St. John's wort extract and hyperforin protect rat and human pancreatic islets against cytokine toxicity

Acta Diabetologica

Volumn 51, Issue 1, 2014, Pages 113-121

  Novelli, Michela ^a   Beffy, Pascale ^b   Menegazzi, Marta ^c   De Tata, Vincenzo ^a   Martino, Luisa ^a   Sgarbossa, Anna ^c   Porozov, Svetlana ^a   Pippa, Anna ^d   Masini, Matilde ^a   Marchetti, Piero ^a   Masiello, Pellegrino ^a  

^a UNIVERSITY OF PISA   (Italy)

^b INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^c UNIVERSITY OF VERONA   (Italy)

^d SCUOLA SUPERIORE SANT ANNA   (Italy)

Author keywords

Beta cell death; Cytokines; Human pancreatic islets; Hyperforin; St. John's wort; Type 1 diabetes

Indexed keywords

CXCL9 CHEMOKINE; CYCLOOXYGENASE 2; CYTOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLUCOSE; HYPERFORIN; HYPERICUM PERFORATUM EXTRACT; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITRIC OXIDE;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; COX2 GENE; CXCL10 GENE; CXCL9 GENE; DOWN REGULATION; HUMAN; HUMAN TISSUE; INOS GENE; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PANCREAS NECROSIS; PRIORITY JOURNAL; RAT; ULTRASTRUCTURE;

ANIMALS; CELLS, CULTURED; CYTOKINES; CYTOPROTECTION; DRUG EVALUATION, PRECLINICAL; GLUCOSE; HUMANS; HYPERICUM; INSULIN; ISLETS OF LANGERHANS; MALE; PHLOROGLUCINOL; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; TERPENES;

EID: 84896707232     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-013-0518-2     Document Type: Article

References (37)

