-
1
-
-
84862068720
-
Regulation of neuronal GABAB receptor functionsby subunit composition
-
Gassmann, M., Bettler, B. Regulation of neuronal GABAB receptor functionsby subunit composition. Nat. Rev. Neurosci. 13, 380-394 (2012).
-
(2012)
Nat. Rev. Neurosci.
, vol.13
, pp. 380-394
-
-
Gassmann, M.1
Bettler, B.2
-
2
-
-
77949516412
-
Metabotropic glutamate receptors: Physiology,pharmacology, and disease
-
Niswender, C. M., Conn, P. J. Metabotropic glutamate receptors: physiology,pharmacology, and disease. Annu. Rev. Pharmacol. Toxicol. 50, 295-322 (2010).
-
(2010)
Annu. Rev. Pharmacol. Toxicol.
, vol.50
, pp. 295-322
-
-
Niswender, C.M.1
Conn, P.J.2
-
3
-
-
77955068362
-
Chemistry and pharmacology of GABAB receptor ligands
-
Froestl, W. Chemistry and pharmacology of GABAB receptor ligands. Adv.Pharmacol. 58, 19-62 (2010).
-
(2010)
Adv.Pharmacol.
, vol.58
, pp. 19-62
-
-
Froestl, W.1
-
4
-
-
84888040704
-
Development of allosteric modulators of GPCRs fortreatment of CNS disorders
-
Nickols, H. H., Conn, P. J. Development of allosteric modulators of GPCRs fortreatment of CNS disorders. Neurobiol. Dis. 61, 55-71 (2014).
-
(2014)
Neurobiol. Dis.
, vol.61
, pp. 55-71
-
-
Nickols, H.H.1
Conn, P.J.2
-
5
-
-
84908159410
-
Structures of mGluRs shed light on the challenges of drug development ofallosteric modulators
-
Bennett, K. A., Doré, A. S., Christopher, J. A., Weiss, D. R., Marshall, F. H.Structures of mGluRs shed light on the challenges of drug development ofallosteric modulators. Curr. Opin. Pharmacol. 20, 1-7 (2015).
-
(2015)
Curr. Opin. Pharmacol.
, vol.20
, pp. 1-7
-
-
Bennett, K.A.1
Doré, A.S.2
Christopher, J.A.3
Weiss, D.R.4
Marshall, F.H.5
-
6
-
-
79951854466
-
Dimers and beyond:The functional puzzles of class C GPCRs
-
Kniazeff, J., Prézeau, L., Rondard, P., Pin, J. P., Goudet, C. Dimers and beyond:the functional puzzles of class C GPCRs. Pharmacol. Ther. 130, 9-25 (2011).
-
(2011)
Pharmacol. Ther.
, vol.130
, pp. 9-25
-
-
Kniazeff, J.1
Prézeau, L.2
Rondard, P.3
Pin, J.P.4
Goudet, C.5
-
7
-
-
0033201455
-
GABAB receptors-thefirst 7TM heterodimers
-
Marshall, F. H., Jones, K. A., Kaupmann, K., Bettler, B. GABAB receptors-thefirst 7TM heterodimers. Trends Pharmacol. Sci. 20, 396-399 (1999).
-
(1999)
Trends Pharmacol. Sci.
, vol.20
, pp. 396-399
-
-
Marshall, F.H.1
Jones, K.A.2
Kaupmann, K.3
Bettler, B.4
-
8
-
-
84997839811
-
Phospho-dependentaccumulation of GABABRs at presynaptic terminals after NMDAR activation
-
Hannan, S., Gerrow, K., Triller, A., Smart, T. G. Phospho-dependentaccumulation of GABABRs at presynaptic terminals after NMDAR activation.Cell Reports 16, 1962-1973 (2016).
-
(2016)
Cell Reports
, vol.16
, pp. 1962-1973
-
-
Hannan, S.1
Gerrow, K.2
Triller, A.3
Smart, T.G.4
-
9
-
-
79251591614
-
A new approach to analyze cell surface proteincomplexes reveals specific heterodimeric metabotropic glutamate receptors
-
Doumazane, E., et al. A new approach to analyze cell surface proteincomplexes reveals specific heterodimeric metabotropic glutamate receptors.FASEB J. 25, 66-77 (2011).
-
(2011)
FASEB J.
, vol.25
, pp. 66-77
-
-
Doumazane, E.1
-
10
-
-
79958785452
-
The oligomeric state sets GABAB receptor signallingefficacy
-
Comps-Agrar, L., et al. The oligomeric state sets GABAB receptor signallingefficacy. EMBO J. 30, 2336-2349 (2011).
-
(2011)
EMBO J.
, vol.30
, pp. 2336-2349
-
-
Comps-Agrar, L.1
-
11
-
-
77952422366
-
Native GABAB receptors are heteromultimers with a family ofauxiliary subunits
-
Proteomic identification of the KCTD proteins that constitutively associatewith the GABAB2 subunit of GABABRs and regulate the kinetics ofG signalling to K+ and Ca2+ effector channels
-
Schwenk, J., et al. Native GABAB receptors are heteromultimers with a family ofauxiliary subunits. Nature 465, 231-235 (2010).Proteomic identification of the KCTD proteins that constitutively associatewith the GABAB2 subunit of GABABRs and regulate the kinetics ofG signalling to K+ and Ca2+ effector channels
-
(2010)
Nature
, vol.465
, pp. 231-235
-
-
Schwenk, J.1
-
12
-
-
84956686910
-
Modular composition and dynamics of native GABABreceptors identified by high-resolution proteomics
-
Comprehensive proteomic study reporting the GABABR interactome in therodent brain, including a functional characterization of the interaction ofGABABRs with hyperpolarization-activated cyclic-nucleotide-gated HCNchannels
-
Schwenk, J., et al. Modular composition and dynamics of native GABABreceptors identified by high-resolution proteomics. Nat. Neurosci. 19,233-242 (2016).Comprehensive proteomic study reporting the GABABR interactome in therodent brain, including a functional characterization of the interaction ofGABABRs with hyperpolarization-activated cyclic-nucleotide-gated HCNchannels.
