Direct interaction of garcinol and related polyisoprenylated benzophenones of Garcinia cambogia fruits with the transcription factor STAT-1 as a likely mechanism of their inhibitory effect on cytokine signaling pathways

Journal of Natural Products

Volumn 77, Issue 3, 2014, Pages 543-549

  Masullo, Milena ^a   Menegazzi, Marta ^b   Di Micco, Simone ^a   Beffy, Pascale ^c   Bifulco, Giuseppe ^a   Dal Bosco, Martina ^b   Novelli, Michela ^d   Pizza, Cosimo ^a   Masiello, Pellegrino ^d   Piacente, Sonia ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c CNR   (Italy)

^d UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOPHENONE DERIVATIVE; GARCINOL; GUTTIFERONE K; GUTTIFERONE M; STAT1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION RESPONSE; DISSOCIATION CONSTANT; DRUG ISOLATION; DRUG MECHANISM; DRUG STRUCTURE; FEMALE; FRUIT; GARCINIA CAMBOGIA; HUMAN; HUMAN CELL; MOLECULAR DOCKING; NONHUMAN; PROTEIN DNA BINDING; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE;

BENZOPHENONES; BLOTTING, NORTHERN; FEMALE; FRUIT; GARCINIA CAMBOGIA; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NF-KAPPA B; SIGNAL TRANSDUCTION; SRI LANKA; STAT1 TRANSCRIPTION FACTOR; TERPENES;

EID: 84897414476     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np400804y     Document Type: Article

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