-
3
-
-
71149085396
-
Discovery of TNF inhibitors from a DNA-encoded chemical library based on diels-alder cycloaddition
-
F. Buller, Y. Zhang, J. Scheuermann, J. Schäfer, P. Bühlmann, and D. Neri Discovery of TNF inhibitors from a DNA-encoded chemical library based on diels-alder cycloaddition Chem. Biol. 16 2009 1075 1086
-
(2009)
Chem. Biol.
, vol.16
, pp. 1075-1086
-
-
Buller, F.1
Zhang, Y.2
Scheuermann, J.3
Schäfer, J.4
Bühlmann, P.5
Neri, D.6
-
4
-
-
69249218864
-
Design, synthesis and selection of DNA-encoded small-molecule libraries
-
M.A. Clark, R.A. Acharya, C.C. Arico-Muendel, S.L. Belyanskaya, D.R. Benjamin, N.R. Carlson, P.A. Centrella, C.H. Chiu, S.P. Creaser, and J.W. Cuozzo Design, synthesis and selection of DNA-encoded small-molecule libraries Nat. Chem. Biol. 5 2009 647 654
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 647-654
-
-
Clark, M.A.1
Acharya, R.A.2
Arico-Muendel, C.C.3
Belyanskaya, S.L.4
Benjamin, D.R.5
Carlson, N.R.6
Centrella, P.A.7
Chiu, C.H.8
Creaser, S.P.9
Cuozzo, J.W.10
-
5
-
-
67449093868
-
In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery
-
L. Coughlan, S. Vallath, A. Saha, M. Flak, I.A. McNeish, G. Vassaux, J.F. Marshall, I.R. Hart, and G.J. Thomas In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery J. Virol. 83 2009 6416 6428
-
(2009)
J. Virol.
, vol.83
, pp. 6416-6428
-
-
Coughlan, L.1
Vallath, S.2
Saha, A.3
Flak, M.4
McNeish, I.A.5
Vassaux, G.6
Marshall, J.F.7
Hart, I.R.8
Thomas, G.J.9
-
6
-
-
34249296349
-
Expanding the scope of PNA-encoded libraries: Divergent synthesis of libraries targeting cysteine, serine and metallo-proteases as well as tyrosine phosphatases
-
DOI 10.1016/j.tet.2007.03.033, PII S004040200700395X, Tetrahedron 50th Anniversary Symposium-in-Print (Part 3)
-
F. Debaene, J.A. Da Silva, Z. Pianowski, F.J. Duran, and N. Winssinger Expanding the scope of PNA-encoded libraries: divergent synthesis of libraries targeting cysteine, serine and metallo-proteases as well as tyrosine phosphatases Tetrahedron 63 2007 6577 6586 (Pubitemid 46817614)
-
(2007)
Tetrahedron
, vol.63
, Issue.28
, pp. 6577-6586
-
-
Debaene, F.1
Da Silva, J.A.2
Pianowski, Z.3
Duran, F.J.4
Winssinger, N.5
-
7
-
-
0028129843
-
Stability of peptide nucleic acids in human serum and cellular extracts
-
DOI 10.1016/0006-2952(94)90171-6
-
V.V. Demidov, V.N. Potaman, M.D. Frank-Kamenetskii, M. Egholm, O. Buchard, S.H. Sönnichsen, and P.E. Nielsen Stability of peptide nucleic acids in human serum and cellular extracts Biochem. Pharmacol. 48 1994 1310 1313 (Pubitemid 24298385)
-
(1994)
Biochemical Pharmacology
, vol.48
, Issue.6
, pp. 1310-1313
-
-
Demidov, V.V.1
Potaman, V.N.2
Frank-Kamenetskil, M.D.3
Egholm, M.4
Buchard, O.5
Sonnichsen, S.H.6
Nlelsen, P.E.7
-
8
-
-
33749076305
-
Dual colour, microarray-based, analysis of 10 000 protease substrates
-
DOI 10.1039/b609029j
-
J.J. Díaz-Mochón, L. Bialy, and M. Bradley Dual colour, microarray-based, analysis of 10,000 protease substrates Chem. Commun. (Camb.) 38 2006 3984 3986 (Pubitemid 44465554)
-
(2006)
Chemical Communications
, Issue.38
, pp. 3984-3986
-
-
Diaz-Mochon, J.J.1
Bialy, L.2
Bradley, M.3
-
9
-
-
16444372370
-
Combinatorial libraries - From solution to 2D microarrays
-
DOI 10.1039/b415847d
-
J.J. Díaz-Mochón, L. Bialy, L. Keinicke, and M. Bradley Combinatorial libraries - from solution to 2D microarrays Chem. Commun. (Camb.) 11 2005 1384 1386 (Pubitemid 40477563)
-
(2005)
Chemical Communications
, Issue.11
, pp. 1384-1386
-
-
Diaz-Mochon, J.J.1
Bialy, L.2
Keinicke, L.3
Bradley, M.4
-
10
-
-
33845890639
-
It's a GPCR world: Cell-based screening assays and structural studies are fueling G-protein coupled receptors as one of the most popular classes of investigational drug targets
-
D. Filmore It's a GPCR world: cell-based screening assays and structural studies are fueling G-protein coupled receptors as one of the most popular classes of investigational drug targets Mod. Drug Discov. 7 2004 24 28
-
(2004)
Mod. Drug Discov.