-
(2016)
Nat. Neurosci.
, vol.19
, pp. 233-242
-
-
Schwenk, J.1
-
13
-
-
0035341213
-
Allosteric interactions between GB1 and GB2 subunits arerequired for optimal GABAB receptor function
-
Galvez, T., et al. Allosteric interactions between GB1 and GB2 subunits arerequired for optimal GABAB receptor function. EMBO J. 20, 2152-2159(2001).
-
(2001)
EMBO J.
, vol.20
, pp. 2152-2159
-
-
Galvez, T.1
-
14
-
-
84876272531
-
Protein complexes are under evolutionary selection toassemble via ordered pathways
-
Marsh, J. A., et al. Protein complexes are under evolutionary selection toassemble via ordered pathways. Cell 153, 461-470 (2013).
-
(2013)
Cell
, vol.153
, pp. 461-470
-
-
Marsh, J.A.1
-
15
-
-
84930341731
-
GABA receptor cell-surface export is controlled by anendoplasmic reticulum gatekeeper
-
Doly, S., et al. GABA receptor cell-surface export is controlled by anendoplasmic reticulum gatekeeper. Mol. Psychiatry 21, 480-490 (2016).
-
(2016)
Mol. Psychiatry
, vol.21
, pp. 480-490
-
-
Doly, S.1
-
16
-
-
84900474163
-
Heterodimeric coiled-coilinteractions of human GABAB receptor
-
Burmakina, S., Geng, Y., Chen, Y., Fan, Q. R. Heterodimeric coiled-coilinteractions of human GABAB receptor. Proc. Natl Acad. Sci. USA 111,6958-6963 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 6958-6963
-
-
Burmakina, S.1
Geng, Y.2
Chen, Y.3
Fan, Q.R.4
-
17
-
-
44449096254
-
Cell-surface protein-protein interaction analysis withtime-resolved FRET and snap-tag technologies: Application to GPCRoligomerization
-
Maurel, D., et al. Cell-surface protein-protein interaction analysis withtime-resolved FRET and snap-tag technologies: application to GPCRoligomerization. Nat. Methods 5, 561-567 (2008).
-
(2008)
Nat. Methods
, vol.5
, pp. 561-567
-
-
Maurel, D.1
-
18
-
-
3543036363
-
Closed state of both binding domains of homodimeric mGlureceptors is required for full activity
-
Kniazeff, J., et al. Closed state of both binding domains of homodimeric mGlureceptors is required for full activity. Nat. Struct. Mol. Biol. 11, 706-713(2004).
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 706-713
-
-
Kniazeff, J.1
-
19
-
-
84883148197
-
Segregation of family A G protein-coupled receptor protomersin the plasma membrane
-
Gavalas, A., et al. Segregation of family A G protein-coupled receptor protomersin the plasma membrane. Mol. Pharmacol. 84, 346-352 (2013).
-
(2013)
Mol. Pharmacol.
, vol.84
, pp. 346-352
-
-
Gavalas, A.1
-
20
-
-
84867045173
-
Distinct roles of metabotropic glutamate receptordimerization in agonist activation and G-protein coupling
-
El Moustaine, D., et al. Distinct roles of metabotropic glutamate receptordimerization in agonist activation and G-protein coupling. Proc. Natl Acad. Sci.USA 109, 16342-16347 (2012).
-
(2012)
Proc. Natl Acad. Sci.USA
, vol.109
, pp. 16342-16347
-
-
El Moustaine, D.1
-
21
-
-
84891438084
-
Selective actions of novel allosteric modulators reveal functionalheteromers of metabotropic glutamate receptors in the CNS
-
Yin, S., et al. Selective actions of novel allosteric modulators reveal functionalheteromers of metabotropic glutamate receptors in the CNS. J. Neurosci. 34,79-94 (2014).
-
(2014)
J. Neurosci.
, vol.34
, pp. 79-94
-
-
Yin, S.1
-
22
-
-
84991201313
-
Group 1 metabotropic glutamate receptors 1 and 5 form aprotein complex in mouse hippocampus and cortex
-
Pandya, N. J., et al. Group 1 metabotropic glutamate receptors 1 and 5 form aprotein complex in mouse hippocampus and cortex. Proteomics 16,2698-2705 (2016).
-
(2016)
Proteomics
, vol.16
, pp. 2698-2705
-
-
Pandya, N.J.1
-
23
-
-
84864773493
-
Stability ofGABAB receptor oligomers revealed by dual TR-FRET and drug-induced cellsurface targeting
-
Comps-Agrar, L., Kniazeff, J., Brock, C., Trinquet, E., Pin, J. P. Stability ofGABAB receptor oligomers revealed by dual TR-FRET and drug-induced cellsurface targeting. FASEB J. 26, 3430-3439 (2012).
-
(2012)
FASEB J.
