The time required for water attack at the phosphorus atom of simple phosphodiesters and of DNA

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 11, 2006, Pages 4052-4055

  Schroeder, Gottfried K ^a   Lad, Chetan ^b   Wyman, Paul ^b   Williams, Nicholas H ^b   Wolfenden, Richard ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

DNA hydrolysis; DNA stability; Nuclease; Phosphate ester; Rate enhancement

Indexed keywords

ALKALI; ANION; CARBON; DNA; ESTER DERIVATIVE; ORGANOPHOSPHATE; OXYGEN; PHOSPHODIESTERASE; PHOSPHORUS; POLYPHOSPHATE; POTASSIUM HYDROXIDE; THYMIDINE; THYMIDINE DERIVATIVE; WATER;

ARTICLE; CHEMICAL BOND; CHEMICAL REACTION; HYDROLYSIS; PRIORITY JOURNAL; TEMPERATURE SENSITIVITY;

BINDING SITES; DNA; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KINETICS; MICROCOCCAL NUCLEASE; MODELS, MOLECULAR; PHOSPHORIC ACID ESTERS; PHOSPHORUS; THERMODYNAMICS; WATER;

EID: 33645212804     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0510879103     Document Type: Article

References (23)

1. Bunton, C. A., Mhala, M. M., Oldham, K. G. & Vernon, C. A. (1960) J. Chem. Soc. 1960, 3293-3301.
2. Kumamoto, J., Cox, J. R., Jr., & Westheimer, F. H. (1956) J. Am. Chem. Soc. 78, 4858-4860.
3. Kirby, A. J. & Younas, M. (1970) J. Chem. Soc. B 1970, 510-513.
4. Wolfenden, R., Ridgway, C. & Young, G. (1998) J. Am. Chem. Soc. 120, 833-834.
5. Takeda, N., Shibata, M., Tajima, N., Hirao, K. & Komiyama, M. (2000) J. Org. Chem. 65, 4391-4396.
6. Williams, N. H. & Wyman, P. (2001) Chem. Commun. 2001, 1268-1269.
7. Serpersu, E., Shortle, D. & Mildvan, A. S. (1987) Biochemistry 26, 1289-1300.
8. Shapiro, R. & Kang, S. (1969) Biochemistry 8, 1806-1810.
9. Bunton, C. A., Llewellyn, D. R., Oldham, K. G. & Vernon, C. A. (1958) J. Chem. Soc. 1958, 3574-3587.
10. Lad, C., Williams, N. H. & Wolfenden, R. (2003) Proc. Natl. Acad. Sci. USA 100, 5607-5610.
11. Aksnes, G. & Bergesen, K. (1966) Acta Chem. Scand. 30, 2508-2514.
12. Barnard, P. W. C., Bunton, C. A., Llewellyn, D. R., Vernon, C. A. & Welch, V. A. (1961) J. Chem. Soc. 1961, 2670-2676.
13. Iché-Tarrat, N., Barthelat, J.-C., Rinaldi, D. & Vigroux, A. (2005) J. Chem. Phys. B 109, 22570-22580.
14. Oivanen, M., Kuusela, S. & Lönnberg, H. (1998) Chem. Rev. 98, 961-990.
15. Järvinen, P., Oivanen, M. & Lönnberg, H. (1991) J. Org. Chem. 56,5396-5401.
16. Radzicka, A. & Wolfenden, R. (1995) Science 267, 90-93.
17. Wolfenden, R., Lu, X. & Young, G. (1998) J. Am. Chem. Soc. 120, 6814-6815.
18. Snider, M. J. & Wolfenden, R. (2000) J. Am. Chem. Soc. 122, 833-834.
19. Wolfenden, R., Snider, M., Ridgway, C. & Miller, B. (1999) J. Am. Chem. Soc. 121, 7419-7420.
20. Kauzmann, W. (1959) Adv. Protein Chem. 14, 1-63.
21. Meot-Ner, M. (2005) Chem. Rev. 105, 213-284.
22. Cotton, F. A., Hazen, E. E., Jr., & Legg, M. J. (1979) Proc. Natl. Acad. Sci. USA 76, 2551-2555.
23. Edsall, J. T. & Wyman, J. (1958) Biophysical Chemistry (Academic, New York), Vol. 1, pp. 452-453.