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Volumn 59, Issue 14, 2016, Pages 6629-6644

Chemical space of DNA-encoded libraries: Miniperspective

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DNA; EPOXIDE HYDROLASE; LIGAND; NICOTINAMIDE ADENINE DINUCLEOTIDE; PHOSPHATASE; PHOSPHOTRANSFERASE; PROTEINASE; MOLECULAR LIBRARY; PROTEIN;

EID: 84979943840     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01874     Document Type: Review
Times cited : (225)

References (100)
  • 2
    • 84923008655 scopus 로고    scopus 로고
    • Selection-based discovery of macrocyclic peptides for the next generation therapeutics
    • Morioka, T.; Loik, N. D.; Hipolito, C. J.; Goto, Y.; Suga, H. Selection-based discovery of macrocyclic peptides for the next generation therapeutics Curr. Opin. Chem. Biol. 2015, 26, 34-41 10.1016/j.cbpa.2015.01.023
    • (2015) Curr. Opin. Chem. Biol. , vol.26 , pp. 34-41
    • Morioka, T.1    Loik, N.D.2    Hipolito, C.J.3    Goto, Y.4    Suga, H.5
  • 3
    • 84892169155 scopus 로고    scopus 로고
    • Directed evolution of bicyclic peptides for therapeutic application
    • Diderich, P.; Heinis, C. Directed evolution of bicyclic peptides for therapeutic application Chimia 2013, 67, 910-915 10.2533/chimia.2013.910
    • (2013) Chimia , vol.67 , pp. 910-915
    • Diderich, P.1    Heinis, C.2
  • 4
    • 84856189292 scopus 로고    scopus 로고
    • Bacteriophages and viruses as a support for organic synthesis and combinatorial chemistry
    • Ng, S.; Jafari, M. R.; Derda, R. Bacteriophages and viruses as a support for organic synthesis and combinatorial chemistry ACS Chem. Biol. 2012, 7, 123-138 10.1021/cb200342h
    • (2012) ACS Chem. Biol. , vol.7 , pp. 123-138
    • Ng, S.1    Jafari, M.R.2    Derda, R.3
  • 5
    • 84898913565 scopus 로고    scopus 로고
    • DNA-encoded chemical libraries: Advancing beyond conventional small-molecule libraries
    • Franzini, R. M.; Neri, D.; Scheuermann, J. DNA-encoded chemical libraries: advancing beyond conventional small-molecule libraries Acc. Chem. Res. 2014, 47, 1247-1255 10.1021/ar400284t
    • (2014) Acc. Chem. Res. , vol.47 , pp. 1247-1255
    • Franzini, R.M.1    Neri, D.2    Scheuermann, J.3
  • 8
    • 4644350506 scopus 로고    scopus 로고
    • DNA-templated organic synthesis and selection of a library of macrocycles
    • Gartner, Z. J.; Tse, B. N.; Grubina, R.; Doyon, J. B.; Snyder, T. M.; Liu, D. R. DNA-templated organic synthesis and selection of a library of macrocycles Science 2004, 305, 1601-1605 10.1126/science.1102629
    • (2004) Science , vol.305 , pp. 1601-1605
    • Gartner, Z.J.1    Tse, B.N.2    Grubina, R.3    Doyon, J.B.4    Snyder, T.M.5    Liu, D.R.6
  • 9
    • 84889241150 scopus 로고    scopus 로고
    • Multistep DNA-templated synthesis using a universal template
    • Li, Y.; Zhao, P.; Zhang, M.; Zhao, X.; Li, X. Multistep DNA-templated synthesis using a universal template J. Am. Chem. Soc. 2013, 135, 17727-17730 10.1021/ja409936r
    • (2013) J. Am. Chem. Soc. , vol.135 , pp. 17727-17730
    • Li, Y.1    Zhao, P.2    Zhang, M.3    Zhao, X.4    Li, X.5
  • 10
    • 77955792293 scopus 로고    scopus 로고
    • In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitors
