An affinity selection-mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries: Discovery of a novel antagonist of E. coli dihydrofolate reductase

International Journal of Mass Spectrometry

Volumn 238, Issue 2, 2004, Pages 77-83

  Annis, D Allen ^a   Athanasopoulos, John ^a   Curran, Patrick J ^a   Felsch, Jason S ^a   Kalghatgi, Krishna ^a   Lee, William H ^a   Nash, Huw M ^a   Orminati, Jean Paul A ^a   Rosner, Kristin E ^a   Shipps Jr , Gerald W ^a   Thaddupathy, G R A ^b   Tyler, Andrew N ^a   Vilenchik, Lev ^a   Wagner, Carston R ^b   Wintner, Edward A ^a  

^a NeoGenesis Pharmaceuticals Inc   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Affinity selection mass spectrometry; Combinatorial chemistry; Multidimensional chromatography

Indexed keywords

BACTERIAL ENZYME; DIHYDROFOLATE REDUCTASE; ENZYME INHIBITOR;

ALGORITHM; ARTICLE; DRUG ACTIVITY; ELECTROSPRAY MASS SPECTROMETRY; ESCHERICHIA COLI; EXPERIMENT; GENETIC CODE; GENOME; ISOMERISM; LIBRARY; LIGAND BINDING; MASS SPECTROMETER; NONHUMAN; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTEIN TARGETING; REVERSED PHASE LIQUID CHROMATOGRAPHY; SCREENING; STEREOISOMERISM; STRUCTURE ANALYSIS; SYNTHESIS;

EID: 8444221197     PISSN: 13873806     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijms.2003.11.022     Document Type: Article

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