, vol.26
, pp. 3430-3439
-
-
Comps-Agrar, L.1
Kniazeff, J.2
Brock, C.3
Trinquet, E.4
Pin, J.P.5
-
24
-
-
84872195772
-
Single-molecule analysis of fluorescently labeled G-proteincoupledreceptors reveals complexes with distinct dynamics and organization
-
Calebiro, D., et al. Single-molecule analysis of fluorescently labeled G-proteincoupledreceptors reveals complexes with distinct dynamics and organization.Proc. Natl Acad. Sci. USA 110, 743-748 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 743-748
-
-
Calebiro, D.1
-
25
-
-
72049124287
-
X-ray structure, symmetry andmechanism of an AMPA-subtype glutamate receptor
-
Sobolevsky, A. I., Rosconi, M. P., Gouaux, E. X-ray structure, symmetry andmechanism of an AMPA-subtype glutamate receptor. Nature 462, 745-756(2009).
-
(2009)
Nature
, vol.462
, pp. 745-756
-
-
Sobolevsky, A.I.1
Rosconi, M.P.2
Gouaux, E.3
-
26
-
-
0034718925
-
Structural basis of glutamate recognition by a dimericmetabotropic glutamate receptor
-
Kunishima, N., et al. Structural basis of glutamate recognition by a dimericmetabotropic glutamate receptor. Nature 407, 971-977 (2000).
-
(2000)
Nature
, vol.407
, pp. 971-977
-
-
Kunishima, N.1
-
27
-
-
0037022586
-
Structuralviews of the ligand-binding cores of a metabotropic glutamate receptorcomplexed with an antagonist and both glutamate and Gd3+
-
Tsuchiya, D., Kunishima, N., Kamiya, N., Jingami, H., Morikawa, K. Structuralviews of the ligand-binding cores of a metabotropic glutamate receptorcomplexed with an antagonist and both glutamate and Gd3+. Proc. Natl Acad.Sci. USA 99, 2660-2665 (2002).
-
(2002)
Proc. Natl Acad.Sci. USA
, vol.99
, pp. 2660-2665
-
-
Tsuchiya, D.1
Kunishima, N.2
Kamiya, N.3
Jingami, H.4
Morikawa, K.5
-
28
-
-
34247210665
-
Structures of the extracellularregions of the group II/III metabotropic glutamate receptors
-
Muto, T., Tsuchiya, D., Morikawa, K., Jingami, H. Structures of the extracellularregions of the group II/III metabotropic glutamate receptors. Proc. Natl Acad.Sci. USA 104, 3759-3764 (2007).
-
(2007)
Proc. Natl Acad.Sci. USA
, vol.104
, pp. 3759-3764
-
-
Muto, T.1
Tsuchiya, D.2
Morikawa, K.3
Jingami, H.4
-
29
-
-
84890434896
-
Structural mechanism ofligand activation in human GABAB receptor
-
Geng, Y., Bush, M., Mosyak, L., Wang, F., Fan, Q. R. Structural mechanism ofligand activation in human GABAB receptor. Nature 504, 254-259 (2013).Crystal structures of the heterodimeric extracellular domains of GABAB1 andGABAB2 in the empty, agonist-bound and antagonist-bound forms, revealthat receptor activation involves the formation of a novel interface betweensubunits.
-
(2013)
Nature
, vol.504
, pp. 254-259
-
-
Geng, Y.1
Bush, M.2
Mosyak, L.3
Wang, F.4
Fan, Q.R.5
-
30
-
-
1642499173
-
Locking the dimeric GABAB G-protein-coupled receptor in itsactive state
-
Kniazeff, J., et al. Locking the dimeric GABAB G-protein-coupled receptor in itsactive state. J. Neurosci. 24, 370-377 (2004).
-
(2004)
J. Neurosci.
, vol.24
, pp. 370-377
-
-
Kniazeff, J.1
-
31
-
-
0037143619
-
Closure of the Venus flytrap module of mGlu8 receptor andthe activation process: Insights from mutations converting antagonists intoagonists
-
Bessis, A.-S., et al. Closure of the Venus flytrap module of mGlu8 receptor andthe activation process: insights from mutations converting antagonists intoagonists. Proc. Natl Acad. Sci. USA 99, 11097-11102 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 11097-11102
-
-
Bessis, A.-S.1
-
32
-
-
84862842176
-
Structure and functional interaction of the extracellular domainof human GABAB receptor GBR2
-
Geng, Y., et al. Structure and functional interaction of the extracellular domainof human GABAB receptor GBR2. Nat. Neurosci. 15, 970-978 (2012).
-
(2012)
Nat. Neurosci.
, vol.15
, pp. 970-978
-
-
Geng, Y.1
-
33
-
-
84904994581
-
Structure of class C GPCR metabotropic glutamate receptor 5transmembrane domain
-
Doré, A. S., et al. Structure of class C GPCR metabotropic glutamate receptor 5transmembrane domain. Nature 511, 557-562 (2014).
-
(2014)
Nature
, vol.511
, pp. 557-562
-
-
Doré, A.S.1
-
34
-
-
84897580006
-
Structure of a class C GPCR metabotropic glutamate receptor 1bound to an allosteric modulator
-
Wu, H., et al. Structure of a class C GPCR metabotropic glutamate receptor 1bound to an allosteric modulator. Science 344, 58-64 (2014).
-
(2014)
Science
, vol.344
, pp. 58-64
-
-
Wu, H.1
-
35
-
-
84940544977
-
Fragment and structure-based drug discovery for aclass C GPCR: Discovery of the mGlu5 negative allosteric modulatorHTL14242 (3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile)
-
Christopher, J. A., et al. Fragment and structure-based drug discovery for aclass C GPCR: discovery of the mGlu5 negative allosteric modulatorHTL14242 (3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile).J. Med. Chem. 58, 6653-6664 (2015).