, vol.7
, pp. 24-28
-
-
Filmore, D.1
-
11
-
-
80055080143
-
-
June U.S. patent WO2007062664
-
Franch, T. Lundorf, M.D., Jacobsen, S.N., Olsen, E.K., Andersen, A.L., Holtmann, A., Hansen, A.H., Sorensen, A.M., Goldbech, A., de Leon, D., et al. June 2007. Enzymatic encoding methods for efficient synthesis of large libraries. U.S. patent WO2007062664.
-
(2007)
Enzymatic Encoding Methods for Efficient Synthesis of Large Libraries
-
-
Franch, T.1
Lundorf, M.D.2
Jacobsen, S.N.3
Olsen, E.K.4
Andersen, A.L.5
Holtmann, A.6
Hansen, A.H.7
Sorensen, A.M.8
Goldbech, A.9
De Leon, D.10
-
12
-
-
0031883487
-
1 arrest and protects from paclitaxel and topotecan: Implications for therapy
-
J. Fueyo, C. Gomez-Manzano, V.K. Puduvalli, P. Martin-Duque, R. Perez-Soler, V.A. Levin, W.K. Yung, and A.P. Kyritsis Adenovirus-mediated p16 transfer to glioma cells induces G1 arrest and protects from paclitaxel and topotecan: implications for therapy Int. J. Oncol. 12 1998 665 669 (Pubitemid 28097299)
-
(1998)
International Journal of Oncology
, vol.12
, Issue.3
, pp. 665-669
-
-
Fueyo, J.1
Gomez-Manzano, C.2
Puduvalli, V.K.3
Martin-Duque, P.4
Perez-Soler, R.5
Levin, V.A.6
Yung, W.K.A.7
Kyritsis, A.P.8
-
13
-
-
4644350506
-
DNA-templated organic synthesis and selection of a library of macrocycles
-
DOI 10.1126/science.1102629
-
Z.J. Gartner, B.N. Tse, R. Grubina, J.B. Doyon, T.M. Snyder, and D.R. Liu DNA-templated organic synthesis and selection of a library of macrocycles Science 305 2004 1601 1605 (Pubitemid 39296351)
-
(2004)
Science
, vol.305
, Issue.5690
, pp. 1601-1605
-
-
Gartner, Z.J.1
Tse, B.N.2
Grubina, R.3
Doyon, J.B.4
Snyder, T.M.5
Liu, D.R.6
-
14
-
-
0030020689
-
Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis
-
C. Gomez-Manzano, J. Fueyo, A.P. Kyritsis, P.A. Steck, J.A. Roth, T.J. McDonnell, K.D. Steck, V.A. Levin, and W.K. Yung Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis Cancer Res. 56 1996 694 699 (Pubitemid 26055454)
-
(1996)
Cancer Research
, vol.56
, Issue.4
, pp. 694-699
-
-
Gomez-Manzano, C.1
Fueyo, J.2
Kyritsis, A.P.3
Steck, P.A.4
Roth, J.A.5
McDonnell, T.J.6
Steck, K.D.7
Levin, V.A.8
Yung, W.K.A.9
-
15
-
-
27944500629
-
PNA encoding (PNA = peptide nucleic acid): From solution-based libraries to organized microarrays
-
DOI 10.1002/chem.200500305
-
