메뉴 건너뛰기




Volumn 169, Issue 1, 2013, Pages 197-212

The β-catenin pathway contributes to the effects of leptin on SREBP-1c expression in rat hepatic stellate cells and liver fibrosis

Author keywords

catenin; glycogen synthase kinase 3 ; hepatic stellate cell; leptin; liver fibrosis; sterol regulatory element binding protein 1c

Indexed keywords

BETA CATENIN; CYCLIN D1; GLYCOGEN SYNTHASE KINASE 3BETA; LEPTIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C;

EID: 84876272648     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12114     Document Type: Article
Times cited : (65)

References (54)
  • 1
    • 77954036677 scopus 로고    scopus 로고
    • Activation of Wnt/beta-catenin signaling increases insulin sensitivity through a reciprocal regulation of Wnt10b and SREBP-1c in skeletal muscle cells
    • Abiola M, Favier M, Christodoulou-Vafeiadou E, Pichard AL, Martelly I, Guillet-Deniau I, (2009). Activation of Wnt/beta-catenin signaling increases insulin sensitivity through a reciprocal regulation of Wnt10b and SREBP-1c in skeletal muscle cells. PLoS ONE 4: e8509.
    • (2009) PLoS ONE , vol.4
    • Abiola, M.1    Favier, M.2    Christodoulou-Vafeiadou, E.3    Pichard, A.L.4    Martelly, I.5    Guillet-Deniau, I.6
  • 2
    • 84859179083 scopus 로고    scopus 로고
    • Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
    • Akhmetshina A, Palumbo K, Dees C, Bergmann C, Venalis P, Zerr P, et al. (2012). Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis. Nat Commun 3: 735-746.
    • (2012) Nat Commun , vol.3 , pp. 735-746
    • Akhmetshina, A.1    Palumbo, K.2    Dees, C.3    Bergmann, C.4    Venalis, P.5    Zerr, P.6
  • 3
    • 32944478021 scopus 로고    scopus 로고
    • Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells
    • Aleffi S, Petrai I, Bertolani C, Parola M, Colombatto S, Novo E, et al. (2005). Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells. Hepatology 42: 1339-1348.
    • (2005) Hepatology , vol.42 , pp. 1339-1348
    • Aleffi, S.1    Petrai, I.2    Bertolani, C.3    Parola, M.4    Colombatto, S.5    Novo, E.6
  • 4
    • 28244487293 scopus 로고    scopus 로고
    • Conditional deletion of beta-catenin in the mesenchyme of the developing mouse uterus results in a switch to adipogenesis in the myometrium
    • Arango NA, Szotek PP, Manganaro TF, Oliva E, Donahoe PK, Teixeira J, (2005). Conditional deletion of beta-catenin in the mesenchyme of the developing mouse uterus results in a switch to adipogenesis in the myometrium. Dev Biol 288: 276-283.
    • (2005) Dev Biol , vol.288 , pp. 276-283
    • Arango, N.A.1    Szotek, P.P.2    Manganaro, T.F.3    Oliva, E.4    Donahoe, P.K.5    Teixeira, J.6
  • 5
    • 77953518830 scopus 로고    scopus 로고
    • Role of adipocytokines in hepatic fibrosis
    • Bertolani C, Marra F, (2010). Role of adipocytokines in hepatic fibrosis. Curr Pharm Des 16: 1929-1940.
    • (2010) Curr Pharm des , vol.16 , pp. 1929-1940
    • Bertolani, C.1    Marra, F.2
  • 6
    • 60849114984 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases and Wnt/beta-catenin signaling: Molecular conversations among signaling pathways
    • Bikkavilli RK, Malbon CC, (2009). Mitogen-activated protein kinases and Wnt/beta-catenin signaling: molecular conversations among signaling pathways. Commun Integr Biol 2: 46-49.
    • (2009) Commun Integr Biol , vol.2 , pp. 46-49
    • Bikkavilli, R.K.1    Malbon, C.C.2
  • 7
    • 59149098536 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase regulates canonical Wnt-beta-catenin signaling by inactivation of GSK3beta
    • Bikkavilli RK, Feigin ME, Malbon CC, (2008). p38 mitogen-activated protein kinase regulates canonical Wnt-beta-catenin signaling by inactivation of GSK3beta. J Cell Sci 121: 3598-3607.
