Extracellular signal-regulated kinase is essential for interleukin-1- induced and nuclear factor κB-mediated gene expression in insulin-producing INS-1E cells

Diabetologia

Volumn 48, Issue 12, 2005, Pages 2582-2590

  Larsen, L ^a   Storling J ^a   Darville, M ^b   Eizirik, D L ^b   Bonny, C ^c   Billestrup, N ^a   Mandrup Poulsen, T ^a,d  

^a STENO DIABETES CENTER   (Denmark)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

IL 1 ; Mitogen activated protein kinases; Nitric oxide; Nuclear factor kappa B; Pancreatic beta cells; Type 1 diabetes

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AMINO ACID; DNA; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INTERLEUKIN 1; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; SERINE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NOS 2; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INSULIN METABOLISM; INSULIN SYNTHESIS; MUTATIONAL ANALYSIS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; REPORTER GENE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; GENE EXPRESSION; HUMANS; IMIDAZOLES; INSULIN; INSULIN-SECRETING CELLS; INTERLEUKIN-1; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; RATS; SERINE; SYNAPTOTAGMIN I;

EID: 28444472055     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-0039-9     Document Type: Article

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