    • Kleiner, R. E.; Dumelin, C. E.; Tiu, G. C.; Sakurai, K.; Liu, D. R. In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitors J. Am. Chem. Soc. 2010, 132, 11779-11791 10.1021/ja104903x
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 11779-11791
    • Kleiner, R.E.1    Dumelin, C.E.2    Tiu, G.C.3    Sakurai, K.4    Liu, D.R.5
  • 11
  • 12
    • 84859065691 scopus 로고    scopus 로고
    • Mesofluidic devices for DNA-programmed combinatorial chemistry
    • Weisinger, R. M.; Marinelli, R. J.; Wrenn, S. J.; Harbury, P. B. Mesofluidic devices for DNA-programmed combinatorial chemistry PLoS One 2012, 7, e32299 10.1371/journal.pone.0032299
    • (2012) PLoS One , vol.7 , pp. e32299
    • Weisinger, R.M.1    Marinelli, R.J.2    Wrenn, S.J.3    Harbury, P.B.4
  • 13
    • 84859048365 scopus 로고    scopus 로고
    • Highly parallel translation of DNA sequences into small molecules
    • Weisinger, R. M.; Wrenn, S. J.; Harbury, P. B. Highly parallel translation of DNA sequences into small molecules PLoS One 2012, 7, e28056 10.1371/journal.pone.0028056
    • (2012) PLoS One , vol.7 , pp. e28056
    • Weisinger, R.M.1    Wrenn, S.J.2    Harbury, P.B.3
  • 14
    • 84906545678 scopus 로고    scopus 로고
    • A DNA-templated synthesis of encoded small molecules by DNA self-assembly
    • Cao, C.; Zhao, P.; Li, Z.; Chen, Z.; Huang, Y.; Bai, Y.; Li, X. A DNA-templated synthesis of encoded small molecules by DNA self-assembly Chem. Commun. 2014, 50, 10997-10999 10.1039/C4CC03380A
    • (2014) Chem. Commun. , vol.50 , pp. 10997-10999
    • Cao, C.1    Zhao, P.2    Li, Z.3    Chen, Z.4    Huang, Y.5    Bai, Y.6    Li, X.7
  • 17
    • 79955615249 scopus 로고    scopus 로고
    • DNA-templated combinatorial assembly of small molecule fragments amenable to selection/amplification cycles
    • Daguer, J. P.; Ciobanu, M.; Alvarez, S.; Barluenga, S.; Winssinger, N. DNA-templated combinatorial assembly of small molecule fragments amenable to selection/amplification cycles Chem. Sci. 2011, 2, 625-632 10.1039/c0sc00574f
    • (2011) Chem. Sci. , vol.2 , pp. 625-632
    • Daguer, J.P.1    Ciobanu, M.2    Alvarez, S.3    Barluenga, S.4    Winssinger, N.5
  • 20
    • 84941567929 scopus 로고    scopus 로고
    • DNA-encoded solid-phase synthesis: Encoding language design and complex oligomer library synthesis
    • MacConnell, A. B.; McEnaney, P. J.; Cavett, V. J.; Paegel, B. M. DNA-encoded solid-phase synthesis: encoding language design and complex oligomer library synthesis ACS Comb. Sci. 2015, 17, 518-534 10.1021/acscombsci.5b00106
    • (2015) ACS Comb. Sci. , vol.17 , pp. 518-534
    • MacConnell, A.B.1    McEnaney, P.J.2    Cavett, V.J.3    Paegel, B.M.4
  • 21
    • 84921977258 scopus 로고    scopus 로고
    • Universal strategies for the DNA-encoding of libraries of small molecules using the chemical ligation of oligonucleotide tags
    • Litovchick, A.; Clark, M. A.; Keefe, A. D. Universal strategies for the DNA-encoding of libraries of small molecules using the chemical ligation of oligonucleotide tags Artif. DNA PNA XNA 2014, 5, e27896 10.4161/adna.27896
    • (2014) Artif. DNA PNA XNA , vol.5 , pp. e27896
    • Litovchick, A.1    Clark, M.A.2    Keefe, A.D.3
  • 23
    • 84915746858 scopus 로고    scopus 로고
    • DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules
    • Daguer, J. P.; Zambaldo, C.; Ciobanu, M.; Morieux, P.; Barluenga, S.; Winssinger, N. DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules Chem. Sci. 2015, 6, 739-744 10.1039/C4SC01654H
    • (2015) Chem. Sci. , vol.6 , pp. 739-744
    • Daguer, J.P.1    Zambaldo, C.2    Ciobanu, M.3    Morieux, P.4    Barluenga, S.5    Winssinger, N.6
  • 24
    • 79959797557 scopus 로고    scopus 로고
    • Encoded peptide libraries and the discovery of new cell binding ligands
    • Svensen, N.; Diaz-Mochon, J. J.; Bradley, M. Encoded peptide libraries and the discovery of new cell binding ligands Chem. Commun. 2011, 47, 7638-7640 10.1039/c1cc11668a
    • (2011) Chem. Commun. , vol.47 , pp. 7638-7640
    • Svensen, N.1    Diaz-Mochon, J.J.2    Bradley, M.3
  • 25
    • 80055067217 scopus 로고    scopus 로고
    • Decoding a PNA encoded peptide library by PCR: The discovery of new cell surface receptor ligands
    • Svensen, N.; Diaz-Mochon, J. J.; Bradley, M. Decoding a PNA encoded peptide library by PCR: the discovery of new cell surface receptor ligands Chem. Biol. 2011, 18, 1284-1289 10.1016/j.chembiol.2011.07.017
    • (2011) Chem. Biol. , vol.18 , pp. 1284-1289
    • Svensen, N.1    Diaz-Mochon, J.J.2    Bradley, M.3
  • 26
    • 84929590844 scopus 로고    scopus 로고
    • PNA as a biosupramolecular tag for programmable assemblies and reactions
    • Barluenga, S.; Winssinger, N. PNA as a biosupramolecular tag for programmable assemblies and reactions Acc. Chem. Res. 2015, 48, 1319-1331 10.1021/acs.accounts.5b00109
    • (2015) Acc. Chem. Res. , vol.48 , pp. 1319-1331
    • Barluenga, S.1    Winssinger, N.2
  • 28
    • 84923301851 scopus 로고    scopus 로고
    • Selection of DNA-encoded small molecule libraries against unmodified and non-immobilized protein targets
    • Zhao, P.; Chen, Z.; Li, Y.; Sun, D.; Gao, Y.; Huang, Y.; Li, X. Selection of DNA-encoded small molecule libraries against unmodified and non-immobilized protein targets Angew. Chem., Int. Ed. 2014, 53, 10056-10059 10.1002/anie.201404830
    • (2014) Angew. Chem., Int. Ed. , vol.53 , pp. 10056-10059
    • Zhao, P.1    Chen, Z.2    Li, Y.3    Sun, D.4    Gao, Y.5    Huang, Y.6    Li, X.7
  • 31
    • 84934956240 scopus 로고    scopus 로고
    • DNA-encoded dynamic combinatorial chemical libraries
    • Reddavide, F. V.; Lin, W.; Lehnert, S.; Zhang, Y. DNA-encoded dynamic combinatorial chemical libraries Angew. Chem., Int. Ed. 2015, 54, 7924-7928 10.1002/anie.201501775
    • (2015) Angew. Chem., Int. Ed. , vol.54 , pp. 7924-7928
    • Reddavide, F.V.1    Lin, W.2    Lehnert, S.3    Zhang, Y.4
  • 32
    • 84946565890 scopus 로고    scopus 로고
    • Design, preparation, and selection of DNA-encoded dynamic libraries
    • Li, G.; Zheng, W.; Chen, Z.; Zhou, Y.; Liu, Y.; Yang, J.; Huang, Y.; Li, X. Design, preparation, and selection of DNA-encoded dynamic libraries Chem. Sci. 2015, 6, 7097-7104 10.1039/C5SC02467F
    • (2015) Chem. Sci. , vol.6 , pp. 7097-7104
    • Li, G.1    Zheng, W.2    Chen, Z.3    Zhou, Y.4    Liu, Y.5    Yang, J.6    Huang, Y.7    Li, X.8
  • 33