    • (2008) J Cell Sci , vol.121 , pp. 3598-3607
    • Bikkavilli, R.K.1    Feigin, M.E.2    Malbon, C.C.3
  • 9
    • 30044443872 scopus 로고    scopus 로고
    • Leptin enhances alpha1(I) collagen gene expression in LX-2 human hepatic stellate cells through JAK-mediated H2O2-dependent MAPK pathways
    • Cao Q, Mak KM, Lieber CS, (2006). Leptin enhances alpha1(I) collagen gene expression in LX-2 human hepatic stellate cells through JAK-mediated H2O2-dependent MAPK pathways. J Cell Biochem 97: 188-197.
    • (2006) J Cell Biochem , vol.97 , pp. 188-197
    • Cao, Q.1    Mak, K.M.2    Lieber, C.S.3
  • 10
    • 43049175154 scopus 로고    scopus 로고
    • TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts
    • Caraci F, Gili E, Calafiore M, Failla M, La Rosa C, Crimi N, et al. (2008). TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts. Pharmacol Res 57: 274-282.
    • (2008) Pharmacol Res , vol.57 , pp. 274-282
    • Caraci, F.1    Gili, E.2    Calafiore, M.3    Failla, M.4    La Rosa, C.5    Crimi, N.6
  • 12
    • 35548978540 scopus 로고    scopus 로고
    • Essential role of Wnt3a-mediated activation of mitogen-activated protein kinase p38 for the stimulation of alkaline phosphatase activity and matrix mineralization in C3H10T1/2 mesenchymal cells
    • Caverzasio J, Manen D, (2007). Essential role of Wnt3a-mediated activation of mitogen-activated protein kinase p38 for the stimulation of alkaline phosphatase activity and matrix mineralization in C3H10T1/2 mesenchymal cells. Endocrinology 148: 5323-5330.
    • (2007) Endocrinology , vol.148 , pp. 5323-5330
    • Caverzasio, J.1    Manen, D.2
  • 13
    • 3843061127 scopus 로고    scopus 로고
    • Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver
    • Chen G, Liang G, Ou J, Goldstein JL, Brown MS, (2004). Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc Natl Acad Sci U S A 101: 11245-11250.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 11245-11250
    • Chen, G.1    Liang, G.2    Ou, J.3    Goldstein, J.L.4    Brown, M.S.5
  • 17
    • 58949090376 scopus 로고    scopus 로고
    • Competitive inhibition of leptin signaling results in amelioration of liver fibrosis through modulation of stellate cell function
    • Elinav E, Ali M, Bruck R, Brazowski E, Phillips A, Shapira Y, et al. (2009). Competitive inhibition of leptin signaling results in amelioration of liver fibrosis through modulation of stellate cell function. Hepatology 49: 278-286.
    • (2009) Hepatology , vol.49 , pp. 278-286
    • Elinav, E.1    Ali, M.2    Bruck, R.3    Brazowski, E.4    Phillips, A.5    Shapira, Y.6
  • 18
    • 80052580981 scopus 로고    scopus 로고
    • Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis
    • Endo H, Hosono K, Uchiyama T, Sakai E, Sugiyama M, Takahashi H, et al. (2011). Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis. Gut 60: 1363-1371.
    • (2011) Gut , vol.60 , pp. 1363-1371
    • Endo, H.1    Hosono, K.2    Uchiyama, T.3    Sakai, E.4    Sugiyama, M.5    Takahashi, H.6
  • 19
    • 84864352752 scopus 로고    scopus 로고
    • Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3β/β-catenin signaling
    • Garza JC, Guo M, Zhang W, Lu XY, (2012). Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3β/β-catenin signaling. Mol Psychiatry 17: 790-808.
    • (2012) Mol Psychiatry , vol.17 , pp. 790-808
    • Garza, J.C.1    Guo, M.2    Zhang, W.3    Lu, X.Y.4
  • 21
    • 0031149476 scopus 로고    scopus 로고
    • Activation of the Wnt signaling pathway: A molecular mechanism for lithium action
    • Hedgepeth CM, Conrad LJ, Zhang J, Huang HC, Lee VM, Klein PS, (1997). Activation of the Wnt signaling pathway: a molecular mechanism for lithium action. Dev Biol 185: 82-91.
