St. John's wort extract and hyperforin inhibit multiple phosphorylation steps of cytokine signaling and prevent inflammatory and apoptotic gene induction in pancreatic β cells

International Journal of Biochemistry and Cell Biology

Volumn 81, Issue , 2016, Pages 92-104

  Novelli, Michela ^a   Menegazzi, Marta ^b   Beffy, Pascale ^c   Porozov, Svetlana ^a   Gregorelli, Alex ^b   Giacopelli, Daniela ^c   De Tata, Vincenzo ^a   Masiello, Pellegrino ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

Author keywords

Cell death; Cytokines; Natural compounds; Pancreatic beta cells; Signaling pathways; Type 1 diabetes

Indexed keywords

CYTOKINE; HYPERFORIN; HYPERICUM PERFORATUM EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOPROTEIN; PROTEIN KINASE B; STAT1 PROTEIN; DNA; MESSENGER RNA; PHLOROGLUCINOL; PLANT EXTRACT; TERPENE;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL VIABILITY; DOSE RESPONSE; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE INDUCTION; GENE TARGETING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INFLAMMATORY CELL; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ENZYME ACTIVATION; GENETICS; HYPERICUM; METABOLISM; PHOSPHORYLATION; RAT; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CYTOKINES; DNA; ENZYME ACTIVATION; HYPERICUM; INSULIN-SECRETING CELLS; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PHLOROGLUCINOL; PHOSPHORYLATION; PLANT EXTRACTS; RATS; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TERPENES; TRANSCRIPTIONAL ACTIVATION;

EID: 84994050561     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2016.10.017     Document Type: Article

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