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski, C. A.; Lombardo, F.; Dominy, B. W.; Feeney, P. J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv. Drug Delivery Rev. 2001, 46, 3-26 10.1016/S0169-409X(00)00129-0
    • (2001) Adv. Drug Delivery Rev. , vol.46 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 34
    • 0037030653 scopus 로고    scopus 로고
    • Molecular properties that influence the oral bioavailability of drug candidates
    • Veber, D. F.; Johnson, S. R.; Cheng, H. Y.; Smith, B. R.; Ward, K. W.; Kopple, K. D. Molecular properties that influence the oral bioavailability of drug candidates J. Med. Chem. 2002, 45, 2615-2623 10.1021/jm020017n
    • (2002) J. Med. Chem. , vol.45 , pp. 2615-2623
    • Veber, D.F.1    Johnson, S.R.2    Cheng, H.Y.3    Smith, B.R.4    Ward, K.W.5    Kopple, K.D.6
  • 35
    • 84921647505 scopus 로고    scopus 로고
    • Novel encoding methods for DNA-templated chemical libraries
    • Li, G.; Zheng, W.; Liu, Y.; Li, X. Novel encoding methods for DNA-templated chemical libraries Curr. Opin. Chem. Biol. 2015, 26, 25-33 10.1016/j.cbpa.2015.01.004
    • (2015) Curr. Opin. Chem. Biol. , vol.26 , pp. 25-33
    • Li, G.1    Zheng, W.2    Liu, Y.3    Li, X.4
  • 36
    • 84923101590 scopus 로고    scopus 로고
    • DNA-encoded chemical libraries of macrocycles
    • Connors, W. H.; Hale, S. P.; Terrett, N. K. DNA-encoded chemical libraries of macrocycles Curr. Opin. Chem. Biol. 2015, 26, 42-47 10.1016/j.cbpa.2015.02.004
    • (2015) Curr. Opin. Chem. Biol. , vol.26 , pp. 42-47
    • Connors, W.H.1    Hale, S.P.2    Terrett, N.K.3
  • 37
    • 84923269246 scopus 로고    scopus 로고
    • Novel selection methods for DNA-encoded chemical libraries
    • Chan, A. I.; McGregor, L. M.; Liu, D. R. Novel selection methods for DNA-encoded chemical libraries Curr. Opin. Chem. Biol. 2015, 26, 55-61 10.1016/j.cbpa.2015.02.010
    • (2015) Curr. Opin. Chem. Biol. , vol.26 , pp. 55-61
    • Chan, A.I.1    McGregor, L.M.2    Liu, D.R.3
  • 38
    • 84923333701 scopus 로고    scopus 로고
    • Fidelity by design: Yoctoreactor and binder trap enrichment for small-molecule DNA-encoded libraries and drug discovery
    • Blakskjaer, P.; Heitner, T.; Hansen, N. J. Fidelity by design: Yoctoreactor and binder trap enrichment for small-molecule DNA-encoded libraries and drug discovery Curr. Opin. Chem. Biol. 2015, 26, 62-71 10.1016/j.cbpa.2015.02.003
    • (2015) Curr. Opin. Chem. Biol. , vol.26 , pp. 62-71
    • Blakskjaer, P.1    Heitner, T.2    Hansen, N.J.3
  • 39
    • 84924270639 scopus 로고    scopus 로고
    • Chemical ligation methods for the tagging of DNA-encoded chemical libraries
    • Keefe, A. D.; Clark, M. A.; Hupp, C. D.; Litovchick, A.; Zhang, Y. Chemical ligation methods for the tagging of DNA-encoded chemical libraries Curr. Opin. Chem. Biol. 2015, 26, 80-88 10.1016/j.cbpa.2015.02.015
    • (2015) Curr. Opin. Chem. Biol. , vol.26 , pp. 80-88
    • Keefe, A.D.1    Clark, M.A.2    Hupp, C.D.3    Litovchick, A.4    Zhang, Y.5
  • 41
    • 4444278259 scopus 로고    scopus 로고
    • Drug Industry's Big Push into Technology Falls Short
    • Dow Jones & Company: New York, Feb 24.
    • Landers, P. Drug Industry's Big Push Into Technology Falls Short. The Wall Street Journal; Dow Jones & Company: New York, Feb 24, 2004.