-
(2015)
J. Med. Chem.
, vol.58
, pp. 6653-6664
-
-
Christopher, J.A.1
-
36
-
-
40849124248
-
N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) actsthrough a novel site as a positive allosteric modulator of group 1 metabotropicglutamate receptors
-
Chen, Y., Goudet, C., Pin, J.-P., Conn, P. J. N. N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) actsthrough a novel site as a positive allosteric modulator of group 1 metabotropicglutamate receptors. Mol. Pharmacol. 73, 909-918 (2008).
-
(2008)
Mol. Pharmacol.
, vol.73
, pp. 909-918
-
-
Chen, Y.1
Goudet, C.2
Pin, J.-P.3
Conn, P.J.N.4
-
37
-
-
84928704210
-
Overlapping binding sites drive allosteric agonism and positivecooperativity in type 4 metabotropic glutamate receptors
-
Rovira, X., et al. Overlapping binding sites drive allosteric agonism and positivecooperativity in type 4 metabotropic glutamate receptors. FASEB J. 29,116-130 (2015).
-
(2015)
FASEB J.
, vol.29
, pp. 116-130
-
-
Rovira, X.1
-
38
-
-
0035927783
-
Agonist-independent activation of metabotropic glutamatereceptors by the intracellular protein Homer
-
Ango, F., et al. Agonist-independent activation of metabotropic glutamatereceptors by the intracellular protein Homer. Nature 411, 962-965(2001).
-
(2001)
Nature
, vol.411
, pp. 962-965
-
-
Ango, F.1
-
39
-
-
27844482134
-
A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamatereceptor subtype 5 and blocks the effects of multiple allosteric modulators
-
Rodriguez, A. L., et al. A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamatereceptor subtype 5 and blocks the effects of multiple allosteric modulators.Mol. Pharmacol. 68, 1793-1802 (2005).
-
(2005)
Mol. Pharmacol.
, vol.68
, pp. 1793-1802
-
-
Rodriguez, A.L.1
-
40
-
-
84930274249
-
Biased mGlu5-positive allosteric modulators provide in vivoefficacy without potentiating mGlu5 modulation of NMDAR currents
-
Rook, J. M., et al. Biased mGlu5-positive allosteric modulators provide in vivoefficacy without potentiating mGlu5 modulation of NMDAR currents. Neuron86, 1029-1040 (2015).Development of a biased mGlu5 PAM with therapeutic efficacy and animproved side-effect profile.
-
(2015)
Neuron
, vol.86
, pp. 1029-1040
-
-
Rook, J.M.1
-
41
-
-
34249661141
-
Common structural requirements for heptahelical domainfunction in class A and class C G protein-coupled receptors
-
Binet, V., et al. Common structural requirements for heptahelical domainfunction in class A and class C G protein-coupled receptors. J. Biol. Chem. 282,12154-12163 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 12154-12163
-
-
Binet, V.1
-
42
-
-
84876065856
-
Illuminating the activation mechanisms and allostericproperties of metabotropic glutamate receptors
-
Doumazane, E., et al. Illuminating the activation mechanisms and allostericproperties of metabotropic glutamate receptors. Proc. Natl Acad. Sci. USA 110,E1416-E1425 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. E1416-E1425
-
-
Doumazane, E.1
-
43
-
-
84948949784
-
Fine tuning of sub-millisecond conformational dynamicscontrols metabotropic glutamate receptors agonist efficacy
-
Olofsson, L., et al. Fine tuning of sub-millisecond conformational dynamicscontrols metabotropic glutamate receptors agonist efficacy. Nat. Commun. 5,5206 (2014).
-
(2014)
Nat. Commun.
, vol.5
, pp. 5206
-
-
Olofsson, L.1
-
44
-
-
84940478169
-
Conformational dynamics of a class CG-protein-coupled receptor
-
Vafabakhsh, R., Levitz, J., Isacoff, E. Y. Conformational dynamics of a class CG-protein-coupled receptor. Nature 524, 497-501 (2015).
-
(2015)
Nature
, vol.524
, pp. 497-501
-
-
Vafabakhsh, R.1
Levitz, J.2
Isacoff, E.Y.3
-
45
-
-
80053057994
-
Interdomain movements in metabotropic glutamate receptoractivation
-
Huang, S., et al. Interdomain movements in metabotropic glutamate receptoractivation. Proc. Natl Acad. Sci. USA 108, 15480-15485,2011
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 15480-15485
-
-
Huang, S.1
-
46
-
-
3042551375
-
Ligand-inducedrearrangement of the dimeric metabotropic glutamate receptor 1
-
Tateyama, M., Abe, H., Nakata, H., Saito, O., Kubo, Y. Ligand-inducedrearrangement of the dimeric metabotropic glutamate receptor 1 .Nat. Struct. Mol. Biol. 11, 637-642 (2004).
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 637-642
-
-
Tateyama, M.1
Abe, H.2
Nakata, H.3
Saito, O.4
Kubo, Y.5
-
47
-
-
84865180885
-
Sequential inter-and intrasubunit rearrangements duringactivation of dimeric metabotropic glutamate receptor 1
-
Hlavackova, V., et al. Sequential inter-and intrasubunit rearrangements duringactivation of dimeric metabotropic glutamate receptor 1. Sci. Signal. 5, 59(2012).
-
(2012)
Sci. Signal.
, vol.5
, pp. 59
-
-
Hlavackova, V.1
-
48
-
-
20044364938
-
Evidence for a single heptahelical domain being turned onupon activation of a dimeric GPCR
-
Hlavackova, V., et al. Evidence for a single heptahelical domain being turned onupon activation of a dimeric GPCR. EMBO J. 24, 499-509 (2005).
