5′-hydroxymethylcytosine precedes loss of CpG methylation in enhancers and genes undergoing activation in cardiomyocyte maturation

PLoS ONE

Volumn 11, Issue 11, 2016, Pages

  Kranzhöfer, David K ^a   Gilsbach, Ralf ^a   Grüning, Björn A ^b   Backofen, Rolf ^b   Nührenberg, Thomas G ^a,c   Hein, Lutz ^a,b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY HEART CENTER FREIBURG BAD KROZINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; DNA; 5 METHYLCYTOSINE; 5-HYDROXYMETHYLCYTOSINE; SPACER DNA;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATP2A2 GENE; CARDIAC MUSCLE CELL; CELL MATURATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA SEQUENCE; ENHANCER REGION; EXON; GENE; GENE ACTIVATION; GENE EXPRESSION; INTRON; MALE; MB GENE; MOUSE; NEWBORN; NONHUMAN; PDK4 GENE; PROMOTER REGION; TNNI3 GENE; TRANSCRIPTION TERMINATION; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CELL DIFFERENTIATION; CELL NUCLEUS; CYTOLOGY; FLOW CYTOMETRY; GENE LOCUS; GENETIC TRANSCRIPTION; GENETICS; GENOME; METABOLISM; TRANSCRIPTION INITIATION;

5-METHYLCYTOSINE; ANIMALS; ANIMALS, NEWBORN; CELL DIFFERENTIATION; CELL NUCLEUS; CPG ISLANDS; DNA METHYLATION; DNA, INTERGENIC; ENHANCER ELEMENTS, GENETIC; FLOW CYTOMETRY; GENETIC LOCI; GENOME; MALE; MICE, INBRED C57BL; MYOCYTES, CARDIAC; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84995595697     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0166575     Document Type: Article

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