    • (2004) The Wall Street Journal
    • Landers, P.1
  • 42
    • 80052094845 scopus 로고    scopus 로고
    • The rise, fall and reinvention of combinatorial chemistry
    • Kodadek, T. The rise, fall and reinvention of combinatorial chemistry Chem. Commun. 2011, 47, 9757-9763 10.1039/c1cc12102b
    • (2011) Chem. Commun. , vol.47 , pp. 9757-9763
    • Kodadek, T.1
  • 43
    • 84874480639 scopus 로고    scopus 로고
    • Drugs in middle space
    • Terrett, N. K. Drugs in middle space MedChemComm 2013, 4, 474-475 10.1039/c2md90062a
    • (2013) MedChemComm , vol.4 , pp. 474-475
    • Terrett, N.K.1
  • 44
    • 56449110342 scopus 로고    scopus 로고
    • Translation of DNA into a library of 13,000 synthetic small-molecule macrocycles suitable for in vitro selection
    • Tse, B. N.; Snyder, T. M.; Shen, Y.; Liu, D. R. Translation of DNA into a library of 13,000 synthetic small-molecule macrocycles suitable for in vitro selection J. Am. Chem. Soc. 2008, 130, 15611-15626 10.1021/ja805649f
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 15611-15626
    • Tse, B.N.1    Snyder, T.M.2    Shen, Y.3    Liu, D.R.4
  • 46
    • 84962163302 scopus 로고    scopus 로고
    • How beyond rule of 5 drugs and clinical candidates bind to their targets
    • in press (DOI:).
    • Doak, B. C.; Zheng, J.; Dobritzsch, D.; Kihlberg, J. How beyond rule of 5 drugs and clinical candidates bind to their targets. J. Med. Chem. 2015, in press (DOI: 10.1021/acs.jmedchem.5b01286).
    • (2015) J. Med. Chem.
    • Doak, B.C.1    Zheng, J.2    Dobritzsch, D.3    Kihlberg, J.4
  • 47
    • 84944326739 scopus 로고    scopus 로고
    • Price-focused analysis of commercially available building blocks for combinatorial library synthesis
    • Kalliokoski, T. Price-focused analysis of commercially available building blocks for combinatorial library synthesis ACS Comb. Sci. 2015, 17, 600-607 10.1021/acscombsci.5b00063
    • (2015) ACS Comb. Sci. , vol.17 , pp. 600-607
    • Kalliokoski, T.1
  • 54
    • 55249121613 scopus 로고    scopus 로고
    • Design and synthesis of a novel DNA-encoded chemical library using Diels-Alder cycloadditions
    • Buller, F.; Mannocci, L.; Zhang, Y.; Dumelin, C. E.; Scheuermann, J.; Neri, D. Design and synthesis of a novel DNA-encoded chemical library using Diels-Alder cycloadditions Bioorg. Med. Chem. Lett. 2008, 18, 5926-5931 10.1016/j.bmcl.2008.07.038
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 5926-5931
    • Buller, F.1    Mannocci, L.2    Zhang, Y.3    Dumelin, C.E.4    Scheuermann, J.5    Neri, D.6
  • 60
    • 84928963032 scopus 로고    scopus 로고
    • Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins
    • Franzini, R. M.; Nauer, A.; Scheuermann, J.; Neri, D. Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins Chem. Commun. 2015, 51, 8014-8016 10.1039/C5CC01230A
    • (2015) Chem. Commun. , vol.51 , pp. 8014-8016
    • Franzini, R.M.1    Nauer, A.2    Scheuermann, J.3    Neri, D.4
  • 63
    • 84923182115 scopus 로고    scopus 로고
    • Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation
    • Wichert, M.; Krall, N.; Decurtins, W.; Franzini, R. M.; Pretto, F.; Schneider, P.; Neri, D.; Scheuermann, J. Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation Nat. Chem. 2015, 7, 241-249 10.1038/nchem.2158
    • (2015) Nat. Chem. , vol.7 , pp. 241-249
    • Wichert, M.1    Krall, N.2    Decurtins, W.3    Franzini, R.M.4    Pretto, F.5    Schneider, P.6    Neri, D.7    Scheuermann, J.8
  • 65
    • 84867095357 scopus 로고    scopus 로고
    • Expanding the scope of PNA-encoded synthesis (PES): Mtt-protected PNA fully orthogonal to Fmoc chemistry and a broad array of robust diversity-generating reactions