J.L. Harris, and N. Winssinger PNA encoding (PNA=peptide nucleic acid): from solution-based libraries to organized microarrays Chemistry 11 2005 6792 6801 (Pubitemid 41682320)
-
(2005)
Chemistry - A European Journal
, vol.11
, Issue.23
, pp. 6792-6801
-
-
Harris, J.L.1
Winssinger, N.2
-
16
-
-
33947379232
-
Impact of GPCRs in clinical medicine: Monogenic diseases, genetic variants and drug targets
-
DOI 10.1016/j.bbamem.2006.09.029, PII S0005273606003865
-
P.A. Insel, C.-M. Tang, I. Hahntow, and M.C. Michel Impact of GPCRs in clinical medicine: monogenic diseases, genetic variants and drug targets Biochim. Biophys. Acta 1768 2007 994 1005 (Pubitemid 46452544)
-
(2007)
Biochimica et Biophysica Acta - Biomembranes
, vol.1768
, Issue.4
, pp. 994-1005
-
-
Insel, P.A.1
Tang, C.-M.2
Hahntow, I.3
Michel, M.C.4
-
17
-
-
0033563736
-
Identification of metastasis-promoting sequences in the mouse laminin α1 chain
-
DOI 10.1006/excr.1999.4497
-
Y. Kuratomi, M. Nomizu, P.K. Nielsen, K. Tanaka, S.-Y. Song, H.K. Kleinman, and Y. Yamada Identification of metastasis-promoting sequences in the mouse laminin alpha 1 chain Exp. Cell Res. 249 1999 386 395 (Pubitemid 29397946)
-
(1999)
Experimental Cell Research
, vol.249
, Issue.2
, pp. 386-395
-
-
Kuratomi, Y.1
Nomizu, M.2
Nielsen, P.K.3
Tanaka, K.4
Song, S.-Y.5
Kleinman, H.K.6
Yamada, Y.7
-
18
-
-
2342505768
-
Encoded self-assembling chemical libraries
-
DOI 10.1038/nbt961
-
S. Melkko, J. Scheuermann, C.E. Dumelin, and D. Neri Encoded self-assembling chemical libraries Nat. Biotechnol. 22 2004 568 574 (Pubitemid 38585909)
-
(2004)
Nature Biotechnology
, vol.22
, Issue.5
, pp. 568-574
-
-
Melkko, S.1
Scheuermann, J.2
Dumelin, C.E.3
Neri, D.4
-
19
-
-
0034283972
-
3 (The vitronectin receptor)
-
DOI 10.1016/S1359-6446(00)01545-2, PII S1359644600015452
-
W.H. Miller, R.M. Keenan, R.N. Willette, and M.W. Lark Identification and in vivo efficacy of small-molecule antagonists of integrin alphavbeta3 (the vitronectin receptor) Drug Discov. Today 5 2000 397 408 (Pubitemid 30645736)
-
(2000)
Drug Discovery Today
, vol.5
, Issue.9
, pp. 397-408
-
-
Miller, W.H.1
Keenan, R.M.2
Willette, R.N.3
Lark, M.W.4
-
20
-
-
80055079319
-
-
June U.S. patent WO2005058479
-
Morgan, B., Hale, S., Arico-Muendel, C.C., Clark, M., Wagner, R., Kavarana, M.J., Creaser, S.P., Franklin, G.J., Centrella, P.A., Israel, D., et al. June 2005. Methods for synthesis of encoded libraries. U.S. patent WO2005058479.
