DNA-encoded chemistry: Enabling the deeper sampling of chemical space

Nature Reviews Drug Discovery

Volumn 16, Issue 2, 2017, Pages 131-147

  Goodnow, Robert A ^a,b   Dumelin, Christoph E ^c   Keefe, Anthony D ^d  

^a ASTRAZENECA   (United Kingdom)

^b PHARMARON   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

^d X Chem Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECANASE 1; BRUTON TYROSINE KINASE INHIBITOR; DIPEPTIDE; DNA; EPOXIDE HYDROLASE; HEPTAPEPTIDE; HYDROLASE INHIBITOR; INSULINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NONSTRUCTURAL PROTEIN 4B; OLIGODEOXYNUCLEOTIDE; OROSOMUCOID; X LINKED INHIBITOR OF APOPTOSIS; MOLECULAR LIBRARY;

BACTERICIDAL ACTIVITY; COMBINATORIAL CHEMISTRY; DIRECTED MOLECULAR EVOLUTION; DNA ENCODED CHEMISTRY; DNA LIBRARY; DRUG RESEARCH; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; GENETIC ENGINEERING AND GENE TECHNOLOGY; HEPATITIS C VIRUS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN RESPIRATORY SYNCYTIAL VIRUS; IC50; NONHUMAN; PEPTIDE SYNTHESIS; REVIEW; ANIMAL; CHEMISTRY; DRUG DEVELOPMENT; GENE LIBRARY; GENETICS; MOLECULAR LIBRARY; TRENDS;

ANIMALS; CHEMISTRY; DNA; DRUG DISCOVERY; GENOMIC LIBRARY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; SMALL MOLECULE LIBRARIES;

EID: 85001785633     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd.2016.213     Document Type: Review

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