    • Chouikhi, D.; Ciobanu, M.; Zambaldo, C.; Duplan, V.; Barluenga, S.; Winssinger, N. Expanding the scope of PNA-encoded synthesis (PES): Mtt-protected PNA fully orthogonal to Fmoc chemistry and a broad array of robust diversity-generating reactions Chem.-Eur. J. 2012, 18, 12698-12704 10.1002/chem.201201337
    • (2012) Chem. - Eur. J. , vol.18 , pp. 12698-12704
    • Chouikhi, D.1    Ciobanu, M.2    Zambaldo, C.3    Duplan, V.4    Barluenga, S.5    Winssinger, N.6
  • 66
    • 0036263805 scopus 로고    scopus 로고
    • Expanding the reaction scope of DNA-templated synthesis
    • Gartner, Z. J.; Kanan, M. W.; Liu, D. R. Expanding the reaction scope of DNA-templated synthesis Angew. Chem., Int. Ed. 2002, 41, 1796-1800 10.1002/1521-3773(20020517)41:10<1796::AID-ANIE1796>3.0.CO;2-Z
    • (2002) Angew. Chem., Int. Ed. , vol.41 , pp. 1796-1800
    • Gartner, Z.J.1    Kanan, M.W.2    Liu, D.R.3
  • 67
    • 84906330932 scopus 로고    scopus 로고
    • Systematic evaluation and optimization of modification reactions of oligonucleotides with amines and carboxylic acids for the synthesis of DNA-encoded chemical libraries
    • Franzini, R. M.; Samain, F.; Abd Elrahman, M.; Mikutis, G.; Nauer, A.; Zimmermann, M.; Scheuermann, J.; Hall, J.; Neri, D. Systematic evaluation and optimization of modification reactions of oligonucleotides with amines and carboxylic acids for the synthesis of DNA-encoded chemical libraries Bioconjugate Chem. 2014, 25, 1453-1461 10.1021/bc500212n
    • (2014) Bioconjugate Chem. , vol.25 , pp. 1453-1461
    • Franzini, R.M.1    Samain, F.2    Abd Elrahman, M.3    Mikutis, G.4    Nauer, A.5    Zimmermann, M.6    Scheuermann, J.7    Hall, J.8    Neri, D.9
  • 69
    • 84921030628 scopus 로고    scopus 로고
    • Robust Suzuki-Miyaura cross-coupling on DNA-linked substrates
    • Ding, Y.; Clark, M. A. Robust Suzuki-Miyaura cross-coupling on DNA-linked substrates ACS Comb. Sci. 2015, 17, 1-4 10.1021/co5001037
    • (2015) ACS Comb. Sci. , vol.17 , pp. 1-4
    • Ding, Y.1    Clark, M.A.2
  • 71
    • 84857214344 scopus 로고    scopus 로고
    • Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries
    • Daguer, J. P.; Ciobanu, M.; Barluenga, S.; Winssinger, N. Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries Org. Biomol. Chem. 2012, 10, 1502-1505 10.1039/c2ob06880j
    • (2012) Org. Biomol. Chem. , vol.10 , pp. 1502-1505
    • Daguer, J.P.1    Ciobanu, M.2    Barluenga, S.3    Winssinger, N.4
  • 72
    • 33645471598 scopus 로고    scopus 로고
    • Selection of streptavidin binders from a DNA-encoded chemical library
    • Dumelin, C. E.; Scheuermann, J.; Melkko, S.; Neri, D. Selection of streptavidin binders from a DNA-encoded chemical library Bioconjugate Chem. 2006, 17, 366-370 10.1021/bc050282y
    • (2006) Bioconjugate Chem. , vol.17 , pp. 366-370
    • Dumelin, C.E.1    Scheuermann, J.2    Melkko, S.3    Neri, D.4
  • 73
    • 71149085396 scopus 로고    scopus 로고
    • Discovery of TNF inhibitors from a DNA-encoded chemical library based on Diels-Alder cycloaddition
    • Buller, F.; Zhang, Y.; Scheuermann, J.; Schafer, J.; Buhlmann, P.; Neri, D. Discovery of TNF inhibitors from a DNA-encoded chemical library based on Diels-Alder cycloaddition Chem. Biol. 2009, 16, 1075-1086 10.1016/j.chembiol.2009.09.011
    • (2009) Chem. Biol. , vol.16 , pp. 1075-1086
    • Buller, F.1    Zhang, Y.2    Scheuermann, J.3    Schafer, J.4    Buhlmann, P.5    Neri, D.6
  • 74
    • 0141726877 scopus 로고    scopus 로고
    • A "rule of three" for fragment-based lead discovery?
