Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor

ACS Combinatorial Science

Volumn 17, Issue 12, 2015, Pages 722-731

  Wu, Zining ^a   Graybill, Todd L ^a   Zeng, Xin ^a   Platchek, Michael ^a   Zhang, Jean ^a   Bodmer, Vera Q ^a   Wisnoski, David D ^a   Deng, Jianghe ^a   Coppo, Frank T ^a   Yao, Gang ^a   Tamburino, Alex ^a   Scavello, Genaro ^a   Franklin, G Joseph ^a   Mataruse, Sibongile ^a   Bedard, Katie L ^a   Ding, Yun ^a   Chai, Jing ^a   Summerfield, Jennifer ^a   Centrella, Paolo A ^a   Messer, Jeffrey A ^a   Pope, Andrew J ^a   Israel, David I ^a   more..

^a GLAXOSMITHKLINE   (United States)

Author keywords

affinity selection; cell associated target protein; combinatorial chemistry; DNA encoded chemical library; drug discovery; G protein coupled receptor

Indexed keywords

ACETIC ACID DERIVATIVE; DNA; LIGAND; MOLECULAR LIBRARY; N-(ALPHA-ETHYLBENZYL)-3-(CARBOXYMETHOXY)-2-PHENYLQUINOLINE-4-CARBOXAMIDE; NEUROKININ 3 RECEPTOR; QUINOLINE DERIVATIVE;

ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HEK293 CELL LINE; HUMAN; MOLECULAR LIBRARY; PHARMACOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACETATES; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; LIGANDS; MOLECULAR STRUCTURE; QUINOLINES; RECEPTORS, NEUROKININ-3; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84949975849     PISSN: 21568952     EISSN: None     Source Type: Journal    
DOI: 10.1021/acscombsci.5b00124     Document Type: Article

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