-
(2005)
EMBO J.
, vol.24
, pp. 499-509
-
-
Hlavackova, V.1
-
49
-
-
84919704267
-
Major ligand-induced rearrangement of the heptahelical domaininterface in a GPCR dimer
-
Xue, L., et al. Major ligand-induced rearrangement of the heptahelical domaininterface in a GPCR dimer. Nat. Chem. Biol. 11, 134-140 (2015).
-
(2015)
Nat. Chem. Biol.
, vol.11
, pp. 134-140
-
-
Xue, L.1
-
50
-
-
80052027428
-
Asymmetry of GPCR oligomers supportstheir functional relevance
-
Maurice, P., Kamal, M. & Jockers, R. Asymmetry of GPCR oligomers supports their functional relevance. Trends Pharmacol. Sci. 32, 514-520 (2011).
-
(2011)
Trends Pharmacol. Sci.
, vol.32
, pp. 514-520
-
-
Maurice, P.1
Kamal, M.2
Jockers, R.3
-
51
-
-
78650920787
-
Trans-activation between 7TM domains: Implication inheterodimeric GABAB receptor activation
-
Monnier, C., et al. Trans-activation between 7TM domains: implication inheterodimeric GABAB receptor activation. EMBO J. 30, 32-42 (2011).
-
(2011)
EMBO J.
, vol.30
, pp. 32-42
-
-
Monnier, C.1
-
52
-
-
21644435532
-
Asymmetric functioning of dimeric metabotropic glutamatereceptors disclosed by positive allosteric modulators
-
Goudet, C., et al. Asymmetric functioning of dimeric metabotropic glutamatereceptors disclosed by positive allosteric modulators. J. Biol. Chem. 280,24380-24385 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 24380-24385
-
-
Goudet, C.1
-
53
-
-
84975311440
-
A negative allosteric modulator modulates GABAB-receptorsignalling through GB2 subunits
-
Sun, B., et al. A negative allosteric modulator modulates GABAB-receptorsignalling through GB2 subunits. Biochem. J. 473, 779-787 (2016).
-
(2016)
Biochem. J.
, vol.473
, pp. 779-787
-
-
Sun, B.1
-
54
-
-
0346458626
-
Heptahelical domain of metabotropic glutamate receptor 5behaves like rhodopsin-like receptors
-
Goudet, C., et al. Heptahelical domain of metabotropic glutamate receptor 5behaves like rhodopsin-like receptors. Proc. Natl Acad. Sci. USA 101, 378-383(2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 378-383
-
-
Goudet, C.1
-
55
-
-
84879118132
-
Arrestins come of age: A personal historical perspective
-
Lefkowitz, R. J. Arrestins come of age: a personal historical perspective. Prog.Mol. Biol. Transl. Sci. 118, 3-18 (2013).
-
(2013)
Prog.Mol. Biol. Transl. Sci.
, vol.118
, pp. 3-18
-
-
Lefkowitz, R.J.1
-
56
-
-
84872138902
-
Molecular mechanisms that desensitizemetabotropic glutamate receptor signaling: An overview
-
Iacovelli, L., Nicoletti, F., De Blasi, A. Molecular mechanisms that desensitizemetabotropic glutamate receptor signaling: an overview. Neuropharmacology66, 24-30 (2013).
-
(2013)
Neuropharmacology
, vol.66
, pp. 24-30
-
-
Iacovelli, L.1
Nicoletti, F.2
De Blasi, A.3
-
57
-
-
0042575596
-
Phosphorylationindependentdesensitization of GABAB receptor by GRK4
-
Perroy, J., Adam, L., Qanbar, R., Chénier, S., Bouvier, M. Phosphorylationindependentdesensitization of GABAB receptor by GRK4. EMBO J. 22,3816-3824 (2003).
-
(2003)
EMBO J.
, vol.22
, pp. 3816-3824
-
-
Perroy, J.1
Adam, L.2
Qanbar, R.3
Chénier, S.4
Bouvier, M.5
-
58
-
-
0038146946
-
The metabotropic glutamate receptor mGluR5 isendocytosed by a clathrin-independent pathway
-
Fourgeaud, L., et al. The metabotropic glutamate receptor mGluR5 isendocytosed by a clathrin-independent pathway. J. Biol. Chem. 278,12222-12230 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 12222-12230
-
-
Fourgeaud, L.1
-
59
-
-
1842424991
-
Phosphorylation and chronic agonist treatment atypicallymodulate GABAB receptor cell surface stability
-
Fairfax, B. P., et al. Phosphorylation and chronic agonist treatment atypicallymodulate GABAB receptor cell surface stability. J. Biol. Chem. 279,12565-12573 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 12565-12573
-
-
Fairfax, B.P.1
-
60
-
-
84855839174
-
GABAB receptors-associated proteins: Potential drugtargets in neurological disorders
-
Lujan, R., Ciruela, F. GABAB receptors-associated proteins: potential drugtargets in neurological disorders Curr. Drug Targets 13, 129-144(2012).
-
(2012)
Curr. Drug Targets
, vol.13
, pp. 129-144
-
-
Lujan, R.1
Ciruela, F.2
-
61
-
-
33646529626
-
Molecular diversity, trafficking and subcellularlocalization of GABAB receptors
-
Bettler, B., Tiao, J. Y. Molecular diversity, trafficking and subcellularlocalization of GABAB receptors. Pharmacol. Ther. 110, 533-543 (2006).
-
(2006)
Pharmacol. Ther.