    • Congreve, M.; Carr, R.; Murray, C.; Jhoti, H. A "rule of three" for fragment-based lead discovery? Drug Discovery Today 2003, 8, 876-877 10.1016/S1359-6446(03)02831-9
    • (2003) Drug Discovery Today , vol.8 , pp. 876-877
    • Congreve, M.1    Carr, R.2    Murray, C.3    Jhoti, H.4
  • 75
    • 61649109015 scopus 로고    scopus 로고
    • The influence of lead discovery strategies on the properties of drug candidates
    • Keseru, G. M.; Makara, G. M. The influence of lead discovery strategies on the properties of drug candidates Nat. Rev. Drug Discovery 2009, 8, 203-212 10.1038/nrd2796
    • (2009) Nat. Rev. Drug Discovery , vol.8 , pp. 203-212
    • Keseru, G.M.1    Makara, G.M.2
  • 76
    • 84862777996 scopus 로고    scopus 로고
    • Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles
    • Georghiou, G.; Kleiner, R. E.; Pulkoski-Gross, M.; Liu, D. R.; Seeliger, M. A. Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles Nat. Chem. Biol. 2012, 8, 366-374 10.1038/nchembio.792
    • (2012) Nat. Chem. Biol. , vol.8 , pp. 366-374
    • Georghiou, G.1    Kleiner, R.E.2    Pulkoski-Gross, M.3    Liu, D.R.4    Seeliger, M.A.5
  • 84
    • 34347266173 scopus 로고    scopus 로고
    • Isolation of high-affinity trypsin inhibitors from a DNA-encoded chemical library
    • Melkko, S.; Zhang, Y.; Dumelin, C. E.; Scheuermann, J.; Neri, D. Isolation of high-affinity trypsin inhibitors from a DNA-encoded chemical library Angew. Chem., Int. Ed. 2007, 46, 4671-4674 10.1002/anie.200700654
    • (2007) Angew. Chem., Int. Ed. , vol.46 , pp. 4671-4674
    • Melkko, S.1    Zhang, Y.2    Dumelin, C.E.3    Scheuermann, J.4    Neri, D.5
  • 89
    • 37249004920 scopus 로고    scopus 로고
    • Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
    • Wells, J. A.; McClendon, C. L. Reaching for high-hanging fruit in drug discovery at protein-protein interfaces Nature 2007, 450, 1001-1009 10.1038/nature06526
    • (2007) Nature , vol.450 , pp. 1001-1009
    • Wells, J.A.1    McClendon, C.L.2
  • 90
    • 84866306870 scopus 로고    scopus 로고
    • A leap into the chemical space of protein-protein interaction inhibitors
    • Villoutreix, B. O.; Labbe, C. M.; Lagorce, D.; Laconde, G.; Sperandio, O. A leap into the chemical space of protein-protein interaction inhibitors Curr. Pharm. Des. 2012, 18, 4648-4667 10.2174/138161212802651571
    • (2012) Curr. Pharm. Des. , vol.18 , pp. 4648-4667
    • Villoutreix, B.O.1    Labbe, C.M.2    Lagorce, D.3    Laconde, G.4    Sperandio, O.5
  • 91
    • 0035324944 scopus 로고    scopus 로고
    • Molecular complexity and its impact on the probability of finding leads for drug discovery
    • Hann, M. M.; Leach, A. R.; Harper, G. Molecular complexity and its impact on the probability of finding leads for drug discovery J. Chem. Inf. Model. 2001, 41, 856-864 10.1021/ci000403i
    • (2001) J. Chem. Inf. Model. , vol.41 , pp. 856-864
    • Hann, M.M.1    Leach, A.R.2    Harper, G.3
  • 92
    • 46449115901 scopus 로고    scopus 로고
    • The exploration of macrocycles for drug discovery-an underexploited structural class
