The peroxisome proliferator-activated receptor γ agonist pioglitazone prevents NF-κB activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1/p300 pathway

Biochemical Pharmacology

Volumn 101, Issue , 2016, Pages 100-111

  Zhang, Jiong ^a,b   Zhang, Ying ^a   Xiao, Fang ^a   Liu, Yanyan ^a   Wang, Jin ^a   Gao, Hongyu ^a   Rong, Song ^c   Yao, Ying ^a   Li, Junhua ^a   Xu, Gang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY OF ELECTRONIC SCIENCE AND TECHNOLOGY OF CHINA   (China)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Acute kidney injury; Cisplatin; NF B p65 acetylation; PPAR

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; ADENYLATE KINASE; BETA ACTIN; CD36 ANTIGEN; CISPLATIN; CREATININE; E1A ASSOCIATED P300 PROTEIN; I KAPPA B ALPHA; I KAPPA B BETA; I KAPPA B KINASE EPSILON; I KAPPA B KINASE GAMMA; INTERLEUKIN 1BETA; INTERLEUKIN 6; KIDNEY INJURY MOLECULE 1; MESSENGER RNA; MYELOPEROXIDASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; SIRTUIN 1; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTINEOPLASTIC AGENT; EP300 PROTEIN, MOUSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTECTIVE AGENT; RELA PROTEIN, MOUSE; SIRT1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CYTOPLASM; DEACETYLATION; DOWN REGULATION; ENZYME ACTIVATION; GENE TARGETING; KIDNEY FUNCTION; KIDNEY INJURY; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN ACETYLATION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RENAL PROTECTION; REPERFUSION INJURY; UREA NITROGEN BLOOD LEVEL; ACETYLATION; ACUTE KIDNEY INJURY; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICALLY INDUCED; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; KIDNEY; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS;

ACETYLATION; ACUTE KIDNEY INJURY; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTINEOPLASTIC AGENTS; CISPLATIN; DOSE-RESPONSE RELATIONSHIP, DRUG; E1A-ASSOCIATED P300 PROTEIN; GENE EXPRESSION REGULATION; KIDNEY; MALE; MICE, INBRED C57BL; PHOSPHORYLATION; PPAR GAMMA; PROTECTIVE AGENTS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SIRTUIN 1; SURVIVAL ANALYSIS; THIAZOLIDINEDIONES; TRANSCRIPTION FACTOR RELA;

EID: 84957440070     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.11.027     Document Type: Article

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