, vol.110
, pp. 533-543
-
-
Bettler, B.1
Tiao, J.Y.2
-
62
-
-
84887476732
-
GABAB receptor trafficking and interacting proteins: Targets for thedevelopment of highly specific therapeutic strategies to treat neurologicaldisorders Biochem
-
Benke, D. GABAB receptor trafficking and interacting proteins: targets for thedevelopment of highly specific therapeutic strategies to treat neurologicaldisorders Biochem. Pharmacol. 86, 1525-1530 (2013).
-
(2013)
Pharmacol.
, vol.86
, pp. 1525-1530
-
-
Benke, D.1
-
63
-
-
77949494310
-
GPCR interactingproteins (GIPs) in the nervous system: Roles in physiology and pathologies
-
Bockaert, J., Perroy, J., Bécamel, C., Marin, P., Fagni, L. GPCR interactingproteins (GIPs) in the nervous system: roles in physiology and pathologies.Annu. Rev. Pharmacol. Toxicol. 50, 89-109 (2010).
-
(2010)
Annu. Rev. Pharmacol. Toxicol.
, vol.50
, pp. 89-109
-
-
Bockaert, J.1
Perroy, J.2
Bécamel, C.3
Marin, P.4
Fagni, L.5
-
64
-
-
84855828229
-
Metabotropic glutamate receptors and interacting proteins: Evolvingdrug targets
-
Enz, R. Metabotropic glutamate receptors and interacting proteins: evolvingdrug targets. Curr. Drug Targets 13, 145-156 (2012).
-
(2012)
Curr. Drug Targets
, vol.13
, pp. 145-156
-
-
Enz, R.1
-
65
-
-
84901840531
-
Auxiliary GABAB receptor subunits uncouple G protein subunits from effector channels to induce desensitization
-
Turecek, R., et al. Auxiliary GABAB receptor subunits uncouple G protein subunits from effector channels to induce desensitization. Neuron 82,1032-1044 (2014).
-
(2014)
Neuron
, vol.82
, pp. 1032-1044
-
-
Turecek, R.1
-
66
-
-
0018125541
-
Mode of coupling between the-adrenergicreceptor and adenylate cyclase in turkey erythrocytes
-
Tolkovsky, A. M., Levitzki, A. Mode of coupling between the-adrenergicreceptor and adenylate cyclase in turkey erythrocytes. Biochemistry 17,3795 (1978).
-
(1978)
Biochemistry
, vol.17
, pp. 3795
-
-
Tolkovsky, A.M.1
Levitzki, A.2
-
67
-
-
84908374412
-
Pharmacological characterization of GABAB receptor subtypesassembled with auxiliary KCTD subunits
-
Rajalu, M., et al. Pharmacological characterization of GABAB receptor subtypesassembled with auxiliary KCTD subunits. Neuropharmacology 88, 145-154(2015).
-
(2015)
Neuropharmacology
, vol.88
, pp. 145-154
-
-
Rajalu, M.1
-
68
-
-
84922708295
-
GABA blocks pathological but not acute TRPV1 pain signals
-
Hanack, C., et al. GABA blocks pathological but not acute TRPV1 pain signals. Cell160, 759-770 (2015).
-
(2015)
Cell
, vol.160
, pp. 759-770
-
-
Hanack, C.1
-
69
-
-
84865412736
-
Endoplasmic reticulum sorting and kinesin-1 command thetargeting of axonal GABAB receptors
-
Valdés, V., et al. Endoplasmic reticulum sorting and kinesin-1 command thetargeting of axonal GABAB receptors. PLoS One 7, e44168 (2012).
-
(2012)
PLoS One
, vol.7
, pp. e44168
-
-
Valdés, V.1
-
70
-
-
0035809914
-
Cargo of kinesin identified as JIP scaffolding proteins andassociated signaling molecules
-
Verhey, K. J., et al. Cargo of kinesin identified as JIP scaffolding proteins andassociated signaling molecules. J. Cell Biol. 152, 959-970 (2001).
-
(2001)
J. Cell Biol.
, vol.152
, pp. 959-970
-
-
Verhey, K.J.1
-
71
-
-
64849104680
-
Calsyntenins mediate TGN exit of APP in a kinesin-1-dependent manner
-
Ludwig, A., et al. Calsyntenins mediate TGN exit of APP in a kinesin-1-dependent manner. Traffic 10, 572-589 (2009).
-
(2009)
Traffic
, vol.10
, pp. 572-589
-
-
Ludwig, A.1
-
72
-
-
84864881068
-
Impairment of GABAB receptor dimer by endogenous 14-3-3in chronic pain conditions
-
Laffray, S., et al. Impairment of GABAB receptor dimer by endogenous 14-3-3in chronic pain conditions. EMBO J. 31, 3239-3251 (2012).
-
(2012)
EMBO J.
, vol.31
, pp. 3239-3251
-
-
Laffray, S.1
-
73
-
-
84924655016
-
Rapid antidepressants stimulate the decoupling ofGABAB receptors from GIRK/Kir3 channels through increased protein stabilityof 14-3-3
-
Workman, E. R., et al. Rapid antidepressants stimulate the decoupling ofGABAB receptors from GIRK/Kir3 channels through increased protein stabilityof 14-3-3 . Mol. Psychiatry 20, 298-310 (2015).
-
(2015)
Mol. Psychiatry
, vol.20
, pp. 298-310
-
-
Workman, E.R.1
-
74
-
-
65549160499
-
Metabotropic glutamate type 5, dopamine D2 and adenosineA2a receptors form higher-order oligomers in living cells
-
Cabello, N., et al. Metabotropic glutamate type 5, dopamine D2 and adenosineA2a receptors form higher-order oligomers in living cells. J. Neurochem. 109,1497-1507 (2009).
