; GENE DELETION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; LENTIVIRUS; MICE, INBRED C57BL; MONOCYTES; PLAQUE, ATHEROSCLEROTIC; RNA, SMALL INTERFERING; SIRTUINS; VASODILATION;

EID: 84961839455     PISSN: 19315244     EISSN: 18781810     Source Type: Journal    
DOI: 10.1016/j.trsl.2016.02.005     Document Type: Article

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