-
(2005)
Methods for Synthesis of Encoded Libraries
-
-
Morgan, B.1
Hale, S.2
Arico-Muendel, C.C.3
Clark, M.4
Wagner, R.5
Kavarana, M.J.6
Creaser, S.P.7
Franklin, G.J.8
Centrella, P.A.9
Israel, D.10
-
21
-
-
0021061819
-
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
-
T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J. Immunol. Methods 65 1983 55 63 (Pubitemid 14203433)
-
(1983)
Journal of Immunological Methods
, vol.65
, Issue.1-2
, pp. 55-63
-
-
Mosmann, T.1
-
22
-
-
0027375520
-
Generation and screening of an oligonucleotide-encoded synthetic peptide library
-
DOI 10.1073/pnas.90.22.10700
-
M.C. Needels, D.G. Jones, E.H. Tate, G.L. Heinkel, L.M. Kochersperger, W.J. Dower, R.W. Barrett, and M.A. Gallop Generation and screening of an oligonucleotide-encoded synthetic peptide library Proc. Natl. Acad. Sci. USA 90 1993 10700 10704 (Pubitemid 23347110)
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, Issue.22
, pp. 10700-10704
-
-
Needels, M.C.1
Jones, D.G.2
Tate, E.H.3
Heinkel, G.L.4
Kochersperger, L.M.5
Dower, W.J.6
Barrett, R.W.7
Gallop, M.A.8
-
24
-
-
84989568285
-
Synthetic methods for the implementation of encoded combinatorial chemistry
-
J. Nielsen, S. Brenner, and K.D. Janda Synthetic methods for the implementation of encoded combinatorial chemistry J. Am. Chem. Soc. 115 1993 9812 9813
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 9812-9813
-
-
Nielsen, J.1
Brenner, S.2
Janda, K.D.3
-
25
-
-
33750311712
-
DNA-encoded chemical libraries
-
DOI 10.1016/j.jbiotec.2006.05.018, PII S016816560600472X
-
J. Scheuermann, C.E. Dumelin, S. Melkko, and D. Neri DNA-encoded chemical libraries J. Biotechnol. 126 2006 568 581 (Pubitemid 44634823)
-
(2006)
Journal of Biotechnology
, vol.126
, Issue.4
, pp. 568-581
-
-
Scheuermann, J.1
Dumelin, C.E.2
Melkko, S.3
Neri, D.4
-
26
-
-
45749139234
-
Nucleic acid encoding to program self-assembly in chemical biology
-
Z.L. Pianowski, and N. Winssinger Nucleic acid encoding to program self-assembly in chemical biology Chem. Soc. Rev. 37 2008 1330 1336
-
(2008)
Chem. Soc. Rev.
, vol.37
, pp. 1330-1336
-
-
Pianowski, Z.L.1
Winssinger, N.2
-
27
-
-
38649143228
-
A 10,000 member PNA-encoded peptide library for profiling tyrosine kinases
-
DOI 10.1021/cb700199k
-
D. Pouchain, J.J. Díaz-Mochón, L. Bialy, and M. Bradley A 10,000 member PNA-encoded peptide library for profiling tyrosine kinases ACS Chem. Biol. 2 2007 810 818 (Pubitemid 351166056)
-
(2007)
ACS Chemical Biology
, vol.2
, Issue.12
, pp. 810-818
-
-
Pouchain, D.1
Diaz-Mochon, J.J.2
Bialy, L.3
Bradley, M.4
-
28
-
-
52949093096
-
Microwave-assisted orthogonal synthesis of PNA-peptide conjugates
-
N. Svensen, J.J. Díaz-Mochón, and M. Bradley Microwave-assisted orthogonal synthesis of PNA-peptide conjugates Tetrahedron Lett. 49 2008 6498 6500
-
(2008)
Tetrahedron Lett.
, vol.49
, pp. 6498-6500
-
-
Svensen, N.1
Díaz-Mochón, J.J.2
Bradley, M.3
-
29
-
-
79959797557
-
Encoded peptide libraries and the discovery of new cell binding ligands
-
N. Svensen, J.J. Díaz-Mochón, and M. Bradley Encoded peptide libraries and the discovery of new cell binding ligands Chem. Commun. (Camb.) 47 2011 7638 7640
-
(2011)
Chem. Commun. (Camb.)
, vol.47
, pp. 7638-7640
-
-
Svensen, N.1
Díaz-Mochón, J.J.2
Bradley, M.3
-
30
-
-
80053122372
-
Microarray generation of thousand-member oligonucleotide libraries
-
10.1371/journal.pone.0024906 in press
-
N. Svensen, J.J. Díaz-Mochón, and M. Bradley Microarray generation of thousand-member oligonucleotide libraries PLoS One 2011 10.1371/journal.pone.0024906 in press
-
(2011)
PLoS One
-
-
Svensen, N.1
Díaz-Mochón, J.J.2
Bradley, M.3
-
31
-
-
79959517842
-
Screening of a combinatorial homing peptide library for selective cellular delivery
-
N. Svensen, J.J. Díaz-Mochón, K. Dhaliwal, S. Planonth, M. Dewar, J.D. Armstrong, and M. Bradley Screening of a combinatorial homing peptide library for selective cellular delivery Angew Chem. Int. Ed. Engl. 50 2011 6133 6136
-
(2011)
Angew Chem. Int. Ed. Engl.