    • Driggers, E. M.; Hale, S. P.; Lee, J.; Terrett, N. K. The exploration of macrocycles for drug discovery-an underexploited structural class Nat. Rev. Drug Discovery 2008, 7, 608-624 10.1038/nrd2590
    • (2008) Nat. Rev. Drug Discovery , vol.7 , pp. 608-624
    • Driggers, E.M.1    Hale, S.P.2    Lee, J.3    Terrett, N.K.4
  • 94
    • 84944754852 scopus 로고    scopus 로고
    • DNA encoded library selections and insights Provided by computational simulations
    • Satz, A. L. DNA encoded library selections and insights Provided by computational simulations ACS Chem. Biol. 2015, 10, 2237-2245 10.1021/acschembio.5b00378
    • (2015) ACS Chem. Biol. , vol.10 , pp. 2237-2245
    • Satz, A.L.1
  • 95
    • 84953860830 scopus 로고    scopus 로고
    • "Cap-and-Catch" purification for enhancing the quality of libraries of DNA conjugates
    • Franzini, R. M.; Biendl, S.; Mikutis, G.; Samain, F.; Scheuermann, J.; Neri, D. "Cap-and-Catch" purification for enhancing the quality of libraries of DNA conjugates ACS Comb. Sci. 2015, 17, 393-398 10.1021/acscombsci.5b00072
    • (2015) ACS Comb. Sci. , vol.17 , pp. 393-398
    • Franzini, R.M.1    Biendl, S.2    Mikutis, G.3    Samain, F.4    Scheuermann, J.5    Neri, D.6
  • 96
    • 84873910351 scopus 로고    scopus 로고
    • Discovery of a class of novel tankyrase inhibitors that bind to both the nicotinamide pocket and the induced pocket
    • Bregman, H.; Gunaydin, H.; Gu, Y.; Schneider, S.; Wilson, C.; DiMauro, E. F.; Huang, X. Discovery of a class of novel tankyrase inhibitors that bind to both the nicotinamide pocket and the induced pocket J. Med. Chem. 2013, 56, 1341-1345 10.1021/jm301607v
    • (2013) J. Med. Chem. , vol.56 , pp. 1341-1345
    • Bregman, H.1    Gunaydin, H.2    Gu, Y.3    Schneider, S.4    Wilson, C.5    DiMauro, E.F.6    Huang, X.7
  • 99
    • 84876257495 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of a series of benzo[de][1,7]naphthyridin-7(8H)-ones bearing a functionalized longer chain appendage as novel PARP1 inhibitors
    • Ye, N.; Chen, C. H.; Chen, T.; Song, Z.; He, J. X.; Huan, X. J.; Song, S. S.; Liu, Q.; Chen, Y.; Ding, J.; Xu, Y.; Miao, Z. H.; Zhang, A. Design, synthesis, and biological evaluation of a series of benzo[de][1,7]naphthyridin-7(8H)-ones bearing a functionalized longer chain appendage as novel PARP1 inhibitors J. Med. Chem. 2013, 56, 2885-2903 10.1021/jm301825t
    • (2013) J. Med. Chem. , vol.56 , pp. 2885-2903
    • Ye, N.1    Chen, C.H.2    Chen, T.3    Song, Z.4    He, J.X.5    Huan, X.J.6    Song, S.S.7    Liu, Q.8    Chen, Y.9    Ding, J.10    Xu, Y.11    Miao, Z.H.12    Zhang, A.13
  • 100
    • 84969617464 scopus 로고    scopus 로고
    • Analysis of past and present synthetic methodologies on medicinal chemistry: Where have all the new reactions gone?
    • in press (DOI:).
    • Brown, D. G.; Bostrom, J. Analysis of past and present synthetic methodologies on medicinal chemistry: Where have all the new reactions gone? J. Med. Chem. 2015, in press (DOI: 10.1021/acs.jmedchem.5b01409).
    • (2015) J. Med. Chem.
    • Brown, D.G.1    Bostrom, J.2


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