    • (1997) Dev Biol , vol.185 , pp. 82-91
    • Hedgepeth, C.M.1    Conrad, L.J.2    Zhang, J.3    Huang, H.C.4    Lee, V.M.5    Klein, P.S.6
  • 23
    • 0036288668 scopus 로고    scopus 로고
    • Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver
    • Honda H, Ikejima K, Hirose M, Yoshikawa M, Lang T, Enomoto N, et al. (2002). Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver. Hepatology 36: 12-21.
    • (2002) Hepatology , vol.36 , pp. 12-21
    • Honda, H.1    Ikejima, K.2    Hirose, M.3    Yoshikawa, M.4    Lang, T.5    Enomoto, N.6
  • 25
    • 0033002786 scopus 로고    scopus 로고
    • Expression of cyclins D1, D2 and e correlates with proliferation of rat stellate cells in culture
    • Kawada N, Ikeda K, Seki S, Kuroki T, (1999). Expression of cyclins D1, D2 and E correlates with proliferation of rat stellate cells in culture. J Hepatol 30: 1057-1064.
    • (1999) J Hepatol , vol.30 , pp. 1057-1064
    • Kawada, N.1    Ikeda, K.2    Seki, S.3    Kuroki, T.4
  • 27
    • 73949090577 scopus 로고    scopus 로고
    • WNT signaling in lung disease: A failure or a regeneration signal?
    • Königshoff M, Eickelberg O, (2010). WNT signaling in lung disease: a failure or a regeneration signal? Am J Respir Cell Mol Biol 42: 21-31.
    • (2010) Am J Respir Cell Mol Biol , vol.42 , pp. 21-31
    • Königshoff, M.1    Eickelberg, O.2
  • 28
    • 82955232388 scopus 로고    scopus 로고
    • β-catenin signaling: A novel mediator of fibrosis and potential therapeutic target
    • Lam AP, Gottardi CJ, (2011). β-catenin signaling: a novel mediator of fibrosis and potential therapeutic target. Curr Opin Rheumatol 23: 562-567.
    • (2011) Curr Opin Rheumatol , vol.23 , pp. 562-567
    • Lam, A.P.1    Gottardi, C.J.2
  • 29
    • 10744220537 scopus 로고    scopus 로고
    • Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c
    • Lee YS, Lee HH, Park J, Yoo EJ, Glackin CA, Choi YI, et al. (2003). Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c. Nucleic Acids Res 31: 7165-7174.
    • (2003) Nucleic Acids Res , vol.31 , pp. 7165-7174
    • Lee, Y.S.1    Lee, H.H.2    Park, J.3    Yoo, E.J.4    Glackin, C.A.5    Choi, Y.I.6
  • 30
    • 0032853754 scopus 로고    scopus 로고
    • Serum leptin concentration in moderate and severe obesity: Relationship with clinical, anthropometric and metabolic factors
    • Liuzzi A, Savia G, Tagliaferri M, Berselli ME, Petroni ML, De Medici C, et al. (1999). Serum leptin concentration in moderate and severe obesity: relationship with clinical, anthropometric and metabolic factors. Int J Obes Relat Metab Disord 23: 1066-1073.
    • (1999) Int J Obes Relat Metab Disord , vol.23 , pp. 1066-1073
    • Liuzzi, A.1    Savia, G.2    Tagliaferri, M.3    Berselli, M.E.4    Petroni, M.L.5    De Medici, C.6
  • 31
    • 0032922804 scopus 로고    scopus 로고
    • Body composition and hepatic steatosis as precursors for fibrotic liver disease
    • McCullough AJ, Falck-Ytter Y, (1999). Body composition and hepatic steatosis as precursors for fibrotic liver disease. Hepatology 29: 1328-1329.
    • (1999) Hepatology , vol.29 , pp. 1328-1329
    • McCullough, A.J.1    Falck-Ytter, Y.2
  • 32
    • 77954331629 scopus 로고    scopus 로고
    • Guidelines for reporting experiments involving animals: The ARRIVE guidelines
    • McGrath J, Drummond G, McLachlan E, Kilkenny C, Wainwright C, (2010). Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160: 1573-1576.
