Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy

Nature Communications

Volumn 5, Issue , 2014, Pages

  Olofsson, Linnea ^a,b   Felekyan, Suren ^c   Doumazane, Etienne ^b,d   Scholler, Pauline ^b,d,e   Fabre, Ludovic ^b,d,e   Zwier, Jurriaan M ^e   Rondard, Philippe ^b,d   Seidel, Claus A M ^c   Pin, Jean Philippe ^b,d   Margeat, Emmanuel ^a,b  

^a CENTRE DE BIOCHIMIE STRUCTURALE   (France)

^b UNIV MONTPELLIER   (France)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^e Cisbio Bioassays   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,3 DICARBOXYCYCLOPROPYL)GLYCINE; 2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; DIMER; DOUBLE STRANDED DNA; G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; METABOTROPIC RECEPTOR; NEUROTRANSMITTER; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; RECEPTOR; BENZYLGUANIDINE; GUANIDINE DERIVATIVE; LIGAND; METABOTROPIC RECEPTOR 2; PROTEIN BINDING;

CELLS AND CELL COMPONENTS; EFFICIENCY MEASUREMENT; LIGAND; MOLECULAR ANALYSIS; NEUROLOGY; PROTEIN; REACTION KINETICS; TIMESCALE;

ARTICLE; BINDING SITE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CONFORMATIONAL DYNAMICS; CONFORMATIONAL TRANSITION; CROSS LINKING; CRYSTAL STRUCTURE; EQUILIBRIUM CONSTANT; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUOROMETRY; HUMAN; HUMAN CELL; LIGAND BINDING; PARTIAL AGONISM; PHOTON; PROTEIN CONFORMATION; SINGLE MOLECULE FORSTER RESONANCE ENERGY TRANSFER; STOICHIOMETRY; TIME RESOLVED LUMINESCENCE RESONANCE ENERGY TRANSFER; WILD TYPE; AGONISTS; CELL COMMUNICATION; CHEMISTRY; CONFORMATION; ENZYME ACTIVE SITE; HEK293 CELL LINE; KINETICS; METABOLISM; MUTATION; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION;

ALLOSTERIC SITE; CATALYTIC DOMAIN; CELL COMMUNICATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GUANIDINES; HEK293 CELLS; HUMANS; KINETICS; LIGANDS; MOLECULAR CONFORMATION; MUTATION; PHOTONS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; RECEPTORS, METABOTROPIC GLUTAMATE; SIGNAL TRANSDUCTION;

EID: 84948949784     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms6206     Document Type: Article

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