A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators

Molecular Pharmacology

Volumn 68, Issue 6, 2005, Pages 1793-1802

  Rodriguez, Alice L ^a   Nong, Yi ^a   Sekaran, Nishant K ^a   Alagille, David ^b   Tamagnan, Gilles D ^b   Conn, P Jeffrey ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUTE FOR NEURODEGENERATIVE DISORDERS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 (3 METHOXYPHENYL)ETHYNYL] 5 METHYLPYRIDINE; 2 [2 (5 BROMOPYRIDIN 3 YL)ETHYNYL] 5 METHYLPYRIDINE; 5 METHYL 6 (PHENYLETHYNYL)PYRIDINE; G PROTEIN COUPLED RECEPTOR; METABOTROPIC RECEPTOR ANTAGONIST; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING SITE; BRAIN NERVE CELL; CELL DEATH; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DRUG BINDING; DRUG EFFECT; EMBRYO; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RAT; SUBTHALAMIC NUCLEUS;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; ANIMALS; BRAIN; CELL LINE, TUMOR; DRUG INTERACTIONS; ELECTROPHYSIOLOGY; GLUTAMIC ACID; HUMANS; LIGANDS; NEURONS; PYRIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; TRANSFECTION;

EID: 27844482134     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.016139     Document Type: Article

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