    • (2010) Br J Pharmacol , vol.160 , pp. 1573-1576
    • McGrath, J.1    Drummond, G.2    McLachlan, E.3    Kilkenny, C.4    Wainwright, C.5
  • 33
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: Components, mechanisms, and diseases
    • MacDonald BT, Tamai K, He X, (2009). Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 17: 9-26.
    • (2009) Dev Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 34
    • 78649713663 scopus 로고    scopus 로고
    • Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes
    • Ohba S, Lanigan TM, Roessler BJ, (2010). Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes. Osteoarthritis Cartilage 18: 1620-1629.
    • (2010) Osteoarthritis Cartilage , vol.18 , pp. 1620-1629
    • Ohba, S.1    Lanigan, T.M.2    Roessler, B.J.3
  • 35
    • 0032489223 scopus 로고    scopus 로고
    • Transdifferentiation of rat hepatic stellate cells results in leptin expression
    • Potter JJ, Womack L, Mezey E, Anania FA, (1998). Transdifferentiation of rat hepatic stellate cells results in leptin expression. Biochem Biophys Res Commun 244: 178-182.
    • (1998) Biochem Biophys Res Commun , vol.244 , pp. 178-182
    • Potter, J.J.1    Womack, L.2    Mezey, E.3    Anania, F.A.4
  • 36
    • 0033830783 scopus 로고    scopus 로고
    • Transcriptional control of adipogenesis
    • Rangwala SM, Lazar MA, (2000). Transcriptional control of adipogenesis. Annu Rev Nutr 20: 535-559.
    • (2000) Annu Rev Nutr , vol.20 , pp. 535-559
    • Rangwala, S.M.1    Lazar, M.A.2
  • 38
    • 29244448718 scopus 로고    scopus 로고
    • Somatostatin at nanomolar concentration reduces collagen i and III synthesis by, but not proliferation of activated rat hepatic stellate cells
    • Reynaert H, Rombouts K, Jia Y, Urbain D, Chatterjee N, Uyama N, et al. (2005). Somatostatin at nanomolar concentration reduces collagen I and III synthesis by, but not proliferation of activated rat hepatic stellate cells. Br J Pharmacol 146: 77-88.
    • (2005) Br J Pharmacol , vol.146 , pp. 77-88
    • Reynaert, H.1    Rombouts, K.2    Jia, Y.3    Urbain, D.4    Chatterjee, N.5    Uyama, N.6
  • 39
    • 33846921242 scopus 로고    scopus 로고
    • GSK-3 mediates differentiation and activation of proinflammatory dendritic cells
    • Rodionova E, Conzelmann M, Maraskovsky E, Hess M, Kirsch M, Giese T, et al. (2007). GSK-3 mediates differentiation and activation of proinflammatory dendritic cells. Blood 109: 1584-1592.
    • (2007) Blood , vol.109 , pp. 1584-1592
    • Rodionova, E.1    Conzelmann, M.2    Maraskovsky, E.3    Hess, M.4    Kirsch, M.5    Giese, T.6
  • 40
    • 77956176288 scopus 로고    scopus 로고
    • Sterol metabolism and SREBP activation
    • Sato R, (2010). Sterol metabolism and SREBP activation. Arch Biochem Biophys 501: 177-181.
    • (2010) Arch Biochem Biophys , vol.501 , pp. 177-181
    • Sato, R.1
  • 41
    • 0036204924 scopus 로고    scopus 로고
    • Leptin in hepatic fibrosis: Evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice
    • Saxena NK, Ikeda K, Rockey DC, Friedman SL, Anania FA, (2002). Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice. Hepatology 35: 762-771.
    • (2002) Hepatology , vol.35 , pp. 762-771
    • Saxena, N.K.1    Ikeda, K.2    Rockey, D.C.3    Friedman, S.L.4    Anania, F.A.5
  • 42
    • 0034668118 scopus 로고    scopus 로고
    • Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: Comparison of endpoint and real-time methods
    • Schmittgen TD, Zakrajsek BA, Mills AG, Gorn V, Singer MJ, Reed MW, (2000). Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods. Anal Biochem 285: 194-204.
    • (2000) Anal Biochem , vol.285 , pp. 194-204
    • Schmittgen, T.D.1    Zakrajsek, B.A.2    Mills, A.G.3    Gorn, V.4    Singer, M.J.5    Reed, M.W.6
  • 43
    • 14244257340 scopus 로고    scopus 로고
    • Adipogenic transcriptional regulation of hepatic stellate cells
    • She H, Xiong S, Hazra S, Tsukamoto H, (2005). Adipogenic transcriptional regulation of hepatic stellate cells. J Biol Chem 280: 4959-4967.
