A negative allosteric modulator modulates GABAB -receptor signalling through GB2 subunits

Biochemical Journal

Volumn 473, Issue 6, 2016, Pages 779-787

  Sun, Bing ^a   Chen, Linhai ^b   Liu, Lei ^a   Xia, Zhixiong ^a   Pin, Jean Philippe ^c   Nan, Fajun ^b   Liu, Jianfeng ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

Author keywords

Cerebellar granular neurons; GabaB receptor; Heptahelical domain; Negative allosteric modulator.

Indexed keywords

2,6 DI TERT BUTYL 4 (3 HYDROXY 2,2 DIMETHYLPROPYL)PHENOL; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; BACLOFEN; CLH 304A; CLH 391; CLH 393; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE B; UNCLASSIFIED DRUG; CLH304A; OXOACID; PHENOL DERIVATIVE; PROTEIN SUBUNIT;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HEK293 CELL LINE; MOUSE; NERVE CELL; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; WILD TYPE; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PROTEIN CONFORMATION; PROTEIN SUBUNIT; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; GABA AGONISTS; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; KETO ACIDS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHENOLS; PROTEIN CONFORMATION; PROTEIN SUBUNITS; RECEPTORS, GABA-B; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84975311440     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20150979     Document Type: Article

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