Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals

Biochemical Pharmacology

Volumn 95, Issue 4, 2015, Pages 279-289

  Kim, So Ra ^a   Ha, Yu Mi ^b   Kim, Young Min ^a   Park, Eun Jung ^a   Kim, Jung Whan ^a   Park, Sang Won ^a   Kim, Hye Jung ^a   Chung, Hun Taeg ^c   Chang, Ki Churl ^a  

^a Gyeongsang National University School of Medicine   (South Korea)

^b Dong A University College of Medicine   (South Korea)

^c University of Ulsan   (South Korea)

Author keywords

Heme oxygenase; HMGB1; Nrf 2; Phosphatidylinositol 3 kinase; Sepsis

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ASCORBIC ACID; CYSTEINE; HEME OXYGENASE 1; HIGH MOBILITY GROUP B1 PROTEIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LIPOPOLYSACCHARIDE; OXYHEMOGLOBIN; SERINE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; CARBON MONOXIDE; HMGB1 PROTEIN, MOUSE; HMOX1 PROTEIN, MOUSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEMBRANE PROTEIN; NFE2L2 PROTEIN, MOUSE; ORGANOMETALLIC COMPOUND; PHOSPHATIDYLINOSITOL 3 KINASE; TRICARBONYLDICHLORORUTHENIUM (II) DIMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; LIVER INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SEPSIS; SIGNAL TRANSDUCTION; SURVIVAL RATE; ACTIVE TRANSPORT; ANIMAL; CELL NUCLEUS; CHLOROCEBUS AETHIOPS; DRUG EFFECTS; INSTITUTE FOR CANCER RESEARCH MOUSE; LIVER; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; METABOLISM; MORTALITY; PATHOLOGY; PATHOPHYSIOLOGY; SECRETION (PROCESS);

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ASCORBIC ACID; CARBON MONOXIDE; CELL LINE; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; ENZYME ACTIVATION; HEME OXYGENASE-1; HMGB1 PROTEIN; LIPOPOLYSACCHARIDES; LIVER; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MEMBRANE PROTEINS; MICE, INBRED ICR; NF-E2-RELATED FACTOR 2; NF-KAPPA B; ORGANOMETALLIC COMPOUNDS; PHOSPHATIDYLINOSITOL 3-KINASES; SEPSIS;

EID: 84929708263     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.04.007     Document Type: Article

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