    • (2005) J Biol Chem , vol.280 , pp. 4959-4967
    • She, H.1    Xiong, S.2    Hazra, S.3    Tsukamoto, H.4
  • 44
    • 0030961960 scopus 로고    scopus 로고
    • Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
    • Shimomura I, Shimano H, Horton JD, Goldstein JL, Brown MS, (1997). Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J Clin Invest 99: 838-845.
    • (1997) J Clin Invest , vol.99 , pp. 838-845
    • Shimomura, I.1    Shimano, H.2    Horton, J.D.3    Goldstein, J.L.4    Brown, M.S.5
  • 45
    • 37549033896 scopus 로고    scopus 로고
    • The influence of obesity on the oxidative stress status and the concentration of leptin in type 2 diabetes mellitus patients
    • Stefanovic A, Kotur-Stevuljevic J, Spasic S, Bogavac-Stanojevic N, Bujisic N, (2008). The influence of obesity on the oxidative stress status and the concentration of leptin in type 2 diabetes mellitus patients. Diabetes Res Clin Pract 79: 156-163.
    • (2008) Diabetes Res Clin Pract , vol.79 , pp. 156-163
    • Stefanovic, A.1    Kotur-Stevuljevic, J.2    Spasic, S.3    Bogavac-Stanojevic, N.4    Bujisic, N.5
  • 46
    • 32044435802 scopus 로고    scopus 로고
    • Adipogenic phenotype of hepatic stellate cells
    • Tsukamoto H, (2005). Adipogenic phenotype of hepatic stellate cells. Alcohol Clin Exp Res 29: 132S-133S.
    • (2005) Alcohol Clin Exp Res , vol.29
    • Tsukamoto, H.1
  • 48
    • 84862171364 scopus 로고    scopus 로고
    • The many faces and functions of β-catenin
    • Valenta T, Hausmann G, Basler K, (2012). The many faces and functions of β-catenin. EMBO J 31: 2714-2736.
    • (2012) EMBO J , vol.31 , pp. 2714-2736
    • Valenta, T.1    Hausmann, G.2    Basler, K.3
  • 50
    • 84863012195 scopus 로고    scopus 로고
    • P38 MAPK and LXRα mediate leptin effect on SREBP-1c expression in hepatic stellate cells
    • Yan K, Deng X, Zhai X, Zhou M, Jia X, Luo L, et al. (2012). p38 MAPK and LXRα mediate leptin effect on SREBP-1c expression in hepatic stellate cells. Mol Med 18: 10-18.
    • (2012) Mol Med , vol.18 , pp. 10-18
    • Yan, K.1    Deng, X.2    Zhai, X.3    Zhou, M.4    Jia, X.5    Luo, L.6
  • 53
    • 64249139719 scopus 로고    scopus 로고
    • PI-3 K/AKT and ERK signaling pathways mediate leptin-induced inhibition of PPARgamma gene expression in primary rat hepatic stellate cells
    • Zhou Y, Jia X, Wang G, Wang X, Liu J, (2009). PI-3 K/AKT and ERK signaling pathways mediate leptin-induced inhibition of PPARgamma gene expression in primary rat hepatic stellate cells. Mol Cell Biochem 325: 131-139.
    • (2009) Mol Cell Biochem , vol.325 , pp. 131-139
    • Zhou, Y.1    Jia, X.2    Wang, G.3    Wang, X.4    Liu, J.5
  • 54
    • 77952955100 scopus 로고    scopus 로고
    • Leptin inhibits PPARgamma gene expression in hepatic stellate cells in the mouse model of liver damage
    • Zhou Y, Jia X, Qin J, Lu C, Zhu H, Li X, et al. (2010). Leptin inhibits PPARgamma gene expression in hepatic stellate cells in the mouse model of liver damage. Mol Cell Endocrinol 323: 193-200.
    • (2010) Mol Cell Endocrinol , vol.323 , pp. 193-200
    • Zhou, Y.1    Jia, X.2    Qin, J.3    Lu, C.4    Zhu, H.5    Li, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.