1. Mathis D, Vence L, Benoist C (2001) Beta-cell death during progression to diabetes. Nature 414:792-798
2. Eizirik DL, Colli ML, Ortis F (2009) The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol 5:219-226
3. Donath MY, Böni-Schnetzler M, Ellingsgaard H, Halban PA, Ehses JA (2010) Cytokine production by islets in health and diabetes: cellular origin, regulation and function. Trends Endocrinol Metab 21:261-267
4. Eizirik DL, Mandrup-Poulsen T (2001) A choice of death- the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 44:2115-2133
5. Pirot P, Cardozo AK, Eizirik DL (2008) Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes. Arquivos Brasileiros de Endocrinol Metab 52:156-165
6. Padgett LE, Bronowska KA, Hansen PA, Corbett JA, Tse HM (2013) The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis. Ann NY Acad Sci 1281:16-35
7. Platanias LC, Fish EN (1999) Signalling pathways activated by interferons. Exp Hematol 27:1583-1592
8. Aaronson DS, Horvath CM (2002) Q road map for those who don't know JAK-STAT. Science 296:1653-1655
9. Ramana CV, Gil MP, Schreiber RD, Stark GR (2002) Stat1-dependent and independent pathways in IFN-gamma-dependent signaling. Trends Immunol 23:96-101
10. Gysemans C, Callewaert H, Overbergh L, Mathieu C (2008) Cytokine signalling in the beta cell: a dual role for IFNgamma. Biochem Soc Trans 36:328-333
11. Gilmore TD (1999) The Rel/NF-kB signal transduction pathway: introduction. Oncogene 18:6842-6844
12. Sekine N, Ishikawa T, Okazaki T, Hayashi M, Wollheim CB, Fujita T (2000) Synergistic activation of NF-kappao and inducible isoform of nitric oxide synthase induction by interferon-gamma and tumor necrosis factor alpha in INS-1 cells. J Cell Physiol 184:46-57
13. Barthson J, Germano CM, Moore F, Maida A, Drucker DJ, Marchetti P, Gysemans C, Mathieu C, Nuňez G, Jurisicova A, Eizirik DL, Gurzov EN (2011) Tumor necrosis factor-α induce pancreatic β-cell apoptosis through STAT1-mediated Bim activation. J Biol Chem 286:39632-39643
14. Kim S, Kim KA, Suk K, Kim YH, Oh SH, Lee MK, Kim KW, Lee MS (2012) Apoptosis of human islet cells by cytokines. Immune Netw 12:113-117
15. Kim EK, Kwon KB, Song MY, Seo MY, Park SJ, Ka SO, Na L, Kim KA, Ryu DG, So HS, Park R, Park BH (2007) Genistein protects pancreatic beta cells against cytokine-mediated toxicity. Mol Cell Endocrinol 278:18-28
16. Lee JH, Song MY, Song EK, Kim EK, Moon WS, Han MK, Park JW, Kwon KB, Park BH (2009) Overexpression of SIRT1 protects pancreatic beta cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway. Diabetes 58:344-351
17. Bae UJ, da Lee Y, Song MY, Lee SM, Park JW, Ryu JH, Park BH (2011) A prenylated flavan from Broussonetia Kazinoki prevents cytokine-induced β-cell death through suppression of nuclear factor-kB activity. Biol Pharm Bull 34:1026-1031
18. Jeong G-S, Lee D-S, Park B-H, Kwon K-B, Kim Y-C (2011) Sauchinone protects pancreatic β-cells against cytokine-mediated toxicity. Toxicol In Vitro 25:505-512
19. Seidel HM, Lamb P, Rosen J (2000) Pharmaceutical intervention in the JAK/STAT signaling pathway. Oncogene 19:2645-2656
20. Zanoli P (2004) Role of hyperforin in the pharmacological activities of St. John's Wort. CNS Drug Rev 10:203-218
21. Kasper S, Caraci F, Forti B, Drago F, Aguglia E (2010) Efficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression. Eur Neuropsychopharmacol 20:747-765
22. Tedeschi E, Menegazzi M, Margotto D, Suzuki H, Förstermann U, Kleiner H (2003) Anti-inflammatory actions of St. John's wort inhibition of human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1alpha(STAT1alpha) activation. J Pharmacol Exp Ther 307:254-261
23. Menegazzi M, Novelli M, Beffy P, D'Aleo V, Tedeschi E, Lupi R, Zoratti E, Marchetti P, Suzuki H, Masiello P (2008) Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell line. Int J Biochem Cell Biol 40:1509-1521
24. Novelli M, Fabregat ME, Fernandez-Alvarez J, Gomis R, Masiello P (2001) Metabolic and functional studies on isolated islets in a new rat model of type 2 diabetes. Mol Cell Endocrinol 175:57-66
25. Lupi R, Del Guerra S, Fierabracci V, Marselli L, Novelli M, Patanè G, Boggi U, Mosca F, Piro S, Del Prato S, Marchetti P (2002) Lipotoxicity in human pancreatic islets and the protective effect of metformin. Diabetes 51:134-137
26. Sgarbossa A, Dal Bosco M, Pressi G, Cuzzocrea S, Dal Toso R, Menegazzi M (2012) Phenylpropanoid glycosides from plant cell cultures induce heme oxygenase 1 gene expression in a human keratinocyte cell line by affecting the balance of NRF2 and BACH1 transcription factors. Chem Biol Interact 199:87-95
27. Masini M, Marselli L, Bugliani M, Martino L, Masiello P, Marchetti P, De Tata V (2012) Ultrastructural morphometric analysis of insulin secretory granules in human type 2 diabetes. Acta Diabetol 49(Suppl 1):S247-S252
28. Trayhurn P, Wood IS (2004) Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92:347-355
29. Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY (2002) Glucose induced beta cell production of IL-1β contributes to glucose toxicity in human pancreatic islets. J Clin Invest 110:851-860
30. Amoli MM, Bagher L (2005) Would blockage of cytokines improve the outcome of pancreatic islets transplantation? Med Hypotheses 66:816-819
31. Donath MI, Schumann DM, Faulenbach M, Ellingsgaard H, Perren A, Ehses JA (2008) Islet inflammation in type 2 diabetes: from metabolic stress to therapy. Diabetes Care 31:S161-S164
32. Giannoukakis N, Rudert WA, Trucco M, Robbins PD (2000) Protection of human islets from the effects of interleukin-1β by adenoviral gene transfer of an IkB repressor. J Biol Chem 275:36509-36513
33. Baker MS, Chen X, Cao XC, Kaufman DB (2001) Expression of a dominant negative inhibitor of NF-kB protects MIN6 beta-cells from cytokine-induced apoptosis. J Surg Res 97:117-122
34. Gysemans CA, Ladrière L, Callewaert H, Rasschaert J, Flamez D, Levy DE, Matthys P, Eizirik DL, Mathieu C (2005) Disruption of the γ-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells. Diabetes 54:2396-2403
35. SoRelle JA, Itoh T, Peng H, Kanak MA, Sugimoto K, Matsumoto S, Levy MF, Lawrence MC, Naziruddin B (2013) Withaferin A inhibits pro-inflammatory cytokine-induced damage to islets in culture and following transplantation. Diabetologia 56:814-824
36. Martino L, Masini M, Novelli M, Beffy P, Bugliani M, Marselli L, Masiello P, Marchetti P, De Tata V (2012) Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic islets. PLoS ONE 7(5):e36188. doi: 10.1371/journal.pone.0036188
37. Gurzov EN, Eizirik DL (2011) Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction. Trends Cell Biol 21:424-431