Tissue-specific DNA demethylation is required for proper B-cell differentiation and function

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 18, 2016, Pages 5018-5023

  Orlanski, Shari ^a   Labi, Verena ^b,c   Reizel, Yitzhak ^a   Spiro, Adam ^a   Lichtenstein, Michal ^a   Levin Klein, Rena ^a   Koralov, Sergei B ^d   Skversky, Yael ^a   Rajewsky, Klaus ^b   Cedar, Howard ^a   Bergman, Yehudit ^a  

^a HEBREW UNIVERSITY   (Israel)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^d Weill Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; IMMUNOGLOBULIN G1; INTERFERON REGULATORY FACTOR 4; ORGANIC CATION TRANSPORTER 2; PROTEIN; TET2 PROTEIN; TET3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2A; TRANSCRIPTION FACTOR EBF1; TRANSCRIPTION FACTOR PAX5; TRANSCRIPTION FACTOR PU 1; UNCLASSIFIED DRUG; DNA BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CELL ISOLATION; CELL LINEAGE; CELL MATURATION; CLINICAL EVALUATION; CONTROLLED STUDY; DEMETHYLATION; DEVELOPMENTAL STAGE; DNA METHYLATION; DNA MODIFICATION; EMBRYO; ENHANCER REGION; ENZYME ANALYSIS; ENZYME MODIFICATION; FLOW CYTOMETRY; GENE ONTOLOGY; IN VIVO STUDY; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SHEEP ERYTHROCYTE; SOMATIC CELL; TISSUE SPECIFICITY; ANIMAL; ANTIBODY SPECIFICITY; B LYMPHOCYTE; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; GENETIC EPIGENESIS; GENETICS; PHYSIOLOGY;

ANIMALS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; DNA METHYLATION; DNA-BINDING PROTEINS; EPIGENESIS, GENETIC; MICE; MICE, INBRED C57BL; ORGAN SPECIFICITY;

EID: 84971524716     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1604365113     Document Type: Article

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