Glycyrrhizin reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and endotoxemic mice by p38/Nrf2-dependent induction of HO-1

International Immunopharmacology

Volumn 26, Issue 1, 2015, Pages 112-118

  Kim, Young Min ^a   Kim, Hye Jung ^a   Chang, Ki Churl ^a  

^a Gyeongsang National University School of Medicine   (South Korea)

Author keywords

Heme oxygenase; HMGB1; Nrf 2; p38MAPK; Sepsis

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALANINE AMINOTRANSFERASE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ASPARTATE AMINOTRANSFERASE; ENDOTOXIN; GLYCYRRHIZIC ACID; HEME OXYGENASE 1; HIGH MOBILITY GROUP B1 PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; HMGB1 PROTEIN, MOUSE; HMOX1 PROTEIN, MOUSE; MEMBRANE PROTEIN; NFE2L2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENDOTOXEMIA; LIVER INJURY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL CULTURE TECHNIQUE; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; INSTITUTE FOR CANCER RESEARCH MOUSE; MACROPHAGE ACTIVATION; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; SECRETION (PROCESS); WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL LINE; CELL SURVIVAL; ENDOTOXEMIA; GLYCYRRHIZIC ACID; HEME OXYGENASE-1; HMGB1 PROTEIN; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED ICR; NF-E2-RELATED FACTOR 2; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84925784464     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2015.03.014     Document Type: Article

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