, vol.50
, pp. 6133-6136
-
-
Svensen, N.1
Díaz-Mochón, J.J.2
Dhaliwal, K.3
Planonth, S.4
Dewar, M.5
Armstrong, J.D.6
Bradley, M.7
-
32
-
-
33750980405
-
Self-assembled small-molecule microarrays for protease screening and profiling
-
DOI 10.1002/cbic.200600242
-
H.D. Urbina, F. Debaene, B. Jost, C. Bole-Feysot, D.E. Mason, P. Kuzmic, J.L. Harris, and N. Winssinger Self-assembled small-molecule microarrays for protease screening and profiling ChemBioChem 7 2006 1790 1797 (Pubitemid 44748665)
-
(2006)
ChemBioChem
, vol.7
, Issue.11
, pp. 1790-1797
-
-
Urbina, H.D.1
Debaene, F.2
Jost, B.3
Bole-Feysot, C.4
Mason, D.E.5
Kuzmic, P.6
Harris, J.L.7
Winssinger, N.8
-
33
-
-
5444241960
-
PNA-encoded protease substrate microarrays
-
DOI 10.1016/j.chembiol.2004.07.015, PII S1074552104002327
-
N. Winssinger, R. Damoiseaux, D.C. Tully, B.H. Geierstanger, K. Burdick, and J.L. Harris PNA-encoded protease substrate microarrays Chem. Biol. 11 2004 1351 1360 (Pubitemid 39351373)
-
(2004)
Chemistry and Biology
, vol.11
, Issue.10
, pp. 1351-1360
-
-
Winssinger, N.1
Damoiseaux, R.2
Tully, D.C.3
Geierstanger, B.H.4
Burdick, K.5
Harris, J.L.6
-
34
-
-
0037143705
-
Profiling protein function with small molecule microarrays
-
DOI 10.1073/pnas.172286899
-
N. Winssinger, S. Ficarro, P.G. Schultz, and J.L. Harris Profiling protein function with small molecule microarrays Proc. Natl. Acad. Sci. USA 99 2002 11139 11144 (Pubitemid 34920892)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.17
, pp. 11139-11144
-
-
Winssinger, N.1
Ficarro, S.2
Schultz, P.G.3
Harris, J.L.4
-
35
-
-
0035801347
-
From split-pool libraries to spatially addressable microarrays and its application to functional proteomic profiling
-
DOI 10.1002/1521-3773(20010903)40:17<3152::AID-ANIE3152>3.0.CO;2-P
-
N. Winssinger, J.L. Harris, B.J. Backes, and P.G. Schultz From split-pool libraries to spatially addressable microarrays and its application to functional proteomic profiling Angew. Chem. Int. Ed. Engl. 40 2001 3152 3155 (Pubitemid 32845380)
-
(2001)
Angewandte Chemie - International Edition
, vol.40
, Issue.17
, pp. 3152-3155
-
-
Winssinger, N.1
Harris, J.L.2
Backes, B.J.3
Schultz, P.G.4
-
36
-
-
35848937985
-
Synthetic ligands discovered by in vitro selection
-
DOI 10.1021/ja073993a
-
S.J. Wrenn, R.M. Weisinger, D.R. Halpin, and P.B. Harbury Synthetic ligands discovered by in vitro selection J. Am. Chem. Soc. 129 2007 13137 13143 (Pubitemid 350058354)
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.43
, pp. 13137-13143
-
-
Wrenn, S.J.1
Weisinger, R.M.2
Halpin, D.R.3
Harbury, P.B.4
-
37
-
-
0030599365
-
Molecular cloning and RNA expression of two new human chemokine receptor-like genes
-
DOI 10.1006/bbrc.1996.1595
-
A. Zaballos, R. Varona, J. Gutiérrez, P. Lind, and G. Márquez Molecular cloning and RNA expression of two new human chemokine receptor-like genes Biochem. Biophys. Res. Commun. 227 1996 846 853 (Pubitemid 26387814)
-
(1996)
Biochemical and Biophysical Research Communications
, vol.227
, Issue.3
, pp. 846-853
-
-
Zaballos, A.1
Varona, R.2
Gutierrez, J.3
Lind, P.4
Marquez, G.5
|