-
(2009)
J. Neurochem.
, vol.109
, pp. 1497-1507
-
-
Cabello, N.1
-
75
-
-
81855189491
-
Decoding the signaling of a GPCR heteromeric complexreveals a unifying mechanism of action of antipsychotic drugs
-
Fribourg, M., et al. Decoding the signaling of a GPCR heteromeric complexreveals a unifying mechanism of action of antipsychotic drugs. Cell 147,1011-1023 (2011).
-
(2011)
Cell
, vol.147
, pp. 1011-1023
-
-
Fribourg, M.1
-
76
-
-
84879966473
-
Ligands that interact with putative MOR-mGluR5 heteromer inmice with inflammatory pain produce potent antinociception
-
Akgün, E., et al. Ligands that interact with putative MOR-mGluR5 heteromer inmice with inflammatory pain produce potent antinociception. Proc. Natl Acad.Sci. USA 110, 11595-11599 (2013).
-
(2013)
Proc. Natl Acad.Sci. USA
, vol.110
, pp. 11595-11599
-
-
Akgün, E.1
-
77
-
-
84975061697
-
A critical role of striatal A2A R-mGlu5 R interactions inmodulating the psychomotor and drug-seeking effects of methamphetamine
-
Wright, S. R., et al. A critical role of striatal A2A R-mGlu5 R interactions inmodulating the psychomotor and drug-seeking effects of methamphetamine.Addict. Biol. 21, 811-825 (2016).
-
(2016)
Addict. Biol.
, vol.21
, pp. 811-825
-
-
Wright, S.R.1
-
78
-
-
84979010983
-
Functional role of striatal A2A D2 and mGlu5 receptorinteractions in regulating striatopallidal GABA neuronal transmission
-
Beggiato, S., et al. Functional role of striatal A2A, D2, and mGlu5 receptorinteractions in regulating striatopallidal GABA neuronal transmission.J. Neurochem. 138, 254-264 (2016).
-
(2016)
J. Neurochem.
, vol.138
, pp. 254-264
-
-
Beggiato, S.1
-
79
-
-
84947500240
-
The effective application of biased signaling to new drug discovery
-
Kenakin, T. The effective application of biased signaling to new drug discovery.Mol. Pharmacol. 88, 1055-1061 (2015).
-
(2015)
Mol. Pharmacol.
, vol.88
, pp. 1055-1061
-
-
Kenakin, T.1
-
80
-
-
78650230675
-
Homeostatic scaling requires group i mGluR activationmediated by Homer1a
-
Hu, J. H., et al. Homeostatic scaling requires group I mGluR activationmediated by Homer1a. Neuron 68, 1128-1142 (2010).
-
(2010)
Neuron
, vol.68
, pp. 1128-1142
-
-
Hu, J.H.1
-
81
-
-
84862777306
-
Disrupted Homer scaffolds mediate abnormal mGluR5function in a mouse model of fragile X syndrome
-
Ronesi, J.A., et al. Disrupted Homer scaffolds mediate abnormal mGluR5function in a mouse model of fragile X syndrome. Nat. Neurosci. 15,431-440 (2012).
-
(2012)
Nat. Neurosci.
, vol.15
, pp. 431-440
-
-
Ronesi, J.A.1
-
82
-
-
84939164437
-
Novel allosteric modulators of Gprotein-coupled receptors
-
Gentry, P. R., Sexton, P. M., Christopoulos, A. Novel allosteric modulators of Gprotein-coupled receptors. J. Biol. Chem. 290, 19478-19488 (2015).
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 19478-19488
-
-
Gentry, P.R.1
Sexton, P.M.2
Christopoulos, A.3
-
83
-
-
84978402413
-
Cellular synaptic, and circuit effects ofantibodies in autoimmune CNS synaptopathies
-
Jain, A., Balice-Gordon, R. Cellular, synaptic, and circuit effects ofantibodies in autoimmune CNS synaptopathies. Handb. Clin. Neurol. 133,77-93 (2016).
-
(2016)
Handb. Clin. Neurol.
, vol.133
, pp. 77-93
-
-
Jain, A.1
Balice-Gordon, R.2
-
84
-
-
84857753632
-
A high-affinity, dimeric inhibitor of PSD-95 bivalently interactswith PDZ1-2 and protects against ischemic brain damage
-
Bach, A., et al. A high-affinity, dimeric inhibitor of PSD-95 bivalently interactswith PDZ1-2 and protects against ischemic brain damage. Proc. Natl Acad. Sci.USA 109, 3317-3322 (2012).
-
(2012)
Proc. Natl Acad. Sci.USA
, vol.109
, pp. 3317-3322
-
-
Bach, A.1
-
85
-
-
57649223726
-
The sushi domains of secreted GABAB1 isoforms selectively impairGABAB heteroreceptor function
-
Tiao, J. Y., et al. The sushi domains of secreted GABAB1 isoforms selectively impairGABAB heteroreceptor function. J. Biol. Chem. 283, 31005-31011 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 31005-31011
-
-
Tiao, J.Y.1
-
86
-
-
83055176269
-
Visualizingprotein partnerships in living cells and organisms
-
Lowder, M. A., Appelbaum, J. S., Hobert, E. M., Schepartz, A. Visualizingprotein partnerships in living cells and organisms. Curr. Opin. Chem. Biol. 15,781-788 (2011).
-
(2011)
Curr. Opin. Chem. Biol.
