Isotope or mass encoding of combinatorial libraries

Chemistry and Biology

Volumn 3, Issue 8, 1996, Pages 679-688

  Geysen, H Mario ^a   Wagner, Craig D ^a   Bodnar, Wanda M ^a   Markworth, Christopher J ^a   Parke, Gillian J ^a   Schoenen, Frank J ^a   Wagner, David S ^a   Kinder, Daniel S ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

combinatorial chemistry; encoding; mass spectrometry; stable isotope

Indexed keywords

ISOTOPE; PEPTIDE LIBRARY;

ARTICLE; DRUG DESIGN; MASS SPECTROMETRY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC CHEMISTRY;

CHEMISTRY, ORGANIC; DRUG DESIGN; ISOTOPES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PEPTIDE LIBRARY;

EID: 80052130082     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1074-5521(96)90136-2     Document Type: Article

References (14)

1. Bunin, B.A. & Ellman, J.A. (1992). A general and expedient method for the solid-phase synthesis of 1,4-benzodiazepine derivatives. J. Am. Chem Soc. 114, 10997-10998.
2. Dewitt, S.H., Kiely, J.S., Stankovic, C.J., Schroeder, M.C., Cody, D.M.R. & Pavia, M.R. (1993). 'Diversomers': an approach to nonpeptide, nonoligomeric chemical diversity. Proc. Natl. Acad. Sci. USA 90, 6909-6913.
3. Geysen, H.M., Rodda, S.J. & Mason, T.J. (1986). A priori delineation of a peptide which mimics a discontinuous antigenic determinant. Immunology 23, 709-715.
4. Furka, A., Sebestyen, F., Asgedom, M. & Dibo, G. (1991). General method for rapid synthesis of multicomponent peptide mixtures. Int. J. Pept. Protein Res. 37, 487-493.
5. Nicolaou, K.C., Xiao, X.-Y., Parandoosh, Z., Senyei, A. & Nova, M.P. (1995) Radiofrequency encoded combinatorial chemistry. Angew. Chem. Intl. Ed Eng. 34, 2289-2291.
6. Nikolaiev, V., et al., & Lebl, M. (1993). Peptide encoding for structure determination of nonsequenceable polymers within libraries synthesized and tested on solid-phase supports. Peptide Res. 6, 161-170.
7. Nielsen, J., Brenner, S. & Janda, K.D. (1993) Synthetic methods for the implementation of encoded combinatorial chemistry. J. Am. Chem. Soc. 115, 9812-9813.
8. Brenner, S. & Lerner, R.A. (1992) Encoded combinatorial chemistry. Proc. Natl. Acad. Sci. USA 89, 5381-5383.
9. Nestler, P.H., Bartlett, RA. & Still, W.C. (1994) A general method for molecular tagging of encoded combinatorial chemistry libraries. J Org. Chem. 59, 4723-4724.
10. Ni, Z.-J., et al., & Gallop, MA (1996). Versatile approach to encoding combinatorial organic syntheses using chemically robust secondary amine tags. J. Med. Chem. 39, 1601-1608.
11. Stankova, M., Issakova, O., Sepetov, N.F., Krchnak, V., Lam, K.S. & Lebl, M. (1994) Application of one-bead one-structure approach to identification of nonpeptidic ligands. Drug Dev. Res. 33, 146-156.
12. Wagner, D.S., et al., & Watson, J.T. (1991). Derivatization of peptides to enhance ionization efficiency and control fragmentation during analysis by FAB-CAD-MS/MS. Biomed. Environ. Mass Spectrom. 20, 419-425.
13. 1H-NMR spectroscopy on the nanoliter scale for static and on-line measurements. Anal. Chem. 66, 3849-3857.
14. Sarkar, S.K., Garigipati, R.S., Adams, J.L. & Keifer, RA. (1996). An NMR method to identify nondestructively chemical compounds bound to a single solid-phase synthesis bead for combinatorial chemistry application. J. Am. Chem. Soc. 118, 2305-2306.