, vol.15
, pp. 781-788
-
-
Lowder, M.A.1
Appelbaum, J.S.2
Hobert, E.M.3
Schepartz, A.4
-
87
-
-
75349088067
-
The sushi domains of GABAB receptors function as axonaltargeting signals
-
Biermann, B., et al. The sushi domains of GABAB receptors function as axonaltargeting signals. J. Neurosci. 30, 1385-1394 (2010).
-
(2010)
J. Neurosci.
, vol.30
, pp. 1385-1394
-
-
Biermann, B.1
-
88
-
-
77956389608
-
NMDA receptor-dependent GABAB receptor internalization viaCaMKII phosphorylation of serine 867 in GABAB1
-
Guetg, N., et al. NMDA receptor-dependent GABAB receptor internalization viaCaMKII phosphorylation of serine 867 in GABAB1. Proc. Natl Acad. Sci. USA107, 13924-13929 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 13924-13929
-
-
Guetg, N.1
-
89
-
-
33846809418
-
GISP: A novel brain-specific protein that promotessurface expression and function of GABAB receptors
-
Kantamneni, S., et al. GISP: a novel brain-specific protein that promotessurface expression and function of GABAB receptors. J. Neurochem. 100,1003-1017 (2007).
-
(2007)
J. Neurochem.
, vol.100
, pp. 1003-1017
-
-
Kantamneni, S.1
-
90
-
-
84934887578
-
GABAB receptor deficiency causes failure of neuronalhomeostasis in hippocampal networks
-
Vertkin, I., et al. GABAB receptor deficiency causes failure of neuronalhomeostasis in hippocampal networks. Proc. Natl Acad. Sci. USA 112,E3291-E3299 (2015).
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. E3291-E3299
-
-
Vertkin, I.1
-
91
-
-
84908014949
-
GINIP, a Gi-interacting protein, functions as a keymodulator of peripheral GABAB receptor-mediated analgesia
-
Gaillard, S., et al. GINIP, a Gi-interacting protein, functions as a keymodulator of peripheral GABAB receptor-mediated analgesia. Neuron 84,123-136 (2014).
-
(2014)
Neuron
, vol.84
, pp. 123-136
-
-
Gaillard, S.1
-
92
-
-
77952886365
-
G 5 recruits R7 RGS proteins to GIRK channels to regulate thetiming of neuronal inhibitory signaling
-
Xie, K., et al. G 5 recruits R7 RGS proteins to GIRK channels to regulate thetiming of neuronal inhibitory signaling. Nat. Neurosci. 13, 661-663 (2010).
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 661-663
-
-
Xie, K.1
-
93
-
-
0032192487
-
Homer binds a novel proline-rich motif and links group 1metabotropic glutamate receptors with IP3 receptors
-
Tu, J. C., et al. Homer binds a novel proline-rich motif and links group 1metabotropic glutamate receptors with IP3 receptors. Neuron 21, 717-726(1998).
-
(1998)
Neuron
, vol.21
, pp. 717-726
-
-
Tu, J.C.1
-
94
-
-
79955776373
-
Differential binding of calmodulin to groupI metabotropic glutamate receptors regulates receptor trafficking andsignaling
-
Choi, K. Y., Chung, S., Roche, K. W. Differential binding of calmodulin to groupI metabotropic glutamate receptors regulates receptor trafficking andsignaling. J. Neurosci. 31, 5921-5930 (2011).
-
(2011)
J. Neurosci.
, vol.31
, pp. 5921-5930
-
-
Choi, K.Y.1
Chung, S.2
Roche, K.W.3
-
95
-
-
84861539413
-
Preso1 dynamically regulates group i metabotropic glutamatereceptors
-
Hu, J. H., et al. Preso1 dynamically regulates group I metabotropic glutamatereceptors. Nat. Neurosci. 15, 836-844 (2012).
-
(2012)
Nat. Neurosci.
, vol.15
, pp. 836-844
-
-
Hu, J.H.1
-
96
-
-
84869068065
-
PKC phosphorylation regulates mGluR5 trafficking by enhancingbinding of Siah-1A
-
Ko, S. J., et al. PKC phosphorylation regulates mGluR5 trafficking by enhancingbinding of Siah-1A. J. Neurosci. 32, 16391-16401 (2012).
-
(2012)
J. Neurosci.
, vol.32
, pp. 16391-16401
-
-
Ko, S.J.1
-
97
-
-
0037083370
-
Tamalin, a PDZ domain-containing protein, links a proteincomplex formation of group 1 metabotropic glutamate receptors and theguanine nucleotide exchange factor cytohesins
-
Kitano, J., et al. Tamalin, a PDZ domain-containing protein, links a proteincomplex formation of group 1 metabotropic glutamate receptors and theguanine nucleotide exchange factor cytohesins. J. Neurosci. 22, 1280-1289(2002).
-
(2002)
J. Neurosci.
, vol.22
, pp. 1280-1289
-
-
Kitano, J.1
-
98
-
-
0344443184
-
Activation of the TRPC1 cation channel by metabotropicglutamate receptor mGluR1
-
Kim, S. J., et al. Activation of the TRPC1 cation channel by metabotropicglutamate receptor mGluR1. Nature 426, 285-291 (2003).
-
(2003)
Nature
, vol.426
, pp. 285-291
-
-
Kim, S.J.1
-
99
-
-
27744487501
-
Metabotropic glutamate receptor 8-expressing nerveterminals target subsets of GABAergic neurons in the hippocampus
-
Ferraguti, F., et al. Metabotropic glutamate receptor 8-expressing nerveterminals target subsets of GABAergic neurons in the hippocampus.J. Neurosci. 25, 10520-10536 (2005).
-
(2005)
J. Neurosci.
, vol.25
, pp. 10520-10536
-
-
Ferraguti, F.1
|